{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:47:21Z","timestamp":1794008841076,"version":"4.8.0"},"reference-count":290,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.niox.2025.02.003","type":"journal-article","created":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T02:58:56Z","timestamp":1740797936000},"page":"9-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Vascular actions of Ang 1\u20137 and Ang 1\u20138 through EDRFs and EDHFs in non-diabetes and diabetes mellitus"],"prefix":"10.1016","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0382-6276","authenticated-orcid":false,"given":"Nazar M. Shareef","family":"Mahmood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almas M.R.","family":"Mahmud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail M.","family":"Maulood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.niox.2025.02.003_bib1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4103\/ajm.ajm_53_20","article-title":"Pathophysiology of diabetes: an overview","volume":"10","author":"Banday","year":"2020","journal-title":"Avicenna journal of medicine"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib2","first-page":"47","article-title":"Gestational diabetes mellitus","volume":"5","author":"McIntyre","year":"2019"},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib3","first-page":"513","article-title":"Risk of infection in type 1 and type 2 diabetes compared with the general population: a matched cohort study","volume":"41","author":"Carey","year":"2018"},{"key":"10.1016\/j.niox.2025.02.003_bib4","series-title":"Complication of Diabetes Mellitus","first-page":"1546","author":"Mezil","year":"2021"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib5","first-page":"27","article-title":"Mechanism of development of atherosclerosis and cardiovascular disease in diabetes mellitus","volume":"25","year":"2018"},{"issue":"9","key":"10.1016\/j.niox.2025.02.003_bib6","article-title":"Cardiovascular complications of diabetes: from microvascular to macrovascular pathways","volume":"15","author":"Zakir","year":"2023"},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib7","article-title":"Renin-angiotensin system: updated understanding and role in physiological and pathophysiological states","volume":"15","author":"Kanugula","year":"2023"},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10286-018-0572-5","article-title":"The renin-angiotensin system in cardiovascular autonomic control: recent developments and clinical implications","volume":"29","author":"Miller","year":"2019","journal-title":"Clin. Auton. Res. : official journal of the Clinical Autonomic Research Society"},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11906-018-0823-9","article-title":"Dysregulation of the renin-angiotensin system and the vasopressinergic system interactions in cardiovascular disorders","volume":"20","author":"Szczepanska-Sadowska","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.niox.2025.02.003_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115370","article-title":"Counter-regulatory renin-angiotensin system in hypertension: review and update in the era of COVID-19 pandemic","volume":"208","author":"Chen","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib11","first-page":"44","article-title":"The investigation of the oxidative stress-related parameters in type 2 diabetes mellitus","volume":"39","author":"Aouacheri","year":"2015"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib12","first-page":"43","article-title":"Oxidative stress and antioxidant mechanisms in human body","volume":"6","author":"Adwas","year":"2019"},{"issue":"24","key":"10.1016\/j.niox.2025.02.003_bib13","first-page":"4527","article-title":"Molecular mechanisms of ROS production and oxidative stress in diabetes","volume":"473","author":"Newsholme","year":"2016"},{"key":"10.1016\/j.niox.2025.02.003_bib14","volume":"vol. 209","author":"Demirci-Cekic","year":"2022"},{"issue":"12","key":"10.1016\/j.niox.2025.02.003_bib15","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3390\/antiox9121257","article-title":"Thioredoxin and glutaredoxin systems as potential targets for the development of new treatments in Friedreich's ataxia","volume":"9","author":"Seco-Cervera","year":"2020","journal-title":"Antioxidants"},{"issue":"12","key":"10.1016\/j.niox.2025.02.003_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9121257","article-title":"Thioredoxin and glutaredoxin systems as potential targets for the development of new treatments in friedreich's ataxia","volume":"9","author":"Seco-Cervera","year":"2020","journal-title":"Antioxidants"},{"issue":"10","key":"10.1016\/j.niox.2025.02.003_bib17","first-page":"684","article-title":"The reactive species interactome: evolutionary emergence, biological significance, and opportunities for redox metabolomics and personalized medicine","volume":"27","author":"Cortese-Krott","year":"2017"},{"key":"10.1016\/j.niox.2025.02.003_bib18","series-title":"Respiratory Syncytial Virus-Induced Oxidative Stress in Lung Pathogenesis","first-page":"297","author":"Hosakote","year":"2020"},{"key":"10.1016\/j.niox.2025.02.003_bib19","volume":"vol. 189","author":"Eggers","year":"2021"},{"key":"10.1016\/j.niox.2025.02.003_bib20","series-title":"Role of Oxidative Stress in Diabetes-Induced Complications and Their Management with Antioxidants","first-page":"1","author":"Singh","year":"2023"},{"issue":"10","key":"10.1016\/j.niox.2025.02.003_bib21","first-page":"1248","article-title":"Role of RAGE in the pathogenesis of neurological disorders","volume":"38","author":"Juranek","year":"2022"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib22","first-page":"35","article-title":"Endothelial permeability, LDL deposition, and cardiovascular risk factors\u2014a review","volume":"114","author":"Mundi","year":"2018"},{"key":"10.1016\/j.niox.2025.02.003_bib23","first-page":"265","article-title":"Endothelium-dependent remote signaling in ischemia and reperfusion: alterations in the cardiometabolic continuum","volume":"165","author":"Erkens","year":"2021"},{"issue":"4","key":"10.1016\/j.niox.2025.02.003_bib24","first-page":"457","article-title":"A review on cellular and molecular mechanisms linked to the development of diabetes complications","volume":"17","author":"Babel","year":"2021"},{"key":"10.1016\/j.niox.2025.02.003_bib25","first-page":"373","volume":"11","author":"Gutowska","year":"2019"},{"key":"10.1016\/j.niox.2025.02.003_bib26","first-page":"989","article-title":"Dysregulation of nitric oxide synthases during early and late pathophysiological conditions of diabetes mellitus leads to amassing of microvascular impedement","volume":"20","author":"Suresh","year":"2021"},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib27","first-page":"C254","article-title":"Nitric oxide: what's new to NO?","volume":"312","author":"Ghimire","year":"2017"},{"key":"10.1016\/j.niox.2025.02.003_bib28","volume":"vol. 9","author":"Hua","year":"2022"},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib29","first-page":"924","article-title":"Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies","volume":"73","author":"Xu","year":"2021"},{"key":"10.1016\/j.niox.2025.02.003_bib30","first-page":"37","volume":"vol. 816","author":"Kovanen","year":"2017"},{"issue":"4","key":"10.1016\/j.niox.2025.02.003_bib31","first-page":"620","article-title":"Endothelial cell dysfunction and the pathobiology of atherosclerosis","volume":"118","author":"Gimbrone","year":"2016"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib32","article-title":"Sex-specific effects of a high fat diet on aortic inflammation and dysfunction","volume":"13","author":"Tran","year":"2023"},{"key":"10.1016\/j.niox.2025.02.003_bib33","first-page":"1","volume":"vol. 19","author":"Taneja","year":"2019"},{"key":"10.1016\/j.niox.2025.02.003_bib34","series-title":"Vasoconstrictor Substances Produced by the Endothelium. Endothelium and Cardiovascular Diseases","first-page":"115","author":"Cau","year":"2018"},{"issue":"5","key":"10.1016\/j.niox.2025.02.003_bib35","first-page":"502","article-title":"The neurovascular unit: focus on the regulation of arterial smooth muscle cells","volume":"16","author":"Quelhas","year":"2019"},{"issue":"11","key":"10.1016\/j.niox.2025.02.003_bib36","first-page":"2884","article-title":"Endothelium-derived relaxing factors and endothelial function","volume":"10","author":"Nappi","year":"2022","journal-title":"Syst. Rev."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib37","first-page":"1","article-title":"Diabetes and cardiovascular disease: inter-relation of risk factors and treatment","volume":"6","author":"Sharma","year":"2020"},{"key":"10.1016\/j.niox.2025.02.003_bib38","first-page":"426","volume":"vol. 585","author":"Palikuqi","year":"2020"},{"issue":"12","key":"10.1016\/j.niox.2025.02.003_bib39","first-page":"747","article-title":"Patrolling the vascular borders: platelets in immunity to infection and cancer","volume":"19","author":"Gaertner","year":"2019"},{"issue":"4","key":"10.1016\/j.niox.2025.02.003_bib40","first-page":"3781","article-title":"Endothelial glycocalyx","volume":"12","author":"Foote","year":"2022"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib41","first-page":"33","article-title":"The conducted vasomotor response and the principles of electrical communication in resistance arteries","volume":"104","author":"Mironova","year":"2024"},{"issue":"11","key":"10.1016\/j.niox.2025.02.003_bib42","first-page":"e233","article-title":"Endothelial response to pathophysiological stress","volume":"39","author":"Peng","year":"2019"},{"key":"10.1016\/j.niox.2025.02.003_bib43","first-page":"376","volume":"vol. 10","author":"Wang","year":"2018"},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib44","first-page":"231","article-title":"Implications of endothelial cell-mediated dysfunctions in vasomotor tone regulation","volume":"1","author":"Mangana","year":"2021"},{"issue":"4","key":"10.1016\/j.niox.2025.02.003_bib45","first-page":"730","article-title":"Microcirculation and physical exercise in hypertension","volume":"80","author":"De Ciuceis","year":"2023"},{"issue":"486","key":"10.1016\/j.niox.2025.02.003_bib46","article-title":"Voltage-dependent Ca2+ entry into smooth muscle during contraction promotes endothelium-mediated feedback vasodilation in arterioles","volume":"10","author":"Garland","year":"2017"},{"key":"10.1016\/j.niox.2025.02.003_bib47","first-page":"48","article-title":"Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity","volume":"52","author":"Frismantiene","year":"2018"},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib48","article-title":"The endothelium in health and in cardiovascular disease","volume":"16","year":"2020"},{"issue":"7","key":"10.1016\/j.niox.2025.02.003_bib49","first-page":"1236","article-title":"Direct impairment of the endothelial function by acute indoxyl sulfate through declined nitric oxide and not endothelium-derived hyperpolarizing factor or vasodilator prostaglandins in the rat superior mesenteric artery","volume":"42","author":"Matsumoto","year":"2019"},{"issue":"4","key":"10.1016\/j.niox.2025.02.003_bib50","first-page":"1055","article-title":"Nitric oxide-cGMP signaling in hypertension: current and future options for pharmacotherapy","volume":"76","author":"Ataei Ataabadi","year":"2020"},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib51","first-page":"R883","article-title":"Activation of CB1 receptors by 2-arachidonoylglycerol attenuates vasoconstriction induced by U46619 and angiotensin II in human and rat pulmonary arteries","volume":"312","author":"Karpi\u0144ska","year":"2017"},{"issue":"1\u20133","key":"10.1016\/j.niox.2025.02.003_bib52","first-page":"84","article-title":"The role of perivascular adipose tissue-derived hydrogen sulfide in the control of vascular homeostasis","volume":"37","author":"Mitidieri","year":"2022"},{"issue":"30","key":"10.1016\/j.niox.2025.02.003_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202303259","article-title":"Nitric oxide: physiological functions, delivery, and Biomedical Applications","volume":"10","author":"Andrabi","year":"2023","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib54","first-page":"3","volume":"98","author":"Eelen","year":"2018","journal-title":"Endothelial cell metabolism"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib55","first-page":"22","article-title":"Endothelial dysfunction and vascular disease\u2013a 30th anniversary update","volume":"219","author":"Vanhoutte","year":"2017"},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib56","first-page":"472","article-title":"Cellular and molecular mechanisms of endothelial dysfunction in diabetes","volume":"10","author":"Roberts","year":"2013"},{"key":"10.1016\/j.niox.2025.02.003_bib57","first-page":"46","article-title":"Heme oxygenase (HO)-1 induction prevents Endoplasmic Reticulum stress-mediated endothelial cell death and impaired angiogenic capacity","volume":"127","author":"Maamoun","year":"2017"},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib58","first-page":"815","article-title":"Physiological roles of mammalian transmembrane adenylyl cyclase isoforms","volume":"102","author":"Ostrom","year":"2022"},{"key":"10.1016\/j.niox.2025.02.003_bib59","series-title":"Platelet Zinc Status Regulates Prostaglandin-Induced Signaling, Altering Thrombus Formation","author":"Coupland","year":"2023"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib60","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3390\/ijms20010187","article-title":"New therapeutic implications of endothelial nitric oxide synthase (eNOS) function\/dysfunction in cardiovascular disease","volume":"20","author":"Daiber","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.niox.2025.02.003_bib61","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.2147\/IJN.S363168","article-title":"A ternary synergistic eNOS gene delivery system based on calcium ion and L-arginine for accelerating angiogenesis by maximizing NO production","author":"Zhang","year":"2022","journal-title":"Int. J. Nanomed."},{"issue":"9","key":"10.1016\/j.niox.2025.02.003_bib62","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3390\/ani9090623","article-title":"A review of endothelium-dependent and-independent vasodilation induced by phytochemicals in isolated rat aorta","volume":"9","author":"Knox","year":"2019","journal-title":"Animals"},{"key":"10.1016\/j.niox.2025.02.003_bib63","article-title":"Regulatory effects of curcumin on nitric oxide signaling in the cardiovascular system","author":"Abolfazli","year":"2023","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2025.02.003_bib64","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s00424-018-2151-y","article-title":"Calcium-and voltage-gated BK channels in vascular smooth muscle","volume":"470","author":"Dopico","year":"2018","journal-title":"Pflueg. Arch. Eur. J. Physiol."},{"issue":"15","key":"10.1016\/j.niox.2025.02.003_bib65","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.3390\/ijms20153775","article-title":"Endothelial dysfunction: is there a hyperglycemia-induced imbalance of NOX and NOS?","volume":"20","author":"Meza","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib66","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13572","article-title":"Endogenous flux of nitric oxide: citrulline is preferred to Arginine","volume":"231","author":"Bahadoran","year":"2021","journal-title":"Acta Physiol."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib67","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s11658-023-00423-2","article-title":"Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets","volume":"28","author":"Janaszak-Jasiecka","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"13","key":"10.1016\/j.niox.2025.02.003_bib68","doi-asserted-by":"crossref","first-page":"6662","DOI":"10.3390\/ijms22136662","article-title":"Decreased expression and uncoupling of endothelial nitric oxide synthase in the cerebral cortex of rats with thioacetamide-induced acute liver failure","volume":"22","author":"Milewski","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.niox.2025.02.003_bib69","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.freeradbiomed.2014.04.019","article-title":"Hemoglobin \u03b1 in the blood vessel wall","volume":"73","author":"Butcher","year":"2014","journal-title":"Free Radic. Biol. Med."},{"issue":"9","key":"10.1016\/j.niox.2025.02.003_bib70","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1093\/cvr\/cvab003","article-title":"The key contribution of platelet and vascular arachidonic acid metabolism to the pathophysiology of atherothrombosis","volume":"117","author":"Badimon","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.niox.2025.02.003_bib71","article-title":"Oxidative pathways of arachidonic acid as targets for regulation of platelet activation","volume":"145","author":"Trostchansky","year":"2019","journal-title":"Prostag. Other Lipid Mediat."},{"issue":"21","key":"10.1016\/j.niox.2025.02.003_bib72","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111644","article-title":"The role of thromboxane in the course and treatment of ischemic stroke","volume":"22","author":"Szczuko","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"20","key":"10.1016\/j.niox.2025.02.003_bib73","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1042\/CS20191209","article-title":"Eicosanoid blood vessel regulation in physiological and pathological states","volume":"134","author":"Imig","year":"2020","journal-title":"Clin. Sci."},{"issue":"4","key":"10.1016\/j.niox.2025.02.003_bib74","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqab025","article-title":"Prostaglandin-endoperoxide synthase 2 (PTGS2) in the oviduct: roles in fertilization and early embryo development","volume":"162","author":"Anamthathmakula","year":"2021","journal-title":"Endocrinology"},{"key":"10.1016\/j.niox.2025.02.003_bib75","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-3-030-11488-6_7","article-title":"Lipid metabolism and signaling in platelet function","author":"Paes","year":"2019","journal-title":"Bioactive Lipids in Health and Disease"},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib76","doi-asserted-by":"crossref","first-page":"H153","DOI":"10.1152\/ajpheart.00206.2015","article-title":"Damaging effects of hyperglycemia on cardiovascular function: spotlight on glucose metabolic pathways","volume":"310","author":"Mapanga","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib77","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/jcp.27164","article-title":"A review of the molecular mechanisms of hyperglycemia\u2010induced free radical generation leading to oxidative stress","volume":"234","author":"Yaribeygi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.niox.2025.02.003_bib78","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/bs.apcsb.2015.11.007","article-title":"Calcium-activated potassium channels: potential target for cardiovascular diseases","volume":"104","author":"Dong","year":"2016","journal-title":"Advances in protein chemistry and structural biology"},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib79","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/joim.13220","article-title":"Promotion of vascular integrity in sepsis through modulation of bioactive adrenomedullin and dipeptidyl peptidase 3","volume":"289","author":"Van Lier","year":"2021","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.niox.2025.02.003_bib80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/s12248-021-00621-w","article-title":"Exosomes in atherosclerosis, a double-edged sword: their role in disease pathogenesis and their potential as novel therapeutics","volume":"23","author":"Patel","year":"2021","journal-title":"AAPS J."},{"key":"10.1016\/j.niox.2025.02.003_bib81","series-title":"Vasculopathies: Behavioral, Chemical, Environmental, and Genetic Factors","author":"Thiriet","year":"2019"},{"key":"10.1016\/j.niox.2025.02.003_bib82","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1007\/s00424-014-1616-x","article-title":"Role of smooth muscle cell mineralocorticoid receptor in vascular tone","volume":"467","author":"Tarjus","year":"2015","journal-title":"Pflueg. Arch. Eur. J. Physiol."},{"issue":"11","key":"10.1016\/j.niox.2025.02.003_bib83","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.3390\/antiox11112237","article-title":"Overview of the mechanisms of oxidative stress: impact in inflammation of the airway diseases","volume":"11","author":"Albano","year":"2022","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib84","doi-asserted-by":"crossref","first-page":"C3","DOI":"10.1152\/ajpcell.00282.2016","article-title":"Hydrogen sulfide, an enhancer of vascular nitric oxide signaling: mechanisms and implications","volume":"312","author":"Szabo","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"4","key":"10.1016\/j.niox.2025.02.003_bib85","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3390\/molecules21040495","article-title":"Overview of antagonists used for determining the mechanisms of action employed by potential vasodilators with their suggested signaling pathways","volume":"21","author":"Loh","year":"2016","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib86","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1161\/HYPERTENSIONAHA.114.03585","article-title":"Epoxyeicosatrienoic acids, hypertension, and kidney injury","volume":"65","author":"Imig","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.niox.2025.02.003_bib87","series-title":"Endothelial Dysfunction-Old Concepts and New Challenges","article-title":"Endothelium at a glance","author":"Lenasi","year":"2018"},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib88","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/j.2040-4603.2020.tb00131.x","article-title":"Human skin microcirculation","volume":"10","author":"Cracowski","year":"2020","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.niox.2025.02.003_bib89","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s12020-015-0709-4","article-title":"Insights into the molecular mechanisms of diabetes-induced endothelial dysfunction: focus on oxidative stress and endothelial progenitor cells","volume":"50","author":"Saad","year":"2015","journal-title":"Endocrine"},{"key":"10.1016\/j.niox.2025.02.003_bib90","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/bs.apha.2016.04.002","article-title":"Endothelial small-and intermediate-conductance K channels and endothelium-dependent hyperpolarization as drug targets in cardiovascular disease","volume":"77","author":"K\u00f6hler","year":"2016","journal-title":"Adv. Pharmacol."},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib91","doi-asserted-by":"crossref","first-page":"C262","DOI":"10.1152\/ajpcell.00369.2016","article-title":"Myoendothelial gap junctions mediate regulation of angiopoietin-2-induced vascular hyporeactivity after hypoxia through connexin 43-gated cAMP transfer","volume":"313","author":"Xu","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.niox.2025.02.003_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.cophys.2023.100674","article-title":"Hyperpolarization and the endothelium","author":"Garland","year":"2023","journal-title":"Current Opinion in Physiology"},{"issue":"12","key":"10.1016\/j.niox.2025.02.003_bib93","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1161\/ATVBAHA.114.303974","article-title":"Hemoglobin \u03b1\/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction","volume":"34","author":"Straub","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib94","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/apha.12630","article-title":"Vascular hyperpolarization in human physiology and cardiovascular risk conditions and disease","volume":"219","author":"Schinzari","year":"2017","journal-title":"Acta Physiol."},{"issue":"13","key":"10.1016\/j.niox.2025.02.003_bib95","first-page":"2525","article-title":"Inflammation during the life cycle of the atherosclerotic plaque","volume":"117","author":"Libby","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib96","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrm3801","article-title":"Cellular mechanisms and physiological consequences of redox-dependent signalling","volume":"15","author":"Holmstr\u00f6m","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.niox.2025.02.003_bib97","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.redox.2016.12.035","article-title":"Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: oxidative eustress","volume":"11","author":"Sies","year":"2017","journal-title":"Redox Biol."},{"issue":"16","key":"10.1016\/j.niox.2025.02.003_bib98","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1021\/bi401700f","article-title":"Reversible cysteine oxidation in hydrogen peroxide sensing and signal transduction","volume":"53","author":"Garc\u00eda-Santamarina","year":"2014","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41401-018-0042-6","article-title":"Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy","volume":"40","author":"Knapp","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"issue":"9","key":"10.1016\/j.niox.2025.02.003_bib100","doi-asserted-by":"crossref","first-page":"864","DOI":"10.3390\/antiox9090864","article-title":"Oxidative stress in cardiovascular diseases","volume":"9","author":"Dubois-Deruy","year":"2020","journal-title":"Antioxidants"},{"issue":"5","key":"10.1016\/j.niox.2025.02.003_bib101","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/2047487319870344","article-title":"Oxidative stress and inflammation in the evolution of heart failure: from pathophysiology to therapeutic strategies","volume":"27","author":"Aimo","year":"2020","journal-title":"European journal of preventive cardiology"},{"key":"10.1016\/j.niox.2025.02.003_bib102","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.freeradbiomed.2017.04.026","article-title":"Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration","volume":"108","author":"Louren\u00e7o","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.niox.2025.02.003_bib103","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.3390\/pr8111424","article-title":"Regulation of metabolic processes by hydrogen peroxide generated by NADPH oxidases","volume":"8","author":"Vilchis-Landeros","year":"2020","journal-title":"Processes"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib104","doi-asserted-by":"crossref","first-page":"8","DOI":"10.21767\/2572-5459.100008","article-title":"Antioxidant systems in poultry biology: superoxide dismutase","volume":"1","author":"Surai","year":"2016","journal-title":"Journal of Animal Research and Nutrition"},{"key":"10.1016\/j.niox.2025.02.003_bib105","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijbiomac.2019.09.083","article-title":"A review on the druggability of a thiol-based enzymatic antioxidant thioredoxin reductase for treating filariasis and other parasitic infections","volume":"142","author":"Joardar","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"10.1016\/j.niox.2025.02.003_bib106","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.3390\/antiox11101921","article-title":"S-denitrosylation: a crosstalk between glutathione and redoxin systems","volume":"11","author":"Chakraborty","year":"2022","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cosmetics3010001","article-title":"Skin redox balance maintenance: the need for an Nrf2-activator delivery system","volume":"3","author":"Ben-Yehuda Greenwald","year":"2016","journal-title":"Cosmetics"},{"issue":"7","key":"10.1016\/j.niox.2025.02.003_bib108","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib109","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41413-021-00138-0","article-title":"Skeleton-vasculature chain reaction: a novel insight into the mystery of homeostasis","volume":"9","author":"Chen","year":"2021","journal-title":"Bone Research"},{"key":"10.1016\/j.niox.2025.02.003_bib110","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cbi.2017.12.024","article-title":"Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis","volume":"281","author":"Phull","year":"2018","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib111","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41392-023-01378-8","article-title":"Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications","volume":"8","author":"Xie","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"14","key":"10.1016\/j.niox.2025.02.003_bib112","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.3390\/ijms21145160","article-title":"EPAC in vascular smooth muscle cells","volume":"21","author":"Wehbe","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.niox.2025.02.003_bib113","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1042\/BCJ20180620","article-title":"Diacylglycerol kinase control of protein kinase C","volume":"476","author":"M\u00e9rida","year":"2019","journal-title":"Biochem. J."},{"issue":"17","key":"10.1016\/j.niox.2025.02.003_bib114","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1042\/CS20160036","article-title":"Protein kinase C mechanisms that contribute to cardiac remodelling","volume":"130","author":"Newton","year":"2016","journal-title":"Clin. Sci."},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib115","doi-asserted-by":"crossref","first-page":"C193","DOI":"10.1152\/ajpcell.00248.2015","article-title":"The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure","volume":"310","author":"Schepelmann","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"5","key":"10.1016\/j.niox.2025.02.003_bib116","doi-asserted-by":"crossref","first-page":"85","DOI":"10.52586\/4926","article-title":"Regulation of NOS expression in vascular diseases","volume":"26","author":"Pautz","year":"2021","journal-title":"Frontiers in Bioscience-Landmark"},{"issue":"7","key":"10.1016\/j.niox.2025.02.003_bib117","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41419-023-05935-5","article-title":"Vascular nitric oxide resistance in type 2 diabetes","volume":"14","author":"Bahadoran","year":"2023","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.niox.2025.02.003_bib118","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41569-021-00646-w","article-title":"Transforming growth factor-\u03b2 in myocardial disease","volume":"19","author":"Frangogiannis","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"issue":"5\u20136","key":"10.1016\/j.niox.2025.02.003_bib119","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1080\/21541248.2020.1822721","article-title":"New insights into RhoA\/Rho-kinase signaling: a key regulator of vascular contraction","volume":"12","author":"Nunes","year":"2021","journal-title":"Small GTPases"},{"key":"10.1016\/j.niox.2025.02.003_bib120","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.atherosclerosis.2019.08.017","article-title":"Inhibition of vascular neointima hyperplasia by FGF21 associated with FGFR1\/Syk\/NLRP3 inflammasome pathway in diabetic mice","volume":"289","author":"Wei","year":"2019","journal-title":"Atherosclerosis"},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib121","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.bbadis.2014.10.016","article-title":"Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases","volume":"1852","author":"Zordoky","year":"2015","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"key":"10.1016\/j.niox.2025.02.003_bib122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2017.05.005","article-title":"Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases","volume":"100","author":"Incalza","year":"2018","journal-title":"Vasc. Pharmacol."},{"issue":"7","key":"10.1016\/j.niox.2025.02.003_bib123","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3390\/biomedicines8070206","article-title":"NADPH oxidases and their role in atherosclerosis","volume":"8","author":"Poznyak","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.niox.2025.02.003_bib124","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102195","article-title":"Xanthine oxidoreductase: a leading actor in cardiovascular disease drama","volume":"48","author":"Polito","year":"2021","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib125","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/cbf.3589","article-title":"Molecular insights of NADPH oxidases and its pathological consequences","volume":"39","author":"Waghela","year":"2021","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.niox.2025.02.003_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107928","article-title":"Obesity-induced changes in human islet G protein-coupled receptor expression: implications for metabolic regulation","volume":"228","author":"Atanes","year":"2021","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.niox.2025.02.003_bib127","series-title":"From Molecular Biology to Clinical Applications","first-page":"1","article-title":"Gene structure, expression, and 5-HT 2B receptor signaling. 5-HT2B receptors","author":"Maroteaux","year":"2021"},{"issue":"9","key":"10.1016\/j.niox.2025.02.003_bib128","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.3390\/biomedicines11092488","article-title":"Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities","volume":"11","author":"Clemente-Su\u00e1rez","year":"2023","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib129","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1017\/S0007114516001884","article-title":"Reversibility of endothelial dysfunction in diabetes: role of polyphenols","volume":"116","author":"Suganya","year":"2016","journal-title":"Br. J. Nutr."},{"issue":"10","key":"10.1016\/j.niox.2025.02.003_bib130","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.3390\/ijms21103405","article-title":"Regulation of vascular function and inflammation via cross talk of reactive oxygen and nitrogen species from mitochondria or NADPH oxidase\u2014implications for diabetes progression","volume":"21","author":"Daiber","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.niox.2025.02.003_bib131","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.3390\/cimb44080233","article-title":"Topical reappraisal of molecular pharmacological approaches to endothelial dysfunction in diabetes mellitus angiopathy","volume":"44","author":"Munteanu","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.niox.2025.02.003_bib132","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12291-014-0446-0","article-title":"Free radicals: properties, sources, targets, and their implication in various diseases","volume":"30","author":"Phaniendra","year":"2015","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.niox.2025.02.003_bib133","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion injury and reactive oxygen species: the evolution of a concept","volume":"6","author":"Granger","year":"2015","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib134","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/NNR.0000000000000068","article-title":"Reactive oxygen and nitrogen species: impact on endothelial dysfunction","volume":"64","author":"Salisbury","year":"2015","journal-title":"Nurs. Res."},{"issue":"11","key":"10.1016\/j.niox.2025.02.003_bib135","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.3390\/biomedicines9111602","article-title":"Dyslipidemia, diabetes and atherosclerosis: role of inflammation and ROS-redox-sensitive factors","volume":"9","author":"Hasheminasabgorji","year":"2021","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib136","first-page":"17","article-title":"The significance of nitrosative pressure in underlying pathophysiology and the pharmacologic therapy of non-communicable disease with fessional and antioxidant potential","volume":"5","author":"Islam","year":"2022","journal-title":"Adv Neur Neur Sci"},{"key":"10.1016\/j.niox.2025.02.003_bib137","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fcvm.2020.00012","article-title":"Mitochondrial ROS formation in the pathogenesis of diabetic cardiomyopathy","volume":"7","author":"Kaludercic","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib138","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000512178","article-title":"Clinical effects of xanthine oxidase inhibitors in hyperuricemic patients","volume":"30","author":"Cicero","year":"2021","journal-title":"Med. Princ. Pract."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib139","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1152\/physrev.00036.2017","article-title":"Sources of vascular nitric oxide and reactive oxygen species and their regulation","volume":"99","author":"Tejero","year":"2019","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.niox.2025.02.003_bib140","doi-asserted-by":"crossref","first-page":"310","DOI":"10.2174\/1389557518666181025153712","article-title":"Association between vitamin D levels and nonalcoholic fatty liver disease: potential confounding variables","volume":"19","author":"Pacifico","year":"2019","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.niox.2025.02.003_bib141","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/978-3-319-96445-4_14","article-title":"Blood-brain barrier integrity and clearance of amyloid-\u03b2 from the BBB","author":"Cockerill","year":"2018","journal-title":"Molecular, cellular, and tissue engineering of the vascular system"},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib142","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000519845","article-title":"Vascular smooth muscle cells mechanosensitive regulators and vascular remodeling","volume":"59","author":"Liu","year":"2022","journal-title":"J. Vasc. Res."},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib143","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1152\/physrev.00053.2021","article-title":"Vascular mechanotransduction","volume":"103","author":"Davis","year":"2023","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.niox.2025.02.003_bib144","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/FJC.0000000000000463","article-title":"Communication is key: mechanisms of intercellular signaling in vasodilation","volume":"69","author":"Freed","year":"2017","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib145","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jphs.2023.08.001","article-title":"Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles","volume":"153","author":"Ishida","year":"2023","journal-title":"J. Pharmacol. Sci."},{"issue":"4","key":"10.1016\/j.niox.2025.02.003_bib146","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3390\/biom12040484","article-title":"Role of ion channel remodeling in endothelial dysfunction induced by pulmonary arterial hypertension","volume":"12","author":"Santos-Gomes","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.niox.2025.02.003_bib147","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.780206","article-title":"Hypoxic regulation of the large-conductance, calcium and voltage-activated potassium channel, BK","volume":"12","author":"Ochoa","year":"2021","journal-title":"Front. Physiol."},{"issue":"8","key":"10.1016\/j.niox.2025.02.003_bib148","doi-asserted-by":"crossref","DOI":"10.1111\/micc.12733","article-title":"Differential hyperpolarization to substance P and calcitonin gene\u2010related peptide in smooth muscle versus endothelium of mouse mesenteric artery","volume":"28","author":"Norton","year":"2021","journal-title":"Microcirculation"},{"key":"10.1016\/j.niox.2025.02.003_bib149","series-title":"Evaluation of Apelin, Chemerin and Omentin Hormone Levels and Their Receptor Activities in Streptozotocin-Induced Diabetes Mellitus in Albino Rats","author":"Othman","year":"2023"},{"issue":"7","key":"10.1016\/j.niox.2025.02.003_bib150","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.3390\/ijms20071589","article-title":"Inhibitors of mammalian aquaporin water channels","volume":"20","author":"Abir-Awan","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.niox.2025.02.003_bib151","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.627458","article-title":"Review of natural resources with vasodilation: traditional medicinal plants, natural products, and their mechanism and clinical efficacy","volume":"12","author":"Tang","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"22","key":"10.1016\/j.niox.2025.02.003_bib152","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214422","article-title":"Involvement of NO\/cGMP signaling pathway, Ca2+ and K+ channels on spasmolytic effect of everlasting flower polyphenolic extract (Helichrysum stoechas (L.) moench)","volume":"23","author":"Valero","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.niox.2025.02.003_bib153","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1172\/JCI134111","article-title":"TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation","volume":"130","author":"Swain","year":"2020","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib154","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.jdiacomp.2016.04.018","article-title":"Metformin attenuates fluctuating glucose-induced endothelial dysfunction through enhancing GTPCH1-mediated eNOS recoupling and inhibiting NADPH oxidase","volume":"30","author":"An","year":"2016","journal-title":"J. Diabetes Complicat."},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib155","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3390\/cancers11030287","article-title":"Implication of voltage-gated potassium channels in neoplastic cell proliferation","volume":"11","author":"Serrano-Novillo","year":"2019","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib156","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.endien.2022.01.005","article-title":"Renin\u2013angiotensin system: basic and clinical aspects\u2014a general perspective. Endocrinolog\u00eda","volume":"69","author":"Vargas","year":"2022","journal-title":"Diabetes y Nutrici\u00f3n (English ed)"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib157","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1152\/physrev.00041.2022","article-title":"Sex differences in blood pressure regulation and hypertension: renal, hemodynamic, and hormonal mechanisms","volume":"104","author":"Drury","year":"2024","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib158","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41392-023-01400-z","article-title":"Diabetic vascular diseases: molecular mechanisms and therapeutic strategies","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.niox.2025.02.003_bib159","first-page":"1380","article-title":"Expanding saga of the renin-angiotensin system: the angiotensin II counter-regulatory AT2 receptor pathway","author":"Jugdutt","year":"2015","journal-title":"Am Heart Assoc"},{"key":"10.1016\/j.niox.2025.02.003_bib160","first-page":"1","article-title":"The angiotensin-(1-7) axis: formation and metabolism pathways. Angiotensin-(1-7)","author":"Chappell","year":"2019","journal-title":"A Comprehensive Review"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib161","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/HYPERTENSIONAHA.119.14071","article-title":"Ang II (angiotensin II) conversion to angiotensin-(1-7) in the circulation is POP (prolyloligopeptidase)-dependent and ACE2 (angiotensin-converting enzyme 2)-independent","volume":"75","author":"Serfozo","year":"2020","journal-title":"Hypertension"},{"issue":"8","key":"10.1016\/j.niox.2025.02.003_bib162","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1161\/CIRCRESAHA.116.307708","article-title":"Role of the ACE2\/angiotensin 1\u20137 axis of the renin\u2013angiotensin system in heart failure","volume":"118","author":"Patel","year":"2016","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib163","doi-asserted-by":"crossref","first-page":"294","DOI":"10.37349\/emed.2021.00047","article-title":"Angiotensin peptides in the regulation of adrenal cortical function","volume":"2","author":"Rossi","year":"2021","journal-title":"Exploration of Medicine"},{"issue":"5","key":"10.1016\/j.niox.2025.02.003_bib164","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1161\/HYPERTENSIONAHA.112.198754","article-title":"cGMP-dependent activation of protein kinase G precludes disulfide activation: implications for blood pressure control","volume":"60","author":"Burgoyne","year":"2012","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.niox.2025.02.003_bib165","doi-asserted-by":"crossref","first-page":"C537","DOI":"10.1152\/ajpcell.00329.2016","article-title":"Vascular biology of hydrogen sulfide","volume":"312","author":"Kanagy","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib166","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1161\/CIRCRESAHA.119.315626","article-title":"Role of nitric oxide carried by hemoglobin in cardiovascular physiology: developments on a three-gas respiratory cycle","volume":"126","author":"Premont","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.niox.2025.02.003_bib167","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3389\/fendo.2019.00519","article-title":"The role of \u03b2-arrestin proteins in organization of signaling and regulation of the AT1 angiotensin receptor","volume":"10","author":"Turu","year":"2019","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib168","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s12935-023-03080-9","article-title":"The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies","volume":"23","author":"Hassani","year":"2023","journal-title":"Cancer Cell Int."},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib169","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.tips.2020.11.013","article-title":"Autoantibodies as endogenous modulators of GPCR signaling","volume":"42","author":"Skiba","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.niox.2025.02.003_bib170","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1089374","article-title":"Phospholipase C: underrated players in microbial infections","volume":"13","author":"Singh","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.niox.2025.02.003_bib171","series-title":"Signal Transduction and Smooth Muscle","first-page":"123","article-title":"Calcium sensitization in smooth muscle involving regulation of myosin light chain phosphatase activity","author":"MacDonald","year":"2018"},{"key":"10.1016\/j.niox.2025.02.003_bib172","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1007\/s12035-020-01964-9","article-title":"The brain AT2R\u2014a potential target for therapy in Alzheimer's disease and vascular cognitive impairment: a comprehensive review of clinical and experimental therapeutics","volume":"57","author":"Ahmed","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib173","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1152\/japplphysiol.00382.2023","article-title":"Angiotensin II type 2 receptor-mediated dilation is greater in the cutaneous microvasculature of premenopausal women compared with men","volume":"135","author":"Schwartz","year":"2023","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.niox.2025.02.003_bib174","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106931","article-title":"Modulation of the nitric oxide\/cGMP pathway in cardiac contraction and relaxation: potential role in heart failure treatment","author":"Mollace","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.niox.2025.02.003_bib175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11906-018-0900-0","article-title":"Inflammation as a regulator of the renin-angiotensin system and blood pressure","volume":"20","author":"Satou","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"issue":"21","key":"10.1016\/j.niox.2025.02.003_bib176","doi-asserted-by":"crossref","first-page":"7943","DOI":"10.3390\/ijms21217943","article-title":"Regulation of male fertility by the renin-angiotensin system","volume":"21","author":"Gianzo","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib177","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3390\/cells10020381","article-title":"Angiotensin II and angiotensin receptors 1 and 2\u2014multifunctional system in cells biology, what do we know?","volume":"10","author":"Ziaja","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.niox.2025.02.003_bib178","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114673","article-title":"Angiotensin II receptor type 1\u2013An update on structure, expression and pathology","volume":"192","author":"Eckenstaler","year":"2021","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib179","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/s41467-022-29072-3","article-title":"Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors","volume":"13","author":"Duan","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib180","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/HYPERTENSIONAHA.116.07572","article-title":"G-protein\u2013coupled receptor MrgD is a receptor for angiotensin-(1\u20137) involving adenylyl cyclase, cAMP, and phosphokinase A","volume":"68","author":"Tetzner","year":"2016","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib181","article-title":"Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling","volume":"8","author":"Liu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.niox.2025.02.003_bib182","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105943","article-title":"Cardiovascular angiotensin II type 1 receptor biased signaling: focus on non-Gq-, non-\u03b2arrestin-dependent signaling","volume":"174","author":"Lymperopoulos","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.niox.2025.02.003_bib183","doi-asserted-by":"crossref","first-page":"F644","DOI":"10.1152\/ajprenal.00550.2020","article-title":"Localization of angiotensin II type 1 receptor gene expression in rodent and human kidneys","volume":"320","author":"Schrankl","year":"2021","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib184","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.niox.2025.02.003_bib185","series-title":"Neuroendocrine Control of the Vascular System. Cardiovascular Neuroendocrinology","first-page":"43","author":"Dalmasso","year":"2023"},{"key":"10.1016\/j.niox.2025.02.003_bib186","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11906-018-0823-9","article-title":"Dysregulation of the renin-angiotensin system and the vasopressinergic system interactions in cardiovascular disorders","volume":"20","author":"Szczepanska-Sadowska","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"issue":"14","key":"10.1016\/j.niox.2025.02.003_bib187","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.3390\/molecules28145481","article-title":"The AT1\/AT2 receptor equilibrium is a cornerstone of the regulation of the renin angiotensin system beyond the cardiovascular system","volume":"28","author":"Colin","year":"2023","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.niox.2025.02.003_bib188","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1177\/1535370215576312","article-title":"Angiotensin II increases matrix metalloproteinase 2 expression in human aortic smooth muscle cells via AT1R and ERK1\/2","volume":"240","author":"Wang","year":"2015","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.niox.2025.02.003_bib189","first-page":"8","article-title":"Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms and exercise effects","volume":"21","author":"Peake","year":"2015","journal-title":"Exerc. Immunol. Rev."},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib190","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1161\/HYPERTENSIONAHA.119.14079","article-title":"Direct actions of AT1 (Type 1 Angiotensin) receptors in cardiomyocytes do not contribute to cardiac hypertrophy","volume":"77","author":"Sparks","year":"2021","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.niox.2025.02.003_bib191","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.3390\/molecules27072048","article-title":"Angiotensin II type I receptor (AT1R): the gate towards COVID-19-associated diseases","volume":"27","author":"El-Arif","year":"2022","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib192","doi-asserted-by":"crossref","first-page":"H718","DOI":"10.1152\/ajpheart.00097.2018","article-title":"High salt intake shifts the mechanisms of flow-induced dilation in the middle cerebral arteries of Sprague-Dawley rats","volume":"315","author":"Matic","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2025.02.003_bib193","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119965","article-title":"Galangin alleviates vascular dysfunction and remodelling through modulation of the TNF-R1, p-NF-\u03baB and VCAM-1 pathways in hypertensive rats","volume":"285","author":"Chaihongsa","year":"2021","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.niox.2025.02.003_bib194","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3390\/nu9040385","article-title":"Dietary sugars and endogenous formation of advanced glycation endproducts: emerging mechanisms of disease","volume":"9","author":"Aragno","year":"2017","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib195","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5551\/jat.RV17014","article-title":"Mechanism of development of atherosclerosis and cardiovascular disease in diabetes mellitus","volume":"25","author":"Katakami","year":"2018","journal-title":"J. Atherosclerosis Thromb."},{"issue":"5\u20136","key":"10.1016\/j.niox.2025.02.003_bib196","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1515\/bmc-2016-0021","article-title":"Advanced glycation end products mediated cellular and molecular events in the pathology of diabetic nephropathy","volume":"7","author":"Kumar Pasupulati","year":"2016","journal-title":"Biomol. Concepts"},{"key":"10.1016\/j.niox.2025.02.003_bib197","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.758414","article-title":"Hyperglycemia and angiotensin-converting enzyme 2 in pulmonary function in the context of SARS-CoV-2 infection","volume":"8","author":"Vargas-Rodriguez","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.niox.2025.02.003_bib198","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12944-015-0141-z","article-title":"Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis","volume":"14","author":"Xu","year":"2015","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.niox.2025.02.003_bib199","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bcp.2016.05.011","article-title":"Nitric oxide up-regulates endothelial expression of angiotensin II type 2 receptors","volume":"112","author":"Dao","year":"2016","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib200","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1024\/0301-1526\/a000387","article-title":"Counter-regulatory effects played by the ACE-Ang II-AT1 and ACE2-Ang-(1-7)-Mas axes on the reactive oxygen species-mediated control of vascular function: perspectives to pharmacological approaches in controlling vascular complications","volume":"43","author":"Pernomian","year":"2014","journal-title":"Vasa"},{"issue":"13","key":"10.1016\/j.niox.2025.02.003_bib201","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.3390\/ijms21134709","article-title":"Pharmacogenomics of hypertension treatment","volume":"21","author":"Rysz","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.niox.2025.02.003_bib202","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10286-018-0572-5","article-title":"The renin\u2013angiotensin system in cardiovascular autonomic control: recent developments and clinical implications","volume":"29","author":"Miller","year":"2019","journal-title":"Clin. Auton. Res."},{"issue":"9","key":"10.1016\/j.niox.2025.02.003_bib203","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1161\/ATVBAHA.123.318237","article-title":"Extracellular matrix remodeling in vascular disease: defining its regulators and pathological influence","volume":"43","author":"Lin","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib204","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1161\/HYPERTENSIONAHA.118.11065","article-title":"Role of renin-angiotensin-aldosterone system activation in promoting cardiovascular fibrosis and stiffness","volume":"72","author":"Jia","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.niox.2025.02.003_bib205","first-page":"29","article-title":"Inhibition of RAS in diabetic nephropathy","author":"Yacoub","year":"2015","journal-title":"Int. J. Nephrol. Renovascular Dis."},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib206","doi-asserted-by":"crossref","first-page":"H461","DOI":"10.1152\/ajpheart.00582.2019","article-title":"Differential expression of angiotensin II type 1 receptor subtypes within the cerebral microvasculature","volume":"318","author":"Yamasaki","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2025.02.003_bib207","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2021.111259","article-title":"Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease","volume":"529","author":"Rianto","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"issue":"15","key":"10.1016\/j.niox.2025.02.003_bib208","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1042\/CS20160243","article-title":"Angiotensin II type 2 receptor (AT2R) in renal and cardiovascular disease","volume":"130","author":"Chow","year":"2016","journal-title":"Clin. Sci."},{"issue":"4","key":"10.1016\/j.niox.2025.02.003_bib209","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1124\/pr.118.017129","article-title":"Novel therapeutic approaches targeting the renin-angiotensin system and associated peptides in hypertension and heart failure","volume":"71","author":"Arendse","year":"2019","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.niox.2025.02.003_bib210","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.automatica.2015.06.032","article-title":"Two globally convergent adaptive speed observers for mechanical systems","volume":"60","author":"Romero","year":"2015","journal-title":"Automatica"},{"issue":"30","key":"10.1016\/j.niox.2025.02.003_bib211","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.2174\/0929867323666161028155611","article-title":"Snake venom peptides and low mass proteins: molecular tools and therapeutic agents","volume":"24","author":"Almeida","year":"2017","journal-title":"Curr. Med. Chem."},{"issue":"5","key":"10.1016\/j.niox.2025.02.003_bib212","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1021\/acs.jmedchem.9b01780","article-title":"The other angiotensin II receptor: AT2R as a therapeutic target","volume":"63","author":"Juillerat-Jeanneret","year":"2020","journal-title":"J. Med. Chem."},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib213","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3390\/biom11060778","article-title":"DEER analysis of GPCR conformational heterogeneity","volume":"11","author":"Elgeti","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.niox.2025.02.003_bib214","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-3-030-16481-2_9","article-title":"Vasoactive peptides: renin-angiotensin-aldosterone system","author":"Nather","year":"2019","journal-title":"Textbook of Vascular Medicine"},{"issue":"5","key":"10.1016\/j.niox.2025.02.003_bib215","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1080\/07388551.2021.1948816","article-title":"Angiotensin I-converting enzyme inhibitory peptide: an emerging candidate for vascular dysfunction therapy","volume":"42","author":"Wu","year":"2022","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1016\/j.niox.2025.02.003_bib216","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.metabol.2019.03.006","article-title":"Angiotensin-(1-7), adipokines and inflammation","volume":"95","author":"de Farias","year":"2019","journal-title":"Metabolism"},{"key":"10.1016\/j.niox.2025.02.003_bib217","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/B978-0-12-822224-9.00025-6","article-title":"Pathophysiology of heart failure and an overview of therapies","author":"Ranek","year":"2022","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.niox.2025.02.003_bib218","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1213320","article-title":"Mast cell-mediated immune regulation in health and disease","volume":"10","author":"Dileepan","year":"2023","journal-title":"Front. Med."},{"key":"10.1016\/j.niox.2025.02.003_bib219","series-title":"Ang-(1-7) and Vessels. Angiotensin-(1-7): A Comprehensive Review","first-page":"105","author":"Sampaio","year":"2019"},{"issue":"11","key":"10.1016\/j.niox.2025.02.003_bib220","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.3390\/biomedicines9111667","article-title":"The role of the ACE2\/MasR axis in ischemic stroke: new insights for therapy","volume":"9","author":"Barzegar","year":"2021","journal-title":"Biomedicines"},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib221","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1161\/HYPERTENSIONAHA.120.15527","article-title":"Mas receptor activation contributes to the improvement of nitric oxide bioavailability and vascular remodeling during chronic AT1R (angiotensin type-1 receptor) blockade in experimental hypertension","volume":"76","author":"Savoia","year":"2020","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib222","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1124\/mol.119.117580","article-title":"Targeting angiotensin-converting enzyme-2\/angiotensin-(1-7)\/Mas receptor axis in the vascular progenitor cells for cardiovascular diseases","volume":"99","author":"Jarajapu","year":"2021","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.niox.2025.02.003_bib223","series-title":"Sex Differences in Cardiovascular Physiology and Pathophysiology","first-page":"167","article-title":"Sex differences and the role of the renin-angiotensin system in atherosclerosis and abdominal aortic aneurysms","author":"AlSiraj","year":"2019"},{"key":"10.1016\/j.niox.2025.02.003_bib224","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fphar.2019.00146","article-title":"Participation of g\u03b1i-adenylate cyclase and ERK1\/2 in Mas receptor signaling pathways","volume":"10","author":"Burghi","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.niox.2025.02.003_bib225","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.3390\/ijms21051593","article-title":"Sirtuin-1 and its relevance in vascular calcification","volume":"21","author":"Lu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.niox.2025.02.003_bib226","series-title":"Development of an in Vitro Thrombosis Model to Assess Endothelial Regulation of Thrombus Formation","author":"Riley","year":"2022"},{"issue":"11","key":"10.1016\/j.niox.2025.02.003_bib227","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.2174\/1389450117666160727142401","article-title":"The anti-inflammatory potential of ACE2\/angiotensin-(1-7)\/Mas receptor axis: evidence from basic and clinical research","volume":"18","author":"Rodrigues Prestes","year":"2017","journal-title":"Curr. Drug Targets"},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib228","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/mmr.2022.12801","article-title":"Reducing VEGFB expression regulates the balance of glucose and lipid metabolism in mice via VEGFR1","volume":"26","author":"Luo","year":"2022","journal-title":"Mol. Med. Rep."},{"issue":"9","key":"10.1016\/j.niox.2025.02.003_bib229","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/bph.13742","article-title":"Significance of angiotensin 1\u20137 coupling with MAS1 receptor and other GPCRs to the renin\u2010angiotensin system: IUPHAR Review 22","volume":"174","author":"Karnik","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.niox.2025.02.003_bib230","first-page":"201","article-title":"Angiotensin 1-7 and inflammation. Angiotensin-(1-7)","author":"Galv\u00e3o","year":"2019","journal-title":"A Comprehensive Review"},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib231","doi-asserted-by":"crossref","first-page":"C1681","DOI":"10.1152\/ajpcell.00271.2021","article-title":"Angiotensin 1\u20137 increases fiber cross-sectional area and force in juvenile mouse skeletal muscle","volume":"323","author":"Albadrani","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.niox.2025.02.003_bib232","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107818","article-title":"RGS proteins, GRKs, and beta-arrestins modulate G protein-mediated signaling pathways in asthma","volume":"223","author":"Fuentes","year":"2021","journal-title":"Pharmacol. Therapeut."},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib233","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1177\/1753944715587424","article-title":"Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal versus heart failure","volume":"9","author":"Zhou","year":"2015","journal-title":"Therapeutic advances in cardiovascular disease"},{"key":"10.1016\/j.niox.2025.02.003_bib234","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fendo.2016.00072","article-title":"Role of ACTH and other hormones in the regulation of aldosterone production in primary aldosteronism","volume":"7","author":"El Ghorayeb","year":"2016","journal-title":"Front. Endocrinol."},{"issue":"4","key":"10.1016\/j.niox.2025.02.003_bib235","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3390\/ijms18040690","article-title":"Biological effect of licochalcone C on the regulation of PI3K\/Akt\/eNOS and NF-\u03baB\/iNOS\/NO signaling pathways in H9c2 cells in response to LPS stimulation","volume":"18","author":"Franceschelli","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.niox.2025.02.003_bib236","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bbr.2018.05.024","article-title":"Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: involvement of PI3-kinase, eNOS and NF\u03baB","volume":"351","author":"Kumar","year":"2018","journal-title":"Behav. Brain Res."},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib237","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/aps.2016.14","article-title":"Methylophiopogonanone A suppresses ischemia\/reperfusion-induced myocardial apoptosis in mice via activating PI3K\/Akt\/eNOS signaling pathway","volume":"37","author":"He","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.niox.2025.02.003_bib238","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3634948","article-title":"Insulin resistance and endothelial dysfunction constitute a common therapeutic target in cardiometabolic disorders","volume":"2016","author":"Janus","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.niox.2025.02.003_bib239","series-title":"The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications","author":"Unger","year":"2015"},{"key":"10.1016\/j.niox.2025.02.003_bib240","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153035","article-title":"Promoting effect of baicalin on nitric oxide production in CMECs via activating the PI3K-AKT-eNOS pathway attenuates myocardial ischemia\u2013reperfusion injury","volume":"63","author":"Bai","year":"2019","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib241","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3390\/nu11030699","article-title":"Twelve-week protocatechuic acid administration improves insulin-induced and insulin-like growth factor-1-induced vasorelaxation and antioxidant activities in aging spontaneously hypertensive rats","volume":"11","author":"Masodsai","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.niox.2025.02.003_bib242","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1007\/s13277-014-2911-z","article-title":"Activation of M3 muscarinic receptor by acetylcholine promotes non-small cell lung cancer cell proliferation and invasion via EGFR\/PI3K\/AKT pathway","volume":"36","author":"Xu","year":"2015","journal-title":"Tumor Biol."},{"issue":"11","key":"10.1016\/j.niox.2025.02.003_bib243","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/cvr\/cvz156","article-title":"Red blood cell dysfunction: a new player in cardiovascular disease","volume":"115","author":"Pernow","year":"2019","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib244","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1080\/13543776.2016.1179283","article-title":"Therapeutic uses for angiotensin-(1-7)","volume":"26","author":"Machado-Silva","year":"2016","journal-title":"Expert Opin. Ther. Pat."},{"issue":"10","key":"10.1016\/j.niox.2025.02.003_bib245","article-title":"Angiotensin-(1-7): a novel peptide to treat hypertension and nephropathy in diabetes?","volume":"6","author":"Padda","year":"2015","journal-title":"J. Diabetes Metabol."},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib246","first-page":"274","article-title":"Vasorelaxation effect of oxysophoridine on isolated thoracicc aorta rings of rats","volume":"64","author":"Li","year":"2021","journal-title":"Journal of Physiology Investigation"},{"issue":"12","key":"10.1016\/j.niox.2025.02.003_bib247","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/ajh\/hpz146","article-title":"Angiotensin-(1-7): translational avenues in cardiovascular control","volume":"32","author":"Medina","year":"2019","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.niox.2025.02.003_bib248","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115183","article-title":"Angiotensin-(1-9) in hypertension","author":"Norambuena-Soto","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.niox.2025.02.003_bib249","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2019.03.007","article-title":"Angiotensin-(1-7) induced vascular relaxation in spontaneously hypertensive rats","volume":"88","author":"Zhang","year":"2019","journal-title":"Nitric Oxide"},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib250","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2174\/1874467215666220301113833","article-title":"Endoplasmic reticulum stress and renin-angiotensin system crosstalk in endothelial dysfunction","volume":"16","author":"Sankrityayan","year":"2023","journal-title":"Curr. Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.niox.2025.02.003_bib251","doi-asserted-by":"crossref","first-page":"H652","DOI":"10.1152\/ajpheart.00621.2019","article-title":"Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm","volume":"318","author":"Liu","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5","key":"10.1016\/j.niox.2025.02.003_bib252","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/HYPERTENSIONAHA.115.06935","article-title":"Chronic angiotensin-(1\u20137) improves insulin sensitivity in high-fat fed mice independent of blood pressure","volume":"67","author":"Williams","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.niox.2025.02.003_bib253","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s12020-020-02296-3","article-title":"Longitudinal study of angiotensin peptides in normal and pre-eclamptic pregnancy","volume":"69","author":"Brosnihan","year":"2020","journal-title":"Endocrine"},{"issue":"7","key":"10.1016\/j.niox.2025.02.003_bib254","doi-asserted-by":"crossref","first-page":"E621","DOI":"10.1152\/ajpendo.00054.2015","article-title":"ACE2 deficiency reduces \u03b2-cell mass and impairs \u03b2-cell proliferation in obese C57BL\/6 mice","volume":"309","author":"Shoemaker","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib255","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1038\/s41467-018-06769-y","article-title":"Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes","volume":"9","author":"Clemmensen","year":"2018","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib256","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvaa007","article-title":"Angiotensin-(1-7) participates in enhanced skeletal muscle insulin sensitivity after a bout of exercise","volume":"4","author":"Echeverr\u00eda-Rodr\u00edguez","year":"2020","journal-title":"Journal of the Endocrine Society"},{"issue":"4","key":"10.1016\/j.niox.2025.02.003_bib257","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1165\/rcmb.2020-0322PS","article-title":"Targeting ACE2 for COVID-19 therapy: opportunities and challenges","volume":"64","author":"Jia","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"10","key":"10.1016\/j.niox.2025.02.003_bib258","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1161\/CIRCRESAHA.120.317015","article-title":"Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2","volume":"126","author":"Gheblawi","year":"2020","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.niox.2025.02.003_bib259","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1161\/HYPERTENSIONAHA.120.15256","article-title":"Interaction of SARS-CoV-2 and other coronavirus with ACE (angiotensin-converting enzyme)-2 as their main receptor: therapeutic implications","volume":"76","author":"Davidson","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.niox.2025.02.003_bib260","series-title":"Angiotensin-converting Enzyme Cleavage of the Alzheimer's Beta-Amyloid Peptide","author":"Larmuth","year":"2015"},{"key":"10.1016\/j.niox.2025.02.003_bib261","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2022.170766","article-title":"Angiotensin-converting enzyme 2 (ACE2): two decades of revelations and re-evaluation","volume":"151","author":"Turner","year":"2022","journal-title":"Peptides"},{"issue":"21","key":"10.1016\/j.niox.2025.02.003_bib262","doi-asserted-by":"crossref","first-page":"6397","DOI":"10.1021\/acs.jafc.1c07161","article-title":"Chicken muscle-derived ACE2 upregulating peptide VVHPKESF inhibits angiotensin II-stimulated inflammation in vascular smooth muscle cells via the ACE2\/Ang (1\u20137)\/MasR axis","volume":"70","author":"Fan","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib263","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1042\/CS20200480","article-title":"ACE2\/Ang-(1-7)\/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease","volume":"135","author":"Kuriakose","year":"2021","journal-title":"Clin. Sci."},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib264","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1177\/1470320314542829","article-title":"ACE2 activity was increased in atherosclerotic plaque by losartan: possible relation to anti-atherosclerosis","volume":"16","author":"Zhang","year":"2015","journal-title":"J. Renin-Angiotensin-Aldosterone Syst. JRAAS"},{"key":"10.1016\/j.niox.2025.02.003_bib265","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.biopha.2018.09.058","article-title":"Molecular pathways associated with oxidative stress in diabetes mellitus","volume":"108","author":"Ighodaro","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.niox.2025.02.003_bib266","article-title":"The ACE2\/angiotensin-(1\u20137)\/MAS axis of the renin-angiotensin system: focus on angiotensin-(1\u20137)","author":"Santos","year":"2017","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.niox.2025.02.003_bib267","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3390\/metabo12050411","article-title":"Renin\u2013angiotensin system in liver metabolism: gender differences and role of incretins","volume":"12","author":"Mastoor","year":"2022","journal-title":"Metabolites"},{"issue":"11","key":"10.1016\/j.niox.2025.02.003_bib268","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.2337\/dci22-0034","article-title":"Management of hyperglycemia in type 2 diabetes, 2022. A consensus report by the American diabetes association (ada) and the European association for the study of diabetes (easd)","volume":"45","author":"Davies","year":"2022","journal-title":"Diabetes Care"},{"key":"10.1016\/j.niox.2025.02.003_bib269","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2020.629933","article-title":"Why is COVID-19 more severe in patients with diabetes? The role of angiotensin-converting enzyme 2, endothelial dysfunction and the immunoinflammatory system","volume":"7","author":"Roberts","year":"2021","journal-title":"Frontiers in cardiovascular medicine"},{"issue":"5","key":"10.1016\/j.niox.2025.02.003_bib270","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1055\/a-1155-0501","article-title":"The ACE-2 in COVID-19: foe or friend?","volume":"52","author":"Dalan","year":"2020","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.niox.2025.02.003_bib271","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.750887","article-title":"Evaluation of endothelial dysfunction and inflammatory vasculopathy after SARS-CoV-2 infection\u2014a cross-sectional study","volume":"8","author":"Jud","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"issue":"24","key":"10.1016\/j.niox.2025.02.003_bib272","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1042\/BCJ20160503C","article-title":"Molecular mechanisms of ROS production and oxidative stress in diabetes","volume":"473","author":"Newsholme","year":"2016","journal-title":"Biochem. J."},{"key":"10.1016\/j.niox.2025.02.003_bib273","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.716332","article-title":"Potential role of protein kinase C in the pathophysiology of diabetes-associated atherosclerosis","volume":"12","author":"Lien","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.niox.2025.02.003_bib274","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2023.102355","article-title":"The blood pressure lowering effects of glucagon-like peptide-1 receptor agonists: a mini-review of the potential mechanisms","volume":"69","author":"Ribeiro-Silva","year":"2023","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.niox.2025.02.003_bib275","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.vph.2016.07.006","article-title":"Apigenin and naringenin ameliorate PKC\u03b2II-associated endothelial dysfunction via regulating ROS\/caspase-3 and NO pathway in endothelial cells exposed to high glucose","volume":"85","author":"Qin","year":"2016","journal-title":"Vasc. Pharmacol."},{"issue":"2","key":"10.1016\/j.niox.2025.02.003_bib276","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/1061186X.2016.1207650","article-title":"Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes","volume":"25","author":"Panigrahy","year":"2017","journal-title":"J. Drug Target."},{"issue":"10","key":"10.1016\/j.niox.2025.02.003_bib277","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.3390\/antiox11102003","article-title":"A synopsis of the associations of oxidative stress, ROS, and antioxidants with diabetes mellitus","volume":"11","author":"Black","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.niox.2025.02.003_bib278","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11906-014-0431-2","article-title":"Angiotensin II and vascular injury","volume":"16","author":"Montezano","year":"2014","journal-title":"Curr. Hypertens. Rep."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib279","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s12933-023-01965-7","article-title":"The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction","volume":"22","author":"An","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib280","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1186\/s12967-023-04361-7","article-title":"Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease","volume":"21","author":"Yan","year":"2023","journal-title":"J. Transl. Med."},{"issue":"15","key":"10.1016\/j.niox.2025.02.003_bib281","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1080\/10408398.2020.1781049","article-title":"The ACE2\/Ang (1\u20137)\/MasR axis as an emerging target for antihypertensive peptides","volume":"61","author":"Liao","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"22","key":"10.1016\/j.niox.2025.02.003_bib282","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1042\/CS20200865","article-title":"Angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functions","volume":"134","author":"Reis","year":"2020","journal-title":"Clin. Sci."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib283","article-title":"Netrin as a novel biomarker and its therapeutic implications in diabetes mellitus and diabetes\u2010associated complications","volume":"2018","author":"Yimer","year":"2018","journal-title":"J. Diabetes Res."},{"issue":"9","key":"10.1016\/j.niox.2025.02.003_bib284","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41569-020-0339-2","article-title":"Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence","volume":"17","author":"Tan","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib285","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.kisu.2021.11.002","article-title":"The renin\u2013angiotensin system biomolecular cascade: a 2022 update of newer insights and concepts","volume":"12","author":"Ferrario","year":"2022","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.niox.2025.02.003_bib286","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s40620-020-00759-4","article-title":"Omics research in diabetic kidney disease: new biomarker dimensions and new understandings?","volume":"33","author":"Tofte","year":"2020","journal-title":"J. Nephrol."},{"issue":"9982","key":"10.1016\/j.niox.2025.02.003_bib287","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/S0140-6736(14)62459-4","article-title":"Comparative efficacy and safety of blood pressure-lowering agents in adults with diabetes and kidney disease: a network meta-analysis","volume":"385","author":"Palmer","year":"2015","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.niox.2025.02.003_bib288","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1900\/RDS.2021.17.1","article-title":"Molecular mechanisms involved in intrarenal renin-angiotensin and alternative pathways in diabetic nephropathy-a review","volume":"17","author":"Bahreini","year":"2021","journal-title":"Rev. Diabet. Stud."},{"issue":"6","key":"10.1016\/j.niox.2025.02.003_bib289","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.3390\/jcm9061995","article-title":"Oxidative stress and new pathogenetic mechanisms in endothelial dysfunction: potential diagnostic biomarkers and therapeutic targets","volume":"9","author":"Scioli","year":"2020","journal-title":"J. Clin. Med."},{"issue":"12","key":"10.1016\/j.niox.2025.02.003_bib290","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.3390\/cells11121935","article-title":"Regulation and dysregulation of endothelial permeability during systemic inflammation","volume":"11","author":"Hellenthal","year":"2022","journal-title":"Cells"}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860325000138?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860325000138?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T17:37:34Z","timestamp":1762364254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860325000138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":290,"alternative-id":["S1089860325000138"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2025.02.003","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vascular actions of Ang 1\u20137 and Ang 1\u20138 through EDRFs and EDHFs in non-diabetes and diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2025.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}