{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:47:57Z","timestamp":1779313677470,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402919"],"award-info":[{"award-number":["81402919"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573421"],"award-info":[{"award-number":["81573421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173054"],"award-info":[{"award-number":["81173054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81330080"],"award-info":[{"award-number":["81330080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.niox.2018.05.004","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T23:57:26Z","timestamp":1526515046000},"page":"11-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["MiR-125b-5p is involved in oxygen and glucose deprivation injury in PC-12 cells via CBS\/H2S pathway"],"prefix":"10.1016","volume":"78","author":[{"given":"Yaqi","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuqing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2018.05.004_bib1","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/s41467-017-01311-y","article-title":"Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics","volume":"8","author":"Akaike","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.niox.2018.05.004_bib2","doi-asserted-by":"crossref","first-page":"12581","DOI":"10.1523\/JNEUROSCI.3338-08.2008","article-title":"MicroRNA-338 regulates local cytochrome c oxidase IV mRNA levels and oxidative phosphorylation in the axons of sympathetic neurons","volume":"28","author":"Aschrafi","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.niox.2018.05.004_bib3","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1681\/ASN.2012030268","article-title":"Cystathionine \u03b3-lyase protects against renal ischemia\/reperfusion by modulating oxidative stress","volume":"24","author":"Bos","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.niox.2018.05.004_bib4","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1002\/jcp.25773","article-title":"Acetoacetate induces hepatocytes apoptosis by the ROS-mediated MAPKs pathway in ketotic cows","volume":"232","author":"Du","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.niox.2018.05.004_bib5","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.lfs.2008.04.005","article-title":"Hydrogen sulfide protects rat lung from ischemia\u2013reperfusion injury","volume":"82","author":"Fu","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.niox.2018.05.004_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejpb.2015.09.020","article-title":"Treatment of stroke with liposomal neuroprotective agents under cerebral ischemia conditions","volume":"97","author":"Fukuta","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.niox.2018.05.004_bib7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s12031-014-0284-9","article-title":"Hydrogen sulfide protects the brain against ischemic reperfusion injury in a transient model of focal cerebral ischemia","volume":"54","author":"Gheibi","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.niox.2018.05.004_bib8","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1007\/s11033-014-3322-3","article-title":"Profiles of serum microRNAs; miR-125b-5p and miR223-3p serve as novel biomarkers for HBV-positive hepatocellular carcinoma","volume":"41","author":"Giray","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.niox.2018.05.004_bib9","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1161\/01.CIR.103.1.163","article-title":"Primary prevention of ischemic stroke A statement for healthcare professionals from the stroke council of the American heart association","volume":"103","author":"Goldstein","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.niox.2018.05.004_bib10","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.freeradbiomed.2015.07.156","article-title":"Preparation for oxidative stress under hypoxia and metabolic depression: revisiting the proposal two decades later","volume":"89","author":"Hermes-Lima","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.niox.2018.05.004_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138383","article-title":"Cardiovascular and cerebrovascular disease associated microRNAs are dysregulated in placental tissues affected with gestational hypertension, preeclampsia and intrauterine growth restriction","volume":"10","author":"Hromadnikova","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.niox.2018.05.004_bib12","doi-asserted-by":"crossref","first-page":"24895","DOI":"10.3390\/ijms161024895","article-title":"MicroRNAs regulate mitochondrial function in cerebral ischemia-reperfusion injury","volume":"16","author":"Hu","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.niox.2018.05.004_bib13","series-title":"Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide","first-page":"3","article-title":"H2S synthesizing enzymes: biochemistry and molecular aspects","author":"Huang","year":"2015"},{"key":"10.1016\/j.niox.2018.05.004_bib14","first-page":"1","article-title":"MicroRNA-29a induces apoptosis via increasing the Bax: Bcl-2 ratio in dermal fibroblasts of patients with systemic sclerosis","author":"Jafarinejad-Farsangi","year":"2015","journal-title":"Autoimmunity"},{"key":"10.1016\/j.niox.2018.05.004_bib15","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/ars.2010.3781","article-title":"The quantitative significance of the transsulfuration enzymes for H2S production in murine tissues","volume":"15","author":"Kabil","year":"2011","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.niox.2018.05.004_bib16","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.2337\/db05-1082","article-title":"l-Cysteine inhibits insulin release from the pancreatic \u03b2-cell possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter","volume":"55","author":"Kaneko","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.niox.2018.05.004_bib17","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.niox.2014.01.002","article-title":"The physiological role of hydrogen sulfide and beyond","volume":"41","author":"Kimura","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2018.05.004_bib18","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1096\/fj.04-1815fje","article-title":"Hydrogen sulfide protects neurons from oxidative stress","volume":"18","author":"Kimura","year":"2004","journal-title":"Faseb. J."},{"key":"10.1016\/j.niox.2018.05.004_bib19","article-title":"MiR-335 regulates Hif-1\u03b1 to reduce cell death in both mouse cell line and rat ischemic models","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.niox.2018.05.004_bib20","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.bbrc.2011.08.101","article-title":"Hydrogen sulphide inhibits cardiomyocyte hypertrophy by up-regulating miR-133a","volume":"413","author":"Liu","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.niox.2018.05.004_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139233","article-title":"Plasma exosomal miRNAs in persons with and without alzheimer disease: altered expression and prospects for biomarkers","volume":"10","author":"Lugli","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.niox.2018.05.004_bib22","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.neuint.2013.06.004","article-title":"Hydrogen sulfide prevents OGD\/R-induced apoptosis via improving mitochondrial dysfunction and suppressing an ROS-mediated caspase-3 pathway in cortical neurons","volume":"63","author":"Luo","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.niox.2018.05.004_bib23","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.bbagen.2013.05.037","article-title":"Chemical aspects of hydrogen sulfide measurements in physiological samples","volume":"1840","author":"Nagy","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.niox.2018.05.004_bib24","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbi.2015.04.014","article-title":"MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation","volume":"49","author":"Ni","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.niox.2018.05.004_bib25","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2174\/138945013804806424","article-title":"microRNAs: innovative targets for cerebral ischemia and stroke","volume":"14","author":"Ouyang","year":"2013","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.niox.2018.05.004_bib26","doi-asserted-by":"crossref","DOI":"10.1186\/1477-7827-7-10","article-title":"The endogenous production of hydrogen sulphide in intrauterine tissues","volume":"7","author":"Patel","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.niox.2018.05.004_bib27","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1261\/rna.044008.113","article-title":"Brain-specific knockdown of miR-29 results in neuronal cell death and ataxia in mice","volume":"20","author":"Roshan","year":"2014","journal-title":"RNA"},{"key":"10.1016\/j.niox.2018.05.004_bib28","article-title":"Hydrogen sulfide improves drought tolerance in Arabidopsis thaliana by microRNA expressions","volume":"8","author":"Shen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.niox.2018.05.004_bib29","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1089\/ars.2014.5909","article-title":"miRNA-30 family inhibition protects against cardiac ischemic injury by regulating cystathionine-\u03b3-lyase expression","volume":"22","author":"Shen","year":"2015","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.niox.2018.05.004_bib30","doi-asserted-by":"crossref","first-page":"9184","DOI":"10.3168\/jds.2016-11219","article-title":"beta-Hydroxybutyrate induces bovine hepatocyte apoptosis via an ROS-p38 signaling pathway","volume":"99","author":"Song","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.niox.2018.05.004_bib31","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1046\/j.1471-4159.2003.01908.x","article-title":"Regulation of brain mitochondrial H2O2 production by membrane potential and NAD (P) H redox state","volume":"86","author":"Starkov","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.niox.2018.05.004_bib32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.redox.2012.11.006","article-title":"Redox biology of hydrogen sulfide: implications for physiology, pathophysiology, and pharmacology","volume":"1","author":"Stein","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.niox.2018.05.004_bib33","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1159\/000478765","article-title":"Histamine induces bovine rumen epithelial cell inflammatory response via NF-kappab pathway","volume":"42","author":"Sun","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.niox.2018.05.004_bib34","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuroscience.2010.02.006","article-title":"Hydrogen sulfide protects neurons against hypoxic injury via stimulation of ATP-sensitive potassium channel\/protein kinase C\/extracellular signal-regulated kinase\/heat shock protein90 pathway","volume":"167","author":"Tay","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.niox.2018.05.004_bib35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/FJC.0b013e3181ac8e12","article-title":"S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia\/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway","volume":"54","author":"Wang","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.niox.2018.05.004_bib36","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.brainres.2015.07.001","article-title":"Hydrogen sulfide induces neuroprotection against experimental stroke in rats by down-regulation of AQP4 via activating PKC","volume":"1622","author":"Wei","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.niox.2018.05.004_bib37","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1089\/ars.2012.5024","article-title":"Hydrogen sulfide treatment promotes glucose uptake by increasing insulin receptor sensitivity and ameliorates kidney lesions in type 2 diabetes","volume":"19","author":"Xue","year":"2013","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.niox.2018.05.004_bib38","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine \u03b3-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.niox.2018.05.004_bib39","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.brainres.2012.10.046","article-title":"Exogenous hydrogen sulfide protects against global cerebral ischemia\/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats","volume":"1491","author":"Yin","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.niox.2018.05.004_bib40","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1159\/000430317","article-title":"ROS-dependent neuroprotective effects of NaHS in ischemia brain injury involves the PARP\/AIF pathway","volume":"36","author":"Yu","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.niox.2018.05.004_bib41","first-page":"1621","article-title":"PUMA is a novel target of miR-221\/222 in human epithelial cancers","volume":"37","author":"Zhang","year":"2010","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.niox.2018.05.004_bib42","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1021\/cn500185g","article-title":"Hydrogen sulfide: a neuromodulator and neuroprotectant in the central nervous system","volume":"5","author":"Zhang","year":"2014","journal-title":"ACS Chem. Neurosci."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860317303373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860317303373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:34:20Z","timestamp":1778589260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860317303373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":42,"alternative-id":["S1089860317303373"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2018.05.004","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MiR-125b-5p is involved in oxygen and glucose deprivation injury in PC-12 cells via CBS\/H2S pathway","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2018.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}