{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:51:28Z","timestamp":1777092688394,"version":"3.51.4"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100012330","name":"Cognitive Sciences and Technologies Council","doi-asserted-by":"publisher","award":["2671"],"award-info":[{"award-number":["2671"]}],"id":[{"id":"10.13039\/100012330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005351","name":"Damghan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005351","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Learning and Memory"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.nlm.2018.11.009","type":"journal-article","created":{"date-parts":[[2018,11,17]],"date-time":"2018-11-17T07:23:00Z","timestamp":1542439380000},"page":"12-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Hippocampal orexin receptor blocking prevented the stress induced social learning and memory deficits"],"prefix":"10.1016","volume":"157","author":[{"given":"Saeedeh","family":"Bahramzadeh Zoeram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Elahdadi Salmani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taghi","family":"Lashkarbolouki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iran","family":"Goudarzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nlm.2018.11.009_b0005","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.nlm.2016.10.005","article-title":"Cellular activation of hypothalamic hypocretin\/orexin neurons facilitates short-term spatial memory in mice","volume":"136","author":"Aitta-Aho","year":"2016","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.nlm.2018.11.009_b0010","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bbr.2007.09.019","article-title":"The effect of antagonization of orexin 1 receptors in CA 1 and dentate gyrus regions on memory processing in passive avoidance task","volume":"187","author":"Akbari","year":"2008","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.nlm.2018.11.009_b0015","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.peptides.2006.11.002","article-title":"The selective orexin 1 receptor antagonist SB-334867-A impairs acquisition and consolidation but not retrieval of spatial memory in Morris water maze","volume":"28","author":"Akbari","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.nlm.2018.11.009_b0020","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0306-4522(02)00745-5","article-title":"Orexin-A (hypocretin-1) impairs Morris water maze performance and CA1-Schaffer collateral long-term potentiation in rats","volume":"119","author":"Aou","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.nlm.2018.11.009_b0025","series-title":"The time-course of the effects of stress on behavior in rodents","author":"Atchley","year":"2010"},{"key":"10.1016\/j.nlm.2018.11.009_b0030","doi-asserted-by":"crossref","first-page":"19168","DOI":"10.1073\/pnas.0507480102","article-title":"Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior","volume":"102","author":"Boutrel","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.nlm.2018.11.009_b0035","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1046\/j.1365-2826.1998.00246.x","article-title":"Corticotropin releasing factor mRNA expression in the hypothalamic paraventricular nucleus and the central nucleus of the amygdala is modulated by repeated acute stress in the immature rat","volume":"10","author":"Carolyn","year":"1998","journal-title":"Journal of Neuroendocrinology"},{"key":"10.1016\/j.nlm.2018.11.009_b0040","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coph.2008.12.018","article-title":"The brain hypocretins and their receptors: Mediators of allostatic arousal","volume":"9","author":"Carter","year":"2009","journal-title":"Current Opinion in Pharmacology"},{"key":"10.1016\/j.nlm.2018.11.009_b0045","doi-asserted-by":"crossref","first-page":"R692","DOI":"10.1152\/ajpregu.2000.278.3.R692","article-title":"Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats","volume":"278","author":"Chen","year":"2000","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.nlm.2018.11.009_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pbb.2014.01.013","article-title":"Blocking of corticotrophin releasing factor receptor-1 during footshock attenuates context fear but not the upregulation of prepro-orexin mRNA in rats","volume":"120","author":"Chen","year":"2014","journal-title":"Pharmacology, Biochemistry and Behavior"},{"key":"10.1016\/j.nlm.2018.11.009_b0055","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.pnpbp.2012.05.018","article-title":"Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex","volume":"39","author":"Chiba","year":"2012","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.nlm.2018.11.009_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10253890.2013.794450","article-title":"Stress-protective neural circuits: Not all roads lead through the prefrontal cortex","volume":"17","author":"Christianson","year":"2014","journal-title":"Stress"},{"key":"10.1016\/j.nlm.2018.11.009_b0065","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1037\/0735-7044.110.6.1321","article-title":"Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine treatment","volume":"110","author":"Conrad","year":"1996","journal-title":"Behavioral Neuroscience"},{"key":"10.1016\/j.nlm.2018.11.009_b0070","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1073\/pnas.96.2.748","article-title":"Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems","volume":"96","author":"Date","year":"1999","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.nlm.2018.11.009_b0075","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0166-2236(99)01438-1","article-title":"Stress and cognition: Are corticosteroids good or bad guys?","volume":"22","author":"de Kloet","year":"1999","journal-title":"Trends in Neurosciences"},{"key":"10.1016\/j.nlm.2018.11.009_b0080","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.pharep.2014.01.004","article-title":"Effect of trimethylgallic acid esters against chronic stress-induced anxiety-like behavior and oxidative stress in mice","volume":"66","author":"Dhingra","year":"2014","journal-title":"Pharmacological Reports"},{"key":"10.1016\/j.nlm.2018.11.009_b0085","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.bbr.2013.09.014","article-title":"Single prolonged stress impairs social and object novelty recognition in rats","volume":"256","author":"Eagle","year":"2013","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.nlm.2018.11.009_b0090","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.brainres.2009.08.046","article-title":"Orexin\/hypocretin modulation of the basal forebrain cholinergic system: Role in attention","volume":"1314","author":"Fadel","year":"2010","journal-title":"Brain Research"},{"key":"10.1016\/j.nlm.2018.11.009_b0095","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0163-1047(87)90664-9","article-title":"Behavioral stress impairs long-term potentiation in rodent hippocampus","volume":"48","author":"Foy","year":"1987","journal-title":"Behavioral and Neural Biology"},{"key":"10.1016\/j.nlm.2018.11.009_b0100","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/10253890.2010.521602","article-title":"Eugenol as an anti-stress agent: Modulation of hypothalamic-pituitary-adrenal axis and brain monoaminergic systems in a rat model of stress","volume":"14","author":"Garabadu","year":"2011","journal-title":"Stress"},{"key":"10.1016\/j.nlm.2018.11.009_b0105","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.conb.2014.07.006","article-title":"Hypocretin (orexin) neuromodulation of stress and reward pathways","volume":"29","author":"Giardino","year":"2014","journal-title":"Current Opinion in Neurobiology"},{"key":"10.1016\/j.nlm.2018.11.009_b0110","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pbb.2015.01.006","article-title":"Hippocampal orexin receptors inactivation reduces PTZ induced seizures of male rats","volume":"130","author":"Goudarzi","year":"2015","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.nlm.2018.11.009_b0115","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1523\/JNEUROSCI.17-07-02492.1997","article-title":"Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation","volume":"17","author":"Gould","year":"1997","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2018.11.009_b0120","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fpsyt.2014.00146","article-title":"Repeated exposure to conditioned fear stress increases anxiety and delays sleep recovery following exposure to an acute traumatic stressor","volume":"5","author":"Greenwood","year":"2014","journal-title":"Frontiers in Psychiatry"},{"key":"10.1016\/j.nlm.2018.11.009_b0125","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.yhbeh.2006.08.011","article-title":"The physical context of previous stress exposure modifies hypothalamic-pituitary-adrenal responses to a subsequent homotypic stress","volume":"51","author":"Grissom","year":"2007","journal-title":"Hormones and Behavior"},{"key":"10.1016\/j.nlm.2018.11.009_b0130","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0196-9781(02)00110-9","article-title":"Effects of orexin-A on memory processing","volume":"23","author":"Jaeger","year":"2002","journal-title":"Peptides"},{"key":"10.1016\/j.nlm.2018.11.009_b0135","first-page":"R581","article-title":"Attenuated defense response and low basal blood pressure in orexin knockout mice","volume":"285","author":"Kayaba","year":"2003","journal-title":"American Journal of Physiology: Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.nlm.2018.11.009_b0140","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrn849","article-title":"The stressed hippocampus, synaptic plasticity and lost memories","volume":"3","author":"Kim","year":"2002","journal-title":"Nature Reviews Neuroscience"},{"key":"10.1016\/j.nlm.2018.11.009_b0145","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1101\/lm.037291.114","article-title":"Stress effects on the hippocampus: A critical review","volume":"22","author":"Kim","year":"2015","journal-title":"Learning & Memory"},{"key":"10.1016\/j.nlm.2018.11.009_b0150","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/0024-3205(96)00118-X","article-title":"Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults","volume":"58","author":"Kirschbaum","year":"1996","journal-title":"Life Sciences"},{"key":"10.1016\/j.nlm.2018.11.009_b0155","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/mp.2016.1","article-title":"Overshadowed by the amygdala: The bed nucleus of the stria terminalis emerges as key to psychiatric disorders","volume":"21","author":"Lebow","year":"2016","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.nlm.2018.11.009_b0160","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.psyneuen.2016.02.027","article-title":"Sympathetic nervous system contributes to enhanced corticosterone levels following chronic stress","volume":"68","author":"Lowrance","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.nlm.2018.11.009_b0165","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0006-8993(94)91778-7","article-title":"Repeated stress causes reversible impairments of spatial memory performance","volume":"639","author":"Luine","year":"1994","journal-title":"Brain Research"},{"key":"10.1016\/j.nlm.2018.11.009_b0170","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.physbeh.2012.05.019","article-title":"Orexin-A induces anxiety-like behavior through interactions with glutamatergic receptors in the bed nucleus of the stria terminalis of rats","volume":"107","author":"Lungwitz","year":"2012","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.nlm.2018.11.009_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0173(97)00004-0","article-title":"The acute effects of corticosteroids on cognition: Integration of animal and human model studies","volume":"24","author":"Lupien","year":"1997","journal-title":"Brain Research Reviews"},{"key":"10.1016\/j.nlm.2018.11.009_b0180","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0006-3223(00)00964-1","article-title":"Effects of adverse experiences for brain structure and function","volume":"48","author":"McEwen","year":"2000","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.nlm.2018.11.009_b0185","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0959-4388(95)80028-X","article-title":"Stress and cognitive function","volume":"5","author":"McEwen","year":"1995","journal-title":"Current Opinion in Neurobiology"},{"key":"10.1016\/j.nlm.2018.11.009_b0190","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neuropharm.2016.07.005","article-title":"Lateral hypothalamus orexinergic system modulates the stress effect on pentylenetetrazol induced seizures through corticotropin releasing hormone receptor type 1","volume":"110","author":"Mokhtarpour","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nlm.2018.11.009_b0195","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0006-8993(99)01336-0","article-title":"Distribution of orexin neurons in the adult rat brain","volume":"827","author":"Nambu","year":"1999","journal-title":"Brain Research"},{"key":"10.1016\/j.nlm.2018.11.009_b0200","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.bbr.2013.11.001","article-title":"Effects of chronic stress in adolescence on learned fear, anxiety, and synaptic transmission in the rat prelimbic cortex","volume":"259","author":"Negron-Oyarzo","year":"2014","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.nlm.2018.11.009_b0205","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jneumeth.2008.12.001","article-title":"A simple and rapid method to collect the cerebrospinal fluid of rats and its application for the assessment of drug penetration into the central nervous system","volume":"178","author":"Nirogi","year":"2009","journal-title":"Journal of Neuroscience Methods"},{"key":"10.1016\/j.nlm.2018.11.009_b0210","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/10253890600965773","article-title":"Psychosocial stress impairs working memory at high loads: An association with cortisol levels and memory retrieval","volume":"9","author":"Oei","year":"2006","journal-title":"Stress"},{"key":"10.1016\/j.nlm.2018.11.009_b0215","doi-asserted-by":"crossref","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","article-title":"Neurons containing hypocretin (orexin) project to multiple neuronal systems","volume":"18","author":"Peyron","year":"1998","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2018.11.009_b0220","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.neuron.2015.02.015","article-title":"Chronic stress induces anxiety via an amygdalar intracellular cascade that impairs endocannabinoid signaling","volume":"85","author":"Qin","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.nlm.2018.11.009_b0225","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.physbeh.2016.09.014","article-title":"Repeated daily restraint stress induces adaptive behavioural changes in both adult and juvenile mice","volume":"167","author":"Sadler","year":"2016","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.nlm.2018.11.009_b0230","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neuron.2005.03.010","article-title":"Input of orexin\/hypocretin neurons revealed by a genetically encoded tracer in mice","volume":"46","author":"Sakurai","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.nlm.2018.11.009_b0235","doi-asserted-by":"crossref","first-page":"20260","DOI":"10.1073\/pnas.1320325110","article-title":"Orexin\/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus","volume":"110","author":"Sears","year":"2013","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.nlm.2018.11.009_b0240","doi-asserted-by":"crossref","first-page":"R1780","DOI":"10.1152\/ajpregu.1999.277.6.R1780","article-title":"Sympathetic and cardiovascular actions of orexins in conscious rats","volume":"277","author":"Shirasaka","year":"1999","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.nlm.2018.11.009_b0245","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/(SICI)1098-2396(199707)26:3<209::AID-SYN2>3.0.CO;2-B","article-title":"Transient and persistent consequences of acute stress on long-term potentiation (LTP), synaptic efficacy, theta rhythms and bursts in area CA1 of the hippocampus","volume":"26","author":"Shors","year":"1997","journal-title":"Synapse (New York, N. Y.)"},{"key":"10.1016\/j.nlm.2018.11.009_b0250","doi-asserted-by":"crossref","first-page":"383","DOI":"10.31887\/DCNS.2006.8.4\/ssmith","article-title":"The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress","volume":"8","author":"Smith","year":"2006","journal-title":"Dialogues in Clinical Neuroscience"},{"key":"10.1016\/j.nlm.2018.11.009_b0255","first-page":"2","article-title":"Anxiety behavior induced in mice by acute stress","author":"Solomonow","year":"2015","journal-title":"Tulane Undergraduate Research Journal"},{"key":"10.1016\/j.nlm.2018.11.009_b0260","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1124\/pr.58.1.4","article-title":"Orexins in the regulation of the hypothalamic-pituitary-adrenal axis","volume":"58","author":"Spinazzi","year":"2006","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.nlm.2018.11.009_b0265","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainres.2005.03.002","article-title":"Orexin-A (hypocretin-1) is possibly involved in generation of anxiety-like behavior","volume":"1044","author":"Suzuki","year":"2005","journal-title":"Brain Research"},{"key":"10.1016\/j.nlm.2018.11.009_b0270","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neulet.2004.03.062","article-title":"Social stress-induced cortisol elevation acutely impairs social memory in humans","volume":"363","author":"Takahashi","year":"2004","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.nlm.2018.11.009_b0275","doi-asserted-by":"crossref","first-page":"3","DOI":"10.15386\/cjm.2014.8872.871.at1cm2","article-title":"The impact of stress and glucocorticoids on memory","volume":"87","author":"Tatomir","year":"2014","journal-title":"Clujul Medical"},{"key":"10.1016\/j.nlm.2018.11.009_b0280","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.psyneuen.2014.10.022","article-title":"The brain mineralocorticoid receptor and stress resilience","volume":"52","author":"ter Heegde","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.nlm.2018.11.009_b0285","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0022-3999(02)00429-4","article-title":"Hypothalamic\u2013pituitary\u2013adrenal axis, neuroendocrine factors and stress","volume":"53","author":"Tsigos","year":"2002","journal-title":"Journal of Psychosomatic Research"},{"key":"10.1016\/j.nlm.2018.11.009_b0290","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fnbeh.2013.00028","article-title":"Role of orexin in modulating arousal, feeding, and motivation","volume":"7","author":"Tsujino","year":"2013","journal-title":"Frontiers in Behavioral Neuroscience"},{"key":"10.1016\/j.nlm.2018.11.009_b0295","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms5995","article-title":"Role for MMP-9 in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioural alterations","volume":"5","author":"Van Der Kooij","year":"2014","journal-title":"Nature Communications"},{"key":"10.1016\/j.nlm.2018.11.009_b0300","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in rodents","volume":"2","author":"Walf","year":"2007","journal-title":"Nature Protocols"},{"key":"10.1016\/j.nlm.2018.11.009_b0305","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000356423","article-title":"Stress, memory, and the hippocampus","volume":"34","author":"Wingenfeld","year":"2014","journal-title":"Frontiers of Neurology and Neuroscience"},{"key":"10.1016\/j.nlm.2018.11.009_b0310","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1385\/MN:32:3:285","article-title":"Stress and arousal: The corticotrophin-releasing factor\/hypocretin circuitry","volume":"32","author":"Winsky-Sommerer","year":"2005","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.nlm.2018.11.009_b0315","doi-asserted-by":"crossref","first-page":"11439","DOI":"10.1523\/JNEUROSCI.3459-04.2004","article-title":"Interaction between the corticotropin-releasing factor system and hypocretins (orexins): A novel circuit mediating stress response","volume":"24","author":"Winsky-Sommerer","year":"2004","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2018.11.009_b0320","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0896-6273(03)00331-3","article-title":"Hypothalamic orexin neurons regulate arousal according to energy balance in mice","volume":"38","author":"Yamanaka","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.nlm.2018.11.009_b0325","doi-asserted-by":"crossref","first-page":"e97689","DOI":"10.1371\/journal.pone.0097689","article-title":"The different roles of glucocorticoids in the hippocampus and hypothalamus in chronic stress-induced HPA axis hyperactivity","volume":"9","author":"Zhu","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nlm.2018.11.009_b0330","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1097\/WNR.0000000000000243","article-title":"Unpredictable chronic mild stress not chronic restraint stress induces depressive behaviours in mice","volume":"25","author":"Zhu","year":"2014","journal-title":"NeuroReport"}],"container-title":["Neurobiology of Learning and Memory"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742718302648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742718302648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T06:05:15Z","timestamp":1662444315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074742718302648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":66,"alternative-id":["S1074742718302648"],"URL":"https:\/\/doi.org\/10.1016\/j.nlm.2018.11.009","relation":{},"ISSN":["1074-7427"],"issn-type":[{"value":"1074-7427","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hippocampal orexin receptor blocking prevented the stress induced social learning and memory deficits","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Learning and Memory","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nlm.2018.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}