{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:38:50Z","timestamp":1788475130394,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.niox.2020.11.005","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T02:08:43Z","timestamp":1606702123000},"page":"11-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Effects of nitrite and far-red light on coagulation"],"prefix":"10.1016","volume":"107","author":[{"given":"Nadeem","family":"Wajih","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3507-4010","authenticated-orcid":false,"given":"Elmira","family":"Alipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rigal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiqing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Perlegas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Caudell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kim-Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2020.11.005_bib1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.addr.2016.07.009","article-title":"Device thrombosis and pre-clinical blood flow models for assessing antithrombogenic efficacy of drug-device combinations","volume":"112","author":"Sukavaneshvar","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.niox.2020.11.005_bib2","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1160\/TH16-03-0230","article-title":"Heparin-induced thrombocytopenia in cardiac surgery and critically ill patients","volume":"116","author":"Selleng","year":"2016","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.niox.2020.11.005_bib3","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.athoracsur.2017.09.061","article-title":"The society of thoracic surgeons, the society of cardiovascular anesthesiologists, and the American society of ExtraCorporeal technology: clinical practice guidelines*-anticoagulation during cardiopulmonary bypass","volume":"105","author":"Shore-Lesserson","year":"2018","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.niox.2020.11.005_bib4","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/S0006-291X(87)80299-1","article-title":"The role OF nitric-oxide and CGMP IN platelet-adhesion to vascular endothelium","volume":"148","author":"Radomski","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.niox.2020.11.005_bib5","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/S0140-6736(94)90287-9","article-title":"Inhibition OF platelet activity BY S-nitrosoglutathione during coronary angioplasty","volume":"344","author":"Langford","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.niox.2020.11.005_bib6","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1073\/pnas.93.4.1480","article-title":"cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase","volume":"93","author":"Moro","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2020.11.005_bib7","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/0735-1097(91)90686-4","article-title":"The antiplatelet effects of organic nitrates and related nitroso-compounds invitro and invivo and their relevance to cardiovascular disorders","volume":"18","author":"Stamler","year":"1991","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.niox.2020.11.005_bib8","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1161\/01.CIR.99.2.189","article-title":"Diabetes, oxidative stress, and platelet activation","volume":"99","author":"Keaney","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.niox.2020.11.005_bib9","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1161\/hh0801.089861","article-title":"Nitric oxide insufficiency, platelet activation, and arterial thrombosis","volume":"88","author":"Loscalzo","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.niox.2020.11.005_bib10","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1182\/blood-2010-01-267112","article-title":"The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model","volume":"116","author":"Hu","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.niox.2020.11.005_bib11","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1161\/01.CIR.0000126837.88743.DD","article-title":"Rapid regulation of platelet activation in vivo by nitric oxide","volume":"109","author":"Schafer","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.niox.2020.11.005_bib12","series-title":"New Therapeutic Agents in Thrombosis and Thrombolysis","first-page":"499","article-title":"Nitric oxide donors as platelet inhibitors","author":"Badimon","year":"2009"},{"key":"10.1016\/j.niox.2020.11.005_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14012-9","article-title":"Liquid-infused nitric oxide-releasing (LINORel) silicone for decreased fouling, thrombosis, and infection of medical devices","volume":"7","author":"Goudie","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.niox.2020.11.005_bib14","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.redox.2017.05.006","article-title":"Potential therapeutic action of nitrite in sickle cell disease","volume":"12","author":"Wajih","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.niox.2020.11.005_bib15","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0162-0134(00)80291-3","article-title":"Oxidation of nitrogen-oxides by bound dioxygen in hemoproteins","volume":"14","author":"Doyle","year":"1981","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.niox.2020.11.005_bib16","doi-asserted-by":"crossref","first-page":"6976","DOI":"10.1021\/bi960442g","article-title":"Mechanism of NO-induced oxidation of myoglobin and hemoglobin","volume":"35","author":"Eich","year":"1996","journal-title":"Biochemistry-US"},{"key":"10.1016\/j.niox.2020.11.005_bib17","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1021\/bi002407m","article-title":"Kinetic and mechanistic studies of the NO center dot-mediated oxidation of oxymyoglobin and oxyhemoglobin","volume":"40","author":"Herold","year":"2001","journal-title":"Biochemistry-US"},{"key":"10.1016\/j.niox.2020.11.005_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030380","article-title":"Platelet inhibition by nitrite is dependent on erythrocytes and deoxygenation","volume":"7","author":"Srihirun","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.niox.2020.11.005_bib19","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.niox.2009.07.002","article-title":"What is the real physiological NO concentration in vivo?","volume":"21","author":"Hall","year":"2009","journal-title":"Nitric Oxide-Biol Ch"},{"key":"10.1016\/j.niox.2020.11.005_bib20","doi-asserted-by":"crossref","DOI":"10.1152\/ajprenal.00090.2004","article-title":"Plasma S-nitrosothiols and chronic renal failure","volume":"287","author":"Giustarini","year":"2004","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.niox.2020.11.005_bib21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.niox.2010.10.002","article-title":"Acute effect of a high nitrate diet on brain perfusion in older adults","volume":"24","author":"Presley","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2020.11.005_bib22","first-page":"368","article-title":"The action of nitrite on Haemoglobin in the absence of oxygen","volume":"123","author":"Brooks","year":"1937","journal-title":"Proc. Royal Soc. London - Series B, Biol. Sci."},{"key":"10.1016\/j.niox.2020.11.005_bib23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.redox.2016.04.004","article-title":"The role of red blood cell S-nitrosation in nitrite bioactivation and its modulation by leucine and glucose","volume":"8","author":"Wajih","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.niox.2020.11.005_bib24","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.redox.2018.11.001","article-title":"Erythrocytic bioactivation of nitrite and its potentiation by far-red light","volume":"20","author":"Wajih","year":"2019","journal-title":"Redox Biology"},{"key":"10.1016\/j.niox.2020.11.005_bib25","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/jth.14002","article-title":"An international study on the feasibility of a standardized combined plasma clot turbidity and lysis assay: communication from the SSC of the ISTH","volume":"16","author":"Pieters","year":"2018","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.niox.2020.11.005_bib26","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1055\/s-0036-1597283","article-title":"Platelet-mediated modulation of fibrinolysis","volume":"43","author":"Whyte","year":"2017","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.niox.2020.11.005_bib27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1538-7836.2011.04576.x","article-title":"Novel roles of cAMP\/cGMP-dependent signaling in platelets","volume":"10","author":"Smolenski","year":"2012","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.niox.2020.11.005_bib28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1152\/physiol.00020.2016","article-title":"New concepts and mechanisms of platelet activation signaling","volume":"32","author":"Estevez","year":"2017","journal-title":"Physiology"},{"key":"10.1016\/j.niox.2020.11.005_bib29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.thromres.2018.12.008","article-title":"Individual variations in platelet reactivity towards ADP, epinephrine, collagen and nitric oxide, and the association to arterial function in young, healthy adults","volume":"174","author":"Lindkvist","year":"2019","journal-title":"Thromb. Res."},{"key":"10.1016\/j.niox.2020.11.005_bib30","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3109\/09537100903159375","article-title":"Nitric oxide inhibits platelet adhesion to collagen through cGMP-dependent and independent mechanisms: the potential role for S-nitrosylation","volume":"20","author":"Irwin","year":"2009","journal-title":"Platelets"},{"key":"10.1016\/j.niox.2020.11.005_bib31","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1160\/TH05-01-0027","article-title":"Regulation of platelet guanylyl cyclase by collagen: evidence that Glycoprotein VI mediates platelet nitric oxide synthesis in response to collagen","volume":"94","author":"Riba","year":"2005","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.niox.2020.11.005_bib32","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1073\/pnas.95.9.4888","article-title":"Mechanism of platelet inhibition by nitric oxide: in vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase","volume":"95","author":"Wang","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2020.11.005_bib33","doi-asserted-by":"crossref","first-page":"5335","DOI":"10.1182\/blood-2011-12-396374","article-title":"Does the NO\/sGC\/cGMP\/PKG pathway play a stimulatory role in platelets?","volume":"119","author":"Gambaryan","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.niox.2020.11.005_bib34","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-016-0139-9","article-title":"Erythrocytes do not activate purified and platelet soluble guanylate cyclases even in conditions favourable for NO synthesis","volume":"14","author":"Gambaryan","year":"2016","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.niox.2020.11.005_bib35","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.niox.2017.02.008","article-title":"Platelet inhibition and increased phosphorylated vasodilator-stimulated phosphoprotein following sodium nitrite inhalation","volume":"66","author":"Parakaw","year":"2017","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2020.11.005_bib36","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1161\/hh0801.089861","article-title":"Nitric oxide insufficiency, platelet activation, and arterial thrombosis","volume":"88","author":"Loscalzo","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.niox.2020.11.005_bib37","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00418-004-0675-z","article-title":"Nitric oxide insufficiency and atherothrombosis","volume":"122","author":"Voetsch","year":"2004","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.niox.2020.11.005_bib38","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.cardiores.2003.11.034","article-title":"Inhibition of thrombosis by a novel platelet selective S-nitrosothiol compound without hemodynamic side effects","volume":"61","author":"Vilahur","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.niox.2020.11.005_bib39","series-title":"New Therapeutic Agents in Thrombosis and Thrombolysis","first-page":"499","article-title":"Nitric oxide donors as platelet inhibitors","author":"Vilahur","year":"2009"},{"key":"10.1016\/j.niox.2020.11.005_bib40","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1002\/ajh.20955","article-title":"The role of nitric oxide in aspirin induced thrombolysis in vitro and the purification of aspirin activated nitric oxide synthase from human blood platelets","volume":"82","author":"Karmohapatra","year":"2007","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.niox.2020.11.005_bib41","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/MBC.0000000000000085","article-title":"Estriol-induced fibrinolysis due to the activation of plasminogen to plasmin by nitric oxide synthesis in platelets","volume":"26","author":"Jana","year":"2015","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"10.1016\/j.niox.2020.11.005_bib42","doi-asserted-by":"crossref","DOI":"10.1186\/cc5937","article-title":"Clinical review: patency of the circuit in continuous renal replacement therapy","volume":"11","author":"Joannidis","year":"2007","journal-title":"Crit. Care"},{"key":"10.1016\/j.niox.2020.11.005_bib43","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood.2020006000","article-title":"COVID-19 and its implications for thrombosis and anticoagulation","volume":"135","author":"Connors","year":"2020","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.niox.2020.11.005_bib44","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1182\/blood.2020007214","article-title":"Platelet gene expression and function in COVID-19 patients","volume":"136","author":"Manne","year":"2020","journal-title":"Blood"}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860320302032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860320302032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:05:46Z","timestamp":1761069946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860320302032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":44,"alternative-id":["S1089860320302032"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2020.11.005","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of nitrite and far-red light on coagulation","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2020.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}