{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:29:55Z","timestamp":1757611795292,"version":"3.44.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K11561"],"award-info":[{"award-number":["21K11561"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.niox.2025.05.007","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T19:37:43Z","timestamp":1748374663000},"page":"18-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effect of acute nitrate supplementation on the superficial conduit venous vascular response at rest and during sympathoexcitation"],"prefix":"10.1016","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5741-0869","authenticated-orcid":false,"given":"Anna","family":"Oue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momo","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Iimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naho","family":"Serizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Miyakoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2025.05.007_bib1","series-title":"Handbook of Physiology, the Cardiovascular System III","first-page":"397","article-title":"Venous system: physiology of the capacitance vessels","author":"Rothe","year":"1983"},{"key":"10.1016\/j.niox.2025.05.007_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1161\/01.CIR.101.2.165","article-title":"Endothelium-derived nitric oxide contributes to the regulation of venous tone in humans","volume":"101","author":"Blackman","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.niox.2025.05.007_bib3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0021-9150(97)00114-7","article-title":"Effects of nitric oxide and superoxide on relaxation in human artery and vein","volume":"133","author":"Hamilton","year":"1997","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.niox.2025.05.007_bib4","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/cvr\/23.12.1053","article-title":"Nitric oxide synthesised from L-arginine mediates endothelium dependent dilatation in human veins in vivo","volume":"23","author":"Vallance","year":"1989","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.niox.2025.05.007_bib5","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nrd2466","article-title":"The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics","volume":"7","author":"Lundberg","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.niox.2025.05.007_bib6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.niox.2015.08.006","article-title":"Acute dietary nitrate supplementation improves arterial endothelial function at high altitude: a double-blinded randomized controlled cross over study, Nitric","volume":"50","author":"Bakker","year":"2015","journal-title":"Oxide"},{"key":"10.1016\/j.niox.2025.05.007_bib7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2011.09.028","article-title":"Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: a randomized controlled trial, Free","volume":"52","author":"Bondonno","year":"2012","journal-title":"Radic. Biol. Med."},{"key":"10.1016\/j.niox.2025.05.007_bib8","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.atherosclerosis.2013.09.001","article-title":"Beetroot juice improves in overweight and slightly obese men postprandial endothelial function after consumption of a mixed meal","volume":"231","author":"Joris","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.niox.2025.05.007_bib9","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/HYPERTENSIONAHA.114.04675","article-title":"Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study","volume":"65","author":"Kapil","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.niox.2025.05.007_bib10","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.jacc.2013.08.691","article-title":"Dietary nitrate reverses vascular dysfunction in older adults with moderately increased cardiovascular risk","volume":"63","author":"Rammos","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.niox.2025.05.007_bib11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3945\/ajcn.115.116244","article-title":"Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, doubleblind, placebo-controlled study","volume":"103","author":"Velmurugan","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.niox.2025.05.007_bib12","doi-asserted-by":"crossref","first-page":"H59","DOI":"10.1152\/ajpheart.00163.2017","article-title":"Acute beetroot juice supplementation on sympathetic nerve activity: a randomized, double-blind, placebo-controlled proof-of-concept study","volume":"313","author":"Notay","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib13","doi-asserted-by":"crossref","first-page":"R331","DOI":"10.1152\/ajpregu.00083.2022","article-title":"Acute dietary nitrate supplementation does not change venous volume and compliance in healthy young adults","volume":"323","author":"Oue","year":"2022","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib14","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.3390\/nu14214464","article-title":"Effect of acute dietary nitrate supplementation on the venous vascular response to static exercise in healthy young adults","volume":"14","author":"Oue","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.niox.2025.05.007_bib15","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1113\/jphysiol.1993.sp019642","article-title":"A reassessment of mercury in silastic strain gauge plethysmography for microvascular permeability assessment in man","volume":"464","author":"Gamble","year":"1993","journal-title":"J. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib16","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1152\/japplphysiol.01166.2004","article-title":"Ultrasound: a reproducible method to measure conduit vein compliance","volume":"98","author":"de Groot","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib17","article-title":"Decreased compliance in the deep and superficial conduit veins of the upper arm during prolonged cycling exercise","volume":"5","author":"Oue","year":"2017","journal-title":"Phys. Rep."},{"key":"10.1016\/j.niox.2025.05.007_bib18","article-title":"Compliance in the deep and superficial conduit veins of the nonexercising arm is unaffected by short-term exercise","volume":"6","author":"Oue","year":"2018","journal-title":"Phys. Rep."},{"key":"10.1016\/j.niox.2025.05.007_bib19","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1152\/japplphysiol.00825.2007","article-title":"Ultrasound assessment of popliteal vein compliance during a short deflation protocol","volume":"104","author":"Young","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib20","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1475-097X.2011.01016.x","article-title":"Diameter and compliance of the greater saphenous vein- effect of age and nitroglycerine","volume":"31","author":"Zachrisson","year":"2011","journal-title":"Clin. Physiol. Funct. Imag."},{"key":"10.1016\/j.niox.2025.05.007_bib21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.niox.2018.05.010","article-title":"Reduced blood pressure responsiveness to skeletal muscle metaboreflex activation in older adults following inorganic nitrate supplementation, Nitric","volume":"78","author":"Schneidera","year":"2018","journal-title":"Oxide"},{"key":"10.1016\/j.niox.2025.05.007_bib22","first-page":"367","article-title":"Muscle metaboreflex control of the circulation during exercise, Acta","volume":"199","author":"Boushel","year":"2010","journal-title":"Physiologist"},{"key":"10.1016\/j.niox.2025.05.007_bib23","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1139\/apnm-2012-0472","article-title":"Superficial venous vascular response of the resting limb during static exercise and post-exercise muscle ischemia","volume":"38","author":"Ooue","year":"2013","journal-title":"Appl. Physiol. Nutr. Metabol."},{"key":"10.1016\/j.niox.2025.05.007_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201600982","article-title":"Development of a reference database for assessing dietary nitrate in vegetables","volume":"61","author":"Blekkenhorst","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.niox.2025.05.007_bib25","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.niox.2009.10.007","article-title":"Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers, Nitric","volume":"22","author":"Sobko","year":"2010","journal-title":"Oxide"},{"key":"10.1016\/j.niox.2025.05.007_bib26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.niox.2008.08.003","article-title":"The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash","volume":"19","author":"Govoni","year":"2008","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2025.05.007_bib27","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/BF00421643","article-title":"Responses in muscle sympathetic nerve activity to sustained hand-grips of different tensions in humans","volume":"55","author":"Saito","year":"1986","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib28","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1046\/j.0306-5251.2001.01404.x","article-title":"Comparison of the effects of nadolol and bisoprolol on the isoprenaline-evoked dilatation of the dorsal hand vein in man","volume":"51","author":"Abdelmawla","year":"2001","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.niox.2025.05.007_bib29","doi-asserted-by":"crossref","first-page":"H1532","DOI":"10.1152\/ajpheart.00673.2004","article-title":"Muscle metaboreflex modulates the arterial baroreflex dynamic effects on peripheral vascular conductance in humans","volume":"288","author":"Ichinose","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib30","first-page":"H79","article-title":"Modulation of sympathetic nerve activity during posthandgrip muscle ischemia in humans","volume":"266","author":"Ray","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib31","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/BF00183004","article-title":"In vivo studies on alpha-adrenergic receptor subtypes in human veins","volume":"344","author":"Bl\u00f6chl-Daum","year":"1991","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.niox.2025.05.007_bib32","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S0022-3565(25)23354-7","article-title":"Decline in beta adrenergic receptor-mediated vascular relaxation with aging in man","volume":"239","author":"Pan","year":"1986","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.niox.2025.05.007_bib33","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1152\/jappl.1999.87.4.1555","article-title":"Measurement of limb venous compliance in humans: technical considerations and physiological findings","volume":"87","author":"Halliwill","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib34","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.niox.2025.05.007_bib35","first-page":"H99","article-title":"Acetylcholine- and flow-induced production and release of nitric oxide in arterial and venous endothelial cells","volume":"270","author":"Fukaya","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib36","first-page":"III296","article-title":"Difference in endothelium-derived hyperpolarizing factor-mediated hyperpolarization and nitric oxide release between human internal mammary artery and saphenous vein","volume":"102","author":"Liu","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.niox.2025.05.007_bib37","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1161\/01.RES.57.3.461","article-title":"Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans","volume":"57","author":"Mark","year":"1985","journal-title":"Circ. Res."},{"key":"10.1016\/j.niox.2025.05.007_bib38","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1152\/jappl.1989.66.1.429","article-title":"Muscle acidosis during static exercise is associated with calf vasoconstriction","volume":"66","author":"Sinoway","year":"1989","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib39","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1172\/JCI113730","article-title":"Sympathetic nerve discharge is coupled to muscle cell pH during exercise in humans","volume":"82","author":"Victor","year":"1988","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.niox.2025.05.007_bib40","first-page":"H105","article-title":"Sympathetic outflow to resting muscles during static handgrip and postcontraction muscle ischemia","volume":"256","author":"Wallin","year":"1989","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib41","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1182\/blood-2005-07-2668","article-title":"Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation","volume":"107","author":"Crawford","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.niox.2025.05.007_bib42","first-page":"9","article-title":"Nitrite-derived nitric oxide: a possible mediator of 'acidic-metabolic' vasodilation, Acta","volume":"171","author":"Modin","year":"2001","journal-title":"Physiol. Scand."},{"key":"10.1016\/j.niox.2025.05.007_bib43","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/00140138008924748","article-title":"The relationship between maximum isometric strength and intramuscular circulatory occlusion","volume":"23","author":"Barnes","year":"1980","journal-title":"Ergonomics"},{"key":"10.1016\/j.niox.2025.05.007_bib44","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.1365-201X.1997.00158.x","article-title":"Brachial arterial blood flow during static handgrip exercise of short duration at varying intensities studied by a Doppler ultrasound method, Acta","volume":"160","author":"Kagaya","year":"1997","journal-title":"Physiol. Scand."},{"key":"10.1016\/j.niox.2025.05.007_bib45","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1152\/japplphysiol.00593.2023","article-title":"Nitrate ingestion blunts the increase in blood pressure during cool air exposure: a double-blind, placebo-controlled, randomized, crossover trial","volume":"136","author":"Rowland","year":"2024","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib46","doi-asserted-by":"crossref","first-page":"H1318","DOI":"10.1152\/ajpheart.00556.2010","article-title":"Exaggerated sympathetic and pressor responses to handgrip exercise in older hypertensive humans: role of the muscle metaboreflex","volume":"299","author":"Delaney","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib47","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1152\/japplphysiol.90574.2008","article-title":"Limb venous tone and responsiveness in hypertensive humans","volume":"105","author":"Delaney","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib48","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1161\/01.HYP.10.2.133","article-title":"Arterial and venous compliance in sustained essential hypertension","volume":"10","author":"Safar","year":"1987","journal-title":"Hypertension"},{"key":"10.1016\/j.niox.2025.05.007_bib49","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1152\/japplphysiol.01328.2003","article-title":"Age- and fitness-related differences in limb venous compliance do not affect tolerance to maximal lower body negative pressure in men and women","volume":"97","author":"Hernandez","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib50","doi-asserted-by":"crossref","first-page":"H1267","DOI":"10.1152\/ajpheart.2001.281.3.H1267","article-title":"Smaller age-associated reductions in leg venous compliance in endurance exercise-trained men","author":"Monahan","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib51","first-page":"H878","article-title":"Reduced venous compliance in lower limbs of aging humans and its importance for capacitance function","volume":"275","author":"Olsen","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.niox.2025.05.007_bib52","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40101-020-00231-z","article-title":"Association between vegetable consumption and calf venous compliance in healthy young adults","volume":"39","author":"Oue","year":"2020","journal-title":"J. Physiol. Anthropol."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860325000473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860325000473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:58:18Z","timestamp":1756947498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860325000473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":52,"alternative-id":["S1089860325000473"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2025.05.007","relation":{},"ISSN":["1089-8603"],"issn-type":[{"type":"print","value":"1089-8603"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of acute nitrate supplementation on the superficial conduit venous vascular response at rest and during sympathoexcitation","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2025.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}