{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:59:06Z","timestamp":1792645146601,"version":"4.5.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Learning and Memory"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.nlm.2017.04.004","type":"journal-article","created":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T10:30:50Z","timestamp":1492770650000},"page":"168-178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Global cerebral ischemia in rats leads to amnesia due to selective neuronal death followed by astroglial scar formation in the CA1 layer"],"prefix":"10.1016","volume":"141","author":[{"given":"Kevin","family":"Sadelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Stamegna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane D.","family":"Girard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Baril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Escoffier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00efna","family":"Brus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine D.","family":"V\u00e9ron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Khrestchatisky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois S.","family":"Roman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.nlm.2017.04.004_b0005","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.nec.2016.05.004","article-title":"Hypothermia in traumatic brain injury","volume":"27","author":"Ahmed","year":"2016","journal-title":"Neurosurgery Clinics of North America"},{"issue":"6","key":"10.1016\/j.nlm.2017.04.004_b0010","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1097\/00000542-199112000-00017","article-title":"Epinephrine dosage effects on cerebral and myocardial blood flow in an infant swine model of cardiopulmonary resuscitation","volume":"75","author":"Berkowitz","year":"1991","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.nlm.2017.04.004_b0015","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1602\/neurorx.1.1.36","article-title":"Neuroprotection for ischemic stroke: Two decades of success and failure","volume":"1","author":"Cheng","year":"2004","journal-title":"NeuroRx"},{"issue":"4466","key":"10.1016\/j.nlm.2017.04.004_b0020","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1126\/science.7414331","article-title":"Preserved learning and retention of pattern-analyzing skill in amnesia: Dissociation of knowing how and knowing that","volume":"210","author":"Cohen","year":"1980","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.nlm.2017.04.004_b0025","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/jnen\/62.2.127","article-title":"Inflammatory mechanisms after ischemia and stroke","volume":"62","author":"Danton","year":"2003","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"issue":"6","key":"10.1016\/j.nlm.2017.04.004_b0030","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1089\/scd.2009.0267","article-title":"The human nose harbors a niche of olfactory ectomesenchymal stem cells displaying neurogenic and osteogenic properties","volume":"19","author":"Delorme","year":"2010","journal-title":"Stem cells and Development"},{"issue":"9","key":"10.1016\/j.nlm.2017.04.004_b0035","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0166-2236(99)01401-0","article-title":"Pathobiology of ischaemic stroke: An integrated view","volume":"22","author":"Dirnagl","year":"1999","journal-title":"Trends in Neurosciences"},{"issue":"4","key":"10.1016\/j.nlm.2017.04.004_b0040","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1748-1716.1972.tb05354.x","article-title":"The effect of bilateral carotid artery ligation upon acid-base parameters and substrate levels in the rat brain","volume":"86","author":"Eklof","year":"1972","journal-title":"Acta Physiologica Scandinavica"},{"issue":"15","key":"10.1016\/j.nlm.2017.04.004_b0045","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1161\/hc4001.097037","article-title":"Hypothermia after cardiac arrest: Feasibility and safety of an external cooling protocol","volume":"104","author":"Felberg","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.nlm.2017.04.004_b0050","doi-asserted-by":"crossref","first-page":"1243659","DOI":"10.1155\/2016\/1243659","article-title":"Secretome of olfactory mucosa mesenchymal stem cell, a multiple potential stem cell","volume":"2016","author":"Ge","year":"2016","journal-title":"Stem Cells International"},{"key":"10.1016\/j.nlm.2017.04.004_b0055","article-title":"Isolating nasal olfactory stem cells from rodents or humans","volume":"54","author":"Girard","year":"2011","journal-title":"Journal of Visualized Experiments"},{"key":"10.1016\/j.nlm.2017.04.004_b0060","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1749-6632.1997.tb48621.x","article-title":"Immune responses and dementia","volume":"835","author":"Giulian","year":"1997","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"3","key":"10.1016\/j.nlm.2017.04.004_b0065","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/jmri.1175","article-title":"Diffusion-weighted magnetic resonance imaging detects early neuropathology following four vessel occlusion ischemia in the rat","volume":"14","author":"Gregory","year":"2001","journal-title":"Journal of Magnetic Resonance Imaging"},{"issue":"4","key":"10.1016\/j.nlm.2017.04.004_b0070","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0091-6773(74)92231-7","article-title":"The hippocampus and contextual retrieval of information from memory: A theory","volume":"12","author":"Hirsh","year":"1974","journal-title":"Behavioral Biology"},{"issue":"3","key":"10.1016\/j.nlm.2017.04.004_b0075","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0166-2236(96)10074-6","article-title":"Bright and dark sides of nitric oxide in ischemic brain injury","volume":"20","author":"Iadecola","year":"1997","journal-title":"Trends in Neurosciences"},{"key":"10.1016\/j.nlm.2017.04.004_b0080","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bbr.2012.10.061","article-title":"Dorsolateral striatum and dorsal hippocampus: A serial contribution to acquisition of cue-reward associations in rats","volume":"239","author":"Jacquet","year":"2013","journal-title":"Behavioural Brain Research"},{"issue":"1","key":"10.1016\/j.nlm.2017.04.004_b0085","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1006\/nlme.2000.3986","article-title":"Cognitive performances and locomotor activity following dentate granule cell damage in rats: Role of lesion extent and type of memory tested","volume":"76","author":"Jeltsch","year":"2001","journal-title":"Neurobiology of Learning and Memory"},{"issue":"8","key":"10.1016\/j.nlm.2017.04.004_b0090","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1073\/pnas.081011098","article-title":"Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat","volume":"98","author":"Jin","year":"2001","journal-title":"Proceedings of the National Academy of Sciences USA"},{"issue":"15","key":"10.1016\/j.nlm.2017.04.004_b0095","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1073\/pnas.1503863112","article-title":"Memory, scene construction, and the human hippocampus","volume":"112","author":"Kim","year":"2015","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"10.1016\/j.nlm.2017.04.004_b0100","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0079-6123(08)61974-3","article-title":"Selective vulnerability of the hippocampus to ischemia\u2013reversible and irreversible types of ischemic cell damage","volume":"63","author":"Kirino","year":"1985","journal-title":"Progress in Brain Research"},{"issue":"1","key":"10.1016\/j.nlm.2017.04.004_b0105","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0959-4388(03)00017-5","article-title":"Neurogenesis after ischaemic brain insults","volume":"13","author":"Kokaia","year":"2003","journal-title":"Current Opinion in Neurobiology"},{"issue":"8","key":"10.1016\/j.nlm.2017.04.004_b0110","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1161\/01.STR.32.8.1847","article-title":"Cooling for acute ischemic brain damage (cool aid): An open pilot study of induced hypothermia in acute ischemic stroke","volume":"32","author":"Krieger","year":"2001","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.nlm.2017.04.004_b0115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00429-007-0141-5","article-title":"Local origin and activity-dependent generation of nestin-expressing protoplasmic astrocytes in CA1","volume":"212","author":"Kronenberg","year":"2007","journal-title":"Brain Structure and Function"},{"issue":"10","key":"10.1016\/j.nlm.2017.04.004_b0120","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1212\/01.WNL.0000144189.83077.8E","article-title":"The neurological and cognitive sequelae of cardiac arrest","volume":"63","author":"Lim","year":"2004","journal-title":"Neurology"},{"issue":"19","key":"10.1016\/j.nlm.2017.04.004_b0125","doi-asserted-by":"crossref","first-page":"7768","DOI":"10.1523\/JNEUROSCI.18-19-07768.1998","article-title":"Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils","volume":"18","author":"Liu","year":"1998","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2017.04.004_b0130","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0021-9258(18)51740-3","article-title":"Effect of ischemia on known substrates and cofactors of the glycolytic pathway in brain","volume":"239","author":"Lowry","year":"1964","journal-title":"Journal of Biological Chemistry"},{"issue":"3","key":"10.1016\/j.nlm.2017.04.004_b0135","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/01.ccx.0000127542.32890.fa","article-title":"Brain function after resuscitation from cardiac arrest","volume":"10","author":"Madl","year":"2004","journal-title":"Current Opinion in Critical Care"},{"issue":"11","key":"10.1016\/j.nlm.2017.04.004_b0140","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/S0028-3908(00)00038-1","article-title":"Differential modulation of the 5-HT(4) receptor agonists and antagonist on rat learning and memory","volume":"39","author":"Marchetti","year":"2000","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.nlm.2017.04.004_b0145","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0006-8993(02)03463-7","article-title":"Transplantation of neural stem cells in a rat model of stroke: Assessment of short-term graft survival and acute host immunological response","volume":"958","author":"Modo","year":"2002","journal-title":"Brain Research"},{"issue":"Suppl 2","key":"10.1016\/j.nlm.2017.04.004_b0150","first-page":"25","article-title":"Adult astrogenesis and the etiology of cortical neurodegeneration","volume":"9","author":"Mohn","year":"2015","journal-title":"Journal of Experimental Neuroscience"},{"issue":"2","key":"10.1016\/j.nlm.2017.04.004_b0155","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/dvdy.20360","article-title":"Multipotent stem cells from adult olfactory mucosa","volume":"233","author":"Murrell","year":"2005","journal-title":"Developmental Dynamics"},{"issue":"8","key":"10.1016\/j.nlm.2017.04.004_b0160","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1634\/stemcells.2008-0074","article-title":"Olfactory mucosa is a potential source for autologous stem cell therapy for Parkinson's disease","volume":"26","author":"Murrell","year":"2008","journal-title":"Stem Cells"},{"issue":"7","key":"10.1016\/j.nlm.2017.04.004_b0165","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1172\/JCI44489","article-title":"Engraftment of human nasal olfactory stem cells restores neuroplasticity in mice with hippocampal lesions","volume":"121","author":"Nivet","year":"2011","journal-title":"The Journal of Clinical Investigation"},{"issue":"1","key":"10.1016\/j.nlm.2017.04.004_b0170","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.scr.2015.04.006","article-title":"Isolation of human adult olfactory sphere cells as a cell source of neural progenitors","volume":"15","author":"Ohnishi","year":"2015","journal-title":"Stem Cell Research"},{"issue":"8","key":"10.1016\/j.nlm.2017.04.004_b0175","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/jnr.23585","article-title":"Olfactory sphere cells are a cell source for gamma-aminobutyric acid-producing neurons","volume":"93","author":"Ohnishi","year":"2015","journal-title":"Journal of Neuroscience Research"},{"issue":"4","key":"10.1016\/j.nlm.2017.04.004_b0180","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/stem.609","article-title":"Functional effects of adult human olfactory stem cells on early-onset sensorineural hearing loss","volume":"29","author":"Pandit","year":"2011","journal-title":"Stem Cells"},{"issue":"2","key":"10.1016\/j.nlm.2017.04.004_b0185","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1124\/mi.3.2.90","article-title":"Blood-brain barrier drug targeting: The future of brain drug development","volume":"3","author":"Pardridge","year":"2003","journal-title":"Molecular Interventions"},{"issue":"3","key":"10.1016\/j.nlm.2017.04.004_b0190","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/01.STR.10.3.267","article-title":"A new model of bilateral hemispheric ischemia in the unanesthetized rat","volume":"10","author":"Pulsinelli","year":"1979","journal-title":"Stroke"},{"issue":"7","key":"10.1016\/j.nlm.2017.04.004_b0195","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1161\/01.STR.19.7.913","article-title":"The four-vessel occlusion rat model: Method for complete occlusion of vertebral arteries and control of collateral circulation","volume":"19","author":"Pulsinelli","year":"1988","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.nlm.2017.04.004_b0200","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1111\/j.1471-4159.1983.tb13599.x","article-title":"Regional energy balance in rat brain after transient forebrain ischemia","volume":"40","author":"Pulsinelli","year":"1983","journal-title":"Journal of Neurochemistry"},{"issue":"4","key":"10.1016\/j.nlm.2017.04.004_b0205","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.neuropharm.2011.05.003","article-title":"MLC901, a traditional Chinese medicine protects the brain against global ischemia","volume":"61","author":"Quintard","year":"2011","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.nlm.2017.04.004_b0210","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1037\/0735-7044.107.1.72","article-title":"Learning and memory of odor-reward association: Selective impairment following horizontal diagonal band lesions","volume":"107","author":"Roman","year":"1993","journal-title":"Behavioral Neuroscience"},{"issue":"2","key":"10.1016\/j.nlm.2017.04.004_b0215","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0006-8993(87)90089-8","article-title":"Evidence for synaptic potentiation in a cortical network during learning","volume":"418","author":"Roman","year":"1987","journal-title":"Brain Research"},{"issue":"3","key":"10.1016\/j.nlm.2017.04.004_b0220","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/cmi.2015.82","article-title":"Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis","volume":"13","author":"Rui","year":"2016","journal-title":"Cellular & Molecular Immunology"},{"issue":"3","key":"10.1016\/j.nlm.2017.04.004_b0225","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0306-4522(91)90001-5","article-title":"Selective vulnerability of the hippocampus in brain ischemia","volume":"40","author":"Schmidt-Kastner","year":"1991","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.nlm.2017.04.004_b0230","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/jnnp.20.1.11","article-title":"Loss of recent memory after bilateral hippocampal lesions","volume":"20","author":"Scoville","year":"1957","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"issue":"3","key":"10.1016\/j.nlm.2017.04.004_b0235","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1748-1716.1980.tb06658.x","article-title":"Post-ischemic coma in rat: Effect of different pre-ischemic blood glucose levels on cerebral metabolic recovery after ischemia","volume":"110","author":"Siemkowicz","year":"1980","journal-title":"Acta Physiologica Scandinavica"},{"key":"10.1016\/j.nlm.2017.04.004_b0240","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev-neuro-061010-113720","article-title":"The cognitive neuroscience of human memory since H.M","volume":"34","author":"Squire","year":"2011","journal-title":"Annual Review of Neuroscience"},{"issue":"24","key":"10.1016\/j.nlm.2017.04.004_b0245","doi-asserted-by":"crossref","first-page":"13515","DOI":"10.1073\/pnas.93.24.13515","article-title":"Structure and function of declarative and nondeclarative memory systems","volume":"93","author":"Squire","year":"1996","journal-title":"Proceedings of the National Academy of Sciences USA"},{"issue":"4","key":"10.1016\/j.nlm.2017.04.004_b0250","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0166-2236(88)90144-0","article-title":"Memory: Brain systems and behavior","volume":"11","author":"Squire","year":"1988","journal-title":"Trends in Neurosciences"},{"issue":"3","key":"10.1016\/j.nlm.2017.04.004_b0255","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.scr.2014.02.010","article-title":"A unique method for the isolation of nasal olfactory stem cells in living rats","volume":"12","author":"Stamegna","year":"2014","journal-title":"Stem Cell Research"},{"issue":"9","key":"10.1016\/j.nlm.2017.04.004_b0260","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1002\/stem.130","article-title":"Identification of nonepithelial multipotent cells in the embryonic olfactory mucosa","volume":"27","author":"Tome","year":"2009","journal-title":"Stem Cells"},{"issue":"2","key":"10.1016\/j.nlm.2017.04.004_b0265","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/ilar.44.2.85","article-title":"Animal models of focal and global cerebral ischemia","volume":"44","author":"Traystman","year":"2003","journal-title":"ILAR Journal"},{"key":"10.1016\/j.nlm.2017.04.004_b0270","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jep.2015.02.027","article-title":"Neuroprotection, learning and memory improvement of a standardized extract from Renshen Shouwu against neuronal injury and vascular dementia in rats with brain ischemia","volume":"165","author":"Wan","year":"2015","journal-title":"Journal of Ethnopharmacology"},{"issue":"4","key":"10.1016\/j.nlm.2017.04.004_b0275","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C","article-title":"Adult rat and human bone marrow stromal cells differentiate into neurons","volume":"61","author":"Woodbury","year":"2000","journal-title":"Journal of Neuroscience Research"}],"container-title":["Neurobiology of Learning and Memory"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742716304051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742716304051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T19:27:09Z","timestamp":1658950029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074742716304051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":55,"alternative-id":["S1074742716304051"],"URL":"https:\/\/doi.org\/10.1016\/j.nlm.2017.04.004","relation":{},"ISSN":["1074-7427"],"issn-type":[{"value":"1074-7427","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Global cerebral ischemia in rats leads to amnesia due to selective neuronal death followed by astroglial scar formation in the CA1 layer","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Learning and Memory","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nlm.2017.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}