{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:06:38Z","timestamp":1789653998134,"version":"4.0.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Learning and Memory"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.nlm.2008.07.013","type":"journal-article","created":{"date-parts":[[2008,8,31]],"date-time":"2008-08-31T05:38:31Z","timestamp":1220161111000},"page":"624-632","source":"Crossref","is-referenced-by-count":83,"title":["Paradoxical sleep deprivation impairs acquisition, consolidation, and retrieval of a discriminative avoidance task in rats"],"prefix":"10.1016","volume":"90","author":[{"given":"Tathiana A.","family":"Alvarenga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla L.","family":"Patti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica L.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina H.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana B.","family":"Calzavara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia B.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Frussa-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Tufik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nlm.2008.07.013_bib1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0959-4388(00)00194-X","article-title":"Molecular mechanisms of memory acquisition, consolidation and retrieval","volume":"11","author":"Abel","year":"2001","journal-title":"Current Opinion in Neurobiology"},{"key":"10.1016\/j.nlm.2008.07.013_bib2","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1111\/j.1471-4159.1989.tb09224.x","article-title":"Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens, and medial frontal cortex","volume":"52","author":"Abercrombie","year":"1989","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.nlm.2008.07.013_bib3","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.pbb.2006.03.010","article-title":"Amphetamine-induced rapid-onset sensitization: Role of novelty, conditioning and behavioral parameters","volume":"83","author":"Alvarez","year":"2006","journal-title":"Pharmacology, Biochemistry and Behavior"},{"key":"10.1016\/j.nlm.2008.07.013_bib4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/13556210220139497","article-title":"Does paradoxical sleep deprivation and cocaine induce penile erection and ejaculation in old rats?","volume":"7","author":"Andersen","year":"2002","journal-title":"Addiction Biology"},{"key":"10.1016\/j.nlm.2008.07.013_bib5","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1590\/S0100-879X2004000600003","article-title":"Different stress modalities result in distinct steroid responses by male rats","volume":"37","author":"Andersen","year":"2004","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"10.1016\/j.nlm.2008.07.013_bib6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0031-9384(02)00972-1","article-title":"Cocaine-induced genital reflexes during paradoxical sleep deprivation and recovery","volume":"78","author":"Andersen","year":"2003","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.nlm.2008.07.013_bib7","series-title":"Ethical and practical principles of the use of laboratory animals","author":"Andersen","year":"2004"},{"key":"10.1016\/j.nlm.2008.07.013_bib8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-2869.2004.00428.x","article-title":"Endocrinological and catecholaminergic alterations during sleep deprivation and recovery in male rats","volume":"14","author":"Andersen","year":"2005","journal-title":"Journal Sleep Research"},{"key":"10.1016\/j.nlm.2008.07.013_bib9","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1369-1600.2000.tb00210.x","article-title":"The effects of acute cocaine administration in paradoxical sleep-deprived rats","volume":"5","author":"Andersen","year":"2000","journal-title":"Addiction Biology"},{"key":"10.1016\/j.nlm.2008.07.013_bib10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.yhbeh.2005.09.005","article-title":"The effects of paradoxical sleep deprivation on estrous cycles of the female rats","volume":"49","author":"Antunes","year":"2006","journal-title":"Hormones and Behavior"},{"key":"10.1016\/j.nlm.2008.07.013_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000118468","article-title":"Effects of lithium on dopamine behavioural supersensitivity induced by rapid eye movement sleep deprivation","volume":"20","author":"Arriaga","year":"1988","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.nlm.2008.07.013_bib12","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.pnpbp.2008.04.001","article-title":"Sleep rebound attenuates context-dependent behavioural sensitization induced by amphetamine","volume":"32","author":"Calzavara","year":"2008","journal-title":"Progress in Neuro-Psychopharmacology & Biological Psychiatry"},{"key":"10.1016\/j.nlm.2008.07.013_bib13","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/00008877-200412000-00003","article-title":"Role of anxiety levels in memory performance of spontaneously hypertensive rats","volume":"15","author":"Calzavara","year":"2004","journal-title":"Behavioural Pharmacology"},{"key":"10.1016\/j.nlm.2008.07.013_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.brainres.2006.09.008","article-title":"Effects of reserpine on the plus-maze discriminative avoidance task: Dissociation between memory and motor impairments","volume":"1122","author":"Carvalho","year":"2006","journal-title":"Brain Research"},{"key":"10.1016\/j.nlm.2008.07.013_bib15","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.physbeh.2005.07.009","article-title":"Effects of long-term continuous exposure to light on memory and anxiety","volume":"86","author":"Castro","year":"2005","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.nlm.2008.07.013_bib16","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0031-9384(99)00099-2","article-title":"Bovine brain phosphatidylserine attenuates scopolamine-induced amnesia","volume":"67","author":"Claro","year":"1999","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.nlm.2008.07.013_bib17","first-page":"1363","article-title":"Effect of withdrawal from long-term nifedipine administration on open-field habituation in the rat","volume":"27","author":"Concei\u00e7\u00e3o","year":"1994","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"10.1016\/j.nlm.2008.07.013_bib18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0166-4328(01)00345-X","article-title":"Social stress does not interact with paradoxical sleep deprivation-induced memory impairment","volume":"129","author":"Dametto","year":"2002","journal-title":"Behavioral Brain Research"},{"key":"10.1016\/j.nlm.2008.07.013_bib19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1037\/0735-7044.106.1.181","article-title":"Sexual behavior increases dopamine transmission in the nucleus accumbens and striatum of male rats: Comparison with novelty and locomotion","volume":"106","author":"Damsma","year":"1992","journal-title":"Behavioral Neuroscience"},{"key":"10.1016\/j.nlm.2008.07.013_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0022-3956(69)90016-8","article-title":"The behavioral effects of amphetamine on REM deprived rats","volume":"7","author":"Ferguson","year":"1969","journal-title":"Journal of Psychiatric Research"},{"key":"10.1016\/j.nlm.2008.07.013_bib21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.brainres.2003.11.050","article-title":"Paradoxical sleep deprivation potentiates amphetamine-induced behavioural sensitization by increasing its conditioned component","volume":"1003","author":"Frussa-Filho","year":"2004","journal-title":"Brain Research"},{"key":"10.1016\/j.nlm.2008.07.013_bib22","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.neuroscience.2006.10.050","article-title":"Rapid eye movement sleep deprivation selectively impairs recall of fear extinction in hippocampus-independent tasks in rats","volume":"144","author":"Fu","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.nlm.2008.07.013_bib23","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbr.2005.06.024","article-title":"Effects of paradoxical sleep deprivation on the performance of rats in a model of visual attention","volume":"165","author":"Godoi","year":"2005","journal-title":"Behavioral Brain Research"},{"key":"10.1016\/j.nlm.2008.07.013_bib24","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1101\/lm.48803","article-title":"Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning","volume":"10","author":"Graves","year":"2003","journal-title":"Learning & Memory"},{"key":"10.1016\/j.nlm.2008.07.013_bib25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0166-2236(00)01744-6","article-title":"Sleep and memory: A molecular perspective","volume":"24","author":"Graves","year":"2001","journal-title":"Trends in Neurosciences"},{"key":"10.1016\/j.nlm.2008.07.013_bib26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00213-006-0684-9","article-title":"Dissociation of the effects of ethanol on memory, anxiety and motor behavior in mice tested in the plus-maze discriminative avoidance task","volume":"192","author":"Kameda","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nlm.2008.07.013_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.brainres.2004.01.019","article-title":"Sleep deprivation induced by the modified multiple platform technique: Quantification of sleep loss and recovery","volume":"1004","author":"Machado","year":"2004","journal-title":"Brain Research"},{"key":"10.1016\/j.nlm.2008.07.013_bib28","doi-asserted-by":"crossref","first-page":"9687","DOI":"10.1523\/JNEUROSCI.23-29-09687.2003","article-title":"Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons","volume":"23","author":"McDermott","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2008.07.013_bib29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.nlm.2005.11.005","article-title":"Sleep deprivation impairs object recognition in mice","volume":"85","author":"Palchykova","year":"2006","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.nlm.2008.07.013_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00213-005-0238-6","article-title":"Effects of morphine on the plus-maze discriminative avoidance task: Role of state-dependent learning","volume":"184","author":"Patti","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nlm.2008.07.013_bib31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.pnpbp.2007.07.017","article-title":"Distinct behavioral and neurochemical alterations induced by intermittent hypoxia or paradoxical sleep deprivation in rats","volume":"32","author":"Perry","year":"2007","journal-title":"Progress in Neuro-Psychopharmacology & Biological Psychiatry"},{"key":"10.1016\/j.nlm.2008.07.013_bib32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0006-8993(95)00679-K","article-title":"Sexual activity increases dopamine transmission in the nucleus accumbens and striatum of female rats","volume":"693","author":"Pfaus","year":"1995","journal-title":"Brain Research"},{"key":"10.1016\/j.nlm.2008.07.013_bib33","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1353\/pbm.1998.0051","article-title":"Current perspectives on the function of sleep","volume":"41","author":"Rechtschaffen","year":"1998","journal-title":"Perspectives in Biology and Medicine"},{"key":"10.1016\/j.nlm.2008.07.013_bib34","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.neuropharm.2003.11.032","article-title":"Role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice","volume":"46","author":"Silva","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nlm.2008.07.013_bib35","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0166-4328(01)00409-0","article-title":"Concomitant development of oral dyskinesia and memory deficits in reserpine-treated male and female mice","volume":"132","author":"Silva","year":"2002","journal-title":"Behavioral Brain Research"},{"key":"10.1016\/j.nlm.2008.07.013_bib36","first-page":"322","article-title":"Effects of long-term ganglioside GM1 administration on a new discriminative avoidance test in normal adult mice","volume":"129","author":"Silva","year":"1997","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nlm.2008.07.013_bib37","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.nlm.2004.04.005","article-title":"Effects of pre- or post-training paradoxical sleep deprivation on two animal models of learning and memory in mice","volume":"82","author":"Silva","year":"2004","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.nlm.2008.07.013_bib38","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s002130050814","article-title":"Ganglioside GM1 attenuates scopolamine-induced amnesia in rats and mice","volume":"141","author":"Silva","year":"1999","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nlm.2008.07.013_bib39","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0197-4580(96)00065-6","article-title":"Effect of ganglioside (GM1) on memory in senescent rats","volume":"17","author":"Silva","year":"1996","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.nlm.2008.07.013_bib40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0165-0270(00)00289-2","article-title":"The plus-maze discriminative avoidance task: A new model to study memory-anxiety interactions. Effects of chlordiazepoxide and caffeine","volume":"102","author":"Silva","year":"2000","journal-title":"Journal of Neuroscience Methods"},{"key":"10.1016\/j.nlm.2008.07.013_bib41","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0024-3205(02)02298-1","article-title":"Naltrexone potentiates both amnestic and anxiolytic effects of chlordiazepoxide in mice","volume":"72","author":"Silva","year":"2002","journal-title":"Life Science"},{"key":"10.1016\/j.nlm.2008.07.013_bib42","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00213-001-0948-3","article-title":"Effects of amphetamine on the plus-maze discriminative avoidance task in mice","volume":"160","author":"Silva","year":"2002","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nlm.2008.07.013_bib43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00213-004-1873-z","article-title":"Anxiogenic effect of sleep deprivation in the elevated plus-maze test in mice","volume":"176","author":"Silva","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nlm.2008.07.013_bib44","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/nlme.1997.3809","article-title":"Brief paradoxical sleep deprivation impairs reference, but not working, memory in the radial arm maze task","volume":"69","author":"Smith","year":"1998","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.nlm.2008.07.013_bib45","doi-asserted-by":"crossref","first-page":"e282","DOI":"10.1371\/journal.pbio.0050282","article-title":"Sleep-related hippocampo-cortical interplay during emotional memory recollection","volume":"5","author":"Sterpenich","year":"2007","journal-title":"PLoS Biology"},{"key":"10.1016\/j.nlm.2008.07.013_bib46","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/nature04286","article-title":"Sleep-dependent memory consolidation","volume":"437","author":"Stickgold","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.nlm.2008.07.013_bib47","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1126\/science.1063530","article-title":"Sleep, learning and dreams: Off-line memory reprocessing","volume":"294","author":"Stickgold","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.nlm.2008.07.013_bib48","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.sleep.2007.03.011","article-title":"Sleep-dependent memory consolidation and reconsolidation","volume":"8","author":"Stickgold","year":"2007","journal-title":"Sleep Medicine"},{"key":"10.1016\/j.nlm.2008.07.013_bib49","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1046\/j.1365-2869.1998.00122.x","article-title":"Increased ACTH and corticosterone secretion induced by different methods of paradoxical sleep deprivation","volume":"4","author":"Suchecki","year":"1998","journal-title":"Journal Sleep Research"},{"key":"10.1016\/j.nlm.2008.07.013_bib50","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1046\/j.1365-2826.2002.00812.x","article-title":"Hormonal and behavioural responses of paradoxical sleep-deprived rats to the elevated plus maze","volume":"14","author":"Suchecki","year":"2002","journal-title":"Journal Neuroendocrinology"},{"key":"10.1016\/j.nlm.2008.07.013_bib51","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0031-9384(99)00181-X","article-title":"Social stability attenuates the stress in the modified multiple platform method for paradoxical sleep deprivation in the rat","volume":"68","author":"Suchecki","year":"2000","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.nlm.2008.07.013_bib52","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/sleep\/31.4.505","article-title":"Glucocorticoids are not responsible for paradoxical sleep deprivation-induced memory impairments","volume":"31","author":"Tiba","year":"2008","journal-title":"Sleep"},{"key":"10.1016\/j.nlm.2008.07.013_bib53","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF00735885","article-title":"Reversal of the increase in apomorphine-induced stereotypy and aggression in REM sleep deprived rats by dopamine agonist pretreatments","volume":"94","author":"Troncone","year":"1988","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nlm.2008.07.013_bib54","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/j.2042-7158.1981.tb13916.x","article-title":"Increased responsiveness to apomorphine after REM sleep deprivation: Supersensitivity of dopamine receptors or increase in dopamine turnover?","volume":"33","author":"Tufik","year":"1981","journal-title":"The Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.nlm.2008.07.013_bib55","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF00431826","article-title":"Changes of response to dopaminergic drugs in rats submitted to REM-sleep deprivation","volume":"72","author":"Tufik","year":"1981","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nlm.2008.07.013_bib56","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000136753","article-title":"Does REM sleep deprivation induce a supersensitivity of dopaminergic receptors in the rat brain?","volume":"16","author":"Tufik","year":"1978","journal-title":"Pharmacology"},{"key":"10.1016\/j.nlm.2008.07.013_bib57","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0031-9384(80)90298-X","article-title":"The pendulum technique for paradoxical sleep deprivation in rats","volume":"25","author":"Van Hulzen","year":"1980","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.nlm.2008.07.013_bib58","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1007\/s00018-004-4351-1","article-title":"Issues surrounding sleep-dependent memory consolidation and plasticity","volume":"61","author":"Walker","year":"2004","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.nlm.2008.07.013_bib59","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev.psych.56.091103.070307","article-title":"Sleep, memory, and plasticity","volume":"57","author":"Walker","year":"2006","journal-title":"Annual Review of Psychology"}],"container-title":["Neurobiology of Learning and Memory"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742708001275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742708001275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T14:44:49Z","timestamp":1557758689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074742708001275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S1074742708001275"],"URL":"https:\/\/doi.org\/10.1016\/j.nlm.2008.07.013","relation":{},"ISSN":["1074-7427"],"issn-type":[{"value":"1074-7427","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}