{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:26:27Z","timestamp":1775082387596,"version":"3.50.1"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.niox.2019.10.007","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T12:05:28Z","timestamp":1571745928000},"page":"54-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Central angiotensin II-Protein inhibitor of neuronal nitric oxide synthase (PIN) axis contribute to neurogenic hypertension"],"prefix":"10.1016","volume":"94","author":[{"given":"Neeru M.","family":"Sharma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea S.","family":"Haibara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Katsurada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaushik P.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2019.10.007_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1081\/CEH-100001196","article-title":"Sympathetic nervous system, diabetes, and hypertension","volume":"23","author":"Perin","year":"2001","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.niox.2019.10.007_bib2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1749-6632.2001.tb03696.x","article-title":"The regulation of sympathetic outflow in heart failure. The roles of angiotensin II, nitric oxide, and exercise training","volume":"940","author":"Zucker","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.niox.2019.10.007_bib3","doi-asserted-by":"crossref","first-page":"R387","DOI":"10.1152\/ajpregu.00046.2012","article-title":"Exercise training normalizes enhanced sympathetic activation from the paraventricular nucleus in chronic heart failure: role of angiotensin II","volume":"303","author":"Zheng","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.niox.2019.10.007_bib4","doi-asserted-by":"crossref","first-page":"H843","DOI":"10.1152\/ajpheart.00170.2013","article-title":"Angiotensin II-mediated posttranslational modification of nNOS in the PVN of rats with CHF: role for PIN","volume":"305","author":"Sharma","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"Suppl 5","key":"10.1016\/j.niox.2019.10.007_bib5","first-page":"S19","article-title":"Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders","volume":"9","author":"Fyhrquist","year":"1995","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.niox.2019.10.007_bib6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s11906-009-0035-4","article-title":"The role of cardiac autonomic function in hypertension and cardiovascular disease","volume":"11","author":"Palatini","year":"2009","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.niox.2019.10.007_bib7","first-page":"734","article-title":"The versatile and complex enzymology of nitric oxide synthase","volume":"63","author":"Gorren","year":"1998","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.niox.2019.10.007_bib8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0005-2728(99)00016-X","article-title":"Mammalian nitric oxide synthases","volume":"1411","author":"Stuehr","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.niox.2019.10.007_bib9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3181\/00379727-219-44331","article-title":"Tetrahydrobiopterin, cytokines, and nitric oxide synthesis","volume":"219","author":"Werner","year":"1998","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.niox.2019.10.007_bib10","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1089\/ars.2007.1959","article-title":"Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective","volume":"10","author":"Chen","year":"2008","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.niox.2019.10.007_bib11","first-page":"R864","article-title":"Nitric oxide within the paraventricular nucleus mediates changes in renal sympathetic nerve activity","volume":"273","author":"Zhang","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.niox.2019.10.007_bib12","first-page":"R728","article-title":"Effect of nitric oxide within the paraventricular nucleus on renal sympathetic nerve discharge:role of GABA","volume":"275","author":"Zhang","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.niox.2019.10.007_bib13","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1113\/EP086744","article-title":"Hypothalamic paraventricular nucleus neuronal nitric oxide synthase activity is a major determinant of renal sympathetic discharge in conscious Wistar rats","volume":"103","author":"McBryde","year":"2018","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.niox.2019.10.007_bib14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0896-6273(00)80439-0","article-title":"CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95","volume":"20","author":"Jaffrey","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.niox.2019.10.007_bib15","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1126\/science.274.5288.774","article-title":"PIN: an associated protein inhibitor of neuronal nitric oxide synthase","volume":"274","author":"Jaffrey","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.niox.2019.10.007_bib16","doi-asserted-by":"crossref","first-page":"33472","DOI":"10.1074\/jbc.273.50.33472","article-title":"Protein inhibitor of neuronal nitric-oxide synthase, PIN, binds to a 17-amino acid residue fragment of the enzyme","volume":"273","author":"Fan","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.niox.2019.10.007_bib17","doi-asserted-by":"crossref","first-page":"17407","DOI":"10.1074\/jbc.M000155200","article-title":"Ubiquitination of neuronal nitric oxide synthase in vitro and in vivo","volume":"275","author":"Bender","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.niox.2019.10.007_bib18","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1124\/mol.104.000125","article-title":"Ubiquitination and degradation of neuronal nitric-oxide synthase in vitro: dimer stabilization protects the enzyme from proteolysis","volume":"66","author":"Dunbar","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.niox.2019.10.007_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1046\/j.1365-201X.2003.01043.x","article-title":"Paraventricular nucleus of the hypothalamus and elevated sympathetic activity in heart failure: altered inhibtory mechanisms","volume":"177","author":"Li","year":"2003","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.niox.2019.10.007_bib20","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/cvr\/cvr217","article-title":"Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure: role for CAPON and Ang II","volume":"92","author":"Sharma","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.niox.2019.10.007_bib21","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1986"},{"key":"10.1016\/j.niox.2019.10.007_bib22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.niox.2019.03.005","article-title":"Exercise training augments neuronal nitric oxide synthase dimerization in the paraventricular nucleus of rats with chronic heart failure","volume":"87","author":"Sharma","year":"2019","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2019.10.007_bib23","doi-asserted-by":"crossref","first-page":"R1035","DOI":"10.1152\/ajpregu.00338.2004","article-title":"Angiotensin-mediated increase in renal sympathetic nerve discharge within the PVN: role of nitric oxide","volume":"290","author":"Li","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.niox.2019.10.007_bib24","series-title":"Brain Microdissection Techniques","article-title":"Brain microdissection techniques","author":"Palkovits","year":"1983"},{"key":"10.1016\/j.niox.2019.10.007_bib25","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1002\/j.1460-2075.1995.tb00038.x","article-title":"Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer","volume":"14","author":"Klatt","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/j.niox.2019.10.007_bib26","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/embor.2009.192","article-title":"Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities","volume":"10","author":"Hjerpe","year":"2009","journal-title":"EMBO Rep."},{"key":"10.1016\/j.niox.2019.10.007_bib27","first-page":"37","article-title":"Ubiquitin proteosome protocols","volume":"301","author":"Furukawa","year":"2005","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.niox.2019.10.007_bib28","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/HYPERTENSIONAHA.111.188714","article-title":"Angiotensin II infusion model of hypertension: is there an important sympathetic component?","volume":"59","author":"Lohmeier","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.niox.2019.10.007_bib29","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1161\/HYPERTENSIONAHA.111.182154","article-title":"Angiotensin II-induced hypertension is modulated by nuclear factor-kappaBin the paraventricular nucleus","volume":"59","author":"Cardinale","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.niox.2019.10.007_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3959087","article-title":"Angiotensin II-induced hypertension is attenuated by overexpressing copper\/zinc superoxide dismutase in the brain organum vasculosum of the lamina terminalis","volume":"2016","author":"Collister","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.niox.2019.10.007_bib31","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1161\/01.HYP.0000243799.84573.f8","article-title":"Chronic low-dose angiotensin II infusion increases venomotor tone by neurogenic mechanisms","volume":"48","author":"King","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.niox.2019.10.007_bib32","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.6272392","article-title":"Renin and angiotensin: the complete system within the neuroblastoma x glioma cell","volume":"214","author":"Fishman","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.niox.2019.10.007_bib33","doi-asserted-by":"crossref","first-page":"R818","DOI":"10.1152\/ajpregu.00426.2010","article-title":"Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension","volume":"300","author":"Hirooka","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.niox.2019.10.007_bib34","article-title":"PVN blockade of p44\/42 MAPK pathway attenuates salt-induced hypertension through modulating neurotransmitters and attenuating oxidative stress","volume":"7","author":"Gao","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.niox.2019.10.007_bib35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrn1902","article-title":"The sympathetic control of blood pressure","volume":"7","author":"Guyenet","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.niox.2019.10.007_bib36","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1161\/HYPERTENSIONAHA.111.176222","article-title":"Gene transfer of neuronal nitric oxide synthase to the paraventricular nucleus reduces the enhanced glutamatergic tone in rats with chronic heart failure","volume":"58","author":"Zheng","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.niox.2019.10.007_bib37","doi-asserted-by":"crossref","first-page":"G442","DOI":"10.1152\/ajpgi.90280.2008","article-title":"PIN\/LC8 is associated with cytosolic but not membrane-bound nNOS in the nitrergic varicosities of mice gut: implications for nitrergic neurotransmission","volume":"295","author":"Chaudhury","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.niox.2019.10.007_bib38","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0014-5793(98)00704-2","article-title":"The protein inhibitor of neuronal nitric oxide synthase (PIN): characterization of its action on pure nitric oxide synthases","volume":"430","author":"Hemmens","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.niox.2019.10.007_bib39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1524-6175.2006.06032.x","article-title":"Nitric oxide in hypertension","volume":"8","author":"Hermann","year":"2006","journal-title":"J. Clin. Hypertens."},{"key":"10.1016\/j.niox.2019.10.007_bib40","doi-asserted-by":"crossref","first-page":"S309","DOI":"10.33549\/physiolres.933442","article-title":"Blood pressure regulation in stress: focus on nitric oxide-dependent mechanisms","volume":"65","author":"Puzserova","year":"2016","journal-title":"Physiol. Res."},{"key":"10.1016\/j.niox.2019.10.007_bib41","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.ne.17.030194.001101","article-title":"Nitric oxide and synaptic function","volume":"17","author":"Schuman","year":"1994","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.niox.2019.10.007_bib42","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1177\/153537020122600902","article-title":"Role of nitric oxide in central sympathetic outflow","volume":"226","author":"Patel","year":"2001","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.niox.2019.10.007_bib43","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1161\/01.RES.84.4.417","article-title":"Regulation of sympathetic nerve activity in heart failure: a role for nitric oxide and angiotensin II","volume":"84","author":"Liu","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.niox.2019.10.007_bib44","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.pneurobio.2005.06.001","article-title":"The physiology and pathophysiology of nitric oxide in the brain","volume":"76","author":"Guix","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.niox.2019.10.007_bib45","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/BF02388298","article-title":"Nitric oxide in physiology and pathology","volume":"27","author":"Whittle","year":"1995","journal-title":"Histochem. J."},{"key":"10.1016\/j.niox.2019.10.007_bib46","doi-asserted-by":"crossref","first-page":"H995","DOI":"10.1152\/ajpheart.2001.281.3.H995","article-title":"Blunted nitric oxide-mediated inhibition of renal nerve discharge within PVN of rats with heart failure","volume":"281","author":"Zhang","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2019.10.007_bib47","doi-asserted-by":"crossref","first-page":"R992","DOI":"10.1152\/ajpregu.00363.2005","article-title":"Blunted nitric oxide-mediated inhibition of sympathetic nerve activity within the paraventricular nucleus in diabetic rats","volume":"290","author":"Zheng","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.niox.2019.10.007_bib48","first-page":"1","article-title":"Post-translational regulation of neuronal nitric oxide synthase: implications for sympathoexcitatory states","author":"Sharma","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.niox.2019.10.007_bib49","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/bj3570593","article-title":"Nitric oxide synthases: structure, function and inhibition","volume":"357","author":"Alderton","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.niox.2019.10.007_bib50","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1073\/pnas.261705799","article-title":"Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON","volume":"99","author":"Jaffrey","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.niox.2019.10.007_bib51","doi-asserted-by":"crossref","first-page":"10454","DOI":"10.1523\/JNEUROSCI.2265-04.2004","article-title":"Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity","volume":"24","author":"Dreyer","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.niox.2019.10.007_bib52","doi-asserted-by":"crossref","first-page":"H2332","DOI":"10.1152\/ajpheart.00473.2004","article-title":"Exercise training improves endogenous nitric oxide mechanisms within the paraventricular nucleus in rats with heart failure","volume":"288","author":"Zheng","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2019.10.007_bib53","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1523\/JNEUROSCI.3712-09.2010","article-title":"Ubiquitination acutely regulates presynaptic neurotransmitter release in mammalian neurons","volume":"30","author":"Rinetti","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.niox.2019.10.007_bib54","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/458421a","article-title":"The ubiquitin system","volume":"458","author":"Nath","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.niox.2019.10.007_bib55","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1681\/ASN.2006010083","article-title":"Protein degradation by the ubiquitin-proteasome pathway in normal and disease states","volume":"17","author":"Lecker","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.niox.2019.10.007_bib56","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1210\/en.2014-1090","article-title":"Defective regulation of the ubiquitin\/proteasome system in the hypothalamus of obese male mice","volume":"155","author":"Ignacio-Souza","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.niox.2019.10.007_bib57","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1038\/emboj.2010.173","article-title":"Protein homeostasis and synaptic plasticity","volume":"29","author":"Cajigas","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.niox.2019.10.007_bib58","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1523\/JNEUROSCI.5078-05.2006","article-title":"Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system","volume":"26","author":"Almeida","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.niox.2019.10.007_bib59","doi-asserted-by":"crossref","first-page":"8189","DOI":"10.1523\/JNEUROSCI.2218-08.2008","article-title":"Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies","volume":"28","author":"Bedford","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.niox.2019.10.007_bib60","doi-asserted-by":"crossref","first-page":"11653","DOI":"10.1523\/JNEUROSCI.23-37-11653.2003","article-title":"Neuronal induction of the immunoproteasome in Huntington's disease","volume":"23","author":"Diaz-Hernandez","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.niox.2019.10.007_bib61","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.nbd.2004.12.007","article-title":"Accumulation of human SOD1 and ubiquitinated deposits in the spinal cord of SOD1G93A mice during motor neuron disease progression correlates with a decrease of proteasome","volume":"18","author":"Cheroni","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.niox.2019.10.007_bib62","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neurobiolaging.2004.12.004","article-title":"Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains","volume":"27","author":"Mishto","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.niox.2019.10.007_bib63","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jneuroim.2006.07.018","article-title":"The role of the proteasome-ubiquitin pathway in regulation of the IFN-gamma mediated anti-VSV response in neurons","volume":"181","author":"Yang","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.niox.2019.10.007_bib64","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/978-1-61779-474-2_12","article-title":"Isolation of ubiquitylated proteins using tandem ubiquitin-binding entities","volume":"832","author":"Aillet","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.niox.2019.10.007_bib65","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jash.2013.07.010","article-title":"RNA silencing targeting PIN (protein inhibitor of neuronal nitric oxide synthase) attenuates the development of hypertension in young spontaneously hypertensive rats","volume":"8","author":"Wang","year":"2014","journal-title":"J Am Soc Hypertens"},{"key":"10.1016\/j.niox.2019.10.007_bib66","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1161\/HYPERTENSIONAHA.114.03777","article-title":"Role of nitric oxide synthase uncoupling at rostral ventrolateral medulla in redox-sensitive hypertension associated with metabolic syndrome","volume":"64","author":"Wu","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.niox.2019.10.007_bib67","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0140-6736(71)91085-3","article-title":"Angiotensin II blood-levels in human hypertension","volume":"1","author":"Catt","year":"1971","journal-title":"Lancet"},{"key":"10.1016\/j.niox.2019.10.007_bib68","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1161\/HYPERTENSIONAHA.113.01743","article-title":"Circulating angiotensin II gains access to the hypothalamus and brain stem during hypertension via breakdown of the blood-brain barrier","volume":"63","author":"Biancardi","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.niox.2019.10.007_bib69","first-page":"187","article-title":"An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy","volume":"23","author":"Grobe","year":"2008","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.niox.2019.10.007_bib70","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/01.RES.0000187447.03525.72","article-title":"Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression","volume":"97","author":"Bendall","year":"2005","journal-title":"Circ. Res."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108986031930179X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108986031930179X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:04:41Z","timestamp":1761069881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S108986031930179X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":70,"alternative-id":["S108986031930179X"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2019.10.007","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Central angiotensin II-Protein inhibitor of neuronal nitric oxide synthase (PIN) axis contribute to neurogenic hypertension","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2019.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}