{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:18:33Z","timestamp":1783099113224,"version":"3.54.6"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.niox.2019.12.004","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T11:54:31Z","timestamp":1576842871000},"page":"17-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["DDAH-1 via HIF-1 target genes improves cerebral ischemic tolerance after hypoxic preconditioning and middle cerebral artery occlusion-reperfusion"],"prefix":"10.1016","volume":"95","author":[{"given":"Yichen","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoye","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2019.12.004_bib1","article-title":"Global brain perfusion and the risk of transient ischemic attack and ischemic stroke: the rotterdam study","volume":"8","author":"L","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.niox.2019.12.004_bib2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuroscience.2014.06.014","article-title":"Transient ischemic attack induced by melted solid lipid microparticles protects rat brains from permanent focal ischemia","volume":"275","author":"Tsai","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.niox.2019.12.004_bib3","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1161\/01.STR.0000143322.20491.0f","article-title":"Ischemic preconditioning from transient ischemic attacks? Data from the Northern California TIA Study","volume":"35","author":"SC","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.niox.2019.12.004_bib4","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1113\/EP087122","article-title":"Ischaemic and hypoxic conditioning: potential for protection of vital organs","volume":"104","author":"JD","year":"2019","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.niox.2019.12.004_bib5","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s00109-018-1707-9","article-title":"Hypoxia-inducible factor 1\u03b1 protects peripheral sensory neurons from diabetic peripheral neuropathy by suppressing accumulation of reactive oxygen species","volume":"96","author":"DR","year":"2018","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.niox.2019.12.004_bib6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.arcmed.2018.11.004","article-title":"Ischemic preconditioning preserves liver energy charge and function on hepatic ischemia\/reperfusion injury in rats","volume":"49","author":"Rodr\u00edguez-Reynoso","year":"2018","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.niox.2019.12.004_bib7","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/s13287-018-1031-x","article-title":"LincRNA-p21 promotes mesenchymal stem cell migration capacity and survival through hypoxic preconditioning","volume":"9","author":"SS","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.niox.2019.12.004_bib8","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S1474-4422(09)70054-7","article-title":"Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use","volume":"8","author":"Ulrich","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.niox.2019.12.004_bib9","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00401-008-0473-0","article-title":"Neuronal plasticity after ischemic preconditioning and TIA-like preconditioning ischemic periods","volume":"117","author":"Sommer","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.niox.2019.12.004_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.15283\/ijsc18109","article-title":"Role of HIF1 regulatory factors in stem cells","volume":"12","author":"HJ","year":"2019","journal-title":"International journal of stem cells"},{"issue":"23","key":"10.1016\/j.niox.2019.12.004_bib11","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1523\/JNEUROSCI.0449-07.2007","article-title":"Neuron-specific inactivation of the hypoxia inducible factor 1? Increases brain injury in a mouse model of transient focal cerebral ischemia","volume":"27","author":"Baranova","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.niox.2019.12.004_bib12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/pr.2014.53","article-title":"Hypoxic preconditioning protection is eliminated in HIF-1\u03b1 knockout mice subjected to neonatal hypoxia-ischemia","volume":"76","author":"Ann","year":"2014","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.niox.2019.12.004_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2017.04.010","article-title":"Ischemic preconditioning with a ketogenic diet improves brain ischemic tolerance through increased extracellular adenosine levels and hypoxia-inducible factors","volume":"1667","author":"Y","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.niox.2019.12.004_bib14","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1074\/jbc.M308197200","article-title":"Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling","volume":"279","author":"Kenji","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.niox.2019.12.004_bib15","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1161\/ATVBAHA.110.215640","article-title":"Dimethylarginine dimethylaminohydrolase 1 modulates endothelial cell growth through nitric oxide and Akt","volume":"31","author":"P","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.niox.2019.12.004_bib16","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/cr.2013.45","article-title":"Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos","volume":"23","author":"Nannan","year":"2013","journal-title":"Cell Res."},{"key":"10.1016\/j.niox.2019.12.004_bib17","article-title":"The blood-brain barrier after stroke: structural studies and the role of transcytotic vesicles","volume":"37","author":"Haley","year":"2016","journal-title":"J. Cereb. Blood Flow Metabol. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.niox.2019.12.004_bib18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2040-7378-2-2","article-title":"Preconditioning-induced ischemic tolerance: a window into endogenous gearing for cerebroprotection","volume":"2","author":"Durukan","year":"2010","journal-title":"Exp. Transl. Stroke Med."},{"issue":"1","key":"10.1016\/j.niox.2019.12.004_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2040-7378-4-1","article-title":"An experimental protocol for mimicking pathomechanisms of traumatic brain injury in mice","volume":"4","author":"Albert-Wei\u00dfenberger","year":"2012","journal-title":"Exp. Transl. Stroke Med."},{"key":"10.1016\/j.niox.2019.12.004_bib20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijcard.2019.07.078","article-title":"Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates monocrotaline-induced pulmonary oxidative stress, pulmonary arterial hypertension and right heart failure in rats","volume":"295","author":"D","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.niox.2019.12.004_bib21","doi-asserted-by":"crossref","first-page":"35338","DOI":"10.1074\/jbc.M109.037036","article-title":"Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production","volume":"284","author":"AJ","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.niox.2019.12.004_bib22","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nm1543","article-title":"Disruption of methylarginine metabolism impairs vascular homeostasis","volume":"13","author":"L","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.niox.2019.12.004_bib23","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cyto.2015.09.002","article-title":"Dimethylarginine dimethylaminohydrolase-1 mediates inhibitory effect of interleukin-10 on angiotensin II-induced hypertensive effects in vascular smooth muscle cells of spontaneously hypertensive rats","volume":"77","author":"Kim","year":"2016","journal-title":"Cytokine"},{"key":"10.1016\/j.niox.2019.12.004_bib24","first-page":"1665","article-title":"Oral L-arginine supplementation in patients with mild arterial hypertension and its effect on plasma level of asymmetric dimethylarginine, L-citruline, L-arginine and antioxidant status","volume":"16","author":"Jabecka","year":"2012","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.niox.2019.12.004_bib25","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1179\/016164111X13007856084403","article-title":"Nitric oxide (NO) and asymmetric dimethylarginine (ADMA): their pathophysiological role and involvement in intracerebral hemorrhage","volume":"33","author":"Li","year":"2011","journal-title":"Neurol. Res."},{"key":"10.1016\/j.niox.2019.12.004_bib26","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s40618-015-0267-x","article-title":"The effect of maternal hypothyroidism on cardiac function and tolerance to ischemia\u2013reperfusion injury in offspring male and female rats","volume":"38","author":"Ghanbari","year":"2015","journal-title":"J. Endocrinol. Investig."},{"key":"10.1016\/j.niox.2019.12.004_bib27","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.mcn.2019.05.003","article-title":"Hippocampal sub-regional differences in the microRNA response to forebrain ischemia","volume":"98","author":"Arvola","year":"2019","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.niox.2019.12.004_bib28","first-page":"147","article-title":"Rational modulation of the innate immune system for neuroprotection in ischemic stroke","volume":"9","author":"A","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.niox.2019.12.004_bib29","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s12264-008-0089-3","article-title":"Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1 alpha and erythropoietin","volume":"24","author":"YX","year":"2008","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.niox.2019.12.004_bib30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2040-7378-2-2","article-title":"Preconditioning-induced ischemic tolerance: a window into endogenous gearing for cerebroprotection","volume":"2","author":"D","year":"2010","journal-title":"Exp. Transl. Stroke Med."},{"key":"10.1016\/j.niox.2019.12.004_bib31","first-page":"4547","article-title":"Adrenomedullin serves a role in the humoral pathway of delayed remote ischemic preconditioning via a hypoxia-inducible factor-1\u03b1-associated mechanism","volume":"17","author":"D","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.niox.2019.12.004_bib32","first-page":"398","article-title":"Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use, the Lancet","volume":"8","author":"U","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.niox.2019.12.004_bib33","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.pneurobio.2013.11.005","article-title":"Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance","volume":"114","author":"S","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.niox.2019.12.004_bib34","article-title":"Astrocytic Toll-like receptor 3 is associated with ischemic preconditioning-induced protection against brain ischemia in rodents","volume":"9","author":"LN","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.niox.2019.12.004_bib35","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0140-6736(03)14412-1","article-title":"Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states","volume":"362","author":"MP","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.niox.2019.12.004_bib36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuroscience.2018.09.024","article-title":"HIF-1<alpha> repression of PTEN transcription mediates protective effects of BMSCs on neurons during hypoxia","volume":"392","author":"Y","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.niox.2019.12.004_bib37","article-title":"Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia","volume":"8","author":"C","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.niox.2019.12.004_bib38","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3389\/fnmol.2017.00257","article-title":"\u03b22-Adrenergic receptor-mediated HIF-1\u03b1 upregulation mediates blood brain barrier damage in acute cerebral ischemia","volume":"10","author":"S","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.niox.2019.12.004_bib39","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s12031-018-1162-7","article-title":"HIF-1\u03b1\/Beclin1-Mediated autophagy is involved in neuroprotection induced by hypoxic preconditioning","volume":"66","author":"L","year":"2018","journal-title":"J. Mol. Neurosci. : MN"},{"key":"10.1016\/j.niox.2019.12.004_bib40","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.brainres.2005.04.029","article-title":"Hypoxic preconditioning up-regulates glucose transport activity and glucose transporter (GLUT1 and GLUT3) gene expression after acute anoxic exposure in the cultured rat hippocampal neurons and astrocytes","volume":"1211","author":"Y","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.niox.2019.12.004_bib41","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/jnr.23203","article-title":"Preischemic exercise reduces brain damage by ameliorating metabolic disorder in ischemia\/reperfusion injury","volume":"91","author":"D","year":"2013","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.niox.2019.12.004_bib42","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1161\/01.STR.0000080381.76409.B2","article-title":"Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin","volume":"34","author":"P","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.niox.2019.12.004_bib43","doi-asserted-by":"crossref","first-page":"10291","DOI":"10.1523\/JNEUROSCI.22-23-10291.2002","article-title":"Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model","volume":"22","author":"R","year":"2002","journal-title":"J. Neurosci. : Off. J. Soc. Neurosci."},{"key":"10.1016\/j.niox.2019.12.004_bib44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ejphar.2018.10.033","article-title":"Cardioprotection and improvement in endothelial-dependent vasodilation during late-phase of whole body hypoxic preconditioning in spontaneously hypertensive rats via VEGF and endothelin-1","volume":"842","author":"XY","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2019.12.004_bib45","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/trf.14914","article-title":"Mesenchymal stem\/stromal cells genetically engineered to produce vascular endothelial growth factor for revascularization in wound healing and ischemic conditions","volume":"59","author":"F","year":"2019","journal-title":"Transfusion"},{"key":"10.1016\/j.niox.2019.12.004_bib46","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1080\/01616412.2018.1477545","article-title":"Hypoxic preconditioning reduces propofol-induced neuroapoptosis via regulation of Bcl-2 and Bax and downregulation of activated caspase-3 in the hippocampus of neonatal rats","volume":"40","author":"J","year":"2018","journal-title":"Neurol. Res."},{"key":"10.1016\/j.niox.2019.12.004_bib47","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41419-019-1410-y","article-title":"Hypoxia preconditioning promotes bone marrow mesenchymal stem cells survival by inducing HIF-1\u03b1 in injured neuronal cells derived exosomes culture system","volume":"10","author":"L","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.niox.2019.12.004_bib48","doi-asserted-by":"crossref","first-page":"H901","DOI":"10.1152\/ajpheart.00715.2007","article-title":"Prevention of HIF-1 activation and iNOS gene targeting by low-dose cadmium results in loss of myocardial hypoxic preconditioning in the rat","volume":"294","author":"B","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2019.12.004_bib49","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.freeradbiomed.2018.10.441","article-title":"Expression of human inducible nitric oxide synthase in response to cytokines is regulated by hypoxia-inducible factor-1","volume":"130","author":"L","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.niox.2019.12.004_bib50","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s11010-011-0979-y","article-title":"Activation of hypoxia-inducible factor-1 ameliorates postischemic renal injury via inducible nitric oxide synthase","volume":"358","author":"Z","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.niox.2019.12.004_bib51","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.freeradbiomed.2012.10.547","article-title":"Does nitric oxide signaling differ in pre- and post-conditioning?;Importance of S-nitrosylation vs. protein kinase G activation","volume":"54","author":"Schulz","year":"2013","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.niox.2019.12.004_bib52","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1161\/CIRCRESAHA.114.303822","article-title":"Circulating nitrite contributes to cardioprotection by remote ischemic preconditioning","volume":"114","author":"R","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.niox.2019.12.004_bib53","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.niox.2019.02.003","article-title":"Effect of long-term sodium nitrate administration on diabetes-induced anemia and glucose homeostasis in obese type 2 diabetic male rats","volume":"86","author":"K","year":"2019","journal-title":"Nitric Oxide : Biol. Chem."},{"key":"10.1016\/j.niox.2019.12.004_bib54","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1074\/jbc.M308197200","article-title":"Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling","volume":"279","author":"K","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.niox.2019.12.004_bib55","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1038\/s41598-019-40086-8","article-title":"Plasma cupping induces VEGF expression in skin cells through nitric oxide-mediated activation of hypoxia inducible factor 1","volume":"9","author":"HY","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.niox.2019.12.004_bib56","first-page":"1665","article-title":"Oral L-arginine supplementation in patients with mild arterial hypertension and its effect on plasma level of asymmetric dimethylarginine, L-citruline, L-arginine and antioxidant status","volume":"16","author":"J","year":"2012","journal-title":"Eur. Rev. Med. Pharmacol. Sci."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860319302794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860319302794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:04:18Z","timestamp":1761069858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860319302794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":56,"alternative-id":["S1089860319302794"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2019.12.004","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DDAH-1 via HIF-1 target genes improves cerebral ischemic tolerance after hypoxic preconditioning and middle cerebral artery occlusion-reperfusion","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2019.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}