{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:50:12Z","timestamp":1761562212187},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Learning and Memory"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.nlm.2017.02.014","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T20:01:09Z","timestamp":1487793669000},"page":"71-81","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["ADRA2B deletion variant influences time-dependent effects of pre-learning stress on long-term memory"],"prefix":"10.1016","volume":"140","author":[{"given":"Phillip R.","family":"Zoladz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison M.","family":"Dailey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah E.","family":"Nagle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda K.","family":"Fiely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brianne E.","family":"Mosley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Callie M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tessa J.","family":"Duffy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda R.","family":"Scharf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"McKenna B.","family":"Earley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyd R.","family":"Rorabaugh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nlm.2017.02.014_b0005","doi-asserted-by":"crossref","first-page":"10530","DOI":"10.1523\/JNEUROSCI.19-23-10530.1999","article-title":"Biphasic modulation of hippocampal plasticity by behavioral stress and basolateral amygdala stimulation in the rat","volume":"19","author":"Akirav","year":"1999","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2017.02.014_b0010","doi-asserted-by":"crossref","first-page":"9912","DOI":"10.1523\/JNEUROSCI.22-22-09912.2002","article-title":"Mechanisms of amygdala modulation of hippocampal plasticity","volume":"22","author":"Akirav","year":"2002","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2017.02.014_b0015","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3928\/00485713-20090526-01","article-title":"Genetics of PTSD: Fear conditioning as a model for future research","volume":"39","author":"Amstadter","year":"2009","journal-title":"Psychiatric Annals"},{"key":"10.1016\/j.nlm.2017.02.014_b0020","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1467-9280.2006.01729.x","article-title":"Glucocorticoid release and memory consolidation in men and women","volume":"17","author":"Andreano","year":"2006","journal-title":"Psychological Science"},{"key":"10.1016\/j.nlm.2017.02.014_b0025","series-title":"Affective norms for English words (ANEW): Instruction manual and affective ratings","author":"Bradley","year":"1999"},{"key":"10.1016\/j.nlm.2017.02.014_b0030","doi-asserted-by":"crossref","first-page":"9867","DOI":"10.1073\/pnas.1003514107","article-title":"Acute stress modulates genotype effects on amygdala processing in humans","volume":"107","author":"Cousijn","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.nlm.2017.02.014_b0035","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/nn1945","article-title":"A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans","volume":"10","author":"de Quervain","year":"2007","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.nlm.2017.02.014_b0040","doi-asserted-by":"crossref","first-page":"60803","DOI":"10.1155\/2007\/60803","article-title":"The temporal dynamics model of emotional memory processing: A synthesis on the neurobiological basis of stress-induced amnesia, flashbulb and traumatic memories, and the Yerkes-Dodson law","volume":"2007","author":"Diamond","year":"2007","journal-title":"Neural Plasticity"},{"key":"10.1016\/j.nlm.2017.02.014_b0045","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.biopsycho.2011.12.006","article-title":"Sex differences in emotional memory consolidation: The effect of stress-induced salivary alpha-amylase and cortisol","volume":"89","author":"Felmingham","year":"2012","journal-title":"Biological Psychology"},{"key":"10.1016\/j.nlm.2017.02.014_b0050","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.euroneuro.2009.12.007","article-title":"Deletion variant of alpha2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance","volume":"20","author":"Gibbs","year":"2010","journal-title":"European Neuropsychopharmacology"},{"key":"10.1016\/j.nlm.2017.02.014_b0055","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.biopsych.2005.08.002","article-title":"Stress differentially modulates fear conditioning in healthy men and women","volume":"59","author":"Jackson","year":"2006","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.nlm.2017.02.014_b0060","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1080\/00207450490476101","article-title":"Acute stress enhances memory for emotional words, but impairs memory for neutral words","volume":"114","author":"Jelicic","year":"2004","journal-title":"International Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2017.02.014_b0065","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tics.2011.04.004","article-title":"Stress and emotional memory: A matter of timing","volume":"15","author":"Joels","year":"2011","journal-title":"Trends in Cognitive Sciences"},{"key":"10.1016\/j.nlm.2017.02.014_b0070","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.psyneuen.2005.07.002","article-title":"The effects of sex and hormonal status on the physiological response to acute psychosocial stress","volume":"31","author":"Kajantie","year":"2006","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.nlm.2017.02.014_b0075","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/00006842-199903000-00006","article-title":"Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis","volume":"61","author":"Kirschbaum","year":"1999","journal-title":"Psychosomatic Medicine"},{"key":"10.1016\/j.nlm.2017.02.014_b0080","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0306-4530(94)00078-O","article-title":"Preliminary evidence for reduced cortisol responsivity to psychological stress in women using oral contraceptive medication","volume":"20","author":"Kirschbaum","year":"1995","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.nlm.2017.02.014_b0085","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.nlm.2013.03.006","article-title":"ADRA2B genotype modulates effects of acute psychosocial stress on emotional memory retrieval in healthy young men","volume":"103","author":"Li","year":"2013","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.nlm.2017.02.014_b0090","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00213-014-3710-3","article-title":"ADRA2B genotype differentially modulates stress-induced neural activity in the amygdala and hippocampus during emotional memory retrieval","volume":"232","author":"Li","year":"2015","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nlm.2017.02.014_b0095","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.nlm.2016.02.009","article-title":"The modulating role of ADRA2B in emotional working memory: Attending the negative but remembering the positive","volume":"130","author":"Mammarella","year":"2016","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.nlm.2017.02.014_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.neuro.27.070203.144157","article-title":"The amygdala modulates the consolidation of memories of emotionally arousing experiences","volume":"27","author":"McGaugh","year":"2004","journal-title":"Annual Review of Neuroscience"},{"key":"10.1016\/j.nlm.2017.02.014_b0105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00213-008-1285-6","article-title":"Drug enhancement of memory consolidation: Historical perspective and neurobiological implications","volume":"202","author":"McGaugh","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nlm.2017.02.014_b0110","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/jnr.23811","article-title":"Sex differences in stress effects on emotional learning","volume":"95","author":"Merz","year":"2017","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.nlm.2017.02.014_b0115","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/jnr.23904","article-title":"Cortisol reactivity and emotional memory after psychosocial stress in oral contraceptive users","volume":"95","author":"Mordecai","year":"2017","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.nlm.2017.02.014_b0120","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1177\/0269881111416688","article-title":"Influence of COMT val158met and ADRA2B deletion polymorphisms on recollection and familiarity components of human emotional memory","volume":"26","author":"Naudts","year":"2011","journal-title":"Journal of Psychopharmacology"},{"key":"10.1016\/j.nlm.2017.02.014_b0125","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.nlm.2011.06.013","article-title":"Hormonal contraception usage is associated with altered memory for an emotional story","volume":"96","author":"Nielsen","year":"2011","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.nlm.2017.02.014_b0130","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.biopsycho.2012.10.007","article-title":"Hormonal contraception use alters stress responses and emotional memory","volume":"92","author":"Nielsen","year":"2013","journal-title":"Biological Psychology"},{"key":"10.1016\/j.nlm.2017.02.014_b0135","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1101\/lm.743507","article-title":"Stress administered prior to encoding impairs neutral but enhances emotional long-term episodic memories","volume":"14","author":"Payne","year":"2007","journal-title":"Learning and Memory"},{"key":"10.1016\/j.nlm.2017.02.014_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/09658210500139176","article-title":"The impact of stress on neutral and emotional aspects of episodic memory","volume":"14","author":"Payne","year":"2006","journal-title":"Memory"},{"key":"10.1016\/j.nlm.2017.02.014_b0145","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1016\/j.psyneuen.2013.09.002","article-title":"Time dependent effects of stress prior to encoding on event-related potentials and 24h delayed retrieval","volume":"38","author":"Quaedflieg","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.nlm.2017.02.014_b0150","doi-asserted-by":"crossref","first-page":"19191","DOI":"10.1073\/pnas.0907425106","article-title":"A genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories","volume":"106","author":"Rasch","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.nlm.2017.02.014_b0155","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pbb.2013.05.007","article-title":"Hormonal contraceptive use diminishes salivary cortisol response to psychosocial stress and naltrexone in healthy women","volume":"109","author":"Roche","year":"2013","journal-title":"Pharmacology, Biochemistry and Behavior"},{"key":"10.1016\/j.nlm.2017.02.014_b0160","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.nlm.2008.02.002","article-title":"Effects of pre-learning stress on memory for neutral, positive and negative words: Different roles of cortisol and autonomic arousal","volume":"90","author":"Schwabe","year":"2008","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.nlm.2017.02.014_b0165","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.psyneuen.2008.03.001","article-title":"HPA axis activation by a socially evaluated cold-pressor test","volume":"33","author":"Schwabe","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.nlm.2017.02.014_b0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroimage.2013.01.057","article-title":"Opposite effects of noradrenergic arousal on amygdala processing of fearful faces in men and women","volume":"73","author":"Schwabe","year":"2013","journal-title":"Neuroimage"},{"key":"10.1016\/j.nlm.2017.02.014_b0175","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.neubiorev.2011.07.002","article-title":"Stress effects on memory: An update and integration","volume":"36","author":"Schwabe","year":"2012","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"10.1016\/j.nlm.2017.02.014_b0180","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.neuropharm.2011.02.013","article-title":"PTSD and gene variants: New pathways and new thinking","volume":"62","author":"Skelton","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nlm.2017.02.014_b0185","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1074\/jbc.M008118200","article-title":"Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization","volume":"276","author":"Small","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.nlm.2017.02.014_b0190","series-title":"Manual for the state-trait anxiety inventory","author":"Spielberger","year":"1983"},{"key":"10.1016\/j.nlm.2017.02.014_b0195","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/da.20292","article-title":"Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder","volume":"25","author":"Strawn","year":"2008","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.nlm.2017.02.014_b0200","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1177\/0956797613492423","article-title":"Genes for emotion-enhanced remembering are linked to enhanced perceiving","volume":"24","author":"Todd","year":"2013","journal-title":"Psychological Science"},{"key":"10.1016\/j.nlm.2017.02.014_b0205","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1037\/0033-2909.132.6.959","article-title":"Sex differences in trauma and posttraumatic stress disorder: A quantitative review of 25 years of research","volume":"132","author":"Tolin","year":"2006","journal-title":"Psychological Bulletin"},{"key":"10.1016\/j.nlm.2017.02.014_b0210","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.psyneuen.2016.04.027","article-title":"Stress in the zoo: Tracking the impact of stress on memory formation over time","volume":"71","author":"Vogel","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.nlm.2017.02.014_b0215","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1037\/0022-3514.54.6.1063","article-title":"Development and validation of brief measures of positive and negative affect: The PANAS scales","volume":"54","author":"Watson","year":"1988","journal-title":"Journal of Personality and Social Psychology"},{"key":"10.1016\/j.nlm.2017.02.014_b0220","series-title":"Elementary signal detection theory","author":"Wickens","year":"2002"},{"key":"10.1016\/j.nlm.2017.02.014_b0225","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.nlm.2013.08.015","article-title":"The downside of strong emotional memories: How human memory-related genes influence the risk for posttraumatic stress disorder \u2013 A selective review","volume":"112","author":"Wilker","year":"2014","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.nlm.2017.02.014_b0230","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3109\/10253890.2011.622012","article-title":"Immediate recall influences the effects of pre-encoding stress on emotional episodic long-term memory consolidation in healthy young men","volume":"15","author":"Wolf","year":"2012","journal-title":"Stress"},{"key":"10.1016\/j.nlm.2017.02.014_b0235","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0306-4530(01)00025-7","article-title":"The relationship between stress induced cortisol levels and memory differs between men and women","volume":"26","author":"Wolf","year":"2001","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.nlm.2017.02.014_b0240","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.physbeh.2011.01.016","article-title":"Pre-learning stress differentially affects long-term memory for emotional words, depending on temporal proximity to the learning experience","volume":"103","author":"Zoladz","year":"2011","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.nlm.2017.02.014_b0245","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.neubiorev.2013.03.024","article-title":"Current status on behavioral and biological markers of PTSD: A search for clarity in a conflicting literature","volume":"37","author":"Zoladz","year":"2013","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"10.1016\/j.nlm.2017.02.014_b0250","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.bandc.2014.01.010","article-title":"Brief, pre-retrieval stress differentially influences long-term memory depending on sex and corticosteroid response","volume":"85","author":"Zoladz","year":"2014","journal-title":"Brain and Cognition"},{"key":"10.1016\/j.nlm.2017.02.014_b0255","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.psyneuen.2014.06.012","article-title":"ADRA2B deletion variant selectively predicts stress-induced enhancement of long-term memory in females","volume":"48","author":"Zoladz","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.nlm.2017.02.014_b0260","series-title":"The handbook of stress: Neuropsychological effects on the brain","first-page":"157","article-title":"Neurobiological basis of the complex effects of stress on memory and synaptic plasticity","author":"Zoladz","year":"2011"},{"key":"10.1016\/j.nlm.2017.02.014_b0265","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.physbeh.2014.02.028","article-title":"Brief, pre-learning stress reduces false memory production and enhances true memory selectively in females","volume":"128","author":"Zoladz","year":"2014","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.nlm.2017.02.014_b0270","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.nlm.2012.12.012","article-title":"Pre-learning stress that is temporally removed from acquisition exerts sex-specific effects on long-term memory","volume":"100","author":"Zoladz","year":"2013","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.nlm.2017.02.014_b0275","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1101\/lm.189106","article-title":"Effects of stress and sex on acquisition and consolidation of human fear conditioning","volume":"13","author":"Zorawski","year":"2006","journal-title":"Learning and Memory"}],"container-title":["Neurobiology of Learning and Memory"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742716302945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742716302945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T20:18:33Z","timestamp":1568837913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074742716302945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":55,"alternative-id":["S1074742716302945"],"URL":"https:\/\/doi.org\/10.1016\/j.nlm.2017.02.014","relation":{},"ISSN":["1074-7427"],"issn-type":[{"value":"1074-7427","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ADRA2B deletion variant influences time-dependent effects of pre-learning stress on long-term memory","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Learning and Memory","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nlm.2017.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}