{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:38:21Z","timestamp":1772815101019,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T00:00:00Z","timestamp":1562371200000},"content-version":"am","delay-in-days":308,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005782","name":"Nara Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS KAKENHI","doi-asserted-by":"publisher","award":["24790774"],"award-info":[{"award-number":["24790774"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS KAKENHI","doi-asserted-by":"publisher","award":["22790567"],"award-info":[{"award-number":["22790567"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS KAKENHI","doi-asserted-by":"publisher","award":["25860447"],"award-info":[{"award-number":["25860447"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS KAKENHI","doi-asserted-by":"publisher","award":["25461393"],"award-info":[{"award-number":["25461393"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS KAKENHI","doi-asserted-by":"publisher","award":["15H04776"],"award-info":[{"award-number":["15H04776"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS KAKENHI","doi-asserted-by":"publisher","award":["15H04777"],"award-info":[{"award-number":["15H04777"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008734","name":"Mitsui Sumitomo Insurance Welfare Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008882","name":"Meiji Yasuda Life Foundation of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008882","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008927","name":"Osaka Gas Group Welfare Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008927","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012627","name":"Japan Diabetes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012627","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005928","name":"Daiwa Securities Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["AS242Z03522P"],"award-info":[{"award-number":["AS242Z03522P"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["AS262Z01692P"],"award-info":[{"award-number":["AS262Z01692P"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"name":"YKK AP Inc."},{"name":"Ushio Inc."},{"name":"Nara Prefecture Health Promotion Foundation"},{"DOI":"10.13039\/501100005782","name":"Nara Medical University Grant-in-Aid for Collaborative Research Projects","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005782","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tokyo Electric Power Company"},{"name":"EnviroLife Research Institute Co., Ltd."},{"DOI":"10.13039\/501100012020","name":"Sekisui Chemical Co., Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012020","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.niox.2018.07.001","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T14:16:36Z","timestamp":1530627396000},"page":"25-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Gender differences in the relationships between chronic kidney disease, asymmetric dimethylarginine, and sleep quality: The HEIJO-KYO cohort"],"prefix":"10.1016","volume":"79","author":[{"given":"Kenji","family":"Obayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Kurumatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Saeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2018.07.001_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/sleep\/23.1.1a","volume":"23","author":"Kim","year":"2000","journal-title":"Sleep"},{"key":"10.1016\/j.niox.2018.07.001_bib2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2188\/jea.10.79","article-title":"Prevalence of sleep disturbance and hypnotic medication use in relation to sociodemographic factors in the general Japanese adult population","volume":"10","author":"Doi","year":"2000","journal-title":"J. Epidemiol."},{"key":"10.1016\/j.niox.2018.07.001_bib3","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1001\/jama.1989.03430110069030","article-title":"Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention?","volume":"262","author":"Ford","year":"1989","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.niox.2018.07.001_bib4","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1056\/NEJM199008233230805","article-title":"Geriatrics: sleep disorders and aging","volume":"323","author":"Prinz","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.niox.2018.07.001_bib5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.5665\/sleep.1700","article-title":"Increased prevalence of insomnia and changes in hypnotics use in England over 15 years: analysis of the 1993, 2000, and 2007 national psychiatric morbidity surveys","volume":"35","author":"Calem","year":"2012","journal-title":"Sleep"},{"key":"10.1016\/j.niox.2018.07.001_bib6","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1093\/oxfordjournals.aje.a116381","article-title":"Myocardial infarction and coronary death among women: psychosocial predictors from a 20-year follow-up of women in the Framingham study","volume":"135","author":"Eaker","year":"1992","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.niox.2018.07.001_bib7","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1046\/j.1532-5415.2001.49235.x","article-title":"The impact of insomnia on cognitive functioning in older adults","volume":"49","author":"Cricco","year":"2001","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.niox.2018.07.001_bib8","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1093\/sleep\/33.12.1693","article-title":"Association between depression and insomnia subtypes: a longitudinal study on the elderly in Japan","volume":"33","author":"Yokoyama","year":"2010","journal-title":"Sleep"},{"key":"10.1016\/j.niox.2018.07.001_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/01.PSY.0000039756.23250.7C","article-title":"Healthy older adults' sleep predicts all-cause mortality at 4 to 19 years of follow-up","volume":"65","author":"Dew","year":"2003","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.niox.2018.07.001_bib10","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1053\/j.ajkd.2012.04.027","article-title":"Sleep disturbances as nontraditional risk factors for development and progression of CKD: review of the evidence","volume":"60","author":"Turek","year":"2012","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.niox.2018.07.001_bib11","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nrn2214","article-title":"Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity","volume":"8","author":"Calabrese","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.niox.2018.07.001_bib12","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.smrv.2012.01.006","article-title":"Nitric oxide in the regulation of the sleep-wake states","volume":"16","author":"Cespuglio","year":"2012","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.niox.2018.07.001_bib13","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1161\/01.CIR.98.18.1842","article-title":"Asymmetric dimethylarginine (ADMA). a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia","volume":"98","author":"B\u00f6ger","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.niox.2018.07.001_bib14","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.CIR.0000027109.14149.67","article-title":"Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase","volume":"106","author":"Lin","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.niox.2018.07.001_bib15","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1210\/jc.2012-1873","article-title":"Positive effect of daylight exposure on nocturnal urinary melatonin excretion in the elderly: a cross-sectional analysis of the HEIJO-KYO study","volume":"97","author":"Obayashi","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.niox.2018.07.001_bib16","unstructured":"Philips Respironics Actiware Tutorials: available at: http:\/\/www.actigraphy.com\/solutions\/actiware\/tutorials.html (accessed on August 20, 2017)."},{"key":"10.1016\/j.niox.2018.07.001_bib17","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/sleep\/31.11.1569","article-title":"Interpreting wrist actigraphic indices of sleep in epidemiologic studies of the elderly: the study of osteoporotic fractures","volume":"31","author":"Mehra","year":"2008","journal-title":"Sleep"},{"key":"10.1016\/j.niox.2018.07.001_bib18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.niox.2018.07.001_bib19","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.2215\/CJN.00010108","article-title":"Coronary artery calcification, ADMA, and insulin resistance in CKD patients","volume":"3","author":"Kobayashi","year":"2008","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.niox.2018.07.001_bib20","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1053\/j.ajkd.2008.12.034","article-title":"Revised equations for estimated GFR from serum creatinine in Japan","volume":"53","author":"Matsuo","year":"2009","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.niox.2018.07.001_bib21","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1053\/j.ajkd.2010.02.344","article-title":"Modification of the CKD epidemiology collaboration (CKD-EPI) equation for Japanese: accuracy and use for population estimates","volume":"56","author":"Horio","year":"2010","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.niox.2018.07.001_bib22","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1177\/0956797613480187","article-title":"The relative trustworthiness of inferential tests of the indirect effect in statistical mediation analysis: does method really matter?","volume":"24","author":"Hayes","year":"2013","journal-title":"Psychol. Sci."},{"key":"10.1016\/j.niox.2018.07.001_bib23","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1053\/j.ajkd.2008.10.045","article-title":"Comparison of sleep\/wake behavior in CKD stages 4 to 5 and hemodialysis populations using wrist actigraphy","volume":"53","author":"Barmar","year":"2009","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.niox.2018.07.001_bib24","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.2215\/CJN.10581110","article-title":"Sleep and activity in chronic kidney disease: a longitudinal study","volume":"6","author":"Agarwal","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.niox.2018.07.001_bib25","doi-asserted-by":"crossref","first-page":"986","DOI":"10.2215\/CJN.05720710","article-title":"Sleep-disordered breathing and excessive daytime sleepiness in chronic kidney disease and hemodialysis","volume":"6","author":"Roumelioti","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.niox.2018.07.001_bib26","doi-asserted-by":"crossref","first-page":"945","DOI":"10.5665\/sleep.5660","article-title":"Sleep characteristics in early stages of chronic kidney disease in the HypnoLaus cohort","volume":"39","author":"Ogna","year":"2016","journal-title":"Sleep"},{"key":"10.1016\/j.niox.2018.07.001_bib27","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1161\/01.ATV.0000136656.26019.6e","article-title":"Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice: involvement of renin-angiotensin system and oxidative stress","volume":"24","author":"Suda","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.niox.2018.07.001_bib28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/01.CIR.0000042700.48769.59","article-title":"Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency","volume":"107","author":"Shlipak","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.niox.2018.07.001_bib29","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1152\/physrev.2001.81.1.209","article-title":"Physiology of nitric oxide in skeletal muscle","volume":"81","author":"Stamler","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.niox.2018.07.001_bib30","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1161\/01.CIR.0000091083.61609.DF","article-title":"Estrogen stimulates dimethylarginine dimethylaminohydrolase activity and the metabolism of asymmetric dimethylarginine","volume":"108","author":"Holden","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.niox.2018.07.001_bib31","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/j.1532-5415.2012.04044.x","article-title":"Objectively measured sleep quality and nursing home placement in older women","volume":"60","author":"Spira","year":"2012","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.niox.2018.07.001_bib32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1365-2869.2007.00592.x","article-title":"Improving actigraphic sleep estimates in insomnia and dementia: how many nights?","volume":"16","author":"Van Someren","year":"2007","journal-title":"J. Sleep Res."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860317303518?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860317303518?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:03:05Z","timestamp":1761069785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860317303518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":32,"alternative-id":["S1089860317303518"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2018.07.001","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gender differences in the relationships between chronic kidney disease, asymmetric dimethylarginine, and sleep quality: The HEIJO-KYO cohort","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2018.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}