{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T04:21:48Z","timestamp":1770524508640,"version":"3.49.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.niox.2021.12.002","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T10:36:18Z","timestamp":1638614178000},"page":"9-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Role of cytoglobin in cigarette smoke constituent-induced loss of nitric oxide bioavailability in vascular smooth muscle cells"],"prefix":"10.1016","volume":"119","author":[{"given":"Elsayed M.","family":"Mahgoup","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar A.","family":"Khaleel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"El-Mahdy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel R.","family":"Abd-Allah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9414-9150","authenticated-orcid":false,"given":"Jay L.","family":"Zweier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2021.12.002_bib1","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/01.RES.0000243586.99701.cf","article-title":"Environmental cardiology: studying mechanistic links between pollution and heart disease","volume":"99","author":"Bhatnagar","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.niox.2021.12.002_bib2","doi-asserted-by":"crossref","first-page":"H388","DOI":"10.1152\/ajpheart.00868.2010","article-title":"Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice","volume":"300","author":"Talukder","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2021.12.002_bib3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1053\/pcad.2003.YPCAD13","article-title":"Smoking and endothelial function","volume":"45","author":"Puranik","year":"2003","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1016\/j.niox.2021.12.002_bib4","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1161\/CIRCULATIONAHA.112.093245","article-title":"The assessment of endothelial function: from research into clinical practice","volume":"126","author":"Flammer","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.niox.2021.12.002_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1573403X14666180913120015","article-title":"Smoking and endothelial dysfunction","volume":"18","author":"Golbidi","year":"2020","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.niox.2021.12.002_bib6","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.1073\/pnas.84.24.9265","article-title":"Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide","volume":"84","author":"Ignarro","year":"1987","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.niox.2021.12.002_bib7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1152\/physrev.00036.2017","article-title":"Sources of vascular nitric oxide and reactive oxygen species and their regulation","volume":"99","author":"Tejero","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.niox.2021.12.002_bib8","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1073\/pnas.74.8.3203","article-title":"Nitric oxide activates guanylate cyclase and increases guanosine 3\u2032: 5\u2032-cyclic monophosphate levels in various tissue preparations","volume":"74","author":"Arnold","year":"1977","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.niox.2021.12.002_bib9","doi-asserted-by":"crossref","first-page":"16266","DOI":"10.1021\/bi051601b","article-title":"Characterization of functional heme domains from soluble guanylate cyclase","volume":"44","author":"Karow","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.niox.2021.12.002_bib10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.niox.2021.12.002_bib11","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/0006-2952(88)90236-5","article-title":"Endothelium-derived relaxing factor: identification as nitric oxide and role in the control of vascular tone and platelet function","volume":"37","author":"Moncada","year":"1988","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.niox.2021.12.002_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/152308603321223522","article-title":"The functions of nitric oxide-mediated signaling and changes in gene expression during the hypersensitive response","volume":"5","author":"Delledonne","year":"2003","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.niox.2021.12.002_bib13","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1089\/ars.2019.7881","article-title":"Regulation of Nitric Oxide Metabolism and Vascular Tone by Cytoglobin","volume":"32","author":"Zweier","year":"2020","journal-title":"Antioxidants & Redox Signaling"},{"key":"10.1016\/j.niox.2021.12.002_bib14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/157016112798829760","article-title":"The role of nitric oxide on endothelial function","volume":"10","author":"Tousoulis","year":"2012","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.niox.2021.12.002_bib15","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/bj3570593","article-title":"Nitric oxide synthases: structure, function and inhibition","volume":"357","author":"Alderton","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.niox.2021.12.002_bib16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0005-2728(99)00016-X","article-title":"Mammalian nitric oxide synthases","volume":"1411","author":"Stuehr","year":"1999","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"10.1016\/j.niox.2021.12.002_bib17","doi-asserted-by":"crossref","first-page":"H2421","DOI":"10.1152\/ajpheart.00487.2004","article-title":"Biphasic modulation of vascular nitric oxide catabolism by oxygen","volume":"287","author":"Liu","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2021.12.002_bib18","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.freeradbiomed.2009.11.024","article-title":"Oxygen regulates the effective diffusion distance of nitric oxide in the aortic wall","volume":"48","author":"Liu","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.niox.2021.12.002_bib19","doi-asserted-by":"crossref","first-page":"25318","DOI":"10.1074\/jbc.M102630200","article-title":"Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells","volume":"276","author":"Kawada","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.niox.2021.12.002_bib20","doi-asserted-by":"crossref","first-page":"8539","DOI":"10.1074\/jbc.M808231200","article-title":"Cytoglobin is expressed in the vasculature and regulates cell respiration and proliferation via nitric oxide dioxygenation","volume":"284","author":"Halligan","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.niox.2021.12.002_bib21","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1021\/bi300291h","article-title":"Characterization of the function of cytoglobin as an oxygen-dependent regulator of nitric oxide concentration","volume":"51","author":"Liu","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.niox.2021.12.002_bib22","doi-asserted-by":"crossref","first-page":"100196","DOI":"10.1074\/jbc.RA120.016394","article-title":"Defining the reducing system of the NO dioxygenase cytoglobin in vascular smooth muscle cells and its critical role in regulating cellular NO decay","volume":"296","author":"Ilangovan","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.niox.2021.12.002_bib23","doi-asserted-by":"crossref","first-page":"19538","DOI":"10.1074\/jbc.M201934200","article-title":"A ubiquitously expressed human hexacoordinate hemoglobin","volume":"277","author":"Trent","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.niox.2021.12.002_bib24","doi-asserted-by":"crossref","first-page":"14807","DOI":"10.1038\/ncomms14807","article-title":"Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall","volume":"8","author":"Liu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.niox.2021.12.002_bib25","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1111\/febs.12352","article-title":"Differences in oxygen\u2010dependent nitric oxide metabolism by cytoglobin and myoglobin account for their differing functional roles","volume":"280","author":"Liu","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.niox.2021.12.002_bib26","doi-asserted-by":"crossref","first-page":"23850","DOI":"10.1074\/jbc.M110.132340","article-title":"Nitric-oxide dioxygenase function of human cytoglobin with cellular reductants and in rat hepatocytes","volume":"285","author":"Gardner","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.niox.2021.12.002_bib27","first-page":"E10","article-title":"Role of hypoxia inducible factor-1 alpha (HIF-1\u03b1) in cytoglobin expression and fibroblast proliferation of Keloids","volume":"65","author":"Jusman","year":"2019","journal-title":"Kobe J. Med. Sci."},{"key":"10.1016\/j.niox.2021.12.002_bib28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/sj.bjc.6605121","article-title":"Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer","volume":"101","author":"Shaw","year":"2009","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.niox.2021.12.002_bib29","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.niox.2018.02.009","article-title":"Cigarette smoke constituents cause endothelial nitric oxide synthase dysfunction and uncoupling due to depletion of tetrahydrobiopterin with degradation of GTP cyclohydrolase","volume":"76","author":"Abdelghany","year":"2018","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2021.12.002_bib30","doi-asserted-by":"crossref","first-page":"H51","DOI":"10.1152\/ajpheart.00657.2019","article-title":"Chronic cigarette smoke exposure triggers a vicious cycle of leukocyte and endothelial-mediated oxidant stress that results in vascular dysfunction","volume":"319","author":"El-Mahdy","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2021.12.002_bib31","doi-asserted-by":"crossref","first-page":"H2122","DOI":"10.1152\/ajpheart.00997.2020","article-title":"Long-Term Electronic Cigarette Exposure Induces Cardiovascular Dysfunction Similar to Tobacco Cigarettes: Role of Nicotine and Exposure Duration","volume":"320","author":"El-Mahdy","year":"2021","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.niox.2021.12.002_bib32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jelechem.2012.09.038","article-title":"Application of electrode methods in studies of nitric oxide metabolism and diffusion kinetics","volume":"688","author":"Liu","year":"2013","journal-title":"J. Electroanal. Chem."},{"key":"10.1016\/j.niox.2021.12.002_bib33","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.niox.2005.04.011","article-title":"Quantitative measurements of NO reaction kinetics with a Clark-type electrode","volume":"13","author":"Liu","year":"2005","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2021.12.002_bib34","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1161\/ATVBAHA.117.309410","article-title":"The hemoglobin homolog cytoglobin in smooth muscle inhibits apoptosis and regulates vascular remodeling","volume":"37","author":"Jourd\u2019heuil","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.niox.2021.12.002_bib35","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0891-5849(98)00163-4","article-title":"Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical","volume":"25","author":"Benov","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.niox.2021.12.002_bib36","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.1021\/acs.biochem.7b00224","article-title":"Efficient reduction of vertebrate cytoglobins by the cytochrome b 5\/cytochrome b 5 reductase\/NADH system","volume":"56","author":"Amdahl","year":"2017","journal-title":"Biochemistry"},{"key":"10.1016\/j.niox.2021.12.002_bib37","doi-asserted-by":"crossref","first-page":"H639","DOI":"10.1152\/ajpheart.00595.2018","article-title":"Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension","volume":"316","author":"Dikalov","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2021.12.002_bib38","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3390\/ijerph16010096","article-title":"Environmental tobacco smoke and cardiovascular disease","volume":"16","author":"DiGiacomo","year":"2019","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.niox.2021.12.002_bib39","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1002\/tox.22321","article-title":"Evaluation of globins expression in brain, heart, and lung in rats exposed to side stream cigarette smoke","volume":"32","author":"Tae","year":"2017","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.niox.2021.12.002_bib40","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1007\/s11064-007-9317-x","article-title":"Cytoglobin up-regulated by hydrogen peroxide plays a protective role in oxidative stress","volume":"32","author":"Li","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.niox.2021.12.002_bib41","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cardiores.2005.10.010","article-title":"On the impact of NO\u2013globin interactions in the cardiovascular system","volume":"69","author":"G\u00f6decke","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.niox.2021.12.002_bib42","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1021\/acs.biochem.9b00406","article-title":"The zebrafish cytochrome b 5\/cytochrome b 5 reductase\/NADH system efficiently reduces cytoglobins 1 and 2: conserved activity of cytochrome b 5\/cytochrome b 5 reductases during vertebrate evolution","volume":"58","author":"Amdahl","year":"2019","journal-title":"Biochemistry"},{"key":"10.1016\/j.niox.2021.12.002_bib43","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s10695-012-9677-2","article-title":"NADH-dependent cytochrome b5 reductase and NADPH methemoglobin reductase activity in the erythrocytes of Oncorhynchus mykiss","volume":"38","author":"Saleh","year":"2012","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.niox.2021.12.002_bib44","doi-asserted-by":"crossref","DOI":"10.1161\/res.123.suppl_1.103","article-title":"Cytochrome b5 reductase 3 regulates myoglobin redox state and controls cardiac function","volume":"123","author":"Carew","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.niox.2021.12.002_bib45","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0309-1740(94)P1821-C","article-title":"Localization of metmyoglobin-reducing enzyme (NADH-cytochrome b5 reductase) system components in bovine skeletal muscle","volume":"39","author":"Arihara","year":"1995","journal-title":"Meat Sci."},{"key":"10.1016\/j.niox.2021.12.002_bib46","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1089\/ars.2013.5479","article-title":"Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2","volume":"21","author":"Siendones","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.niox.2021.12.002_bib47","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.molmet.2019.12.008","article-title":"Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with \u03b2-cell failure","volume":"34","author":"Fan","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.niox.2021.12.002_bib48","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2105053118","article-title":"Cytoglobin has potent superoxide dismutase function","author":"Zweier","year":"2021","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.niox.2021.12.002_bib49","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3350\/cmh.2020.0037","article-title":"Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis","volume":"26","author":"Le Thi Thanh Thuy","year":"2020","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.niox.2021.12.002_bib50","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1667\/RR2517.1","article-title":"Knockdown of cytoglobin expression sensitizes human glioma cells to radiation and oxidative stress","volume":"176","author":"Fang","year":"2011","journal-title":"Radiat. Res."},{"key":"10.1016\/j.niox.2021.12.002_bib51","doi-asserted-by":"crossref","first-page":"101468","DOI":"10.1016\/j.redox.2020.101468","article-title":"Emerging perspectives on cytoglobin, beyond NO dioxygenase and peroxidase","volume":"32","author":"Mathai","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.niox.2021.12.002_bib52","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/ATVBAHA.113.300156","article-title":"Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis","volume":"34","author":"Messner","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.niox.2021.12.002_bib53","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3389\/fpls.2016.00316","article-title":"Nitric oxide level is self-regulating and also regulates its ROS partners","volume":"7","author":"Romero-Puertas","year":"2016","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.niox.2021.12.002_bib54","doi-asserted-by":"crossref","first-page":"1245049","DOI":"10.1155\/2016\/1245049","article-title":"Role of ROS and RNS sources in physiological and pathological conditions","volume":"2016","author":"Di Meo","year":"2016","journal-title":"Oxidative medicine and cellular longevity"},{"key":"10.1016\/j.niox.2021.12.002_bib55","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1097\/01.hjh.0000358835.25934.5e","article-title":"Chronic antioxidant therapy fails to ameliorate hypertension: potential mechanisms behind","volume":"27","author":"Pechanova","year":"2009","journal-title":"J. Hypertens."},{"key":"10.1016\/j.niox.2021.12.002_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jtbi.2018.08.014","article-title":"Why antioxidant therapies have failed in clinical trials","volume":"457","author":"Davies","year":"2018","journal-title":"J. Theor. Biol."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860321001245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860321001245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:07:00Z","timestamp":1761070020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860321001245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":56,"alternative-id":["S1089860321001245"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2021.12.002","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of cytoglobin in cigarette smoke constituent-induced loss of nitric oxide bioavailability in vascular smooth muscle cells","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2021.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}