{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T03:36:46Z","timestamp":1778211406514,"version":"3.51.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.niox.2020.04.004","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T20:12:06Z","timestamp":1586549526000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Cellular mechanisms underlying carbon monoxide stimulated anion secretion in rat epididymal epithelium"],"prefix":"10.1016","volume":"100-101","author":[{"given":"Lei","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Dong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Wen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Bang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Jiao","family":"Ke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo-Er","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Xin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Liang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2020.04.004_bib1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/humupd\/dmn055","article-title":"New insights into epididymal biology and function","volume":"15","author":"Cornwall","year":"2009","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.niox.2020.04.004_bib2","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/humupd\/dmw015","article-title":"The human epididymis: its function in sperm maturation","volume":"22","author":"Sullivan","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.niox.2020.04.004_bib3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/molehr\/gav066","article-title":"Expression profiles of human epididymis epithelial cells reveal the functional diversity of caput, corpus and cauda regions","volume":"22","author":"Browne","year":"2016","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.niox.2020.04.004_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/jemt.1070300106","article-title":"Epididymal epithelium: its contribution to the formation of a luminal fluid microenvironment","volume":"30","author":"Hinton","year":"1995","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.niox.2020.04.004_bib5","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1210\/endo-101-5-1391","article-title":"Hormonal regulation of fluid reabsorption in isolated rat cauda epididymidis","volume":"101","author":"Wong","year":"1977","journal-title":"Endocrinology"},{"key":"10.1016\/j.niox.2020.04.004_bib6","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1095\/biolreprod.103.024257","article-title":"Secretin controls anion secretion in the rat epididymis in an autocrine\/paracrine fashion","volume":"70","author":"Chow","year":"2004","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.niox.2020.04.004_bib7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jcp.10086","article-title":"COX-dependent and -independent pathways in bradykinin-induced anion secretion in rat epididymis","volume":"191","author":"Cheuk","year":"2002","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.niox.2020.04.004_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1095\/biolreprod.108.068346","article-title":"Stimulating effects of dopamine on chloride transport across the rat caudal epididymal epithelium in culture","volume":"80","author":"Du","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.niox.2020.04.004_bib9","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1242\/jeb.027284","article-title":"Regulation of luminal acidification in the male reproductive tract via cell-cell crosstalk","volume":"212","author":"Shum","year":"2009","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.niox.2020.04.004_bib10","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.3389\/fphys.2018.01886","article-title":"Cellular mechanism underlying hydrogen sulfide mediated epithelial K(+) secretion in rat epididymis","volume":"9","author":"Gao","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.niox.2020.04.004_bib11","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00702-005-0408-z","article-title":"Regulation and expression of heme oxygenase enzymes in aged-rat brain: age related depression in HO-1 and HO-2 expression and altered stress-response","volume":"113","author":"Ewing","year":"2006","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.niox.2020.04.004_bib12","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrd3228","article-title":"The therapeutic potential of carbon monoxide","volume":"9","author":"Motterlini","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.niox.2020.04.004_bib13","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1165\/rcmb.2008-0458OC","article-title":"Carbon monoxide rapidly impairs alveolar fluid clearance by inhibiting epithelial sodium channels","volume":"41","author":"Althaus","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.niox.2020.04.004_bib14","doi-asserted-by":"crossref","first-page":"G207","DOI":"10.1152\/ajpgi.00407.2010","article-title":"Effects of carbon monoxide on ion transport across rat distal colon","volume":"300","author":"Steidle","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.niox.2020.04.004_bib15","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1248\/bpb.34.789","article-title":"Regulation of colonic ion transport by gasotransmitters","volume":"34","author":"Pouokam","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.niox.2020.04.004_bib16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrn2117","article-title":"The neuronal background K2P channels: focus on TREK1","volume":"8","author":"Honore","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.niox.2020.04.004_bib17","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1096\/fj.10-173450","article-title":"Carbon monoxide protects against oxidant-induced apoptosis via inhibition of Kv2.1","volume":"25","author":"Dallas","year":"2011","journal-title":"Faseb. J."},{"key":"10.1016\/j.niox.2020.04.004_bib18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1124\/jpet.106.116665","article-title":"Carbon monoxide-mediated activation of large-conductance calcium-activated potassium channels contributes to mesenteric vasodilatation in cirrhotic rats","volume":"321","author":"Bolognesi","year":"2007","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.niox.2020.04.004_bib19","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1073\/pnas.78.3.1675","article-title":"Isolation, culture, and immunocytochemical characterization of epididymal epithelial cells from pubertal and adult rats","volume":"78","author":"Kierszenbaum","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.niox.2020.04.004_bib20","doi-asserted-by":"crossref","first-page":"G1151","DOI":"10.1152\/ajpgi.90649.2008","article-title":"A guide to Ussing chamber studies of mouse intestine","volume":"296","author":"Clarke","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.niox.2020.04.004_bib21","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1124\/pr.57.4.3","article-title":"Carbon monoxide: endogenous production, physiological functions, and pharmacological applications","volume":"57","author":"Wu","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.niox.2020.04.004_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.molmed.2008.12.004","article-title":"Heme oxygenase-1: from biology to therapeutic potential","volume":"15","author":"Soares","year":"2009","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.niox.2020.04.004_bib23","doi-asserted-by":"crossref","first-page":"G207","DOI":"10.1152\/ajpgi.00407.2010","article-title":"Effects of carbon monoxide on ion transport across rat distal colon","volume":"300","author":"Steidle","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.niox.2020.04.004_bib24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1124\/jpet.110.175216","article-title":"Carbon monoxide involved in modulating HCO3- secretion in rat duodenum","volume":"337","author":"Takasuka","year":"2011","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.niox.2020.04.004_bib25","doi-asserted-by":"crossref","first-page":"17e","DOI":"10.1161\/hh0202.104530","article-title":"Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities","volume":"90","author":"Motterlini","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.niox.2020.04.004_bib26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/MNH.0000000000000479","article-title":"New insights regarding epithelial Na+ channel regulation and its role in the kidney, immune system and vasculature","volume":"28","author":"Mutchler","year":"2019","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.niox.2020.04.004_bib27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/molehr\/4.2.107","article-title":"CFTR gene and male fertility","volume":"4","author":"Wong","year":"1998","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.niox.2020.04.004_bib28","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3904\/kjim.2013.28.2.123","article-title":"Carbon monoxide: present and future indications for a medical gas","volume":"28","author":"Ryter","year":"2013","journal-title":"Korean J. Intern. Med."},{"key":"10.1016\/j.niox.2020.04.004_bib29","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1039\/C7MT00065K","article-title":"Mechanistic insight into the heme-independent interplay between iron and carbon monoxide in CFTR and Slo1 BKCa channels","volume":"9","author":"Wang","year":"2017","journal-title":"Metallomics"},{"key":"10.1016\/j.niox.2020.04.004_bib30","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1291\/hypres.27.253","article-title":"Erectile dysfunction in hypertensive rats results from impairment of the relaxation evoked by neurogenic carbon monoxide and nitric oxide","volume":"27","author":"Masayuki","year":"2004","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.niox.2020.04.004_bib31","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1210\/endo.136.5.7720678","article-title":"Distribution of constitutive (HO-2) and heat-inducible (HO-1) heme oxygenase isozymes in rat testes: HO-2 displays stage-specific expression in germ cells","volume":"136","author":"Ewing","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.niox.2020.04.004_bib32","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ab.2005.03.019","article-title":"Determination of carbon monoxide (CO) in rodent tissue: effect of heme administration and environmental CO exposure","volume":"341","author":"Vreman","year":"2005","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.niox.2020.04.004_bib33","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1139\/y95-065","article-title":"Heme oxygenase activity in the adult rat aorta and liver as measured by carbon monoxide formation","volume":"73","author":"Cook","year":"1995","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.niox.2020.04.004_bib34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0003-2697(88)90006-1","article-title":"Heme oxygenase activity as measured by carbon monoxide production","volume":"168","author":"Vreman","year":"1988","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.niox.2020.04.004_bib35","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/oxfordjournals.humrep.a138237","article-title":"Cystic fibrosis mutations impair the fertilization rate of epididymal sperm from men with congenital absence of the vas deferens","volume":"8","author":"Patrizio","year":"1993","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.niox.2020.04.004_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006715","article-title":"Loss of SLC9A3 decreases CFTR protein and causes obstructed azoospermia in mice","volume":"13","author":"Wang","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.niox.2020.04.004_bib37","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/sj.bjp.0705825","article-title":"Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule","volume":"142","author":"Foresti","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.niox.2020.04.004_bib38","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.1021\/bi00184a036","article-title":"Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states","volume":"33","author":"Stone","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.niox.2020.04.004_bib39","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1523\/JNEUROSCI.16-18-05621.1996","article-title":"The regulation of heme turnover and carbon monoxide biosynthesis in cultured primary rat olfactory receptor neurons","volume":"16","author":"Ingi","year":"1996","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.niox.2020.04.004_bib40","article-title":"NO', CO and 'OH Endogenous soluble guanylyl cyclase-activating factors","volume":"307","author":"Schmidt","year":"1992"},{"key":"10.1016\/j.niox.2020.04.004_bib41","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/sj.emboj.7601521","article-title":"NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism","volume":"26","author":"Ma","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.niox.2020.04.004_bib42","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1042\/BSR20120051","article-title":"Identification of a haem domain in human soluble adenylate cyclase","volume":"32","author":"Middelhaufe","year":"2012","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.niox.2020.04.004_bib43","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1085\/jgp.200910339","article-title":"Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion","volume":"135","author":"Hoque","year":"2010","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.niox.2020.04.004_bib44","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.tibs.2006.10.002","article-title":"Epac proteins: multi-purpose cAMP targets","volume":"31","author":"Bos","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.niox.2020.04.004_bib45","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1085\/jgp.201611626","article-title":"Coupling of TRPV6 and TMEM16A in epithelial principal cells of the rat epididymis","volume":"148","author":"Gao","year":"2016","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.niox.2020.04.004_bib46","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1152\/ajpcell.00252.2014","article-title":"A novel role for carbon monoxide as a potent regulator of intracellular Ca2+ and nitric oxide in rat pancreatic acinar cells","volume":"307","author":"Amira","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.niox.2020.04.004_bib47","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","article-title":"Calcium signaling","volume":"131","author":"Clapham","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.niox.2020.04.004_bib48","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1513\/pats.200704-047VS","article-title":"Calcium signaling in airway smooth muscle","volume":"5","author":"Jude","year":"2008","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.niox.2020.04.004_bib49","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1089\/ars.2011.4398","article-title":"Peroxynitrite mediates disruption of Ca2+ homeostasis by carbon monoxide via Ca2+ ATPase degradation","volume":"17","author":"Hettiarachchi","year":"2012","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.niox.2020.04.004_bib50","doi-asserted-by":"crossref","first-page":"40438","DOI":"10.1074\/jbc.M110.161497","article-title":"State-dependent regulation of cystic fibrosis transmembrane conductance regulator (CFTR) gating by a high affinity Fe3+ bridge between the regulatory domain and cytoplasmic loop 3","volume":"285","author":"Wang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.niox.2020.04.004_bib51","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1021\/bi501318h","article-title":"Interplay between inhibitory ferric and stimulatory curcumin regulates phosphorylation-dependent human cystic fibrosis transmembrane conductance regulator and \u0394F508 activity","volume":"54","author":"Wang","year":"2015","journal-title":"Biochemistry"},{"key":"10.1016\/j.niox.2020.04.004_bib52","doi-asserted-by":"crossref","DOI":"10.1039\/C7MT00065K","article-title":"Mechanistic insight into the heme-independent interplay between iron and carbon monoxide in CFTR and Slo1 BKCa channels","volume":"9","author":"Wang","year":"2017","journal-title":"Metallomics"},{"key":"10.1016\/j.niox.2020.04.004_bib53","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1439-0272.2008.00856.x","article-title":"Heme oxygenase enzyme activity in human seminal plasma of fertile and infertile males","volume":"40","author":"Abdel Aziz","year":"2008","journal-title":"Andrologia"},{"key":"10.1016\/j.niox.2020.04.004_bib54","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1095\/biolreprod.111.096826","article-title":"The physiology of bicarbonate transporters in mammalian reproduction","volume":"86","author":"Liu","year":"2012","journal-title":"Biol. Reprod."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860319302472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860319302472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:05:19Z","timestamp":1761069919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860319302472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":54,"alternative-id":["S1089860319302472"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2020.04.004","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular mechanisms underlying carbon monoxide stimulated anion secretion in rat epididymal epithelium","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2020.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}