{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:34:00Z","timestamp":1780054440200,"version":"3.54.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/14414-8"],"award-info":[{"award-number":["2021\/14414-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["2017\/061008"],"award-info":[{"award-number":["2017\/061008"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["2017\/15175-1"],"award-info":[{"award-number":["2017\/15175-1"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303839\/2019-8"],"award-info":[{"award-number":["303839\/2019-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005288","name":"Funda\u00e7\u00e3o Amaz\u00f4nia Paraense de Amparo \u00e0 Pesquisa","doi-asserted-by":"publisher","award":["2019\/16805-4"],"award-info":[{"award-number":["2019\/16805-4"]}],"id":[{"id":"10.13039\/501100005288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.niox.2023.06.001","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T22:27:32Z","timestamp":1685658452000},"page":"26-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["The importance of the endothelial nitric oxide synthase on the release of 6-nitrodopamine from mouse isolated atria and ventricles and their role on chronotropism"],"prefix":"10.1016","volume":"138-139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0250-8468","authenticated-orcid":false,"given":"Jos\u00e9","family":"Britto-J\u00fanior","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo L.","family":"Pereira do Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Chiavegatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel Odorico","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Elisabete A. Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola Z.","family":"Monica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"De Nucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2023.06.001_bib1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/416337a","article-title":"Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms","volume":"416","author":"Barouch","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.niox.2023.06.001_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119425","article-title":"6-Nitrodopamine is released by human umbilical cord vessels and modulates vascular reactivity","volume":"276","author":"Britto-J\u00fanior","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.niox.2023.06.001_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2022.109403","article-title":"6-Nitrodopamine is an endogenous selective dopamine receptor antagonist in Chelonoidis carbonaria aorta","volume":"260","author":"Britto-J\u00fanior","year":"2022","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.niox.2023.06.001_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2022.109471","article-title":"Release of 6-nitrodopamine modulates vascular reactivity of Pantherophis guttatus aortic rings","volume":"262","author":"Lima","year":"2022","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.niox.2023.06.001_bib5","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x2023e12622","article-title":"Relaxation of marmoset (Callithrix spp.) thoracic aorta and pulmonary artery rings by endothelium-derived 6-nitrodopamine","volume":"56","author":"Britto-J\u00fanior","year":"2023","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.niox.2023.06.001_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120879","article-title":"6-NitroDopamine is an endogenous modulator of rat heart chronotropism","volume":"307","author":"Britto-J\u00fanior","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.niox.2023.06.001_bib7","article-title":"6-nitrodopamine is the most potent endogenous positive inotropic agent in the rat isolated heart","author":"Britto-J\u00fanior","year":"2023","journal-title":"WCP2023 - World Congress of Basic & Clinical Pharmacology"},{"key":"10.1016\/j.niox.2023.06.001_bib8","article-title":"Basal release of 6-cyanodopamine, 6-nitrodopa, 6-nitrodopamine and 6-nitroadrenaline from rabbit isolated ventricles","author":"Campos","year":"2023","journal-title":"WCP2023 - World Congress of Basic & Clinical Pharmacology"},{"issue":"1\u20132","key":"10.1016\/j.niox.2023.06.001_bib9","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.chroma.2007.07.005","article-title":"Determination of nitrocatecholamines in rat brain using high-performance liquid chromatography-peroxyoxalate chemiluminescence reaction detection","volume":"1164","author":"Tsunoda","year":"2007","journal-title":"J. Chromatogr. A"},{"issue":"23","key":"10.1016\/j.niox.2023.06.001_bib10","doi-asserted-by":"crossref","first-page":"13561","DOI":"10.1074\/jbc.271.23.13561","article-title":"Bioactive 6-nitronorepinephrine identified in mammalian brain","volume":"271","author":"Shintani","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.niox.2023.06.001_bib11","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1002\/ejic.200600436","article-title":"Kinetics and thermodynamics of halide and nitrite oxidation by mammalian heme peroxidases","volume":"19","author":"Arnhold","year":"2006","journal-title":"Eur. J. Inorg. Chem."},{"issue":"27","key":"10.1016\/j.niox.2023.06.001_bib12","doi-asserted-by":"crossref","first-page":"20597","DOI":"10.1074\/jbc.M000181200","article-title":"Mechanism of reaction of myeloperoxidase with nitrite","volume":"275","author":"Burner","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.niox.2023.06.001_bib13","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1161\/01.RES.43.6.931","article-title":"Age-related changes in Purkinje fiber action potentials of adult dogs","volume":"43","author":"Rosen","year":"1978","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.niox.2023.06.001_bib14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4161\/chan.2.6.7429","article-title":"Interaction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin","volume":"2","author":"Lee","year":"2008","journal-title":"Channels"},{"issue":"24","key":"10.1016\/j.niox.2023.06.001_bib15","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1161\/CIRCULATIONAHA.105.539437","article-title":"nNOS gene deletion exacerbates pathological left ventricular remodeling and functional deterioration after myocardial infarction","volume":"112","author":"Dawson","year":"2005","journal-title":"Circulation"},{"issue":"17","key":"10.1016\/j.niox.2023.06.001_bib16","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/j.lfs.2006.05.014","article-title":"Heart rate dynamics in iNOS knockout mice","volume":"79","author":"Mani","year":"2006","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.niox.2023.06.001_bib17","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/01.HYP.32.5.856","article-title":"Role of nNOS in blood pressure regulation in eNOS null mutant mice","volume":"32","author":"Kurihara","year":"1998","journal-title":"Hypertension"},{"issue":"23","key":"10.1016\/j.niox.2023.06.001_bib18","doi-asserted-by":"crossref","first-page":"13176","DOI":"10.1073\/pnas.93.23.13176","article-title":"Elevated blood pressures in mice lacking endothelial nitric oxide synthase","volume":"93","author":"Shesely","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.niox.2023.06.001_bib19","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1476-5381.1990.tb14151.x","article-title":"Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo","volume":"101","author":"D Rees","year":"1990","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.niox.2023.06.001_bib20","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1124\/mol.58.5.1026","article-title":"The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes","volume":"58","author":"Boer","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.niox.2023.06.001_bib21","series-title":"Guia brasileiro de produ\u00e7\u00e3o, manuten\u00e7\u00e3o ou utiliza\u00e7\u00e3o de animais em atividade de ensino ou pesquisa cientifica, Conselho nacional de controle de experimenta\u00e7\u00e3o animal","author":"Andersen","year":"2016"},{"issue":"18","key":"10.1016\/j.niox.2023.06.001_bib22","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"14","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.niox.2023.06.001_bib23","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1161\/01.HYP.34.4.802","article-title":"Long-term nitric oxide inhibition and chronotropic responses in rat isolated right atria","volume":"34","author":"Riado","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.niox.2023.06.001_bib24","first-page":"1173","article-title":"Quantification of 6-nitrodopamine in Krebs-Henseleit's solution by LC-MS\/MS for the assessment of its basal release from Chelonoidis carbonaria aortae in vitro","volume":"22","author":"Campos","year":"2021","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"issue":"1\u20133","key":"10.1016\/j.niox.2023.06.001_bib25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0014-2999(94)90093-0","article-title":"Nitric oxide has no chronotropic effect in right atria isolated from rat heart","volume":"255","author":"Kennedy","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2023.06.001_bib26","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1161\/01.RES.77.5.984","article-title":"Effect of NO modulation on cardiac arrhythmias in the rat isolated heart","volume":"77","author":"Pabla","year":"1995","journal-title":"Circ. Res."},{"key":"10.1016\/j.niox.2023.06.001_bib27","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0165-1838(98)00173-8","article-title":"Nitric oxide inhibits the positive chronotropica and inotropic responses to sympathetic nerve stimulation in the isolated Guinea-pig atria","volume":"75","author":"Choate","year":"1999","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.niox.2023.06.001_bib28","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0008-6363(98)00314-9","article-title":"Regulation of basal myocardial function by NO","volume":"41","author":"Kojda","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.niox.2023.06.001_bib29","first-page":"H1250","article-title":"Nitric oxide modulates epicardial coronary basal vasomotor tone in awake dogs","volume":"258","author":"Chu","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.niox.2023.06.001_bib30","first-page":"H10","article-title":"Contribution of nitric oxide to dilation of resistance coronary vessels in conscious dogs","volume":"262","author":"Parent","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.niox.2023.06.001_bib31","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1476-5381.1990.tb14131.x","article-title":"Regional and haemodynamioc effects of NG-nitro-L-arginine methyl ester in conscious, Long Evans rats","volume":"101","author":"Gardiner","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.niox.2023.06.001_bib32","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1440-1681.1991.tb01466.x","article-title":"Haemodynamic responses to N-nitro-L-arginine in conscious rabbits","volume":"18","author":"Du","year":"1991","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.niox.2023.06.001_bib33","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1440-1681.1991.tb01456.x","article-title":"Haemodynamic and hormonal effect of N-nitro-L-arginine, an inhibitor of nitric oxide synthesis, in sheep","volume":"18","author":"Tresham","year":"1991","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.niox.2023.06.001_bib34","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0306-3623(95)02042-X","article-title":"The heart rate after inhibition of nitric oxide release in the anaesthetized dog","volume":"27","author":"Pagliaro","year":"1996","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.niox.2023.06.001_bib35","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1097\/00005344-199305000-00018","article-title":"Acute and chronic inhibition of nitric oxide synthase in conscious rabbits: role of nitric oxide in the control of vascular tone","volume":"21","author":"Ward","year":"1993","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.niox.2023.06.001_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/S0165-1838(98)00123-4","article-title":"Effect of nitric oxide synthase inhibition of the sympatho-vagal control of heart rate","volume":"73","author":"Sears","year":"1998","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.niox.2023.06.001_bib37","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1476-5381.1992.tb09034.x","article-title":"The influence of atropine and atenolol on the cardiac hemodynamic effects of NG-nitro-L-arginine methyl ester in conscious, Long Evans rats","volume":"105","author":"Widdop","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.niox.2023.06.001_bib38","first-page":"R18","article-title":"Baroreflex control of heart rate in humans during nitroprusside-induced hypotension","volume":"243","author":"Chen","year":"1982","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.niox.2023.06.001_bib39","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0002-9149(86)80034-0","article-title":"Effects of orthotopic heart transplantation on sympathetic control mechanisms in congestive heart failure","volume":"58","author":"Levine","year":"1986","journal-title":"Am. J. Cardiol."},{"issue":"4","key":"10.1016\/j.niox.2023.06.001_bib40","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0735-1097(94)00463-Z","article-title":"Iodine-123 metaiodobenzylguanidine scintigraphic assessment of the transplanted human heart: evidence for late reinnervation","volume":"25","author":"De Marco","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.niox.2023.06.001_bib41","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0014-2999(97)01168-0","article-title":"Inhibition of nitric oxide synthase and soluble guanylated cyclase induces cardiopressive effects in normal rat hearts","volume":"334","author":"Kojda","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2023.06.001_bib42","doi-asserted-by":"crossref","DOI":"10.1007\/s00210-023-02394-9","article-title":"Investigation on the positive chronotropic action of 6-nitrodopamine in the rat isolated atria","author":"Britto-J\u00fanior","year":"2023","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"3","key":"10.1016\/j.niox.2023.06.001_bib43","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1476-5381.1963.tb01494.x","article-title":"Cardiac noradrenaline stores","volume":"20","author":"Fawaz","year":"1963","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.niox.2023.06.001_bib44","doi-asserted-by":"crossref","first-page":"H354","DOI":"10.1152\/ajpheart.00898.2007","article-title":"Sympathetic control of heart rate in nNOS knockout mice","volume":"294","author":"Choate","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"25","key":"10.1016\/j.niox.2023.06.001_bib45","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1161\/01.CIR.0000019516.31040.2D","article-title":"Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytes","volume":"105","author":"Ashley","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.niox.2023.06.001_bib46","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.autneu.2006.03.001","article-title":"Baroreflex responses in neuronal nitric oxide synthase knockout mice (nNOS)","volume":"126\u2013127","author":"Carvalho","year":"2006","journal-title":"Auton. Neurosci.: Basic and Clinical"},{"key":"10.1016\/j.niox.2023.06.001_bib47","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jare.2022.03.003","article-title":"iNOS contributes to heart failure with preserved ejection fraction through mitochondrial dysfunction and Akt S-nitrosylation","volume":"43","author":"Guo","year":"2023","journal-title":"J. Adv. Res."},{"issue":"3","key":"10.1016\/j.niox.2023.06.001_bib48","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1053\/j.jvca.2012.04.015","article-title":"Endothelial nitric oxide synthase mediates the first and inducible nitric oxide synthase mediates the second window of desflurane-induced preconditioning","volume":"27","author":"Redel","year":"2013","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"issue":"10","key":"10.1016\/j.niox.2023.06.001_bib49","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1006\/jmcc.1996.0202","article-title":"Endogenous protection against reperfusion-induced ventricular fibrillation: role of neuronal versus non-neuronal sources of nitric oxide and species dependence in the rat versus rabbit isolated heart","volume":"28","author":"Pabla","year":"1996","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.niox.2023.06.001_bib50","doi-asserted-by":"crossref","first-page":"H971","DOI":"10.1152\/ajpheart.2000.278.3.H971","article-title":"Modulation of mouse cardiac function in vivo by eNOS and ANP","volume":"278","author":"Gyurko","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.niox.2023.06.001_bib51","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jphs.2014.10.002","article-title":"Significance of nitric oxide synthases: lessons from triple nitric oxide synthases null mice","volume":"127","author":"Tsutsui","year":"2015","journal-title":"J. Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.niox.2023.06.001_bib52","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1161\/01.HYP.20.3.298","article-title":"Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension","volume":"20","author":"Ribeiro","year":"1992","journal-title":"Hypertension"}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860323000538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860323000538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:09:13Z","timestamp":1761070153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860323000538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":52,"alternative-id":["S1089860323000538"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2023.06.001","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The importance of the endothelial nitric oxide synthase on the release of 6-nitrodopamine from mouse isolated atria and ventricles and their role on chronotropism","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2023.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}