{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:30:14Z","timestamp":1786995014017,"version":"build-2736575974"},"reference-count":159,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.niox.2024.09.005","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T12:18:34Z","timestamp":1726748314000},"page":"48-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Nitric oxide in the cardio-cerebrovascular system: Source, regulation and application"],"prefix":"10.1016","volume":"152","author":[{"given":"Xiaoming","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinghe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyong","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7539-9502","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2024.09.005_bib1","doi-asserted-by":"crossref","first-page":"e740","DOI":"10.1016\/j.wneu.2018.10.130","article-title":"Traumatic brain injury increases the risk of major adverse cardiovascular and cerebrovascular events: a 13-year, population-based study","volume":"122","author":"Eric Nyam","year":"2019","journal-title":"World neurosurgery"},{"key":"10.1016\/j.niox.2024.09.005_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.748396","article-title":"Late cardiac pathology in severe covid-19. A postmortem series of 30 patients","volume":"8","author":"Ferrer-G\u00f3mez","year":"2021","journal-title":"Frontiers in cardiovascular medicine"},{"key":"10.1016\/j.niox.2024.09.005_bib3","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1007\/s00415-020-09750-2","article-title":"Symptomatic and asymptomatic intracranial atherosclerotic stenosis: 3 years' prospective study","volume":"267","author":"Fischer","year":"2020","journal-title":"J. Neurol."},{"issue":"14","key":"10.1016\/j.niox.2024.09.005_bib4","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00126-22","article-title":"Nitric oxide attenuates human cytomegalovirus infection yet disrupts neural cell differentiation and tissue organization","volume":"96","author":"Mokry","year":"2022","journal-title":"J. Virol."},{"key":"10.1016\/j.niox.2024.09.005_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101238","article-title":"L-NAME releases nitric oxide and potentiates subsequent nitroglycerin-mediated vasodilation","volume":"26","author":"Liu","year":"2019","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.niox.2024.09.005_bib6","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1021\/acsnano.9b08587","article-title":"Platelet membrane biomimetic magnetic nanocarriers for targeted delivery and in situ generation of nitric oxide in early ischemic stroke","volume":"14","author":"Li","year":"2020","journal-title":"ACS Nano"},{"issue":"15","key":"10.1016\/j.niox.2024.09.005_bib7","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1007\/s00018-019-03331-x","article-title":"Nitric oxide and peroxynitrite trigger and enhance release of neutrophil extracellular traps","volume":"77","author":"Manda-Handzlik","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.niox.2024.09.005_bib8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/10715762.2019.1566605","article-title":"L-Arginine and tetrahydrobiopterin supported nitric oxide production is crucial for the microbicidal activity of neutrophils","volume":"53","author":"Nagarkoti","year":"2019","journal-title":"Free Radic. Res."},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib9","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1152\/physrev.00036.2017","article-title":"Sources of vascular nitric oxide and reactive oxygen species and their regulation","volume":"99","author":"Tejero","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.niox.2024.09.005_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101550","article-title":"Nitric oxide in cellular adaptation and disease","volume":"34","author":"Gantner","year":"2020","journal-title":"Redox Biol."},{"issue":"9","key":"10.1016\/j.niox.2024.09.005_bib11","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1161\/STROKEAHA.120.029781","article-title":"Rapamycin induces an eNOS (endothelial nitric oxide synthase) dependent increase in brain collateral perfusion in wistar and spontaneously hypertensive rats","volume":"51","author":"Beard","year":"2020","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib12","article-title":"Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K\/Akt\/eNOS and Nrf2\/HO-1 pathways","volume":"14","author":"Wang","year":"2024","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.niox.2024.09.005_bib13","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: regulation and function","volume":"33","author":"F\u00f6rstermann","year":"2012","journal-title":"Eur. Heart J."},{"issue":"7","key":"10.1016\/j.niox.2024.09.005_bib14","doi-asserted-by":"crossref","first-page":"5646","DOI":"10.1007\/s12035-016-0110-1","article-title":"Neuronal NOS induces neuronal differentiation through a pkc\u03b1-dependent GSK3\u03b2 inactivation pathway in hippocampal neural progenitor cells","volume":"54","author":"Park","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"13","key":"10.1016\/j.niox.2024.09.005_bib15","first-page":"7399","article-title":"Involvement of nNOS in the antinociceptive activity of melatonin in inflammatory pain at the level of sensory neurons","volume":"24","author":"Xie","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.niox.2024.09.005_bib16","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s12640-019-00067-1","article-title":"Chronic isolation stress affects subsequent crowding stress-induced brain nitric oxide synthase (NOS) isoforms and hypothalamic-pituitary-adrenal (HPA) Axis responses","volume":"36","author":"G\u0105dek-Michalska","year":"2019","journal-title":"Neurotox. Res."},{"issue":"3","key":"10.1016\/j.niox.2024.09.005_bib17","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/npp.2014.212","article-title":"Homeostatic sleep pressure is the primary factor for activation of cortical nNOS\/NK1 neurons","volume":"40","author":"Dittrich","year":"2015","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/j.niox.2024.09.005_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41419-024-06557-1","article-title":"nNOS in Erbb4-positive neurons regulates GABAergic transmission in mouse hippocampus","volume":"15","author":"Wan","year":"2024","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.niox.2024.09.005_bib19","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.bbadis.2018.11.007","article-title":"Functions and dysfunctions of nitric oxide in brain","volume":"1865","author":"Pic\u00f3n-Pag\u00e8s","year":"2019","journal-title":"Biochimica et Biophysica Acta-molecular Basis of Disease"},{"issue":"7","key":"10.1016\/j.niox.2024.09.005_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2021.119018","article-title":"nNOS induction and NOSIP interaction impact granulopoiesis and neutrophil differentiation by modulating nitric oxide generation","volume":"1868","author":"Sadaf","year":"2021","journal-title":"Biochimica et Biophysica Acta-molecular Cell Research"},{"issue":"4","key":"10.1016\/j.niox.2024.09.005_bib21","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10456-018-9620-y","article-title":"eNOS expression and NO release during hypoxia is inhibited by miR-200b in human endothelial cells","volume":"21","author":"Janaszak-Jasiecka","year":"2018","journal-title":"Angiogenesis"},{"key":"10.1016\/j.niox.2024.09.005_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152380","article-title":"Use of embryonic stem cell-derived cardiomyocytes to study cardiotoxicity of bisphenol AF via the GPER\/CAM\/eNOS pathway","volume":"432","author":"Yang","year":"2020","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib23","first-page":"88","article-title":"Expression and activity of platelet endothelial nitric oxide synthase are decreased in patients with coronary thrombosis and stenosis","volume":"11","author":"Emami","year":"2019","journal-title":"Avicenna J. Med. Biotechnol. (AJMB)"},{"key":"10.1016\/j.niox.2024.09.005_bib24","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3389\/fncel.2017.00180","article-title":"Endothelial nitric oxide synthase is present in dendritic spines of neurons in primary cultures","volume":"11","author":"Caviedes","year":"2017","journal-title":"Front. Cell. Neurosci."},{"issue":"2pt3","key":"10.1016\/j.niox.2024.09.005_bib25","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.gene.2015.09.061","article-title":"Endothelial nitric oxide synthase: from biochemistry and gene structure to clinical implications of NOS3 polymorphisms","volume":"575","author":"Oliveira-Paula","year":"2016","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.niox.2024.09.005_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jphs.2015.09.002","article-title":"Vascular nitric oxide: beyond Enos","volume":"129","author":"Zhao","year":"2015","journal-title":"J. Pharmacol. Sci."},{"issue":"17","key":"10.1016\/j.niox.2024.09.005_bib27","doi-asserted-by":"crossref","first-page":"9407","DOI":"10.3390\/ijms22179407","article-title":"Rutaecarpine increases nitric oxide synthesis via eNOS phosphorylation by TRPV1-dependent CaMKII and CaMKK\u03b2\/AMPK signaling pathway in human endothelial cells","volume":"22","author":"Lee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.niox.2024.09.005_bib28","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/cns.13275","article-title":"The Sphkl\/SlP pathway regulates angiogenesis via NOS\/NO synthesis following cerebral ischemia-reperfusion","volume":"26","author":"Lv","year":"2020","journal-title":"CNS Neurosci. Ther."},{"issue":"3","key":"10.1016\/j.niox.2024.09.005_bib29","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41440-019-0363-y","article-title":"Impact of cigarette smoking on nitric oxide-sensitive and nitric oxide-insensitive soluble guanylate cyclase-mediated vascular tone regulation","volume":"43","author":"Tawa","year":"2020","journal-title":"Hypertens. Res."},{"issue":"4","key":"10.1016\/j.niox.2024.09.005_bib30","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1074\/jbc.M114.599985","article-title":"Extracellular signal-regulated kinase mediates expression of arginase II but not inducible nitric-oxide synthase in lipopolysaccharide-stimulated macrophages","volume":"290","author":"Jin","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.niox.2024.09.005_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153289","article-title":"Investigating the role of TNF-\u03b1 and IFN-\u03b3 activation on the dynamics of iNOS gene expression in LPS stimulated macrophages","volume":"11","author":"Salim","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.niox.2024.09.005_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8364848","article-title":"The dual role of inducible nitric oxide synthase in myocardial ischemia\/reperfusion injury: friend or foe?","volume":"2018","author":"Yu","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.niox.2024.09.005_bib33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/path.4545","article-title":"High nitric oxide production, secondary to inducible nitric oxide synthase expression, is essential for regulation of the tumour-initiating properties of colon cancer stem cells","volume":"236","author":"Puglisi","year":"2015","journal-title":"J. Pathol."},{"key":"10.1016\/j.niox.2024.09.005_bib34","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.neuroscience.2013.08.018","article-title":"Mitochondrial dysfunction in the hippocampus of rats caused by chronic oxidative stress","volume":"252","author":"Rodr\u00edguez-Mart\u00ednez","year":"2013","journal-title":"Neuroscience"},{"issue":"18","key":"10.1016\/j.niox.2024.09.005_bib35","doi-asserted-by":"crossref","first-page":"7617","DOI":"10.1021\/acs.jmedchem.6b01672","article-title":"Nitric oxide donor-based cancer therapy: advances and prospects","volume":"60","author":"Huang","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.niox.2024.09.005_bib36","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.niox.2016.02.001","article-title":"Nitroxide antioxidant as a potential strategy to attenuate the oxidative\/nitrosative stress induced by hydrogen peroxide plus nitric oxide in cultured neurons","volume":"54","author":"Lee","year":"2016","journal-title":"Nitric Oxide"},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12951-022-01457-y","article-title":"Heart-targeted amelioration of sepsis-induced myocardial dysfunction by microenvironment responsive nitric oxide nanogenerators in situ","volume":"20","author":"Ouyang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.niox.2024.09.005_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202303259","article-title":"Nitric oxide: physiological functions, delivery, and biomedical applications","author":"Andrabi","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.niox.2024.09.005_bib39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.coph.2018.02.009","article-title":"Nitric oxide donors for peripheral artery disease","volume":"39","author":"Falconer","year":"2018","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.niox.2024.09.005_bib40","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3389\/fphys.2015.00243","article-title":"The new nitric oxide donor cyclohexane nitrate induces vasorelaxation, hypotension, and antihypertensive effects via NO\/cGMP\/PKG pathway","volume":"6","author":"Mendes-J\u00fanior","year":"2015","journal-title":"Front. Physiol."},{"issue":"12","key":"10.1016\/j.niox.2024.09.005_bib41","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1177\/0271678X15605848","article-title":"Nitric oxide inhalation reduces brain damage, prevents mortality, and improves neurological outcome after subarachnoid hemorrhage by resolving early pial microvasospasms","volume":"36","author":"Terpolilli","year":"2016","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.niox.2024.09.005_bib42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jsbmb.2017.05.006","article-title":"Role of GPER in estrogen-dependent nitric oxide formation and vasodilation","volume":"176","author":"Fredette","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"11","key":"10.1016\/j.niox.2024.09.005_bib43","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1161\/CIRCULATIONAHA.120.049606","article-title":"Red blood cell and endothelial eNOS independently regulate circulating nitric oxide metabolites and blood pressure","volume":"144","author":"Leo","year":"2021","journal-title":"Circulation"},{"issue":"23","key":"10.1016\/j.niox.2024.09.005_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300340","article-title":"Biomimetic antithrombotic tissue-engineered vascular grafts for converting cholesterol and free radicals into nitric oxide","volume":"12","author":"Yang","year":"2023","journal-title":"Adv. Healthcare Mater."},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib45","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3400\/avd.ra.17-00134","article-title":"Nitric oxide: from good to bad","volume":"11","author":"Vanhoutte","year":"2018","journal-title":"Annals of Vascular Diseases"},{"issue":"8","key":"10.1016\/j.niox.2024.09.005_bib46","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.3390\/ijms23084243","article-title":"Roles of nitric oxide in brain ischemia and reperfusion","volume":"23","author":"Wang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3390\/ijms20010187","article-title":"New therapeutic implications of endothelial nitric oxide synthase (eNOS) function\/dysfunction in cardiovascular disease","volume":"20","author":"Daiber","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"18","key":"10.1016\/j.niox.2024.09.005_bib48","doi-asserted-by":"crossref","first-page":"6691","DOI":"10.3390\/molecules28186691","article-title":"Neuronal nitric oxide synthase and post-translational modifications in the development of central nervous system diseases: implications and regulation","volume":"28","author":"Maccallini","year":"2023","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1515\/revneuro-2014-0041","article-title":"Nitric oxide synthase in hypoxic or ischemic brain injury","volume":"26","author":"Liu","year":"2015","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.niox.2024.09.005_bib50","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00414-019-02051-y","article-title":"Increased inducible nitric oxide synthase (iNOS) expression in human myocardial infarction","volume":"134","author":"Wilmes","year":"2020","journal-title":"Int. J. Leg. Med."},{"issue":"3","key":"10.1016\/j.niox.2024.09.005_bib51","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1124\/pr.110.002907","article-title":"cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action","volume":"62","author":"Francis","year":"2010","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"10.1016\/j.niox.2024.09.005_bib52","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1161\/HYPERTENSIONAHA.120.15856","article-title":"Nitric oxide-cGMP signaling in hypertension: current and future options for pharmacotherapy","volume":"76","author":"Ataabadi","year":"2020","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.niox.2024.09.005_bib53","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1159\/000471938","article-title":"Triiodothyronine potentiates vasorelaxation via PKG\/VASP signaling in vascular smooth muscle cells","volume":"41","author":"Samuel","year":"2017","journal-title":"Cell. Physiol. Biochem. : international journal of experimental cellular physiology, biochemistry, and pharmacology"},{"key":"10.1016\/j.niox.2024.09.005_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107499","article-title":"Ion channels as effectors of cyclic nucleotide pathways: functional relevance for arterial tone regulation","volume":"209","author":"Manoury","year":"2020","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.niox.2024.09.005_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106931","article-title":"Modulation of the nitric oxide\/cGMP pathway in cardiac contraction and relaxation: potential role in heart failure treatment","volume":"196","author":"Mollace","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"11","key":"10.1016\/j.niox.2024.09.005_bib56","doi-asserted-by":"crossref","first-page":"719","DOI":"10.4330\/wjc.v7.i11.719","article-title":"Vascular endothelial dysfunction and pharmacological treatment","volume":"7","author":"Su","year":"2015","journal-title":"World J. Cardiol."},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib57","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000606","article-title":"Direct renin inhibition with aliskiren protects against myocardial ischemia\/reperfusion injury by activating nitric oxide synthase signaling in spontaneously hypertensive rats","volume":"3","author":"Zhang","year":"2014","journal-title":"J. Am. Heart Assoc."},{"issue":"11","key":"10.1016\/j.niox.2024.09.005_bib58","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1002\/jcb.30139","article-title":"Stability of S-nitrosothiols and S-nitrosylated proteins: a struggle for cellular existence","volume":"122","author":"Chatterji","year":"2021","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.niox.2024.09.005_bib59","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.niox.2018.01.007","article-title":"RhoA inactivation by S-nitrosylation regulates vascular smooth muscle contractive signaling","volume":"74","author":"Lin","year":"2018","journal-title":"Nitric Oxide: biology and chemistry"},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib60","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.maturitas.2014.10.002","article-title":"Hyperaggregability and impaired nitric oxide production in platelets from postmenopausal women","volume":"80","author":"Mury","year":"2015","journal-title":"Maturitas"},{"issue":"2","key":"10.1016\/j.niox.2024.09.005_bib61","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1074\/jbc.M114.609222","article-title":"Mechanisms of human erythrocytic bioactivation of nitrite","volume":"290","author":"Liu","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.niox.2024.09.005_bib62","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3390\/ijms23031042","article-title":"Impairment of anti-aggregatory responses to nitric oxide and prostacyclin: mechanisms and clinical implications in cardiovascular disease","volume":"23","author":"Chirkov","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.niox.2024.09.005_bib63","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.niox.2018.03.008","article-title":"Effects of the NO\/soluble guanylate cyclase\/cGMP system on the functions of human platelets","volume":"76","author":"Makhoul","year":"2018","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2024.09.005_bib64","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/B978-0-12-800254-4.00006-4","article-title":"Hippocampus and nitric oxide","volume":"96","author":"Hu","year":"2014","journal-title":"Vitam. Horm."},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib65","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s12974-023-02988-3","article-title":"Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke","volume":"20","author":"Sienel","year":"2023","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.niox.2024.09.005_bib66","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/2045-9912.215750","article-title":"The role of nitric oxide in stroke","volume":"7","author":"Chen","year":"2017","journal-title":"Med. Gas Res."},{"issue":"7","key":"10.1016\/j.niox.2024.09.005_bib67","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1021\/acschemneuro.1c00046","article-title":"Rational application of \u03b2-hydroxybutyrate attenuates ischemic stroke by suppressing oxidative stress and mitochondrial-dependent apoptosis via activation of the erk\/CREB\/eNOS pathway","volume":"12","author":"Li","year":"2021","journal-title":"ACS Chem. Neurosci."},{"issue":"5","key":"10.1016\/j.niox.2024.09.005_bib68","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s12264-008-0324-y","article-title":"Minocycline attenuates cognitive impairment and restrains oxidative stress in the hippocampus of rats with chronic cerebral hypoperfusion","volume":"24","author":"Cai","year":"2008","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.niox.2024.09.005_bib69","article-title":"Epigallocatechin-3-Gallate reduces neuronal apoptosis in rats after middle cerebral artery occlusion injury via PI3K\/AKT\/eNOS signaling pathway","volume":"2018","author":"Wang","year":"2018","journal-title":"BioMed Res. Int."},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib70","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41419-020-03338-4","article-title":"eNOS-dependent S-nitrosylation of the NF-\u03baB subunit p65 has neuroprotective effects","volume":"12","author":"Caviedes","year":"2021","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.niox.2024.09.005_bib71","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1177\/0271678X18822474","article-title":"Partial loss of endothelial nitric oxide leads to increased cerebrovascular beta amyloid","volume":"40","author":"Austin","year":"2020","journal-title":"J. Cerebr. Blood Flow Metabol."},{"issue":"20","key":"10.1016\/j.niox.2024.09.005_bib72","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.017477","article-title":"Role of endothelial nitric oxide synthase in isoflurane conditioning-induced neurovascular protection in subarachnoid hemorrhage","volume":"9","author":"Athiraman","year":"2020","journal-title":"J. Am. Heart Assoc."},{"issue":"3","key":"10.1016\/j.niox.2024.09.005_bib73","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.etap.2013.02.009","article-title":"Protective effect of puerarin on lead-induced mouse cognitive impairment via altering activities of acetyl cholinesterase, monoamine oxidase and nitric oxide synthase","volume":"35","author":"Liu","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.niox.2024.09.005_bib74","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1007\/s12035-020-01975-6","article-title":"Morphine induces apoptosis, inflammation, and mitochondrial oxidative stress via activation of TRPM2 channel and nitric oxide signaling pathways in the Hippocampus","volume":"57","author":"Osmanl\u0131o\u011flu","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.niox.2024.09.005_bib75","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.brainres.2014.11.035","article-title":"Chronic intermittent hypoxia-induced neuronal apoptosis in the hippocampus is attenuated by telmisartan through suppression of iNOS\/NO and inhibition of lipid peroxidation and inflammatory responses","volume":"1596","author":"Yuan","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.niox.2024.09.005_bib76","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbi.2015.07.025","article-title":"Clematichinenoside protects blood brain barrier against ischemic stroke superimposed on systemic inflammatory challenges through up-regulating A20","volume":"51","author":"Han","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.niox.2024.09.005_bib77","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ejphar.2019.05.005","article-title":"Vasoreactivity of isolated aortic rings from dyslipidemic and insulin resistant inducible nitric oxide synthase knockout mice","volume":"855","author":"Pathak","year":"2019","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.niox.2024.09.005_bib78","doi-asserted-by":"crossref","first-page":"10835","DOI":"10.1096\/fj.202000734R","article-title":"Endoplasmic reticulum stress-dependent activation of iNOS\/NO-NF-\u03baB signaling and NLRP3 inflammasome contributes to endothelial inflammation and apoptosis associated with microgravity","volume":"34","author":"Jiang","year":"2020","journal-title":"Faseb. J. : official publication of the Federation of American Societies for Experimental Biology"},{"issue":"4","key":"10.1016\/j.niox.2024.09.005_bib79","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/CIRCRESAHA.116.309326","article-title":"Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis","volume":"120","author":"F\u00f6rstermann","year":"2017","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib80","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s11658-023-00423-2","article-title":"Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets","volume":"28","author":"Janaszak-Jasiecka","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"11","key":"10.1016\/j.niox.2024.09.005_bib81","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11883-017-0678-6","article-title":"Oxidative stress in atherosclerosis","volume":"19","author":"Kattoor","year":"2017","journal-title":"Curr. Atherosclerosis Rep."},{"key":"10.1016\/j.niox.2024.09.005_bib82","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.biopha.2018.03.107","article-title":"Ginkgetin ameliorates experimental atherosclerosis in rats","volume":"102","author":"Lian","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"8","key":"10.1016\/j.niox.2024.09.005_bib83","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.3390\/biom11081097","article-title":"Nitric oxide-dependent pathways as critical factors in the consequences and recovery after brain ischemic hypoxia","volume":"11","author":"Wiero\u0144ska","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.niox.2024.09.005_bib84","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.csbj.2015.03.004","article-title":"The role of excitotoxic programmed necrosis in acute brain injury","volume":"13","author":"Fujikawa","year":"2015","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"11","key":"10.1016\/j.niox.2024.09.005_bib85","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.prp.2015.12.009","article-title":"Overproduction of nitric oxide intensifies brain infarction and cerebrovascular damage through reduction of claudin-5 and ZO-1 expression in striatum of ischemic brain","volume":"212","author":"Mohammadi","year":"2016","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.niox.2024.09.005_bib86","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.freeradbiomed.2023.07.032","article-title":"Reactive nitrogen species as therapeutic targets for autophagy\/mitophagy modulation to relieve neurodegeneration in multiple sclerosis: potential application for drug discovery","volume":"208","author":"Li","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.niox.2024.09.005_bib87","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.freeradbiomed.2013.09.006","article-title":"Inhibition of autophagy and glycolysis by nitric oxide during hypoxia\u2013reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons","volume":"65","author":"Benavides","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.niox.2024.09.005_bib88","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/ar.23295","article-title":"Effects and mechanism of action of inducible nitric oxide synthase on apoptosis in a rat model of cerebral ischemia-reperfusion injury","volume":"299","author":"Zheng","year":"2016","journal-title":"Anat. Rec."},{"issue":"10","key":"10.1016\/j.niox.2024.09.005_bib89","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2009579118","article-title":"Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease","volume":"118","author":"Bourgognon","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2024.09.005_bib90","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s12311-018-0934-5","article-title":"Inhibition of inducible nitric oxide synthase attenuates deficits in synaptic plasticity and brain functions following traumatic brain injury","volume":"17","author":"Wang","year":"2018","journal-title":"Cerebellum"},{"issue":"2","key":"10.1016\/j.niox.2024.09.005_bib91","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s12031-019-01295-y","article-title":"Rab7b overexpression-ameliorated ischemic brain damage following tMCAO involves suppression of TLR4 and NF-\u03baB p65","volume":"68","author":"Qi","year":"2019","journal-title":"J. Mol. Neurosci."},{"issue":"5","key":"10.1016\/j.niox.2024.09.005_bib92","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.3390\/ijms20051242","article-title":"Increased iNOS and nitrosative stress in dopaminergic neurons of MDMA-exposed rats","volume":"20","author":"Schiavone","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.niox.2024.09.005_bib93","first-page":"72","volume":"78","author":"Buys","year":"2018","journal-title":"Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential, Nitric oxide"},{"issue":"9","key":"10.1016\/j.niox.2024.09.005_bib94","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.3390\/ijms22094540","article-title":"The roles of nitric oxide synthase\/nitric oxide pathway in the pathology of vascular dementia and related therapeutic approaches","volume":"22","author":"Zhu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.niox.2024.09.005_bib95","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.817072","article-title":"Inhaled nitric oxide treatment for aneurysmal SAH patients with delayed cerebral ischemia","volume":"13","author":"Fung","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.niox.2024.09.005_bib96","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbr.2016.10.037","article-title":"GSNO promotes functional recovery in experimental TBI by stabilizing HIF-1\u03b1","volume":"340","author":"Khan","year":"2018","journal-title":"Behav. Brain Res."},{"issue":"19","key":"10.1016\/j.niox.2024.09.005_bib97","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1016\/j.jacc.2017.09.1064","article-title":"The role of nitroglycerin and other nitrogen oxides in cardiovascular therapeutics","volume":"70","author":"Divakaran","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"10.1016\/j.niox.2024.09.005_bib98","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.jvir.2018.01.777","article-title":"An economic analysis of stent grafts for treatment of vascular access stenosis: point-of-care and medicare perspectives in the United States","volume":"29","author":"Dolmatch","year":"2018","journal-title":"J. Vasc. Intervent. Radiol.: JVIR."},{"issue":"6","key":"10.1016\/j.niox.2024.09.005_bib99","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1177\/1708538117706273","article-title":"Restenosis after carotid artery stenting","volume":"25","author":"Dai","year":"2017","journal-title":"Vascular"},{"issue":"3","key":"10.1016\/j.niox.2024.09.005_bib100","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2174\/092986712803414321","article-title":"Nitric oxide: state of the art in drug design","volume":"19","author":"Serafim","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"8","key":"10.1016\/j.niox.2024.09.005_bib101","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1089\/ars.2015.6363","article-title":"Targeted nitric oxide delivery by supramolecular nanofibers for the prevention of restenosis after arterial injury","volume":"24","author":"Bahnson","year":"2016","journal-title":"Antioxidants Redox Signal."},{"issue":"11","key":"10.1016\/j.niox.2024.09.005_bib102","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1021\/acs.langmuir.0c00112","article-title":"Coronary stents decorated by heparin\/NONOate nanoparticles for anticoagulant and endothelialized effects","volume":"36","author":"Zhu","year":"2020","journal-title":"Langmuir: the ACS journal of surfaces and colloids"},{"issue":"3","key":"10.1016\/j.niox.2024.09.005_bib103","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202200448","article-title":"Photocurable nitric oxide-releasing copolyester for the 3D printing of bioresorbable vascular stents","volume":"23","author":"Oliveira","year":"2023","journal-title":"Macromol. Biosci."},{"issue":"9968","key":"10.1016\/j.niox.2024.09.005_bib104","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0140-6736(14)61121-1","article-title":"Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial","volume":"385","year":"2015","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.niox.2024.09.005_bib105","first-page":"845","article-title":"A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia\u2013reperfusion injury in mice","volume":"61","author":"Atochin","year":"2016","journal-title":"Neurosci. Lett."},{"issue":"15","key":"10.1016\/j.niox.2024.09.005_bib106","doi-asserted-by":"crossref","first-page":"10919","DOI":"10.1021\/acs.jmedchem.1c00282","article-title":"Design, synthesis, and biological evaluation of organic nitrite (NO2-) donors as potential anticerebral ischemia agents","volume":"64","author":"Wu","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.niox.2024.09.005_bib107","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jns.2016.09.032","article-title":"Early NO-donor treatment improves acute perfusion deficit and brain damage after experimental subarachnoid hemorrhage in rats","volume":"370","author":"Lilla","year":"2016","journal-title":"J. Neurol. Sci."},{"issue":"11","key":"10.1016\/j.niox.2024.09.005_bib108","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1161\/STROKEAHA.115.009647","article-title":"ENOS investigators, effect of hyperacute administration (within 6 hours) of transdermal glyceryl trinitrate, a nitric oxide donor, on outcome after stroke: subgroup analysis of the efficacy of nitric oxide in stroke (ENOS) trial","volume":"46","author":"Woodhouse","year":"2015","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.niox.2024.09.005_bib109","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00232-014-9758-5","article-title":"Riboflavin and vitamin E increase brain calcium and antioxidants, and microsomal calcium-ATP-ase values in rat headache models induced by glyceryl trinitrate","volume":"248","author":"B\u00fct\u00fcn","year":"2015","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.niox.2024.09.005_bib110","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.freeradbiomed.2016.05.023","article-title":"Artemisinin conferred ERK mediated neuroprotection to PC12 cells and cortical neurons exposed to sodium nitroprusside-induced oxidative insult","volume":"97","author":"Zheng","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.niox.2024.09.005_bib111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2018.08.002","article-title":"Don't just say no: differential pathways and pharmacological responses to diverse nitric oxide donors","volume":"156","author":"Chiesa","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.niox.2024.09.005_bib112","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.niox.2013.09.005","article-title":"In vitro organic nitrate bioactivation to nitric oxide by recombinant aldehyde dehydrogenase 3A1","volume":"35","author":"Lin","year":"2013","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2024.09.005_bib113","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7845629","article-title":"The endothelin receptor antagonist macitentan improves isosorbide-5-mononitrate (ISMN) and isosorbide dinitrate (ISDN) induced endothelial dysfunction, oxidative stress, and vascular inflammation","volume":"2018","author":"Steven","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.niox.2024.09.005_bib114","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ejphar.2014.04.002","article-title":"The effects of nitroglycerin during cardiopulmonary resuscitation","volume":"734","author":"Stefaniotou","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.niox.2024.09.005_bib115","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/FJC.0000000000000673","article-title":"Role of mitochondrial aldehyde dehydrogenase in nitroglycerin-mediated vasodilation: observations concerning the dose-response relationship","volume":"73","author":"He","year":"2019","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.niox.2024.09.005_bib116","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2217\/cer-2019-0099","article-title":"Comparative analysis of cost-effectiveness between isosorbide-5-mononitrate and isosorbide: a retrospective real-world evaluation","volume":"9960","author":"Zhang","year":"2020","journal-title":"Journal of Comparative Effectiveness Research"},{"key":"10.1016\/j.niox.2024.09.005_bib117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2017.11.003","article-title":"Inorganic nitrite and nitrate in cardiovascular therapy: a better alternative to organic nitrates as nitric oxide donors?","volume":"102","author":"M\u00fcnzel","year":"2018","journal-title":"Vasc. Pharmacol."},{"issue":"9","key":"10.1016\/j.niox.2024.09.005_bib118","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/cmdc.201700113","article-title":"Molecular hybridization tools in the development of furoxan-based NO-donor prodrugs","volume":"12","author":"Fershtat","year":"2017","journal-title":"ChemMedChem"},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib119","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3390\/ph16010033","article-title":"Changes in pharmacokinetics and pharmacodynamics of losartan in experimental diseased rats treated with curcuma longa and lepidium sativum","volume":"16","author":"Ahad","year":"2022","journal-title":"Pharmaceuticals"},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib120","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2174\/157018010789869370","article-title":"Synthesis and biological study of 3-Butyl-1-(2,6-dichlorophenyl)-1H-[1,2,4]triazol- 5(4H)-one derivatives as anti-hypertension drugs","volume":"7","author":"Zhang","year":"2010","journal-title":"Lett. Drug Des. Discov."},{"issue":"4","key":"10.1016\/j.niox.2024.09.005_bib121","doi-asserted-by":"crossref","first-page":"462","DOI":"10.4103\/0970-9185.142799","article-title":"Sodium nitroprusside in 2014: a clinical concepts review","volume":"30","author":"Hottinger","year":"2014","journal-title":"J. Anaesthesiol. Clin. Pharmacol."},{"issue":"2","key":"10.1016\/j.niox.2024.09.005_bib122","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/fcp.12103","article-title":"Enhancement on reactive oxygen species and COX-1 mRNA levels modulate the vascular relaxation induced by sodium nitroprusside in denuded mice aorta","volume":"29","author":"Kangussu","year":"2015","journal-title":"Fund. Clin. Pharmacol."},{"issue":"7","key":"10.1016\/j.niox.2024.09.005_bib123","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1021\/jm049857n","article-title":"Sodium nitroprusside: mechanism of NO release mediated by sulfhydryl-containing molecules","volume":"48","author":"Grossi","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.niox.2024.09.005_bib124","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.niox.2019.02.004","article-title":"NO donors induce vascular relaxation by different cellular mechanisms in hypertensive and normotensive rats","volume":"86","author":"Ara\u00fajo","year":"2019","journal-title":"Nitric Oxide : biology and chemistry"},{"issue":"11","key":"10.1016\/j.niox.2024.09.005_bib125","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.025400","article-title":"Effects of sodium nitroprusside administered via a subdural intracranial catheter on the microcirculation, oxygenation, and electrocortical activity of the cerebral cortex in a pig cardiac arrest model","volume":"11","author":"Lee","year":"2022","journal-title":"J. Am. Heart Assoc."},{"issue":"2","key":"10.1016\/j.niox.2024.09.005_bib126","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1152\/japplphysiol.00167.2017","article-title":"Comparison of the vasodilatory effects of sodium nitroprusside vs. nitroglycerin","volume":"123","author":"Ranadive","year":"2017","journal-title":"J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib127","first-page":"261","article-title":"Role of recombinant human brain natriuretic peptide combined with sodium nitroprusside in improving quality of life and cardiac function in patients with acute heart failure","volume":"20","author":"Peng","year":"2020","journal-title":"Exp. Ther. Med."},{"issue":"Suppl 5","key":"10.1016\/j.niox.2024.09.005_bib128","doi-asserted-by":"crossref","first-page":"S591","DOI":"10.33549\/physiolres.933536","article-title":"Early changes of brain perfusion after subarachnoid hemorrhage - the effect of sodium nitroprusside","volume":"65","author":"Kolar","year":"2016","journal-title":"Physiol. Res."},{"issue":"21","key":"10.1016\/j.niox.2024.09.005_bib129","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202002330","article-title":"Mimicking the nitric oxide-releasing and glycocalyx functions of endothelium on vascular stent surfaces","volume":"7","author":"Lyu","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.niox.2024.09.005_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118377","article-title":"Functional implications of vascular endothelium in regulation of endothelial nitric oxide synthesis to control blood pressure and cardiac functions","volume":"259","author":"Kumar","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.niox.2024.09.005_bib131","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3389\/fbioe.2020.00578","article-title":"Nitric oxide-producing cardiovascular stent coatings for prevention of thrombosis and restenosis","volume":"8","author":"Rao","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.niox.2024.09.005_bib132","doi-asserted-by":"crossref","DOI":"10.1016\/j.porgcoat.2023.108177","article-title":"Construction and biocompatibility evaluation of MOF\/S-HA composite coating on the surface of magnesium alloy vascular stent","volume":"187","author":"Sun","year":"2024","journal-title":"Prog. Org. Coating"},{"issue":"29","key":"10.1016\/j.niox.2024.09.005_bib133","doi-asserted-by":"crossref","first-page":"33745","DOI":"10.1021\/acsami.1c00340","article-title":"High-density three-dimensional network of covalently linked nitric oxide donors to achieve antibacterial and antibiofilm surfaces","volume":"13","author":"Wang","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.niox.2024.09.005_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118387","article-title":"Diethylenetriamine\/NONOate-doped alginate hydrogel with sustained nitric oxide release and minimal toxicity to accelerate healing of MRSA-infected wounds","volume":"270","author":"Hasan","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.niox.2024.09.005_bib135","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3389\/fphar.2020.00923","article-title":"Recent developments in pharmacological effect, mechanism and application prospect of diazeniumdiolates","volume":"11","author":"Li","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.niox.2024.09.005_bib136","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.micromeso.2013.07.017","article-title":"Storage and delivery of nitric oxide via diazeniumdiolated metal organic framework","volume":"181","author":"Lowe","year":"2013","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.niox.2024.09.005_bib137","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2019.00530","article-title":"Nitric oxide (NO)-Releasing macromolecules: rational design and biomedical applications","volume":"7","author":"Cheng","year":"2019","journal-title":"Front. Chem."},{"issue":"12","key":"10.1016\/j.niox.2024.09.005_bib138","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.104470","article-title":"S-nitrosoglutathione mimics the beneficial activity of endothelial nitric oxide synthase-derived nitric oxide in a mouse model of stroke","volume":"28","author":"Khan","year":"2019","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.niox.2024.09.005_bib139","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.abb.2014.08.002","article-title":"Mechanisms and targets of the modulatory action of S-nitrosoglutathione (GSNO) on inflammatory cytokines expression","volume":"562","author":"Corti","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.niox.2024.09.005_bib140","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113686","article-title":"S-Nitrosothiols as potential therapeutics to induce a mobilizable vascular store of nitric oxide to counteract endothelial dysfunction","volume":"173","author":"Perrin-Sarrado","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib141","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/smll.201200458","article-title":"Nitric oxide donors for cardiovascular implant applications","volume":"9","author":"Naghavi","year":"2013","journal-title":"Small"},{"issue":"5","key":"10.1016\/j.niox.2024.09.005_bib142","first-page":"1464","article-title":"In-situ biotransformation of nitric oxide by functionalized surfaces of cardiovascular stents","volume":"6","author":"Qian","year":"2020","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.niox.2024.09.005_bib143","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.niox.2015.08.007","article-title":"Inhaled nitric oxide: current clinical concepts","volume":"50","author":"Bhatraju","year":"2015","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2024.09.005_bib144","series-title":"Inhaled Nitric Oxide (iNO) Administration in Intubated and Nonintubated Patients: Delivery Systems, Interfaces, Dose Administration, and Monitoring Techniques, Nitric Oxide in Health and Disease","first-page":"247","author":"Gianni","year":"2023"},{"key":"10.1016\/j.niox.2024.09.005_bib145","series-title":"Inhaled Nitric Oxide (iNO): Clinical Applications in Critical Care Medicine, Delivery Devices, and Measuring Techniques, Nitric Oxide in Health and Disease","first-page":"257","author":"Fakhr","year":"2023"},{"issue":"2","key":"10.1016\/j.niox.2024.09.005_bib146","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/jcbfm.2012.176","article-title":"Inhaled nitric oxide reduces secondary brain damage after traumatic brain injury in mice","volume":"33","author":"Terpolilli","year":"2013","journal-title":"J. Cerebr. Blood Flow Metabol."},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib147","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40635-022-00455-6","article-title":"Inhaled nitric oxide: role in the pathophysiology of cardio-cerebrovascular and respiratory diseases","volume":"10","author":"Signori","year":"2022","journal-title":"Intensive Care Medicine Experimental."},{"issue":"2","key":"10.1016\/j.niox.2024.09.005_bib148","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.21037\/qims-22-682","article-title":"Predictors of hyperperfusion syndrome after stent implantation in symptomatic intracranial atherosclerotic stenosis","volume":"13","author":"Yan","year":"2023","journal-title":"Quant. Imag. Med. Surg."},{"issue":"2","key":"10.1016\/j.niox.2024.09.005_bib149","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1039\/D0NR07484E","article-title":"Advanced nitric oxide donors: chemical structure of NO drugs, NO nanomedicines and biomedical applications","volume":"13","author":"Yang","year":"2021","journal-title":"Nanoscale"},{"key":"10.1016\/j.niox.2024.09.005_bib150","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.carbon.2021.07.063","article-title":"Duplex metal co-doped carbon quantum dots-based drug delivery system with intelligent adjustable size as adjuvant for synergistic cancer therapy","volume":"183","author":"Han","year":"2021","journal-title":"Carbon"},{"issue":"12","key":"10.1016\/j.niox.2024.09.005_bib151","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1021\/acsmacrolett.9b00758","article-title":"Functional biodegradable nitric oxide donor-containing polycarbonate-based micelles for reduction-triggered drug release and overcoming multidrug resistance","volume":"8","author":"Gao","year":"2019","journal-title":"ACS Macro Lett."},{"issue":"30","key":"10.1016\/j.niox.2024.09.005_bib152","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202101701","article-title":"Sphingosine 1-phosphate liposomes for targeted nitric oxide delivery to mediate anticancer effects against brain glioma tumors","volume":"33","author":"Liu","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.niox.2024.09.005_bib153","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.2147\/IJN.S174989","article-title":"Inducing angiogenesis with the controlled release of nitric oxide from biodegradable and biocompatible copolymeric nanoparticles","volume":"13","author":"Yang","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.niox.2024.09.005_bib154","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jconrel.2015.02.007","article-title":"Delivering nitric oxide with nanoparticles","volume":"205","author":"Quinn","year":"2015","journal-title":"J. Contr. Release"},{"issue":"6 Pt3","key":"10.1016\/j.niox.2024.09.005_bib155","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.biotechadv.2015.01.005","article-title":"State of the art, challenges and perspectives in the design of nitric oxide-releasing polymeric nanomaterials for biomedical applications","volume":"33","author":"Seabra","year":"2015","journal-title":"Biotechnol. Adv."},{"issue":"10","key":"10.1016\/j.niox.2024.09.005_bib156","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1080\/14787210.2021.1908125","article-title":"Nanomaterials as drug delivery systems with antibacterial properties: current trends and future priorities","volume":"19","author":"Khorsandi","year":"2021","journal-title":"Expert Rev. Anti-infect. Ther."},{"key":"10.1016\/j.niox.2024.09.005_bib157","article-title":"Nanotechnology based drug delivery system: current strategies and emerging therapeutic potential for medical science","volume":"63","author":"Sahu","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"30","key":"10.1016\/j.niox.2024.09.005_bib158","article-title":"Dual intratumoral redox\/enzyme-responsive NO-releasing nanomedicine for the specific, high-efficacy, and low-toxic cancer therapy","volume":"30","author":"Jia","year":"2018","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.niox.2024.09.005_bib159","first-page":"1","article-title":"Development of a sustained-release system for nitric oxide delivery using alginate\/chitosan nanoparticles","volume":"9","author":"Marcato","year":"2013","journal-title":"Curr. Nanosci."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860324001150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860324001150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T14:54:31Z","timestamp":1729004071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860324001150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":159,"alternative-id":["S1089860324001150"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2024.09.005","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric oxide in the cardio-cerebrovascular system: Source, regulation and application","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2024.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}