{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:19:23Z","timestamp":1778588363534,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Learning and Memory"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.nlm.2008.04.011","type":"journal-article","created":{"date-parts":[[2008,6,3]],"date-time":"2008-06-03T11:23:30Z","timestamp":1212492210000},"page":"301-308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Synaptic localization of GluR4-containing AMPARs and Arc during acquisition, extinction, and reacquisition of in vitro classical conditioning"],"prefix":"10.1016","volume":"90","author":[{"given":"Joyce","family":"Keifer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoqing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxim","family":"Mokin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nlm.2008.04.011_bib1","doi-asserted-by":"crossref","first-page":"9736","DOI":"10.1523\/JNEUROSCI.17-24-09736.1997","article-title":"The cerebellum and red nucleus are not required for in vitro classical conditioning of the turtle abducens nerve response","volume":"17","author":"Anderson","year":"1997","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2008.04.011_bib2","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1152\/jn.1999.81.3.1242","article-title":"Properties of conditioned abducens nerve responses in a highly reduced in vitro brain stem preparation from the turtle","volume":"81","author":"Anderson","year":"1999","journal-title":"Journal of Neurophysiology"},{"key":"10.1016\/j.nlm.2008.04.011_bib3","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1523\/JNEUROSCI.19-12-04748.1999","article-title":"Characterization of phosphorylation sites on the glutamate receptor 4 subunit of the AMPA receptors","volume":"19","author":"Carvalho","year":"1999","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2008.04.011_bib4","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.neuron.2006.08.033","article-title":"Arc\/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking","volume":"52","author":"Chowdhury","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.nlm.2008.04.011_bib5","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1523\/JNEUROSCI.23-03-00798.2003","article-title":"Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4 1 protein","volume":"23","author":"Coleman","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2008.04.011_bib6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0006-8993(88)91383-2","article-title":"A rapid Percoll gradient procedure for isolation of synaptosomes directly from an S1 fraction: Homogeneity and morphology of subcellular fractions","volume":"441","author":"Dunkley","year":"1988","journal-title":"Brain Research"},{"key":"10.1016\/j.nlm.2008.04.011_bib7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nn997","article-title":"PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity","volume":"6","author":"Esteban","year":"2003","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.nlm.2008.04.011_bib8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1600-0854.2006.00521.x","article-title":"PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression","volume":"8","author":"Gomes","year":"2007","journal-title":"Traffic"},{"key":"10.1016\/j.nlm.2008.04.011_bib9","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1471-4159.2004.02519.x","article-title":"Metabotropic glutamate and dopamine receptors co-regulate AMPA receptor activity through PKA in cultured chick retinal neurones: Effect on GluR4 phosphorylation and surface expression","volume":"90","author":"Gomes","year":"2004","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.nlm.2008.04.011_bib10","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/hipo.10010","article-title":"Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches","volume":"12","author":"Guzowski","year":"2002","journal-title":"Hippocampus"},{"key":"10.1016\/j.nlm.2008.04.011_bib11","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.1523\/JNEUROSCI.20-11-03993.2000","article-title":"Inhibition of activity-dependent Arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory","volume":"20","author":"Guzowski","year":"2000","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2008.04.011_bib12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00228693","article-title":"In vitro eye-blink reflex model: Role of excitatory amino acids and labeling of network activity with sulforhodamine","volume":"97","author":"Keifer","year":"1993","journal-title":"Experimental Brain Research"},{"key":"10.1016\/j.nlm.2008.04.011_bib13","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1523\/JNEUROSCI.21-07-02434.2001","article-title":"In vitro eye-blink classical conditioning is NMDA receptor-dependent and involves redistribution of AMPA receptor subunit GluR4","volume":"21","author":"Keifer","year":"2001","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2008.04.011_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/14734220310015610","article-title":"In vi tro classical conditioning of the turtle eyeblink reflex: Approaching cellular mechanisms of acquisition","volume":"2","author":"Keifer","year":"2003","journal-title":"Cerebellum"},{"key":"10.1016\/j.nlm.2008.04.011_bib15","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.1523\/JNEUROSCI.15-07-05036.1995","article-title":"Arc\/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking","volume":"15","author":"Keifer","year":"1995","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2008.04.011_bib16","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00221-003-1494-5","article-title":"Abducens conditioning in in vitro turtle brain stem without cerebellum requires NMDA receptors and involves upregulation of GluR4-containing AMPA receptors","volume":"151","author":"Keifer","year":"2003","journal-title":"Experimental Brain Research"},{"key":"10.1016\/j.nlm.2008.04.011_bib17","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1152\/jn.01154.2006","article-title":"MAPK signaling pathways mediate AMPA receptor trafficking in an in vitro model of classical conditioning","volume":"97","author":"Keifer","year":"2007","journal-title":"Journal of Neurophysiology"},{"key":"10.1016\/j.nlm.2008.04.011_bib18","doi-asserted-by":"crossref","first-page":"8310","DOI":"10.1523\/JNEUROSCI.23-23-08310.2003","article-title":"The similarities and diversities of signal pathways leading to consolidation of conditioning and consolidation of extinction of fear memory","volume":"23","author":"Lin","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2008.04.011_bib19","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0896-6273(95)90299-6","article-title":"Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites","volume":"14","author":"Lyford","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.nlm.2008.04.011_bib20","doi-asserted-by":"crossref","first-page":"8892","DOI":"10.1523\/JNEUROSCI.0365-06.2006","article-title":"Extinction training in conjunction with a partial agonist of the glycine site on the NMDA receptor erases memory trace","volume":"26","author":"Mao","year":"2006","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2008.04.011_bib21","doi-asserted-by":"crossref","first-page":"18020","DOI":"10.1073\/pnas.0608398103","article-title":"Recent fear is resistant to extinction","volume":"103","author":"Maren","year":"2006","journal-title":"Proceedings of the National Academy of Science"},{"key":"10.1016\/j.nlm.2008.04.011_bib22","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1101\/lm.83504","article-title":"Extinction as new learning versus unlearning: Considerations from a computer simulation of the cerebellum","volume":"11","author":"Mauk","year":"2004","journal-title":"Learning and Memory"},{"key":"10.1016\/j.nlm.2008.04.011_bib23","doi-asserted-by":"crossref","first-page":"10445","DOI":"10.1523\/JNEUROSCI.2883-07.2007","article-title":"Sustained Arc\/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo","volume":"27","author":"Messaoudi","year":"2007","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2008.04.011_bib24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neuroscience.2004.06.009","article-title":"Targeting of GluR4-containing AMPA receptors to synaptic sites during in vitro classical conditioning","volume":"128","author":"Mokin","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.nlm.2008.04.011_bib25","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jneumeth.2006.04.016","article-title":"Quantitative analysis of immunofluorescent punctate staining of synaptically localized proteins using confocal microscopy and stereology","volume":"157","author":"Mokin","year":"2006","journal-title":"Journal of Neuroscience Methods"},{"key":"10.1016\/j.nlm.2008.04.011_bib26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1152\/jn.00737.2005","article-title":"Immediate-early gene-encoded protein Arc is associated with synaptic delivery of GluR4-containing AMPA receptors during in vitro classical conditioning","volume":"95","author":"Mokin","year":"2006","journal-title":"Journal of Neurophysiology"},{"key":"10.1016\/j.nlm.2008.04.011_bib27","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1152\/jn.00212.2007","article-title":"Conversion of silent synapses into the active pool by selective GluR1-3 and GluR4 AMPAR trafficking during in vitro classical conditioning","volume":"98","author":"Mokin","year":"2007","journal-title":"Journal of Neurophysiology"},{"key":"10.1016\/j.nlm.2008.04.011_bib28","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/sj.mp.4001939","article-title":"Mechanisms of fear extinction","volume":"12","author":"Myers","year":"2007","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.nlm.2008.04.011_bib29","doi-asserted-by":"crossref","first-page":"4487","DOI":"10.1523\/JNEUROSCI.22-11-04487.2002","article-title":"Synaptically targeted Narp plays and essential role in the aggregation of AMPA receptors at excitatory synapses in cultured spinal neurons","volume":"22","author":"O\u2019Brien","year":"2002","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2008.04.011_bib30","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.neuron.2006.08.024","article-title":"Arc\/Arg3.1 is essential for the consolidation of synaptic plasticity and memories","volume":"52","author":"Plath","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.nlm.2008.04.011_bib31","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nn1708","article-title":"AMPA receptors regulate transcription of the plasticity-related immediate-early gene Arc","volume":"9","author":"Rao","year":"2006","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.nlm.2008.04.011_bib32","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.neuron.2006.09.031","article-title":"Increased expression of the immediate-early gene Arc\/Arg3.1 reduces AMPA receptor-mediated synaptic transmission","volume":"52","author":"Rial Verde","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.nlm.2008.04.011_bib33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.1103944","article-title":"Postsynaptic receptor trafficking underlying a form of associative learning","volume":"308","author":"Rumpel","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.nlm.2008.04.011_bib34","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.neuron.2006.08.034","article-title":"Arc\/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors","volume":"52","author":"Shepherd","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.nlm.2008.04.011_bib35","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0896-6273(00)80591-7","article-title":"Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites","volume":"21","author":"Steward","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.nlm.2008.04.011_bib36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0896-6273(01)00275-6","article-title":"Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation","volume":"30","author":"Steward","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.nlm.2008.04.011_bib37","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1523\/JNEUROSCI.5491-03.2004","article-title":"Memory reconsolidation and extinction have distinct temporal and biochemical signatures","volume":"24","author":"Suzuki","year":"2004","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2008.04.011_bib38","unstructured":"Zheng, Z., & Keifer, J. (2007). PKC signaling pathways mediate AMPA receptor trafficking in an in vitro model of classical conditioning. Program No. 935.12, 2007 abstract viewer\/itenerary planner. Washington, DC: Society for Neuroscience."}],"container-title":["Neurobiology of Learning and Memory"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742708000658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742708000658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:27:37Z","timestamp":1761031657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074742708000658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S1074742708000658"],"URL":"https:\/\/doi.org\/10.1016\/j.nlm.2008.04.011","relation":{},"ISSN":["1074-7427"],"issn-type":[{"value":"1074-7427","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synaptic localization of GluR4-containing AMPARs and Arc during acquisition, extinction, and reacquisition of in vitro classical conditioning","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Learning and Memory","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nlm.2008.04.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}