{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:49:03Z","timestamp":1786942143009,"version":"build-2736575974"},"reference-count":128,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.niox.2017.10.001","type":"journal-article","created":{"date-parts":[[2017,10,14]],"date-time":"2017-10-14T01:01:31Z","timestamp":1507942891000},"page":"68-83","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Targeting nitric oxide and NMDA receptor-associated pathways in treatment of high grade glial tumors. Hypotheses for nitro-memantine and nitrones"],"prefix":"10.1016","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7804-4087","authenticated-orcid":false,"given":"Meric A.","family":"Altinoz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lhan","family":"Elmaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.niox.2017.10.001_bib1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s12094-017-1613-6","article-title":"Rabies virus vaccine as an immune adjuvant against cancers and glioblastoma: new studies may resurrect a neglected potential","volume":"19","author":"Altinoz","year":"2017","journal-title":"Clin. Transl. Oncol."},{"issue":"3","key":"10.1016\/j.niox.2017.10.001_bib2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1055\/s-0035-1566120","article-title":"Hemoglobins, hemorphins, and 11p15.5 chromosomal region in cancer biology and immunity with special emphasis for brain tumors","volume":"77","author":"Altinoz","year":"2016","journal-title":"J. Neurol. Surg. A Cent. Eur. Neurosurg."},{"issue":"5","key":"10.1016\/j.niox.2017.10.001_bib3","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1021\/tx300042g","article-title":"Connecting the chemical and biological properties of nitric oxide","volume":"25","author":"Toledo","year":"2012","journal-title":"Chem. Res. Toxicol."},{"issue":"5","key":"10.1016\/j.niox.2017.10.001_bib4","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4103\/2319-4170.158624","article-title":"Nitric oxide: protein tyrosine phosphorylation and protein S-nitrosylation in cancer","volume":"38","author":"Monteiro","year":"2015","journal-title":"Biomed. J."},{"issue":"8","key":"10.1016\/j.niox.2017.10.001_bib5","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2174\/1566524011313080002","article-title":"iNOS: a potential therapeutic target for malignant glioma","volume":"13","author":"Jahani-Asl","year":"2013","journal-title":"Curr. Mol. Med."},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/nrm1569","article-title":"Protein S-nitrosylation: purview and parameters","volume":"6","author":"Hess","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.freeradbiomed.2011.04.010","article-title":"Nitric oxide signaling: classical, less classical, and nonclassical mechanisms","volume":"51","author":"Mart\u00ednez-Ruiz","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3109\/10715769309145868","article-title":"The reaction of no with superoxide","volume":"18","author":"Huie","year":"1993","journal-title":"Free Radic. Res. Commun."},{"issue":"12","key":"10.1016\/j.niox.2017.10.001_bib9","doi-asserted-by":"crossref","first-page":"7617","DOI":"10.1074\/jbc.272.12.7617","article-title":"Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite. A potential additional mechanism of nitric oxide-dependent toxicity","volume":"272","author":"van der Vliet","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.niox.2017.10.001_bib10","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/bph.12217","article-title":"Biological nitric oxide signalling: chemistry and terminology","volume":"169","author":"Heinrich","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.10.001_bib11","series-title":"Methods in Nitric Oxide Research","first-page":"71","article-title":"Donors of nitrogen oxides","author":"Feelisch","year":"1996"},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib12","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jmb.2009.10.042","article-title":"Structural analysis of cysteine S-nitrosylation: a modified acid-based motif and the emerging role of trans-nitrosylation","volume":"395","author":"Marino","year":"2010","journal-title":"J. Mol. Biol."},{"issue":"5","key":"10.1016\/j.niox.2017.10.001_bib13","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1089\/ars.2007.1853","article-title":"Protein tyrosine phosphorylation and protein tyrosine nitration in redox signaling","volume":"10","author":"Monteiro","year":"2008","journal-title":"Antioxid. Redox Signal"},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib14","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cardiores.2007.04.023","article-title":"Balancing reactivity against selectivity: the evolution of protein S-nitrosylation as an effector of cell signaling by nitric oxide","volume":"75","author":"Derakhshan","year":"2007","journal-title":"Cardiovasc Res."},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cbpa.2010.10.012","article-title":"The SNO-proteome: causation and classifications","volume":"15","author":"Seth","year":"2011","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"7187","key":"10.1016\/j.niox.2017.10.001_bib16","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nature06778","article-title":"Tumour maintenance is mediated by eNOS","volume":"452","author":"Lim","year":"2008","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.niox.2017.10.001_bib17","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1172\/JCI35079","article-title":"Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer","volume":"119","author":"Nanni","year":"2009","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.niox.2017.10.001_bib18","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1089\/ars.2012.4563","article-title":"Targeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma","volume":"19","author":"Yang","year":"2013","journal-title":"Antioxid. Redox Signal"},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.semcancer.2005.04.004","article-title":"Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin","volume":"15","author":"Lechner","year":"2005","journal-title":"Semin. Cancer Biol."},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib20","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.urology.2009.03.004","article-title":"Phase II study of nitric oxide donor for men with increasing prostate-specific antigen level after surgery or radiotherapy for prostate cancer","volume":"74","author":"Siemens","year":"2009","journal-title":"Urology"},{"issue":"Pt 5","key":"10.1016\/j.niox.2017.10.001_bib21","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1042\/BST0351364","article-title":"Novel agents for cancer prevention based on nitric oxide","volume":"35","author":"Rigas","year":"2007","journal-title":"Biochem. Soc. Trans."},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2174\/187152011795677517","article-title":"Anti-cancer activity of nitrones and observations on mechanism of action","volume":"11","author":"Floyd","year":"2011","journal-title":"Anticancer Agents Med. Chem."},{"issue":"7\u20138","key":"10.1016\/j.niox.2017.10.001_bib23","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1089\/ars.2006.8.1329","article-title":"The biphasic nature of nitric oxide responses in tumor biology","volume":"8","author":"Ridnour","year":"2006","journal-title":"Antioxid. Redox Signal"},{"issue":"6","key":"10.1016\/j.niox.2017.10.001_bib24","first-page":"1648","article-title":"Nitric oxide inhibits apoptosis downstream of cytochrome C release by nitrosylating caspase 9","volume":"62","author":"T\u00f6r\u00f6k","year":"2002","journal-title":"Cancer Res."},{"issue":"45","key":"10.1016\/j.niox.2017.10.001_bib25","doi-asserted-by":"crossref","first-page":"34124","DOI":"10.1074\/jbc.M602551200","article-title":"S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation. A novel antiapoptotic mechanism that suppresses apoptosis","volume":"281","author":"Azad","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.niox.2017.10.001_bib26","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1124\/mol.104.010504","article-title":"Redox regulation of PTEN by S-nitrosothiols","volume":"68","author":"Yu","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.niox.2017.10.001_bib27","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.freeradbiomed.2014.11.012","article-title":"Cancer cell metabolism and the modulating effects of nitric oxide","volume":"79","author":"Chang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"9","key":"10.1016\/j.niox.2017.10.001_bib28","doi-asserted-by":"crossref","first-page":"e44081","DOI":"10.1371\/journal.pone.0044081","article-title":"Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation","volume":"7","author":"Ridnour","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.niox.2017.10.001_bib29","doi-asserted-by":"crossref","first-page":"R125","DOI":"10.1186\/bcr3319","article-title":"Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer","volume":"14","author":"Switzer","year":"2012","journal-title":"Breast Cancer Res."},{"issue":"9","key":"10.1016\/j.niox.2017.10.001_bib30","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1158\/1541-7786.MCR-12-0124","article-title":"S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer","volume":"10","author":"Switzer","year":"2012","journal-title":"Mol. Cancer Res."},{"issue":"6","key":"10.1016\/j.niox.2017.10.001_bib31","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1074\/jbc.M109.059782","article-title":"S-nitrosylation at cysteine 498 of c-Src tyrosine kinase regulates nitric oxide-mediated cell invasion","volume":"285","author":"Rahman","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib32","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.niox.2008.02.001","article-title":"The low molecular weight S-nitrosothiol, S-nitroso-N-acetylpenicillamine, promotes cell cycle progression in rabbit aortic endothelial cells","volume":"18","author":"Oliveira","year":"2008","journal-title":"Nitric Oxide"},{"issue":"3","key":"10.1016\/j.niox.2017.10.001_bib33","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1089\/ars.2011.4455","article-title":"S-nitrosoglutathione and endothelial nitric oxide synthase-derived nitric oxide regulate compartmentalized ras S-nitrosylation and stimulate cell proliferation","volume":"18","author":"Batista","year":"2013","journal-title":"Antioxid. Redox Signal"},{"issue":"12","key":"10.1016\/j.niox.2017.10.001_bib34","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1016\/j.freeradbiomed.2010.10.691","article-title":"Thioredoxin 1 as a subcellular biomarker of redox imbalance in human prostate cancer progression","volume":"49","author":"Shan","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib35","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.niox.2017.10.001_bib36","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1084\/jem.169.5.1543","article-title":"Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells","volume":"169","author":"Stuehr","year":"1989","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib37","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.niox.2008.04.018","article-title":"Novel therapeutic applications of nitric oxide donors in cancer: roles in chemo- and immunosensitization to apoptosis and inhibition of metastases","volume":"19","author":"Bonavida","year":"2008","journal-title":"Nitric Oxide"},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/taap.1994.1189","article-title":"Bioactivation of nitroprusside by porcine endothelial cells","volume":"128","author":"Rochelle","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib39","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1021\/cr000040l","article-title":"Nitric oxide donors: chemical activities and biological applications","volume":"102","author":"Wang","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1016\/j.niox.2017.10.001_bib40","article-title":"Differential loss of cell viability after exposure of MCF-7 breast cancer cells and normal human mammary fibroblasts to s-nitroso-arylamides","volume":"246","author":"Monteiro","year":"2013","journal-title":"Abstr. Pap. ACS"},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib41","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1042\/BJ20080701","article-title":"Macrophage activation induces formation of the anti-inflammatory lipid cholesteryl-nitrolinoleate","volume":"417","author":"Ferreira","year":"2009","journal-title":"Biochem. J."},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib42","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.bbrc.2009.07.030","article-title":"Nitrated fatty acids prevent TNFalpha-stimulated inflammatory and atherogenic responses in endothelial cells","volume":"387","author":"Hwang","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"22","key":"10.1016\/j.niox.2017.10.001_bib43","doi-asserted-by":"crossref","first-page":"8167","DOI":"10.1073\/pnas.1402965111","article-title":"Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase","volume":"111","author":"Charles","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib44","doi-asserted-by":"crossref","first-page":"F942","DOI":"10.1152\/ajprenal.90236.2008","article-title":"Nitro-oleic acid protects the mouse kidney from ischemia and reperfusion injury","volume":"295","author":"Liu","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"5","key":"10.1016\/j.niox.2017.10.001_bib45","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s10528-016-9754-9","article-title":"A metabolic inhibitory cocktail for grave cancers: metformin, pioglitazone and lithium combination in treatment of pancreatic cancer and glioblastoma multiforme","volume":"54","author":"Elmaci","year":"2016","journal-title":"Biochem. Genet."},{"key":"10.1016\/j.niox.2017.10.001_bib46","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.niox.2013.04.004","article-title":"Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide","volume":"34","author":"Sawa","year":"2013","journal-title":"Nitric Oxide"},{"issue":"2\u20133","key":"10.1016\/j.niox.2017.10.001_bib47","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0014-5793(95)00763-Y","article-title":"Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase","volume":"369","author":"Brown","year":"1995","journal-title":"FEBS Lett."},{"issue":"2\u20133","key":"10.1016\/j.niox.2017.10.001_bib48","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0014-5793(94)01290-3","article-title":"Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase","volume":"356","author":"Brown","year":"1994","journal-title":"FEBS Lett."},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib49","doi-asserted-by":"crossref","first-page":"C840","DOI":"10.1152\/ajpcell.00325.2004","article-title":"Nitric oxide-induced persistent inhibition and nitrosylation of active site cysteine residues of mitochondrial cytochrome-c oxidase in lung endothelial cells","volume":"288","author":"Zhang","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib50","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1073\/pnas.0304653101","article-title":"Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: role of mitochondrial respiratory complexes and heat shock proteins","volume":"101","author":"Ramachandran","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.niox.2017.10.001_bib51","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.freeradbiomed.2010.01.015","article-title":"Mitochondrial reserve capacity in endothelial cells: the impact of nitric oxide and reactive oxygen species","volume":"48","author":"Dranka","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"Pt 3","key":"10.1016\/j.niox.2017.10.001_bib52","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1042\/BJ20051435","article-title":"Direct evidence for S-nitrosation of mitochondrial complex I","volume":"394","author":"Burwell","year":"2006","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s702-002-8232-1","article-title":"Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells","volume":"109","author":"Yamamoto","year":"2002","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib54","doi-asserted-by":"crossref","first-page":"R394","DOI":"10.1152\/ajpregu.00504.2004","article-title":"Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages","volume":"288","author":"Frost","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib55","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/abbi.1996.0276","article-title":"The effects of nitric oxide on electron transport complexes","volume":"331","author":"Welter","year":"1996","journal-title":"Arch. Biochem. Biophys."},{"issue":"5","key":"10.1016\/j.niox.2017.10.001_bib56","doi-asserted-by":"crossref","first-page":"E978","DOI":"10.1152\/ajpendo.00739.2009","article-title":"Nitration of specific tyrosines in FoF1 ATP synthase and activity loss in aging","volume":"298","author":"Haynes","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.niox.2017.10.001_bib57","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/sj.cdd.4401244","article-title":"Nitric oxide signaling regulates mitochondrial number and function","volume":"10","author":"Bossy-Wetzel","year":"2003","journal-title":"Cell Death Differ."},{"issue":"11","key":"10.1016\/j.niox.2017.10.001_bib58","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.freeradbiomed.2012.09.014","article-title":"Redox regulation of mitochondrial biogenesis","volume":"53","author":"Piantadosi","year":"2012","journal-title":"Free Radic. Biol. Med."},{"issue":"5608","key":"10.1016\/j.niox.2017.10.001_bib59","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1126\/science.1079368","article-title":"Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide","volume":"299","author":"Nisoli","year":"2003","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib60","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.cbpb.2005.04.022","article-title":"Nitric oxide and mitochondrial biogenesis: a key to long-term regulation of cellular metabolism","volume":"142","author":"Clementi","year":"2005","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib61","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ncb1080","article-title":"Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway","volume":"6","author":"Almeida","year":"2004","journal-title":"Nat. Cell Biol."},{"issue":"Pt 3","key":"10.1016\/j.niox.2017.10.001_bib62","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1042\/BJ20040886","article-title":"Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5'-AMP-activated protein kinase","volume":"384","author":"Cidad","year":"2004","journal-title":"Biochem. J."},{"issue":"5652","key":"10.1016\/j.niox.2017.10.001_bib63","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1126\/science.1088805","article-title":"Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha","volume":"302","author":"Hagen","year":"2003","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib64","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1158\/0008-5472.CAN-05-0333","article-title":"Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation","volume":"66","author":"Quintero","year":"2006","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib65","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1182\/blood.V97.4.1009","article-title":"Accumulation of HIF-1alpha under the influence of nitric oxide","volume":"97","author":"Sandau","year":"2001","journal-title":"Blood"},{"issue":"28","key":"10.1016\/j.niox.2017.10.001_bib66","doi-asserted-by":"crossref","first-page":"9727","DOI":"10.1523\/JNEUROSCI.0879-12.2012","article-title":"Endothelial cell-derived nitric oxide enhances aerobic glycolysis in astrocytes via HIF-1\u03b1-mediated target gene activation","volume":"32","author":"Brix","year":"2012","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib67","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1515\/BC.2003.026","article-title":"Modifications of glyceraldehyde-3-phosphate dehydrogenase induced by increasing concentrations of peroxynitrite: early recognition by 20S proteasome","volume":"384","author":"Buchczyk","year":"2003","journal-title":"Biol. Chem."},{"issue":"6","key":"10.1016\/j.niox.2017.10.001_bib68","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1074\/mcp.M300141-MCP200","article-title":"Tyrosine nitration impairs mammalian aldolase A activity","volume":"3","author":"Koeck","year":"2004","journal-title":"Mol. Cell Proteom."},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib69","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0022-3565(24)29541-0","article-title":"Inducible nitric oxide synthase neutralizes carbamoylating potential of 1,3-bis(2-chloroethyl)-1-nitrosourea in c6 glioma cells","volume":"297","author":"Yin","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib70","doi-asserted-by":"crossref","first-page":"428","DOI":"10.2174\/138161210790232158","article-title":"The dual role of nitric oxide in glioma","volume":"16","author":"Badn","year":"2010","journal-title":"Curr. Pharm. Des."},{"issue":"8","key":"10.1016\/j.niox.2017.10.001_bib71","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.neuint.2006.07.001","article-title":"Malignant glioma progression and nitric oxide","volume":"49","author":"Lam-Himlin","year":"2006","journal-title":"Neurochem. Int."},{"issue":"11","key":"10.1016\/j.niox.2017.10.001_bib72","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/ni.3545","article-title":"Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype","volume":"17","author":"Shen","year":"2016","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib73","first-page":"458","article-title":"Core canonical pathways involved in developing human glioblastoma multiforme (GBM)","volume":"3","author":"Ghosh","year":"2017","journal-title":"Int. J. Sci. Res. Sci. Eng. Technol."},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib74","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.yexcr.2015.05.018","article-title":"Development of resistance to antiglioma agents in rat C6 cells caused collateral sensitivity to doxorubicin","volume":"335","author":"Stojkovi\u0107","year":"2015","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib75","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0167-4889(98)00126-8","article-title":"Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX catalytic activity by phenyl-N-tert-butylnitrone (PBN)","volume":"1448","author":"Kotake","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"issue":"5\u20136","key":"10.1016\/j.niox.2017.10.001_bib76","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.currproblcancer.2016.05.001","article-title":"Giving another chance to mifepristone in pharmacotherapy for aggressive meningiomas-A likely synergism with hydroxyurea?","volume":"40","author":"Elmaci","year":"2016","journal-title":"Curr. Probl. Cancer"},{"issue":"5","key":"10.1016\/j.niox.2017.10.001_bib77","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/ijc.26106","article-title":"Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-\u03c0-activated nitric oxide donor PABA\/NO in malignant gliomas","volume":"130","author":"Kogias","year":"2012","journal-title":"Int. J. Cancer"},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib78","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/bit.24775","article-title":"Targeted nitric oxide delivery preferentially induces glioma cell chemosensitivity via altered p53 and O(6)-methylguanine-DNA methyltransferase activity","volume":"110","author":"Safdar","year":"2013","journal-title":"Biotechnol. Bioeng."},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib79","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1023\/B:NEON.0000027759.54516.7c","article-title":"Sclerosing meningioma: clinicopathological study of four cases","volume":"68","author":"Im","year":"2004","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.niox.2017.10.001_bib80","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(00)81871-1","article-title":"p53, the cellular gatekeeper for growth and division","volume":"88","author":"Levine","year":"1997","journal-title":"Cell"},{"issue":"18","key":"10.1016\/j.niox.2017.10.001_bib81","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1038\/sj.onc.1202154","article-title":"Synthesis and biological effects of NO in malignant glioma cells: modulation by cytokines including CD95L and TGF-beta, dexamethasone, and p53 gene transfer","volume":"17","author":"Rieger","year":"1998","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.niox.2017.10.001_bib82","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1080\/09553000050201145","article-title":"Induction of radioresistance to accelerated carbon-ion beams in recipient cells by nitric oxide excreted from irradiated donor cells of human glioblastoma","volume":"76","author":"Matsumoto","year":"2000","journal-title":"Int. J. Radiat. Biol."},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib83","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/abbi.2001.2540","article-title":"Evidence for peroxynitrite-mediated modifications to p53 in human gliomas: possible functional consequences","volume":"394","author":"Cobbs","year":"2001","journal-title":"Arch. Biochem. Biophys."},{"issue":"24","key":"10.1016\/j.niox.2017.10.001_bib84","first-page":"8670","article-title":"Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells","volume":"63","author":"Cobbs","year":"2003","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib85","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/j.1471-4159.2004.02395.x","article-title":"Nitric oxide-induced cell death of cerebrocortical murine astrocytes is mediated through p53- and Bax-dependent pathways","volume":"89","author":"Yung","year":"2004","journal-title":"J. Neurochem."},{"issue":"6","key":"10.1016\/j.niox.2017.10.001_bib86","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1111\/j.1471-4159.2006.03991.x","article-title":"The chemical biology of clinically tolerated NMDA receptor antagonists","volume":"97","author":"Chen","year":"2006","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.niox.2017.10.001_bib87","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1073\/pnas.89.8.3399","article-title":"mRNA coding for neurotransmitter receptors in a human astrocytoma","volume":"89","author":"Matute","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.niox.2017.10.001_bib88","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/nm0901-1010","article-title":"Glutamate release promotes growth of malignant gliomas","volume":"7","author":"Takano","year":"2001","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.niox.2017.10.001_bib89","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1006\/bbrc.1995.2533","article-title":"NMDA-dependent prostaglandin E2 release by human cultured astroglial cells is driven by nitric oxide","volume":"215","author":"Mollace","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib90","doi-asserted-by":"crossref","first-page":"854","DOI":"10.3171\/2013.12.JNS13641","article-title":"Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models","volume":"120","author":"Yohay","year":"2014","journal-title":"J. Neurosurg."},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib91","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3340\/jkns.2016.0101.006","article-title":"Memantine induces NMDAR1-mediated autophagic cell death in malignant glioma cells","volume":"60","author":"Yoon","year":"2017","journal-title":"J. Korean Neurosurg. Soc."},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib92","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.crad.2003.08.006","article-title":"In vivo single-voxel proton MR spectroscopy in the differentiation of high-grade gliomas and solitary metastases","volume":"59","author":"Fan","year":"2004","journal-title":"Clin. Radiol."},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib93","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/nbm.807","article-title":"Characterization of oligodendrogliomas using short echo time 1H MR spectroscopic imaging","volume":"16","author":"Rijpkema","year":"2003","journal-title":"NMR Biomed."},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib94","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1471-4159.2008.05301.x","article-title":"A role for glutamate in growth and invasion of primary brain tumors","volume":"105","author":"Sontheimer","year":"2008","journal-title":"J. Neurochem."},{"issue":"11","key":"10.1016\/j.niox.2017.10.001_bib95","doi-asserted-by":"crossref","first-page":"6372","DOI":"10.1073\/pnas.091113598","article-title":"Glutamate antagonists limit tumor growth","volume":"98","author":"Rzeski","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.niox.2017.10.001_bib96","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.neulet.2005.10.027","article-title":"Amantadine and memantine induce the expression of the glial cell line-derived neurotrophic factor in C6 glioma cells","volume":"394","author":"Caumont","year":"2006","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib97","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1750-3639.2008.00175.x","article-title":"EGR-1 is regulated by N-methyl-D-aspartate-receptor stimulation and associated with patient survival in human high grade astrocytomas","volume":"19","author":"Mittelbronn","year":"2009","journal-title":"Brain Pathol."},{"issue":"6","key":"10.1016\/j.niox.2017.10.001_bib98","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1007\/s10637-012-9794-x","article-title":"Blood glutamate scavengers prolong the survival of rats and mice with brain-implanted gliomas","volume":"30","author":"Ruban","year":"2012","journal-title":"Invest. New Drugs"},{"issue":"6","key":"10.1016\/j.niox.2017.10.001_bib99","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s10072-013-1604-5","article-title":"Activation of NMDA receptor of glutamate influences MMP-2 activity and proliferation of glioma cells","volume":"35","author":"Ramaswamy","year":"2014","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.niox.2017.10.001_bib100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7742(07)82001-0","article-title":"Inflammatory mediators leading to protein misfolding and uncompetitive\/fast off-rate drug therapy for neurodegenerative disorders","volume":"82","author":"Lipton","year":"2007","journal-title":"Int. Rev. Neurobiol."},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib101","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ceca.2009.12.009","article-title":"Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies","volume":"47","author":"Nakamura","year":"2010","journal-title":"Cell Calcium"},{"issue":"5","key":"10.1016\/j.niox.2017.10.001_bib102","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1179\/174313209X459075","article-title":"Expressions of some vital molecules: glioblastoma multiforme versus normal tissues","volume":"32","author":"Atukeren","year":"2010","journal-title":"Neurol. Res."},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib103","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1179\/1351000214Y.0000000106","article-title":"Comparative analysis of antioxidative systems in malignant and benign brain tumours","volume":"20","author":"Bogosavljevi\u0107","year":"2015","journal-title":"Redox Rep."},{"key":"10.1016\/j.niox.2017.10.001_bib104","first-page":"113","article-title":"The decrease in antioxidant potential in human brain tumours","volume":"47","author":"Dudek","year":"2002","journal-title":"Rocz. Akad. Med. Bialymst."},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib105","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.clineuro.2008.11.008","article-title":"Alterations in lipid peroxidation and antioxidant status in different types of intracranial tumors within their relative peritumoral tissues","volume":"111","author":"Zengin","year":"2009","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"27","key":"10.1016\/j.niox.2017.10.001_bib106","doi-asserted-by":"crossref","first-page":"E2518","DOI":"10.1073\/pnas.1306832110","article-title":"A\u03b2 induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss","volume":"110","author":"Talantova","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib107","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00441-013-1789-1","article-title":"Reciprocal disruption of neuronal signaling and A\u03b2 production mediated by extrasynaptic NMDA receptors: a downward spiral","volume":"356","author":"Rush","year":"2014","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.niox.2017.10.001_bib108","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1750-1326-9-48","article-title":"Oligomeric A\u03b2-induced synaptic dysfunction in Alzheimer's disease","volume":"9","author":"Tu","year":"2014","journal-title":"Mol. Neurodegener."},{"issue":"6","key":"10.1016\/j.niox.2017.10.001_bib109","doi-asserted-by":"crossref","first-page":"E17","DOI":"10.3171\/2014.9.FOCUS14485","article-title":"Phosphorylation of NMDA 2B at S1303 in human glioma peritumoral tissue: implications for glioma epileptogenesis","volume":"37","author":"Gao","year":"2014","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.niox.2017.10.001_bib110","doi-asserted-by":"crossref","first-page":"14781","DOI":"10.1038\/srep14781","article-title":"Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease","volume":"5","author":"Takahashi","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib111","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.tips.2015.10.002","article-title":"Protein S-nitrosylation as a therapeutic target for neurodegenerative diseases","volume":"37","author":"Nakamura","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib112","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s12031-015-0651-1","article-title":"Differential effects of pharmacologic and genetic modulation of NMDA receptor activity on HIV\/gp120-induced neuronal damage in an in vivo mouse model","volume":"58","author":"Nakanishi","year":"2016","journal-title":"J. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib113","first-page":"89","article-title":"Chemotherapy-related cognitive impairment or \u00ab chemobrain \u00bb: concept and state of art","volume":"15","author":"Bompaire","year":"2017","journal-title":"Geriatr. Psychol. Neuropsychiatr. Vieil."},{"key":"10.1016\/j.niox.2017.10.001_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2017.06.010","article-title":"Attention, processing speed, and executive functioning in pediatric brain tumor survivors treated with proton beam radiation therapy","author":"Antonini","year":"2017","journal-title":"Radiother. Oncol."},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib115","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/jmri.22106","article-title":"Multiparametric assessment of the anti-glioma properties of OKN007 by magnetic resonance imaging","volume":"31","author":"Garteiser","year":"2010","journal-title":"J. Magn. Reson Imaging"},{"issue":"3","key":"10.1016\/j.niox.2017.10.001_bib116","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/gcc.22022","article-title":"The human sulfatase 2 inhibitor 2,4-disulfonylphenyl-tert-butylnitrone (OKN-007) has an antitumor effect in hepatocellular carcinoma mediated via suppression of TGFB1\/SMAD2 and Hedgehog\/GLI1 signaling","volume":"52","author":"Zheng","year":"2013","journal-title":"Genes Chromosom. Cancer"},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib117","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/niox.2000.0281","article-title":"Inhibition of the cytokine-mediated inducible nitric oxide synthase expression in rat insulinoma cells by phenyl N-tert-butylnitrone","volume":"4","author":"Tabatabaie","year":"2000","journal-title":"Nitric Oxide"},{"issue":"15","key":"10.1016\/j.niox.2017.10.001_bib118","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.2174\/1389557516666160505115743","article-title":"Influencing COX-2 activity by COX related pathways in inflammation and cancer","volume":"16","author":"Yu","year":"2016","journal-title":"Mini Rev. Med. Chem."},{"issue":"3","key":"10.1016\/j.niox.2017.10.001_bib119","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/neuonc\/nov265","article-title":"Nuclear factor-\u03baB in glioblastoma: insights into regulators and targeted therapy","volume":"18","author":"Cahill","year":"2016","journal-title":"Neuro Oncol."},{"issue":"9","key":"10.1016\/j.niox.2017.10.001_bib120","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1080\/10715760701447322","article-title":"Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats","volume":"41","author":"Inoue","year":"2007","journal-title":"Free Radic. Res."},{"issue":"3","key":"10.1016\/j.niox.2017.10.001_bib121","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/jmri.21474","article-title":"Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography","volume":"28","author":"Asanuma","year":"2008","journal-title":"J. Magn. Reson Imaging"},{"issue":"1","key":"10.1016\/j.niox.2017.10.001_bib122","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.freeradbiomed.2007.09.006","article-title":"Phenyl-tert-butylnitrone induces tumor regression and decreases angiogenesis in a C6 rat glioma model","volume":"44","author":"Doblas","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.niox.2017.10.001_bib123","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.freeradbiomed.2011.04.037","article-title":"Effects of PBN and OKN007 in rodent glioma models assessed by 1H MR spectroscopy","volume":"51","author":"He","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.niox.2017.10.001_bib124","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/jmri.24935","article-title":"OKN-007 decreases tumor necrosis and tumor cell proliferation and increases apoptosis in a preclinical F98 rat glioma model","volume":"42","author":"de Souza","year":"2015","journal-title":"J. Magn. Reson Imaging"},{"issue":"3","key":"10.1016\/j.niox.2017.10.001_bib125","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/neuonc\/nos337","article-title":"Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007","volume":"15","author":"Towner","year":"2013","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.niox.2017.10.001_bib126","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.freeradbiomed.2015.06.026","article-title":"OKN-007 decreases free radical levels in a preclinical F98 rat glioma model","volume":"87","author":"Coutinho de Souza","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.niox.2017.10.001_bib127","first-page":"363","article-title":"OKN-007 decreases VEGFR-2 levels in a preclinical GL261 mouse glioma model","volume":"5","author":"de Souza","year":"2015","journal-title":"Am. J. Nucl. Med. Mol. Imaging"},{"issue":"8","key":"10.1016\/j.niox.2017.10.001_bib128","doi-asserted-by":"crossref","first-page":"e0134276","DOI":"10.1371\/journal.pone.0134276","article-title":"Inhibition of pediatric glioblastoma tumor growth by the anti-cancer agent OKN-007 in orthotopic mouse xenografts","volume":"10","author":"Coutinho de Souza","year":"2015","journal-title":"PLoS One"}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860317302148?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860317302148?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:03:50Z","timestamp":1761069830000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860317302148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":128,"alternative-id":["S1089860317302148"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2017.10.001","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting nitric oxide and NMDA receptor-associated pathways in treatment of high grade glial tumors. Hypotheses for nitro-memantine and nitrones","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2017.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}