{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:55:23Z","timestamp":1793692523866,"version":"4.5.1"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018973","name":"Lovely Professional University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018973","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.niox.2024.09.001","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T16:07:45Z","timestamp":1725638865000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Advancements in increasing efficiency of hydrogen sulfide in therapeutics: Strategies for targeted delivery as prodrugs"],"prefix":"10.1016","volume":"152","author":[{"given":"Tejasvi","family":"Pandey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6354-9525","authenticated-orcid":false,"given":"Vivek","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2024.09.001_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114506","article-title":"Hydrogen sulfide and its donors for the treatment of cerebral ischaemia-reperfusion injury: a comprehensive review","volume":"161","author":"Huang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.niox.2024.09.001_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2023.106449","article-title":"Reperfusion-induced injury and the effects of the dithioacetate type hydrogen sulfide donor ibuprofen derivative, BM-88, in isolated rat hearts","volume":"185","author":"Vass","year":"2023","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.niox.2024.09.001_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.niox.2024.01.004","article-title":"Hydrogen sulfide (H2S) metabolism: unraveling cellular regulation, disease implications, and therapeutic prospects for precision medicine","author":"Pandey","year":"2024","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2024.09.001_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2021.129881","article-title":"A novel near-infrared fluorescent probe to in vivo evaluate the release efficiency of H2S prodrug","volume":"339","author":"Yang","year":"2021","journal-title":"Sensor. Actuator. B Chem."},{"issue":"4","key":"10.1016\/j.niox.2024.09.001_bib5","first-page":"296","article-title":"Prodrugs of hydrogen sulfide and related sulfur species: recent development","volume":"18","author":"Zheng-Nan","year":"2020","journal-title":"Chin. J. Nat. Med."},{"issue":"8","key":"10.1016\/j.niox.2024.09.001_bib6","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1016\/j.cclet.2021.02.065","article-title":"A H2S-triggered two-photon ratiometric fluorescent theranostic prodrug for bio-imaging","volume":"32","author":"Wu","year":"2021","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.niox.2024.09.001_bib7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jconrel.2022.09.026","article-title":"External stimuli-responsive gasotransmitter prodrugs: chemistry and spatiotemporal release","volume":"351","author":"Ji","year":"2022","journal-title":"J. Contr. Release"},{"issue":"5","key":"10.1016\/j.niox.2024.09.001_bib8","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1002\/med.21913","article-title":"Progress and perspective on hydrogen sulfide donors and their biomedical applications","volume":"42","author":"Song","year":"2022","journal-title":"Med. Res. Rev."},{"issue":"4","key":"10.1016\/j.niox.2024.09.001_bib9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.21608\/jabps.2021.80739.1131","article-title":"Current trends and future perspectives of hydrogen sulfide donors","volume":"4","author":"Shabib","year":"2021","journal-title":"Journal of advanced Biomedical and Pharmaceutical Sciences"},{"issue":"4","key":"10.1016\/j.niox.2024.09.001_bib10","first-page":"296","article-title":"Prodrugs of hydrogen sulfide and related sulfur species: recent development","volume":"18","author":"Zheng-Nan","year":"2020","journal-title":"Chin. J. Nat. Med."},{"issue":"14","key":"10.1016\/j.niox.2024.09.001_bib11","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1089\/ars.2020.8060","article-title":"SG1002 and catenated divalent organic sulfur compounds as promising hydrogen sulfide prodrugs","volume":"33","author":"Gojon","year":"2020","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.niox.2024.09.001_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2023.102329","article-title":"Prodrugs of sulfide and persulfide species: implications in their different pharmacological activities","volume":"75","author":"Yu","year":"2023","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"11","key":"10.1016\/j.niox.2024.09.001_bib13","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1039\/D1AN00457C","article-title":"A self-immolated fluorogenic agent triggered by H 2 S exhibiting potential anti-glioblastoma activity","volume":"146","author":"Ge","year":"2021","journal-title":"Analyst"},{"key":"10.1016\/j.niox.2024.09.001_bib14","article-title":"Hydrogen sulfide responsive nanoplatforms: novel gas responsive drug delivery carriers for biomedical applications","volume":"19","author":"Zou","year":"2023","journal-title":"Asian J. Pharm. Sci."},{"issue":"4\u20136","key":"10.1016\/j.niox.2024.09.001_bib15","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1089\/ars.2021.0088","article-title":"Methods for suppressing hydrogen sulfide in biological systems","volume":"36","author":"Wang","year":"2022","journal-title":"Antioxidants Redox Signal."},{"issue":"2","key":"10.1016\/j.niox.2024.09.001_bib16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1089\/ars.2019.7896","article-title":"Biological effects of morpholin-4-Ium 4 methoxyphenyl (morpholino) phosphinodithioate and other phosphorothioate-based hydrogen sulfide donors","volume":"32","author":"Nin","year":"2020","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.niox.2024.09.001_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.564281","article-title":"Roles of hydrogen sulfide donors in common kidney diseases","volume":"11","author":"Ngowi","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.niox.2024.09.001_bib18","first-page":"198","article-title":"Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications","volume":"19","author":"Rong","year":"2023","journal-title":"Bioact. Mater."},{"issue":"2","key":"10.1016\/j.niox.2024.09.001_bib19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1089\/ars.2019.7864","article-title":"The benefits of macromolecular\/supramolecular approaches in hydrogen sulfide delivery: a review of polymeric and self-assembled hydrogen sulfide donors","volume":"32","author":"Kaur","year":"2020","journal-title":"Antioxidants Redox Signal."},{"issue":"31","key":"10.1016\/j.niox.2024.09.001_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202203902","article-title":"Recyclable endogenous H2S activation of self\u2010assembled nanoprobe with controllable biodegradation for synergistically enhanced colon cancer\u2010specific therapy","volume":"9","author":"Huang","year":"2022","journal-title":"Adv. Sci."},{"issue":"19","key":"10.1016\/j.niox.2024.09.001_bib21","doi-asserted-by":"crossref","first-page":"19242","DOI":"10.1021\/acsnano.3c05936","article-title":"H2S-Reactivating antitumor immune response after microwave thermal therapy for long-term tumor suppression","volume":"17","author":"Li","year":"2023","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.niox.2024.09.001_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-021-00784-w","article-title":"Novel controlled and targeted releasing hydrogen sulfide system exerts combinational cerebral and myocardial protection after cardiac arrest","volume":"19","author":"Sun","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.niox.2024.09.001_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2022.110740","article-title":"A dynamic thiol-disulfide exchange assisted high cell-penetrating fluorescent probe for intracellular H2S detection","volume":"207","author":"Feng","year":"2022","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.niox.2024.09.001_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2022.111656","article-title":"Deletions of the cystathionine-\u03b2-synthase (CBS) and cystathionine-\u03b3-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of Drosophila melanogaster","volume":"203","author":"Shaposhnikov","year":"2022","journal-title":"Mechanisms of Ageing and Development"},{"issue":"1","key":"10.1016\/j.niox.2024.09.001_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-71469-x","article-title":"Cystathionine \u03b2-synthase is involved in cysteine biosynthesis and H2S generation in Toxoplasma gondii","volume":"10","author":"Conter","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.niox.2024.09.001_bib26","article-title":"Hydrogen sulfide-induced vasodilation: the involvement of vascular potassium channels","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.niox.2024.09.001_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.143985","article-title":"H2S-releasing versatile hydrogel dressing with potent antimicrobial, anti-inflammatory, epithelialization and angiogenic capabilities for diabetic wound healing","volume":"469","author":"Chen","year":"2023","journal-title":"Chem. Eng. J."},{"issue":"3","key":"10.1016\/j.niox.2024.09.001_bib28","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1007\/s00210-023-02729-6","article-title":"Using mechanism-based combinations of H2S-donors to maximize the cardioprotective action of H2S","volume":"397","author":"Ravani","year":"2024","journal-title":"Naunyn-schmiedeberg's Archives of Pharmacology"},{"issue":"1","key":"10.1016\/j.niox.2024.09.001_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-44877-y","article-title":"Hydrogen sulfide and polysulfides induce GABA\/glutamate\/D-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity","volume":"13","author":"Furuie","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.niox.2024.09.001_bib30","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41392-020-00410-5","article-title":"Inhibition of cystathionine \u03b2-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.niox.2024.09.001_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111801","article-title":"H2S exposure-induced oxidative stress promotes LPS-mediated hepatocyte autophagy through the PI3K\/AKT\/TOR pathway","volume":"209","author":"Guo","year":"2021","journal-title":"Ecotoxicology and environmental safety"},{"key":"10.1016\/j.niox.2024.09.001_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101772","article-title":"Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics","volume":"38","author":"Paul","year":"2021","journal-title":"Redox Biol."},{"issue":"9","key":"10.1016\/j.niox.2024.09.001_bib35","doi-asserted-by":"crossref","first-page":"13513","DOI":"10.1021\/acsnano.2c05379","article-title":"Emerging strategies in stimuli-responsive prodrug nanosystems for cancer therapy","volume":"16","author":"Ding","year":"2022","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.niox.2024.09.001_bib62","doi-asserted-by":"crossref","first-page":"650","DOI":"10.3390\/antiox12030650","article-title":"H2S donors with cytoprotective effects in models of MI\/R injury and chemotherapy-induced cardiotoxicity","volume":"12","author":"Hu","year":"2023","journal-title":"Antioxidants"},{"issue":"20","key":"10.1016\/j.niox.2024.09.001_bib36","article-title":"Prodrugs of persulfide and sulfide: is there a pharmacological difference between the two in the context of rapid exchanges among various sulfur species in vivo?","volume":"61","author":"Yu","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"issue":"4","key":"10.1016\/j.niox.2024.09.001_bib37","first-page":"296","article-title":"Prodrugs of hydrogen sulfide and related sulfur species: recent development","volume":"18","author":"Zheng-Nan","year":"2020","journal-title":"Chin. J. Nat. Med."},{"issue":"4","key":"10.1016\/j.niox.2024.09.001_bib38","first-page":"296","article-title":"Prodrugs of hydrogen sulfide and related sulfur species: recent development","volume":"18","author":"Zheng-Nan","year":"2020","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.niox.2024.09.001_bib39","doi-asserted-by":"crossref","DOI":"10.1111\/bph.16211","article-title":"Hydrogen sulfide: recent development of its dual donors and hybrid drugs","author":"Xu","year":"2023","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.niox.2024.09.001_bib40","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1089\/ars.2019.7896","article-title":"Biological effects of morpholin-4-Ium 4 methoxyphenyl (morpholino) phosphinodithioate and other phosphorothioate-based hydrogen sulfide donors","volume":"32","author":"Nin","year":"2020","journal-title":"Antioxidants Redox Signal."},{"issue":"12","key":"10.1016\/j.niox.2024.09.001_bib41","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.3390\/biom11121899","article-title":"H2S donors and their use in medicinal chemistry","volume":"11","author":"Magli","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.niox.2024.09.001_bib42","article-title":"5-(4-Hydroxyphenyl)-3H-1, 2-dithiole-3-thione derivatives of brefeldin A: design, synthesis and cytotoxicity in MDA-MB-231 human breast cancer cells","volume":"12","author":"Wang","year":"2023","journal-title":"Bioorg. Med. Chem."},{"issue":"40","key":"10.1016\/j.niox.2024.09.001_bib43","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.2174\/0929867330666230126100638","article-title":"Hydrogen sulfide (H2S): as a potent modulator and therapeutic prodrug in cancer","volume":"30","author":"Faris","year":"2023","journal-title":"Curr. Med. Chem."},{"issue":"7","key":"10.1016\/j.niox.2024.09.001_bib44","doi-asserted-by":"crossref","first-page":"984","DOI":"10.3390\/ph16070984","article-title":"Towards symmetric thioamides: microwave-aided synthesis of terephthalic acid derivatives","volume":"16","author":"Bak","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.niox.2024.09.001_bib45","unstructured":"Hu Q. Advancements in stimulus-responsive, H2S-donating motifs: design, synthesis, and biological applications (Doctoral Dissertation, Wake Forest University)."},{"issue":"21","key":"10.1016\/j.niox.2024.09.001_bib46","doi-asserted-by":"crossref","first-page":"19727","DOI":"10.1021\/acsanm.3c03525","article-title":"Polyzwitterionic nanogels for the controlled and sustained delivery of NO and H2S","volume":"6","author":"Bairagi","year":"2023","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.niox.2024.09.001_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2023.215616","article-title":"Recent advances of nanomaterials for intervention in Parkinson's disease in the context of anti-inflammation","volume":"502","author":"Zhang","year":"2024","journal-title":"Coord. Chem. Rev."},{"issue":"23","key":"10.1016\/j.niox.2024.09.001_bib48","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.3390\/cells12232684","article-title":"Chemistry of hydrogen sulfide\u2014pathological and physiological functions in mammalian cells","volume":"12","author":"Andr\u00e9s","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.niox.2024.09.001_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.139089","article-title":"Physiological functions and donor design of hydrogen sulfide and its application in central nervous system diseases","volume":"452","author":"Zhao","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.niox.2024.09.001_bib50","doi-asserted-by":"crossref","DOI":"10.1111\/bph.16170","article-title":"Hydrogen sulfide signalling in neurodegenerative diseases","author":"Tripathi","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.niox.2024.09.001_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102875","article-title":"Untargeted polysulfide omics analysis of alternations in polysulfide production during the germination of broccoli sprouts","volume":"67","author":"Kasamatsu","year":"2023","journal-title":"Redox Biol."},{"issue":"28","key":"10.1016\/j.niox.2024.09.001_bib52","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1039\/D3CC00684K","article-title":"Insights into self-degradation of cysteine esters and amides under physiological conditions yield new cleavable chemistry","volume":"59","author":"Kang","year":"2023","journal-title":"Chem. Commun."},{"key":"10.1016\/j.niox.2024.09.001_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.niox.2024.01.003","article-title":"Hydrogen sulfide donors across time: from origins to cutting-edge applications","author":"Zhao","year":"2024","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2024.09.001_bib54","unstructured":"Fosnacht K, Dorogin J, Jefferis P, Hettiaratchi M, Pluth M. An expanded palette of fluorescent COS\/H2S-releasing donors for H2S delivery, detection, and In Vivo Application."},{"issue":"1","key":"10.1016\/j.niox.2024.09.001_bib55","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202300138","article-title":"Hydrogels for Gasotransmitter Delivery: nitric oxide, carbon monoxide, and hydrogen sulfide","volume":"24","author":"Sarkar","year":"2024","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.niox.2024.09.001_bib56","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jconrel.2023.11.014","article-title":"Strategies for gaseous neuromodulator release in chemical neuroscience: experimental approaches and translational validation","volume":"365","author":"Ali","year":"2024","journal-title":"J. Contr. Release"},{"issue":"4","key":"10.1016\/j.niox.2024.09.001_bib57","article-title":"Manganese porphyrin\u2010containing polymeric micelles: a novel approach for intracellular catalytic formation of per\/polysulfide species from a hydrogen sulfide donor","volume":"13","author":"Young","year":"2024","journal-title":"Adv. Healthcare Mater."},{"issue":"1","key":"10.1016\/j.niox.2024.09.001_bib58","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1080\/13813455.2021.1976209","article-title":"H2S-mediated blockage of protein acetylation and oxidative stress attenuates lipid overload-induced cardiac senescence","volume":"130","author":"Yu","year":"2024","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.niox.2024.09.001_bib59","article-title":"The role of hydrogen sulfide regulation of pyroptosis in different pathological processes","volume":"16","author":"Zhang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"66","key":"10.1016\/j.niox.2024.09.001_bib60","doi-asserted-by":"crossref","DOI":"10.1002\/chem.202302197","article-title":"Dual\u2010stimuli\u2010activatable hybrid prodrug for the self\u2010immolative delivery of an anticancer agent and hydrogen sulfide with turn\u2010on fluorescence","volume":"29","author":"Sufian","year":"2023","journal-title":"Chem.--Eur. J."},{"key":"10.1016\/j.niox.2024.09.001_bib61","doi-asserted-by":"crossref","DOI":"10.1111\/bph.16211","article-title":"Hydrogen sulfide: recent development of its dual donors and hybrid drugs","author":"Xu","year":"2023","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.niox.2024.09.001_bib63","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1021\/acs.jmedchem.2c01706","article-title":"Novel insights on cai\u2013CORM hybrids: evaluation of the CO releasing properties and pain-relieving activity of differently substituted coumarins for the treatment of rheumatoid arthritis","volume":"66","author":"Berrino","year":"2023","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.niox.2024.09.001_bib64","doi-asserted-by":"crossref","first-page":"908","DOI":"10.3390\/antiox12040908","article-title":"The impact of drugs on hydrogen sulfide homeostasis in mammals","volume":"12","author":"Alsaeedi","year":"2023","journal-title":"Antioxidants"},{"issue":"8","key":"10.1016\/j.niox.2024.09.001_bib65","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.3390\/antiox12081545","article-title":"Hydrogen sulfide-releasing indomethacin-derivative (ATB-344) prevents the development of oxidative gastric mucosal injuries","volume":"12","author":"G\u0142owacka","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.niox.2024.09.001_bib66","first-page":"1","article-title":"Unveiling the potential of prodrug and drug-conjugate strategies in treatment of diabetes mellitus and its complications","volume":"29","author":"Bhilare","year":"2024","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.niox.2024.09.001_bib67","article-title":"The recent developments of camptothecin and its derivatives as potential anti-tumor agents","volume":"4","author":"Wang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"14","key":"10.1016\/j.niox.2024.09.001_bib68","doi-asserted-by":"crossref","first-page":"9823","DOI":"10.1021\/acs.jmedchem.3c00617","article-title":"Exploring the anticancer activity of tamoxifen-based metal complexes targeting mitochondria","volume":"66","author":"Scalcon","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.niox.2024.09.001_bib69","first-page":"198","article-title":"Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications","volume":"19","author":"Rong","year":"2023","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.niox.2024.09.001_bib70","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202300138","article-title":"Hydrogels for Gasotransmitter Delivery: nitric oxide, carbon monoxide, and hydrogen sulfide","volume":"24","author":"Sarkar","year":"2024","journal-title":"Macromol. Biosci."},{"issue":"5","key":"10.1016\/j.niox.2024.09.001_bib71","doi-asserted-by":"crossref","DOI":"10.1002\/adtp.202200349","article-title":"Current status and future prospects of hydrogen sulfide donor\u2010based delivery systems","volume":"6","author":"Lu","year":"2023","journal-title":"Advanced Therapeutics"},{"issue":"11","key":"10.1016\/j.niox.2024.09.001_bib72","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202300215","article-title":"Biocompatible polymer\u2010modified nanoplatform for ferroptosis\u2010enhanced combination cancer therapy","volume":"23","author":"He","year":"2023","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.niox.2024.09.001_bib73","doi-asserted-by":"crossref","DOI":"10.1021\/acs.chas.3c00008","article-title":"Toxicity of polymeric nanodrugs as drug carriers","author":"Sairam","year":"2023","journal-title":"ACS Chemical Health & Safety"},{"issue":"2","key":"10.1016\/j.niox.2024.09.001_bib76","first-page":"114","article-title":"A review of patents on therapeutic potential and delivery of hydroge n sulfide","volume":"11","author":"Verma","year":"2017","journal-title":"Recent Pat. Drug Deliv. Formulation"},{"issue":"14","key":"10.1016\/j.niox.2024.09.001_bib77","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1089\/ars.2020.8060","article-title":"SG1002 and catenated divalent organic sulfur compounds as promising hydrogen sulfide prodrugs","volume":"33","author":"Gojon","year":"2020","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.niox.2024.09.001_bib78","unstructured":"Singh N. Development and Characterization of a Topical Ocular Delivery System for Hydrogen Sulfide for the Treatment of Glaucoma (Doctoral Dissertation, Creighton University)."},{"key":"10.1016\/j.niox.2024.09.001_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113953","article-title":"Mesoporous silica nanoparticles for pulmonary drug delivery","volume":"177","author":"Garcia-Fernandez","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.niox.2024.09.001_bib83","doi-asserted-by":"crossref","first-page":"5729","DOI":"10.2147\/IJN.S210116","article-title":"Smart nanomedicine agents for cancer, triggered by pH, glutathione, H2O2, or H2S","volume":"24","author":"Li","year":"2019","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.niox.2024.09.001_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-021-01078-x","article-title":"Near-infrared light-triggered nano-prodrug for cancer gas therapy","volume":"19","author":"Liu","year":"2021","journal-title":"J. Nanobiotechnol."},{"issue":"2","key":"10.1016\/j.niox.2024.09.001_bib85","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/bio.2965","article-title":"Nucleation temperature\u2010controlled synthesis and in vitro toxicity evaluation of l\u2010cysteine\u2010capped Mn: ZnS quantum dots for intracellular imaging","volume":"31","author":"Pandey","year":"2016","journal-title":"Luminescence"},{"key":"10.1016\/j.niox.2024.09.001_bib86","first-page":"578","article-title":"Nanomotor-based H2S donor with mitochondrial targeting function for treatment of Parkinson's disease","volume":"31","author":"Zhao","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.niox.2024.09.001_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122212","article-title":"Exosome camouflaged coordination-assembled Iridium (III) photosensitizers for apoptosis-autophagy-ferroptosis induced combination therapy against melanoma","volume":"301","author":"Feng","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.niox.2024.09.001_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.133570","article-title":"Hydrogen sulfide detection induced burst release of model drug from polymeric micelles","volume":"382","author":"Sharma","year":"2023","journal-title":"Sensor. Actuator. B Chem."},{"issue":"23","key":"10.1016\/j.niox.2024.09.001_bib89","doi-asserted-by":"crossref","DOI":"10.1002\/marc.202300496","article-title":"Semiconducting polymers for cancer immunotherapy","volume":"44","author":"Li","year":"2023","journal-title":"Macromol. Rapid Commun."},{"key":"10.1016\/j.niox.2024.09.001_bib90","article-title":"Nanomaterials\u2010Induced redox imbalance: challenged and opportunities for nanomaterials in cancer therapy","volume":"21","author":"Wu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.niox.2024.09.001_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.133570","article-title":"Hydrogen sulfide detection induced burst release of model drug from polymeric micelles","volume":"382","author":"Sharma","year":"2023","journal-title":"Sensor. Actuator. B Chem."},{"issue":"3","key":"10.1016\/j.niox.2024.09.001_bib92","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2174\/1389557523666230427152234","article-title":"Chemical strategies toward prodrugs and fluorescent probes for gasotransmitters","volume":"24","author":"Su","year":"2024","journal-title":"Mini Rev. Med. Chem."},{"issue":"14","key":"10.1016\/j.niox.2024.09.001_bib93","doi-asserted-by":"crossref","first-page":"6745","DOI":"10.1039\/D3NR00062A","article-title":"pH\/ROS-responsive propelled nanomotors for the active treatment of renal injury","volume":"15","author":"Tong","year":"2023","journal-title":"Nanoscale"},{"issue":"21","key":"10.1016\/j.niox.2024.09.001_bib94","doi-asserted-by":"crossref","first-page":"19727","DOI":"10.1021\/acsanm.3c03525","article-title":"Polyzwitterionic nanogels for the controlled and sustained delivery of NO and H2S","volume":"6","author":"Bairagi","year":"2023","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.niox.2024.09.001_bib95","article-title":"Recent advances in sulfur dioxide releasing nanoplatforms for cancer therapy","author":"He","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.niox.2024.09.001_bib97","article-title":"Enzyme\u2010triggered chemodynamic therapy via a peptide\u2010H2S donor conjugate with complexed Fe2+","author":"Zhu","year":"2023","journal-title":"Angew. Chem. Int. Ed."},{"issue":"3","key":"10.1016\/j.niox.2024.09.001_bib98","doi-asserted-by":"crossref","first-page":"650","DOI":"10.3390\/antiox12030650","article-title":"H2S donors with cytoprotective effects in models of MI\/R injury and chemotherapy-induced cardiotoxicity","volume":"12","author":"Hu","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.niox.2024.09.001_bib99","article-title":"Doxorubicin prodrug-based nanomedicines for the treatment of cancer","author":"Zhao","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"32","key":"10.1016\/j.niox.2024.09.001_bib100","doi-asserted-by":"crossref","first-page":"17497","DOI":"10.1021\/jacs.3c01682","article-title":"meso-Methyl BODIPY photocages: mechanisms, photochemical properties, and applications","volume":"145","author":"Shrestha","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.niox.2024.09.001_bib101","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.chempr.2022.11.007","article-title":"Photo-controllable biochemistry: exploiting the photocages in phototherapeutic window","volume":"9","author":"Xiong","year":"2023","journal-title":"Chem"},{"key":"10.1016\/j.niox.2024.09.001_bib102","first-page":"1","article-title":"Exploring the next generation of antibody\u2013drug conjugates","volume":"8","author":"Tsuchikama","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"23","key":"10.1016\/j.niox.2024.09.001_bib103","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202300474","article-title":"Bioorthogonal chemistry in translational research: advances and opportunities","volume":"24","author":"Chaudhuri","year":"2023","journal-title":"Chembiochem"},{"key":"10.1016\/j.niox.2024.09.001_bib104","series-title":"Design of Functional Polymeric Materials for Cancer-Targeted Drug Delivery and Cellular Capture and Isolation","author":"Radaha","year":"2021"},{"issue":"13","key":"10.1016\/j.niox.2024.09.001_bib105","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1021\/acs.biochem.0c00363","article-title":"Enzyme-directed functionalization of designed, two-dimensional protein lattices","volume":"60","author":"Subramanian","year":"2020","journal-title":"Biochemistry"},{"issue":"12","key":"10.1016\/j.niox.2024.09.001_bib106","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.3390\/catal11121466","article-title":"Protein modifications: from chemoselective probes to novel biocatalysts","volume":"11","author":"Pessatti","year":"2021","journal-title":"Catalysts"},{"key":"10.1016\/j.niox.2024.09.001_bib107","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.939855","article-title":"Functionalization strategies of polymeric nanoparticles for drug delivery in Alzheimer's disease: current trends and future perspectives","volume":"16","author":"La Barbera","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.niox.2024.09.001_bib108","unstructured":"Pessatti TB. Res\u00edduos reativos de ciste\u00edna: estudos qu\u00edmico-biol\u00f3gicos em prote\u00ednas."},{"key":"10.1016\/j.niox.2024.09.001_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113931","article-title":"The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: a new era of customized medications","volume":"176","author":"Dillon","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.niox.2024.09.001_bib110","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00044-022-02859-1","article-title":"An insight into prodrug strategy for the treatment of Alzheimer's disease","volume":"31","author":"Bhilare","year":"2022","journal-title":"Med. Chem. Res."},{"issue":"9","key":"10.1016\/j.niox.2024.09.001_bib111","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1021\/jacs.1c12006","article-title":"Cysteine-activated small-molecule H2Se donors inspired by synthetic H2S donors","volume":"144","author":"Kang","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"38","key":"10.1016\/j.niox.2024.09.001_bib112","doi-asserted-by":"crossref","first-page":"17651","DOI":"10.1021\/jacs.2c07225","article-title":"Subcellular delivery of hydrogen sulfide using small molecule donors impacts organelle stress","volume":"144","author":"Gilbert","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"6547","key":"10.1016\/j.niox.2024.09.001_bib113","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1126\/science.abd8377","article-title":"Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance","volume":"372","author":"Shatalin","year":"2021","journal-title":"Science"}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860324001058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860324001058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T18:54:09Z","timestamp":1729018449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860324001058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":105,"alternative-id":["S1089860324001058"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2024.09.001","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advancements in increasing efficiency of hydrogen sulfide in therapeutics: Strategies for targeted delivery as prodrugs","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2024.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}