{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:50:17Z","timestamp":1762145417542},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Cukurova University Research Foundation","award":["TF2013BAP2"],"award-info":[{"award-number":["TF2013BAP2"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.niox.2019.02.001","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T23:12:14Z","timestamp":1550013134000},"page":"54-60","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Involvement of RhoA\/Rho-kinase in l-cysteine\/H2S pathway-induced inhibition of agonist-mediated corpus cavernosal smooth muscle contraction"],"prefix":"10.1016","volume":"85","author":[{"given":"Fatma","family":"Aydinoglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif \u00d6zveren","family":"Ad\u0131belli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didem","family":"Y\u0131lmaz-Oral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuran","family":"Ogulener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.niox.2019.02.001_bib1","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"FASEB J."},{"issue":"8","key":"10.1016\/j.niox.2019.02.001_bib2","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s12272-009-1806-9","article-title":"Subtle interplay of endogenous bioactive gases (NO, CO and H(2)S in inflammation","volume":"32","author":"Pae","year":"2009","journal-title":"Arch Pharm. Res."},{"issue":"2","key":"10.1016\/j.niox.2019.02.001_bib3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ceca.2012.07.001","article-title":"Hydrogen sulfide as a regulator of calcium channels","volume":"53","author":"Munaron","year":"2013","journal-title":"Cell Calcium"},{"issue":"3","key":"10.1016\/j.niox.2019.02.001_bib4","first-page":"243","article-title":"Endogenous production of hydrogen sulfide in mammals","volume":"26","author":"Kamaoun","year":"2004","journal-title":"Amino Acids"},{"issue":"9","key":"10.1016\/j.niox.2019.02.001_bib5","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/ars.2009.2919","article-title":"Hydrogen sulfide: from brain to gut","volume":"12","author":"Kimura","year":"2010","journal-title":"Antioxidants Redox Signal."},{"issue":"1","key":"10.1016\/j.niox.2019.02.001_bib6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00726-010-0510-x","article-title":"Hydrogen sulfide: its production, release and functions","volume":"41","author":"Kimura","year":"2011","journal-title":"Amino Acids"},{"issue":"11","key":"10.1016\/j.niox.2019.02.001_bib7","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6","author":"Szab\u00f3","year":"2007","journal-title":"Nat. Rev. Drug"},{"issue":"5","key":"10.1016\/j.niox.2019.02.001_bib8","doi-asserted-by":"crossref","first-page":"H2316","DOI":"10.1152\/ajpheart.00331.2004","article-title":"Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats","volume":"287","author":"Cheng","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1\u20133","key":"10.1016\/j.niox.2019.02.001_bib9","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ejphar.2009.01.011","article-title":"Myosin light chain phosphatase activation is involved in the hydrogen sulfide-induced relaxation in mouse gastric fundus","volume":"606","author":"Dhaese","year":"2009","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.niox.2019.02.001_bib10","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/1440-1681.12554","article-title":"Characterization of relaxant mechanism of H2S in mouse corpus cavernosum","volume":"43","author":"Aydinoglu","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"5","key":"10.1016\/j.niox.2019.02.001_bib11","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/j.1743-6109.2007.00561.x","article-title":"Hydrogen sulphide: a novel endogenous gasotransmitter facilitates erectile function","volume":"4","author":"Srilatha","year":"2007","journal-title":"J. Sex. Med."},{"issue":"11","key":"10.1016\/j.niox.2019.02.001_bib12","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1073\/pnas.0807974105","article-title":"Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation","volume":"106","author":"d'Emmanuele di Villa Bianca","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"9","key":"10.1016\/j.niox.2019.02.001_bib13","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.bcp.2012.01.026","article-title":"Role of endogenous hydrogen sulfide in neurogenic relaxation of rat corpus cavernosum","volume":"83","author":"Ghasemi","year":"2012","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.niox.2019.02.001_bib14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/ijir.2012.39","article-title":"P Ganesan Adaikan, B. Srilatha, Hydrogen sulfide promotes nitric oxide production in corpus cavernosum by enhancing expression of endothelial nitric oxide synthase","volume":"25","author":"Meng","year":"2013","journal-title":"Int. J. Impot. Res."},{"issue":"5","key":"10.1016\/j.niox.2019.02.001_bib15","doi-asserted-by":"crossref","first-page":"H835","DOI":"10.1152\/ajpheart.00293.2015","article-title":"Analysis of erectile responses to H2S donors in the anesthetized rat","volume":"309","author":"Jupiter","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2019.02.001_bib16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/372231a0","article-title":"Signal transduction and regulation in smooth muscle","volume":"372","author":"Somlyo","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.niox.2019.02.001_bib17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1540\/jsmr.40.155","article-title":"The role of RhoA-mediated Ca2+ sensitization of bronchial smooth muscle contraction in airway hyperresponsiveness","volume":"40","author":"Chiba","year":"2004","journal-title":"J. Smooth Muscle Res."},{"key":"10.1016\/j.niox.2019.02.001_bib18","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1038\/sj.ijir.3901068","article-title":"Vasoconstriction, RhoA\/Rho-kinase and the erectile response","volume":"15","author":"Mills","year":"2003","journal-title":"Int. J. Impot. Res."},{"issue":"5","key":"10.1016\/j.niox.2019.02.001_bib19","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1111\/j.1743-6109.2012.02662.x","article-title":"Rho kinase (ROK)-related proteins in human cavernous arteries: an immunohistochemical and functional approach","volume":"9","author":"Waldkirch","year":"2012","journal-title":"J. Sex. Med."},{"issue":"3","key":"10.1016\/j.niox.2019.02.001_bib20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00210-015-1204-4","article-title":"The effect of sub-chronic systemic ethanol treatment on corpus cavernosal smooth muscle contraction: the contribution of RhoA\/Rho-kinase","volume":"389","author":"Kumcu","year":"2016","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"5","key":"10.1016\/j.niox.2019.02.001_bib21","first-page":"1","article-title":"Inhibition of RhoA\/Rho kinase pathway and smooth muscle contraction by hydrogen sulfide","author":"Nalli","year":"2017","journal-title":"Pharmacol. Res. Perspect"},{"issue":"1","key":"10.1016\/j.niox.2019.02.001_bib22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1124\/jpet.115.227017","article-title":"Involvement of potassium channels and calcium-independent mechanisms in hydrogen sulfide-induced relaxation of rat Mesenteric small arteries","volume":"356","author":"Hedegaard","year":"2016","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"6","key":"10.1016\/j.niox.2019.02.001_bib23","doi-asserted-by":"crossref","first-page":"C485","DOI":"10.1152\/ajpcell.00280.2014","article-title":"Inhibition of RhoA-dependent pathway and contraction by endogenous hydrogen sulfide in rabbit gastric smooth muscle cells","volume":"308","author":"Nalli","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"4","key":"10.1016\/j.niox.2019.02.001_bib24","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.pharep.2017.02.018","article-title":"The role of arachidonic acid\/cyclooxygenase cascade, phosphodiesterase IV and Rho-kinase in H2S-induced relaxation in the mouse corpus cavernosum","volume":"69","author":"Aydinoglu","year":"2017","journal-title":"Pharmacol. Rep."},{"issue":"1\u20133","key":"10.1016\/j.niox.2019.02.001_bib25","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ejphar.2006.02.001","article-title":"Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction--a pilot study","volume":"535","author":"Srilatha","year":"2006","journal-title":"Eur. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.niox.2019.02.001_bib26","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1111\/jsm.12993","article-title":"Resveratrol stimulates hydrogen sulfide (H2S) formation to relax murine corpus cavernosum","volume":"12","author":"Yetik-Anacak","year":"2015","journal-title":"J. Sex. Med."},{"issue":"21","key":"10.1016\/j.niox.2019.02.001_bib27","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"issue":"2","key":"10.1016\/j.niox.2019.02.001_bib28","doi-asserted-by":"crossref","first-page":"H474","DOI":"10.1152\/ajpheart.00013.2002","article-title":"H(2)S-induced vasorelaxation and underlying cellular and molecular mechanisms","volume":"283","author":"Zhao","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5","key":"10.1016\/j.niox.2019.02.001_bib29","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/00029330-200803010-00010","article-title":"Effects of nitric oxide and hydrogen sulfide on the relaxation of pulmonary arteries in rats","volume":"121","author":"Wang","year":"2008","journal-title":"Chin. Med. J. (Engl)."},{"key":"10.1016\/j.niox.2019.02.001_bib30","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.niox.2017.08.005","article-title":"The interaction of l-cysteine\/H2S pathway and muscarinic acetylcholine receptors (mAChRs) in mouse corpus cavernosum","volume":"70","author":"Aydinoglu","year":"2017","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2019.02.001_bib31","first-page":"856","article-title":"Inhibition of sympathetic neuroeffector transmission in human corpus cavernosum","volume":"110","author":"Gur","year":"2012","journal-title":"Br. JUI."},{"issue":"1","key":"10.1016\/j.niox.2019.02.001_bib32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/83258","article-title":"Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway","volume":"7","author":"Chitaley","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.niox.2019.02.001_bib33","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/sj.bjp.0704124","article-title":"Y-27632, an inhibitor of Rho-kinase, antagonizes noradrenergic contractions in the rabbit and human penile corpus cavernosum","volume":"133","author":"Rees","year":"2001","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.niox.2019.02.001_bib34","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00345-005-0026-2","article-title":"Cyclic AMP-specific and cyclic GMP-specific phosphodiesterase isoenzymes in human cavernous arteries-immunohistochemical distribution and functional significance","volume":"23","author":"Waldkirch","year":"2005","journal-title":"World J. Urol."},{"issue":"4","key":"10.1016\/j.niox.2019.02.001_bib35","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1152\/physrev.00023.2003","article-title":"Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase","volume":"83","author":"Somlyo","year":"2003","journal-title":"Physiol. Rev."},{"issue":"52","key":"10.1016\/j.niox.2019.02.001_bib36","doi-asserted-by":"crossref","first-page":"37385","DOI":"10.1074\/jbc.274.52.37385","article-title":"Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase","volume":"274","author":"Feng","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.niox.2019.02.001_bib37","doi-asserted-by":"crossref","first-page":"9121","DOI":"10.1073\/pnas.0400520101","article-title":"RhoA\/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction","volume":"101","author":"Bivalacqua","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860318303367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860318303367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T15:28:42Z","timestamp":1573918122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860318303367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":37,"alternative-id":["S1089860318303367"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2019.02.001","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of RhoA\/Rho-kinase in l-cysteine\/H2S pathway-induced inhibition of agonist-mediated corpus cavernosal smooth muscle contraction","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2019.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}