{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T11:58:23Z","timestamp":1775908703060,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Learning and Memory"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1016\/j.nlm.2004.11.004","type":"journal-article","created":{"date-parts":[[2005,1,5]],"date-time":"2005-01-05T12:29:50Z","timestamp":1104928190000},"page":"180-187","source":"Crossref","is-referenced-by-count":39,"title":["Fragile X mental retardation protein levels increase following complex environment exposure in rat brain regions undergoing active synaptogenesis"],"prefix":"10.1016","volume":"83","author":[{"given":"Scott A.","family":"Irwin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chariya A.","family":"Christmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron W.","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Galvez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soong Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"DeGrush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan Jeanne","family":"Weiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William T.","family":"Greenough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nlm.2004.11.004_bib1","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1523\/JNEUROSCI.0099-04.2004","article-title":"Metabotropic glutamate receptor activation regulates fragile X mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses","volume":"24","author":"Antar","year":"2004","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2004.11.004_bib2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0092-8674(01)00566-9","article-title":"Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function","volume":"107","author":"Darnell","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.nlm.2004.11.004_bib3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/ng0893-335","article-title":"The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation","volume":"4","author":"Devys","year":"1993","journal-title":"Nature Genetics"},{"key":"10.1016\/j.nlm.2004.11.004_bib4","series-title":"From conditioning to conscious recollection: Memory systems of the brain","author":"Eichenbaum","year":"2001"},{"key":"10.1016\/j.nlm.2004.11.004_bib5","doi-asserted-by":"crossref","first-page":"10579","DOI":"10.1523\/JNEUROSCI.2185-04.2004","article-title":"Visual experience regulates transient expression and dendritic localization of fragile X mental retardation protein","volume":"24","author":"Gabel","year":"2004","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2004.11.004_bib6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0006-8993(03)02363-1","article-title":"Somatosensory cortical barrel dendritic abnormalities in a mouse model of the fragile X mental retardation syndrome","volume":"971","author":"Galvez","year":"2003","journal-title":"Brain and Research"},{"key":"10.1016\/j.nlm.2004.11.004_bib7","series-title":"Cerebral cortex: Development and maturation of cerebral cortex","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4615-6619-9_11","article-title":"Plasticity of synapse structure and pattern in the cerebral cortex","author":"Greenough","year":"1988"},{"key":"10.1016\/j.nlm.2004.11.004_bib8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/ajmg.1320410306","article-title":"Analysis of neocortex in three males with the fragile X syndrome","volume":"41","author":"Hinton","year":"1991","journal-title":"American Journal of Medical Genetics"},{"key":"10.1016\/j.nlm.2004.11.004_bib9","doi-asserted-by":"crossref","first-page":"7746","DOI":"10.1073\/pnas.122205699","article-title":"Altered synaptic plasticity in a mouse model of fragile X mental retardation","volume":"99","author":"Huber","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.nlm.2004.11.004_bib10","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1093\/cercor\/10.10.1038","article-title":"Dendritic spine structural anomalies in fragile-X mental retardation syndrome","volume":"10","author":"Irwin","year":"2000","journal-title":"Cerebral Cortex"},{"key":"10.1016\/j.nlm.2004.11.004_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/nlme.1999.3914","article-title":"Evidence for altered Fragile-X mental retardation protein expression in response to behavioral stimulation","volume":"74","author":"Irwin","year":"2000","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.nlm.2004.11.004_bib12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/1096-8628(20010115)98:2<161::AID-AJMG1025>3.0.CO;2-B","article-title":"Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: A quantitative examination","volume":"98","author":"Irwin","year":"2001","journal-title":"American Journal of Medical Genetics"},{"key":"10.1016\/j.nlm.2004.11.004_bib13","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/ajmg.10500","article-title":"Dendritic spine and dendritic field characteristics of layer V pyramidal neurons in the visual cortex of fragile-X knockout mice","volume":"111","author":"Irwin","year":"2002","journal-title":"American Journal of Medical Genetics"},{"key":"10.1016\/j.nlm.2004.11.004_bib14","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0079-6123(08)64436-2","article-title":"Sex differences in developmental plasticity in the visual cortex and hippocampal dentate gyrus","volume":"61","author":"Juraska","year":"1984","journal-title":"Progress in Brain Research"},{"issue":"36","key":"10.1016\/j.nlm.2004.11.004_bib15","doi-asserted-by":"crossref","first-page":"13357","DOI":"10.1073\/pnas.0405398101","article-title":"Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles","volume":"101","author":"Khandjian","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.nlm.2004.11.004_bib16","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/mcne.2001.1085","article-title":"Reduced cortical synaptic plasticity and GluR1 expression associated with fragile X mental retardation protein deficiency","volume":"19","author":"Li","year":"2002","journal-title":"Molecular and Cellular Neuroscience"},{"key":"10.1016\/j.nlm.2004.11.004_bib17","unstructured":"McKinney, B. C., Grossman, A. W., Elisseou, N. M., & Greenough, W. T. (in press). Dendritic spine abnormalities in the occipital cortex of C57BL\/6 Fmr1 knockout mice. American Journal of Medical Genetics"},{"key":"10.1016\/j.nlm.2004.11.004_bib18","doi-asserted-by":"crossref","first-page":"5798","DOI":"10.1523\/JNEUROSCI.1102-04.2004","article-title":"Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants","volume":"24","author":"Michel","year":"2004","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2004.11.004_bib19","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0896-6273(03)00034-5","article-title":"RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice","volume":"37","author":"Miyashiro","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.nlm.2004.11.004_bib20","doi-asserted-by":"crossref","first-page":"12673","DOI":"10.1073\/pnas.91.26.12673","article-title":"An increase in dendritic spine density on hippocampal CA1 pyramidal cells following spatial learning in adult rats suggests the formation of new synapses","volume":"91","author":"Moser","year":"1994","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.nlm.2004.11.004_bib21","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/j.cub.2004.09.085","article-title":"The Drosophila fragile x gene negatively regulates neuronal elaboration and synaptic differentiation","volume":"14","author":"Pan","year":"2004","journal-title":"Current Biology"},{"key":"10.1016\/j.nlm.2004.11.004_bib22","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/72945","article-title":"Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice","volume":"3","author":"Rampon","year":"2000","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.nlm.2004.11.004_bib23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0165-3806(85)90193-2","article-title":"Differential rearing effects on rat visual cortex synapses. II. Synaptic morphometry","volume":"351","author":"Sirevaag","year":"1985","journal-title":"Brain Research"},{"key":"10.1016\/j.nlm.2004.11.004_bib24","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/0006-8993(87)91477-6","article-title":"Differential rearing effects on rat visual cortex synapses. III. Neuronal and glial nuclei, boutons, dendrites, and capillaries","volume":"424","author":"Sirevaag","year":"1987","journal-title":"Brain Research"},{"key":"10.1016\/j.nlm.2004.11.004_bib25","doi-asserted-by":"crossref","first-page":"9272","DOI":"10.1523\/JNEUROSCI.2306-04.2004","article-title":"Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells","volume":"24","author":"Stefani","year":"2004","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2004.11.004_bib26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0169-328X(00)00098-X","article-title":"Sensory stimulation increases cortical expression of the fragile X mental retardation protein in vivo","volume":"80","author":"Todd","year":"2000","journal-title":"Brain Research Molecular Brain Research"},{"key":"10.1016\/j.nlm.2004.11.004_bib27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0169-328X(02)00657-5","article-title":"Whisker stimulation-dependent translation of FMRP in the barrel cortex requires activation of type I metabotropic glutamate receptors","volume":"110","author":"Todd","year":"2003","journal-title":"Brain Research Molecular Brain Research"},{"key":"10.1016\/j.nlm.2004.11.004_bib28","doi-asserted-by":"crossref","first-page":"14374","DOI":"10.1073\/pnas.2336265100","article-title":"The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95","volume":"100","author":"Todd","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.nlm.2004.11.004_bib29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0006-8993(85)90525-6","article-title":"Differential rearing effects on rat visual cortex synapses. I. Synaptic and neuronal density and synapses per neuron","volume":"329","author":"Turner","year":"1985","journal-title":"Brain Research"},{"key":"10.1016\/j.nlm.2004.11.004_bib30","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0163-1047(92)90937-Y","article-title":"Increases in dendritic length in occipital cortex after 4 days of differential housing in weanling rats","volume":"58","author":"Wallace","year":"1992","journal-title":"Behavioral and Neural Biology"},{"key":"10.1016\/j.nlm.2004.11.004_bib31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/(SICI)1096-8628(19990402)83:4<248::AID-AJMG3>3.0.CO;2-1","article-title":"Synaptic synthesis of the Fragile X protein: Possible involvement in synapse maturation and elimination","volume":"83","author":"Weiler","year":"1999","journal-title":"American Journal of Medical Genetics"},{"key":"10.1016\/j.nlm.2004.11.004_bib32","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1073\/pnas.94.10.5395","article-title":"Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation","volume":"94","author":"Weiler","year":"1997","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"50","key":"10.1016\/j.nlm.2004.11.004_bib33","doi-asserted-by":"crossref","first-page":"17504","DOI":"10.1073\/pnas.0407533101","article-title":"Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses","volume":"101","author":"Weiler","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"container-title":["Neurobiology of Learning and Memory"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742704001261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742704001261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T11:55:22Z","timestamp":1548849322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074742704001261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S1074742704001261"],"URL":"https:\/\/doi.org\/10.1016\/j.nlm.2004.11.004","relation":{},"ISSN":["1074-7427"],"issn-type":[{"value":"1074-7427","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}