{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:58:05Z","timestamp":1784235485079,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025MS1447"],"award-info":[{"award-number":["ZR2025MS1447"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011324","name":"Qingdao University","doi-asserted-by":"publisher","award":["YHDYY-2022012"],"award-info":[{"award-number":["YHDYY-2022012"]}],"id":[{"id":"10.13039\/501100011324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.niox.2026.02.003","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T17:00:12Z","timestamp":1771952412000},"page":"9-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["PRMT1 regulates glioblastoma stemness and immunosuppression via nitric oxide metabolism: Multi-cohort analysis and experimental validation"],"prefix":"10.1016","volume":"162","author":[{"given":"Kun","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caifeng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0593-7391","authenticated-orcid":false,"given":"Yang","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Supplement_1","key":"10.1016\/j.niox.2026.02.003_bib1","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1093\/neuonc\/noaf168","article-title":"CBTRUS statistical report: pediatric brain tumor foundation childhood and adolescent primary brain and other central nervous system tumors diagnosed in the United States in 2017-2021","volume":"27","author":"Price","year":"2025","journal-title":"Neuro Oncol."},{"issue":"7","key":"10.1016\/j.niox.2026.02.003_bib2","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1001\/jama.2023.0023","article-title":"Glioblastoma and other primary brain malignancies in adults: a review","volume":"329","author":"Schaff","year":"2023","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.niox.2026.02.003_bib3","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.3390\/cells10123529","article-title":"Glioblastoma: relationship between metabolism and immunosuppressive microenvironment","volume":"10","author":"Hern\u00e1ndez","year":"2021","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.niox.2026.02.003_bib4","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.molmed.2024.02.004","article-title":"Epigenetic regulation of tumor-immune symbiosis in glioma","volume":"30","author":"Liu","year":"2024","journal-title":"Trends Mol. Med."},{"issue":"1","key":"10.1016\/j.niox.2026.02.003_bib5","first-page":"53","article-title":"Immunogenic cell death, DAMPs and anticancer therapeutics: an emerging amalgamation","volume":"1805","author":"Garg","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.niox.2026.02.003_bib6","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.celrep.2019.06.018","article-title":"Nitric oxide modulates metabolic remodeling in inflammatory macrophages through TCA cycle regulation and itaconate accumulation","volume":"28","author":"Bailey","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.niox.2026.02.003_bib7","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.niox.2019.09.005","article-title":"Nitric oxide and its derivatives in the cancer battlefield","volume":"93","author":"Kamm","year":"2019","journal-title":"Nitric Oxide"},{"issue":"17","key":"10.1016\/j.niox.2026.02.003_bib8","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1089\/ars.2016.6820","article-title":"NOS expression and NO function in Glioma and implications for patient therapies","volume":"26","author":"Tran","year":"2017","journal-title":"Antioxidants Redox Signal."},{"issue":"11","key":"10.1016\/j.niox.2026.02.003_bib9","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1182\/blood-2018-01-829424","article-title":"Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer\/T-cell lymphoma","volume":"132","author":"Song","year":"2018","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.niox.2026.02.003_bib10","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1084\/jem.20131916","article-title":"PD-L1 is a novel direct target of HIF-1\u03b1, and its blockade under hypoxia enhanced MDSC-mediated T cell activation","volume":"211","author":"Noman","year":"2014","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.niox.2026.02.003_bib11","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1182\/blood.V97.4.1009","article-title":"Accumulation of HIF-1alpha under the influence of nitric oxide","volume":"97","author":"Sandau","year":"2001","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.niox.2026.02.003_bib12","first-page":"1147","article-title":"Structure, activity, and function of PRMT1","volume":"11","author":"Thiebaut","year":"2021","journal-title":"Life (Basel)"},{"issue":"1","key":"10.1016\/j.niox.2026.02.003_bib13","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12964-024-01506-z","article-title":"PRMT1 in human neoplasm: cancer biology and potential therapeutic target","volume":"22","author":"Shen","year":"2024","journal-title":"Cell Commun. Signal."},{"issue":"1","key":"10.1016\/j.niox.2026.02.003_bib14","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1038\/s41467-023-38443-3","article-title":"PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity","volume":"14","author":"Liu","year":"2023","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.niox.2026.02.003_bib15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s43018-020-00154-9","article-title":"Gradient of developmental and injury response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity","volume":"2","author":"Richards","year":"2021","journal-title":"Nat. Cancer"},{"issue":"1","key":"10.1016\/j.niox.2026.02.003_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gpb.2020.10.005","article-title":"Chinese Glioma Genome Atlas (CGGA): a comprehensive resource with functional genomic data from Chinese glioma patients","volume":"19","author":"Zhao","year":"2021","journal-title":"Genom. Proteom. Bioinform."},{"issue":"3","key":"10.1016\/j.niox.2026.02.003_bib17","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.cell.2015.12.028","article-title":"Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma","volume":"164","author":"Ceccarelli","year":"2016","journal-title":"Cell"},{"issue":"6389","key":"10.1016\/j.niox.2026.02.003_bib18","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1126\/science.aaf2666","article-title":"An anatomic transcriptional atlas of human glioblastoma","volume":"360","author":"Puchalski","year":"2018","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.niox.2026.02.003_bib19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"13","key":"10.1016\/j.niox.2026.02.003_bib20","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"issue":"D1","key":"10.1016\/j.niox.2026.02.003_bib21","doi-asserted-by":"crossref","first-page":"D672","DOI":"10.1093\/nar\/gkae909","article-title":"KEGG: biological systems database as a model of the real world","volume":"53","author":"Kanehisa","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.niox.2026.02.003_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The gene ontology consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.niox.2026.02.003_bib23","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"issue":"43","key":"10.1016\/j.niox.2026.02.003_bib24","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"7","key":"10.1016\/j.niox.2026.02.003_bib25","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","article-title":"Determining cell type abundance and expression from bulk tissues with digital cytometry","volume":"37","author":"Newman","year":"2019","journal-title":"Nat. Biotechnol."},{"issue":"none","key":"10.1016\/j.niox.2026.02.003_bib26","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1214\/13-EJS815","article-title":"The lasso problem and uniqueness","volume":"7","author":"Tibshirani","year":"2013","journal-title":"Electron. J. Statist."},{"issue":"1-2","key":"10.1016\/j.niox.2026.02.003_bib27","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jim.2009.06.008","article-title":"ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays","volume":"347","author":"Hu","year":"2009","journal-title":"J. Immunol. Methods"},{"issue":"11","key":"10.1016\/j.niox.2026.02.003_bib28","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/nrc.2016.89","article-title":"The multifaceted roles of fatty acid synthesis in cancer","volume":"16","author":"R\u00f6hrig","year":"2016","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.niox.2026.02.003_bib29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40880-018-0301-4","article-title":"Lipid metabolism reprogramming and its potential targets in cancer","volume":"38","author":"Cheng","year":"2018","journal-title":"Cancer Commun."},{"issue":"4","key":"10.1016\/j.niox.2026.02.003_bib30","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nm.4055","article-title":"Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer","volume":"22","author":"Camarda","year":"2016","journal-title":"Nat. Med."},{"issue":"20","key":"10.1016\/j.niox.2026.02.003_bib31","first-page":"10996","article-title":"BTN2A2, a new biomarker and therapeutic target for glioma","volume":"15","author":"Wang","year":"2023","journal-title":"Aging (Albany NY)"},{"issue":"15","key":"10.1016\/j.niox.2026.02.003_bib32","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3390\/cells14151209","article-title":"B7-H3 in cancer immunotherapy-prospects and challenges: a review of the literature","volume":"14","author":"Mielcarska","year":"2025","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.niox.2026.02.003_bib33","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/s41467-021-21204-5","article-title":"PRMT5 inhibition disrupts splicing and stemness in glioblastoma","volume":"12","author":"Sachamitr","year":"2021","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.niox.2026.02.003_bib34","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/neuonc\/nox206","article-title":"PRMT5 as a druggable target for glioblastoma therapy","volume":"20","author":"Banasavadi-Siddegowda","year":"2018","journal-title":"Neuro Oncol."},{"issue":"5","key":"10.1016\/j.niox.2026.02.003_bib35","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.3390\/ijms25052950","article-title":"Inhibition of PRMT1 suppresses the growth of U87MG-Derived glioblastoma stem cells by blocking the STAT3 signaling pathway","volume":"25","author":"Yuk","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.niox.2026.02.003_bib36","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.3390\/ijms19092801","article-title":"Involvement of NOS2 activity on human glioma cell growth, clonogenic potential, and neurosphere generation","volume":"19","author":"Palumbo","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.niox.2026.02.003_bib37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11604-024-01651-y","article-title":"PRMT1 promotes radiotherapy resistance in glioma stem cells by inhibiting ferroptosis","volume":"43","author":"Li","year":"2025","journal-title":"Jpn. J. Radiol."},{"issue":"1","key":"10.1016\/j.niox.2026.02.003_bib38","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13046-024-02964-6","article-title":"TRIM25 promotes glioblastoma cell growth and invasion via regulation of the PRMT1\/c-MYC pathway by targeting the splicing factor NONO","volume":"43","author":"Chen","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860326000182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860326000182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:06:46Z","timestamp":1777608406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860326000182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":38,"alternative-id":["S1089860326000182"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2026.02.003","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PRMT1 regulates glioblastoma stemness and immunosuppression via nitric oxide metabolism: Multi-cohort analysis and experimental validation","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2026.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}