{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:43:23Z","timestamp":1771461803459,"version":"3.50.1"},"reference-count":127,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100011769","name":"Scripps Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Learning and Memory"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.nlm.2019.107034","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T12:08:33Z","timestamp":1559822913000},"page":"107034","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Emerging roles for long noncoding RNAs in learning, memory and associated disorders"],"prefix":"10.1016","volume":"163","author":[{"given":"Eddie","family":"Grinman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Espadas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sathyanarayanan V.","family":"Puthanveettil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6420","key":"10.1016\/j.nlm.2019.107034_b0005","doi-asserted-by":"crossref","first-page":"6576","DOI":"10.1126\/science.aat6576","article-title":"Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder","volume":"362","author":"An","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.nlm.2019.107034_b9000","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.cell.2015.01.009","article-title":"A micropeptide encoded by a putative long noncoding RNA regulates muscle performance","volume":"160","author":"Anderson","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.nlm.2019.107034_b9005","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s007020050104","article-title":"Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer\u00e2\u20ac\u2122s disease","volume":"105","author":"Arendt","year":"1998","journal-title":"Journal of Neural Transmission (Vienna)"},{"issue":"4","key":"10.1016\/j.nlm.2019.107034_b0010","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3233\/JAD-2011-101881","article-title":"Gene expression biomarkers in the brain of a mouse model for Alzheimer's disease: Mining of microarray data by logic classification and feature selection","volume":"24","author":"Arisi","year":"2011","journal-title":"Journal of Alzheimer's Disease"},{"key":"10.1016\/j.nlm.2019.107034_b0015","article-title":"Molecular mechanisms of the memory trace","author":"Asok","year":"2018","journal-title":"Trends in Neurosciences"},{"issue":"4","key":"10.1016\/j.nlm.2019.107034_b0020","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/mp.2013.45","article-title":"The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing","volume":"19","author":"Barry","year":"2014","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.nlm.2019.107034_b0025","doi-asserted-by":"crossref","first-page":"40127","DOI":"10.1038\/srep40127","article-title":"The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states","volume":"7","author":"Barry","year":"2017","journal-title":"Scientific reports"},{"issue":"18","key":"10.1016\/j.nlm.2019.107034_b0030","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1038\/emboj.2010.199","article-title":"A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression","volume":"29","author":"Bernard","year":"2010","journal-title":"The EMBO Journal"},{"issue":"9","key":"10.1016\/j.nlm.2019.107034_b0035","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.1128\/jvi.71.9.6641-6649.1997","article-title":"Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector","volume":"71","author":"Bl\u00f6mer","year":"1997","journal-title":"Journal of Virology"},{"issue":"3","key":"10.1016\/j.nlm.2019.107034_b0040","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/s41594-018-0032-x","article-title":"MicroRNA degradation by a conserved target RNA regulates animal behavior","volume":"25","author":"Bitetti","year":"2018","journal-title":"Nature Structural & Molecular Biology"},{"key":"10.1016\/j.nlm.2019.107034_b0045","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/nn.2371","article-title":"Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry","volume":"12","author":"Bond","year":"2009","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.nlm.2019.107034_b0050","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1017\/S1092852900013560","article-title":"Non-motor aspects of Parkinson\u2019s disease","volume":"11","author":"Borek","year":"2006","journal-title":"CNS Spectrums"},{"key":"10.1016\/j.nlm.2019.107034_b0055","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41467-017-00311-2","article-title":"The non-coding RNA BC1 regulates experience-dependent structural plasticity and learning","volume":"8","author":"Briz","year":"2017","journal-title":"Nature Communications"},{"key":"10.1016\/j.nlm.2019.107034_b0060","doi-asserted-by":"crossref","DOI":"10.1242\/dev.126318","article-title":"Evf2 lncRNA\/BRG1\/DLX1 interactions reveal RNA-dependent chromatin remodeling inhibition","author":"Cajigas","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.nlm.2019.107034_b0065","doi-asserted-by":"crossref","DOI":"10.1261\/rna.053561.115","article-title":"Cytoplasmic long noncoding RNAs are frequently bound to and degraded at ribosomes in human cells","author":"Carlevaro-Fita","year":"2016","journal-title":"RNA"},{"key":"10.1016\/j.nlm.2019.107034_b9015","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nature11508","article-title":"Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat","volume":"15","author":"Carrieri","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.nlm.2019.107034_b0075","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3389\/fncel.2015.00114","article-title":"Expression analysis of the long non-coding RNA antisense to Uchl1 (AS Uchl1) during dopaminergic cells' differentiation in vitro and in neurochemical models of Parkinson's disease","volume":"9","author":"Carrieri","year":"2015","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"1","key":"10.1016\/j.nlm.2019.107034_b0085","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13059-016-0880-9","article-title":"Evolutionary analysis across mammals reveals distinct classes of long non-coding RNAs","volume":"17","author":"Chen","year":"2016","journal-title":"Genome Biology"},{"issue":"11","key":"10.1016\/j.nlm.2019.107034_b0090","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1111\/jcmm.12904","article-title":"Long non-coding RNA Malat1 promotes neurite outgrowth through activation of ERK\/MAPK signalling pathway in N2a cells","volume":"20","author":"Chen","year":"2016","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10.1016\/j.nlm.2019.107034_b0095","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.12659\/MSM.896927","article-title":"Aberrant expression of long non-coding RNAs in schizophrenia patients","volume":"22","author":"Chen","year":"2016","journal-title":"Medical Science Monitor"},{"issue":"45","key":"10.1016\/j.nlm.2019.107034_b0100","doi-asserted-by":"crossref","first-page":"19096","DOI":"10.1073\/pnas.0910672106","article-title":"Genetic diagnosis by whole exome capture and massively parallel DNA sequencing","volume":"106","author":"Choi","year":"2009","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"2","key":"10.1016\/j.nlm.2019.107034_b0105","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.cell.2015.03.025","article-title":"Systematic discovery of Xist RNA binding proteins","volume":"161","author":"Chu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.nlm.2019.107034_b0110","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1101\/lm.045617.117","article-title":"Effects of regulatory BC1 RNA deletion on synaptic plasticity, learning and memory","volume":"24","author":"Chung","year":"2017","journal-title":"Learning and Memory"},{"issue":"2","key":"10.1016\/j.nlm.2019.107034_b0115","first-page":"424","article-title":"An intronic ncRNA-dependent regulation of SORL1 expression affecting A\u03b2 formation is upregulated in post-mortem Alzheimer's disease brain samples","volume":"6","author":"Ciarlo","year":"2013","journal-title":"Disease Models & Mechanisms"},{"issue":"3","key":"10.1016\/j.nlm.2019.107034_b0120","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1083\/jcb.132.3.259","article-title":"XIST RNA paints the inactive X chromosome at interphase: Evidence for a novel RNA involved in nuclear\/chromosome structure","volume":"132","author":"Clemson","year":"1996","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.nlm.2019.107034_b0125","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.12659\/MSM.899372","article-title":"Long non-coding RNA: Potential diagnostic and therapeutic biomarker for major depressive disorder","volume":"22","author":"Cui","year":"2016","journal-title":"Medical Science Monitor: International Medical Journal of Experimental and Clinical Research"},{"issue":"6","key":"10.1016\/j.nlm.2019.107034_b0130","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.molcel.2013.08.029","article-title":"Telomeric noncoding RNA TERRA is induced by telomere shortening to nucleate telomerase molecules at short telomeres","volume":"51","author":"Cusanelli","year":"2013","journal-title":"Molecular Cell"},{"issue":"9","key":"10.1016\/j.nlm.2019.107034_b0135","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1101\/gr.132159.111","article-title":"The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression","volume":"22","author":"Derrien","year":"2012","journal-title":"Genome rResearch"},{"key":"10.1016\/j.nlm.2019.107034_b0140","doi-asserted-by":"crossref","first-page":"28396","DOI":"10.1038\/srep28396","article-title":"Identification of long non-coding RNAs involved in neuronal development and intellectual disability","volume":"6","author":"D\u2019haene","year":"2016","journal-title":"Scientific Reports"},{"issue":"5910","key":"10.1016\/j.nlm.2019.107034_b0145","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1126\/science.1162986","article-title":"Real-time DNA sequencing from single polymerase molecules","volume":"323","author":"Eid","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.nlm.2019.107034_b0150","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nm1784","article-title":"Expression of noncoding RNA is elevated in Alzheimer\u2019s disease and drives rapid feed-forward regulation of beta-secretase","volume":"14","author":"Faghihi","year":"2008","journal-title":"Nature Medicine"},{"key":"10.1016\/j.nlm.2019.107034_b9030","doi-asserted-by":"crossref","first-page":"R56","DOI":"10.1186\/gb-2010-11-5-r56","article-title":"Evidence for natural antisense transcript-mediated inhibition of microRNA function","volume":"11","author":"Faghihi","year":"2010","journal-title":"Genome Biology"},{"key":"10.1016\/j.nlm.2019.107034_b0155","first-page":"1381","article-title":"Bioinformatics and co-expression network analysis of differentially expressed lncRNAs and mRNAs in hippocampus of APP\/PS1 transgenic mice with Alzheimer disease","volume":"9","author":"Fang","year":"2017","journal-title":"American Journal of Translational Research"},{"key":"10.1016\/j.nlm.2019.107034_b0160","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1101\/gad.1416106","article-title":"The Evf-2 noncoding RNA is transcribed from the Dlx-5\/6 ultraconserved region and function as a Dlx2 transcriptional coactivatior","volume":"20","author":"Feng","year":"2006","journal-title":"Genes and Development"},{"key":"10.1016\/j.nlm.2019.107034_b0165","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fnmol.2014.00005","article-title":"MicroRNAs in brain development and function: A matter of flexibility and stability","volume":"7","author":"Follert","year":"2014","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"10.1016\/j.nlm.2019.107034_b0170","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature12929","article-title":"De novo mutations in schizophrenia implicate synaptic networks","volume":"506","author":"Fromer","year":"2014","journal-title":"Nature"},{"issue":"6420","key":"10.1016\/j.nlm.2019.107034_b0175","doi-asserted-by":"crossref","first-page":"8127","DOI":"10.1126\/science.aat8127","article-title":"Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder","volume":"362","author":"Gandal","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.nlm.2019.107034_b0180","doi-asserted-by":"crossref","first-page":"992","DOI":"10.18632\/aging.100710","article-title":"Long noncoding RNAs(lncRNAs) and the molecular hallmarks of aging","volume":"6","author":"Grammatikakis","year":"2014","journal-title":"Aging"},{"key":"10.1016\/j.nlm.2019.107034_b0185","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1089\/dna.2017.4012","article-title":"Long noncoding RNA EBF3-AS promotes neuron apoptosis in Alzheimer\u2019s disease","volume":"37","author":"Gu","year":"2018","journal-title":"DNA and Cell Biology"},{"issue":"3","key":"10.1016\/j.nlm.2019.107034_b0190","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/hmg\/ddx417","article-title":"Interplay between FMRP and lncRNA TUG1 regulates axonal development through mediating SnoN\u2013Ccd1 pathway","volume":"27","author":"Guo","year":"2017","journal-title":"Human Molecular Genetics"},{"issue":"7235","key":"10.1016\/j.nlm.2019.107034_b0195","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature07672","article-title":"Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals","volume":"458","author":"Guttman","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.nlm.2019.107034_b0200","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3233\/JPD-150737","article-title":"Transcriptomic profiling extracellular RNAs present in cerebrospinal fluid identifies differentially expressed transcripts in Parkinson\u2019s disease","volume":"6","author":"Hossein-Nezhad","year":"2016","journal-title":"Journal of Parkinson\u2019s Disease"},{"key":"10.1016\/j.nlm.2019.107034_b0205","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fgene.2014.00084","article-title":"Asymmetric localization of natural antisense RNA of neuropeptide sensorin in Aplysia sensory neurons during aging and activity","volume":"5","author":"Kadakkuzha","year":"2014","journal-title":"Frontiers in Genetics"},{"key":"10.1016\/j.nlm.2019.107034_b0210","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fncel.2015.00063","article-title":"Transcriptome analyses of adult mouse brain reveal enrichment of lncRNAs in specific brain regions and neuronal populations","volume":"9","author":"Kadakkuzha","year":"2015","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"5544","key":"10.1016\/j.nlm.2019.107034_b0215","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1126\/science.1067020","article-title":"The molecular biology of memory storage: A dialogue between genes and synapses","volume":"294","author":"Kandel","year":"2001","journal-title":"Science"},{"issue":"17","key":"10.1016\/j.nlm.2019.107034_b0220","doi-asserted-by":"crossref","first-page":"6131","DOI":"10.1073\/pnas.1318948111","article-title":"Defining functional DNA elements in the human genome","volume":"111","author":"Kellis","year":"2014","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.nlm.2019.107034_b0225","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.cell.2018.05.022","article-title":"A network of noncoding regulatory RNAs acts in the mammalian brain","volume":"174","author":"Kleaveland","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.nlm.2019.107034_b0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2015.12.001","article-title":"Long noncoding RNAs in aging and age-related diseases","volume":"26","author":"Kour","year":"2016","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.nlm.2019.107034_b0240","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s12035-015-9634-z","article-title":"Age-related expression of a repeat-rich intergenic long noncoding RNA in the rat brain","volume":"54","author":"Kour","year":"2017","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.nlm.2019.107034_b0245","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1007\/s12035-016-9854-x","article-title":"Altered long noncoding RNA expression precedes the course of Parkinson\u2019s disease: A preliminary report","volume":"54","author":"Kraus","year":"2017","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.nlm.2019.107034_b0250","doi-asserted-by":"crossref","first-page":"44558","DOI":"10.1038\/srep44558","article-title":"S-nitrosylation of UCHL1 induces its structural instability and promotes alpha-synuclein aggregation","volume":"7","author":"Kumar","year":"2017","journal-title":"Scientific Reports"},{"issue":"7","key":"10.1016\/j.nlm.2019.107034_b0255","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002841","article-title":"Rapid turnover of long noncoding RNAs and the evolution of gene expression","volume":"8","author":"Kutter","year":"2012","journal-title":"PLoS Genetics"},{"issue":"12","key":"10.1016\/j.nlm.2019.107034_b0260","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1038\/ng.3988","article-title":"High-throughput annotation of full-length long noncoding RNAs with capture long-read sequencing","volume":"49","author":"Lagarde","year":"2017","journal-title":"Nature Genetics"},{"key":"10.1016\/j.nlm.2019.107034_b0265","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.bbr.2004.02.015","article-title":"Role of a neuronal small non-messenger RNA: behavioral alterations in BC1 RNA-deleted mice","volume":"154","author":"Lewejohann","year":"2004","journal-title":"Behavioral Brain Research"},{"key":"10.1016\/j.nlm.2019.107034_b0270","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jpsychires.2018.09.005","article-title":"Relationship between schizophrenia and changes in the expression of the long non-coding RNAs Meg3, Miat, Neat1 and Neat2","volume":"106","author":"Li","year":"2018","journal-title":"Journal of Psychiatric Research"},{"key":"10.1016\/j.nlm.2019.107034_b0275","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3389\/fnmol.2017.00454","article-title":"Profiling and co-expression network analysis of learned helplessness regulated mRNAs and lncRNAs in the mouse hippocampus","volume":"10","author":"Li","year":"2018","journal-title":"Fronteirs in Molecular Neuroscience"},{"key":"10.1016\/j.nlm.2019.107034_b0280","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1097\/WNR.0000000000001057","article-title":"Identification of the biological affection of long noncoding RNA BC200 in Alzheimer\u2019s disease","volume":"29","author":"Li","year":"2018","journal-title":"NeuroReport"},{"key":"10.1016\/j.nlm.2019.107034_b0285","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1038\/s41467-018-04072-4","article-title":"Activity dependent LoNA regulates translation by coordinating rRNA transcription and methylation","volume":"9","author":"Li","year":"2018","journal-title":"Nature Communications"},{"key":"10.1016\/j.nlm.2019.107034_b0290","article-title":"Microarry profiling and co-expression network analysis of circulating lncRNAs and mRNAs associated with major depressive disorder","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nlm.2019.107034_b0295","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/1567202613666160316155228","article-title":"Long non-coding RNA HOTAIR promotes Parkinson\u2019s disease induced by MPTP through up-regulation the expression of LRRK2","volume":"13","author":"Liu","year":"2016","journal-title":"Current Neurovascular Research"},{"key":"10.1016\/j.nlm.2019.107034_b0300","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.schres.2018.05.015","article-title":"Systems-level analysis of risk genes reveals the modular nature of schizophrenia","volume":"201","author":"Liu","year":"2018","journal-title":"Schizophrenia Research"},{"key":"10.1016\/j.nlm.2019.107034_b0305","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3389\/fnins.2015.00351","article-title":"Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity","volume":"9","author":"Maag","year":"2015","journal-title":"Frontiers in Neuroscience"},{"key":"10.1016\/j.nlm.2019.107034_b9025","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3233\/JAD-150398","article-title":"Transcriptomics profiling of Alzheimer's disease reveal neurovascular defects, atlered amyloid-beta homeostasis, and deregulated expression of long noncoding RNAs","volume":"48","author":"Magistri","year":"2015","journal-title":"Journal of Alzheimer's Disease"},{"key":"10.1016\/j.nlm.2019.107034_b0315","series-title":"Regulatory non-coding RNAs","first-page":"87","article-title":"RNA pulldown protocol for in vitro detection and identification of RNA-associated proteins","author":"Mar\u00edn-B\u00e9jar","year":"2015"},{"issue":"11","key":"10.1016\/j.nlm.2019.107034_b0320","doi-asserted-by":"crossref","first-page":"R124","DOI":"10.1186\/gb-2009-10-11-r124","article-title":"Catalogues of mammalian long noncoding RNAs: Modest conservation and incompleteness","volume":"10","author":"Marques","year":"2009","journal-title":"Genome Biology"},{"issue":"7","key":"10.1016\/j.nlm.2019.107034_b0325","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.bbamcr.2012.05.001","article-title":"NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid \u03b2 secretion","volume":"1823","author":"Massone","year":"2012","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Cell Research"},{"key":"10.1016\/j.nlm.2019.107034_b0330","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1152\/physrev.00036.2006","article-title":"Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease","volume":"87","author":"Mehler","year":"2007","journal-title":"Physiolical Reviews"},{"issue":"9","key":"10.1016\/j.nlm.2019.107034_b0335","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/hipo.20701","article-title":"Expression of the snoRNA host gene gas5 in the hippocampus is upregulated by age and psychogenic stress and correlates with reduced novelty-induced behavior in C57BL\/6 mice","volume":"20","author":"Meier","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.nlm.2019.107034_b0340","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1177\/1073858408319187","article-title":"Noncoding RNAs in long-term memory formation","volume":"14","author":"Mercer","year":"2008","journal-title":"Neuroscientist"},{"key":"10.1016\/j.nlm.2019.107034_b0345","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-2202-11-14","article-title":"Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation","volume":"11","author":"Mercer","year":"2010","journal-title":"BMC Neuroscience"},{"issue":"7539","key":"10.1016\/j.nlm.2019.107034_b0350","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nature13975","article-title":"Towards a therapy for Angelman syndrome by targeting a long non-coding RNA","volume":"518","author":"Meng","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.nlm.2019.107034_b0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2017.03.004","article-title":"Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer\u2019s disease: An integrative review","volume":"156","author":"Millan","year":"2017","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.nlm.2019.107034_b9035","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s12031-016-0745-4","article-title":"LINC00507 is specifically expressed in the primate cortex and has age-dependent expression patterns","volume":"59","author":"Mills","year":"2016","journal-title":"J Mol Neurosci."},{"issue":"5","key":"10.1016\/j.nlm.2019.107034_b0360","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nbt.2158","article-title":"Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation","volume":"30","author":"Modarresi","year":"2012","journal-title":"Nature Biotechnology"},{"key":"10.1016\/j.nlm.2019.107034_b0365","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000335909","article-title":"Prevalence and profile of mild cognitive impairment in Parkinson\u2019s disease","volume":"10","author":"Monastero","year":"2012","journal-title":"Neurodegener Diseases"},{"issue":"6","key":"10.1016\/j.nlm.2019.107034_b0370","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrg3722","article-title":"The rise of regulatory RNA","volume":"15","author":"Morris","year":"2014","journal-title":"Nature Reviews Genetics"},{"key":"10.1016\/j.nlm.2019.107034_b0375","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ygeno.2017.02.004","article-title":"Candiadate novel long noncoding RNAs, miRNAs and putative drugs for Parkinson\u2019s disease using a robust and efficient genome-wide association study","volume":"109","author":"Mortezaei","year":"2017","journal-title":"Genomics"},{"issue":"1","key":"10.1016\/j.nlm.2019.107034_b0380","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nsmb.3325","article-title":"Integrative classification of human coding and noncoding genes through RNA metabolism profiles","volume":"24","author":"Mukherjee","year":"2017","journal-title":"Nature Structural & Molecular Biology"},{"key":"10.1016\/j.nlm.2019.107034_b0385","doi-asserted-by":"crossref","first-page":"10679","DOI":"10.1073\/pnas.0701532104","article-title":"Dendritic BC200 RNA in aging and in Alzheimer\u2019s disease","volume":"104","author":"Mus","year":"2007","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"7485","key":"10.1016\/j.nlm.2019.107034_b0395","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nature12943","article-title":"The evolution of lncRNA repertoires and expression patterns in tetrapods","volume":"505","author":"Necsulea","year":"2014","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.nlm.2019.107034_b0400","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.molcel.2013.07.017","article-title":"The long noncoding RNA RMST interacts with SOX2 to regulate neurogenesis","volume":"51","author":"Ng","year":"2013","journal-title":"Molecular Cell"},{"key":"10.1016\/j.nlm.2019.107034_b0405","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10571-016-0373-0","article-title":"Investigation of long non-coding RNA expression profiles in the substantia nigra of Parkinson\u2019s disease","volume":"37","author":"Ni","year":"2017","journal-title":"Cell Molecular Neurobiology"},{"key":"10.1016\/j.nlm.2019.107034_b0410","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fgene.2015.00002","article-title":"Non-coding RNA: What is functional and what is junk?","volume":"6","author":"Palazzo","year":"2015","journal-title":"Frontiers in Genetics"},{"issue":"7633","key":"10.1016\/j.nlm.2019.107034_b0415","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nature20612","article-title":"Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism","volume":"540","author":"Parikshak","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.nlm.2019.107034_b0420","first-page":"4","article-title":"Long non-coding RNAs in neuronal aging","author":"Pereira Fernandes","year":"2018","journal-title":"Noncoding RNA"},{"key":"10.1016\/j.nlm.2019.107034_b9040","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1101\/gr.6406307","article-title":"Raising the estimate of functional human sequences","volume":"17","author":"Pheasant","year":"2007","journal-title":"Genome Research"},{"issue":"1","key":"10.1016\/j.nlm.2019.107034_b0425","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.genet.36.042902.092433","article-title":"Xist RNA and the mechanism of X chromosome inactivation","volume":"36","author":"Plath","year":"2002","journal-title":"Annual Review of Genetics"},{"issue":"4","key":"10.1016\/j.nlm.2019.107034_b0430","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cell.2009.02.006","article-title":"Evolution and functions of long noncoding RNAs","volume":"136","author":"Ponting","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.nlm.2019.107034_b0435","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1304422110","article-title":"A strategy to capture and characterize the synaptic transcriptome","author":"Puthanveettil","year":"2013","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"9","key":"10.1016\/j.nlm.2019.107034_b0440","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/nbt.2943","article-title":"Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification","volume":"32","author":"Quinn","year":"2014","journal-title":"Nature Biotechnology"},{"issue":"43","key":"10.1016\/j.nlm.2019.107034_b0445","doi-asserted-by":"crossref","first-page":"E10197","DOI":"10.1073\/pnas.1722587115","article-title":"Long noncoding RNA GM12371 acts as a transcriptional regulator of synapse function","volume":"115","author":"Raveendra","year":"2018","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"11","key":"10.1016\/j.nlm.2019.107034_b0450","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.2174\/1567205013666160622112234","article-title":"The long non-coding RNAs in neurodegenerative diseases: Novel mechanisms of pathogenesis","volume":"13","author":"Riva","year":"2016","journal-title":"Current Alzheimer Research"},{"key":"10.1016\/j.nlm.2019.107034_b0455","article-title":"The cognitive effects of antidepressants in major depressive disorder: A systematic review and meta-analysis of randomized clinical trials","volume":"19","author":"Rosenblat","year":"2015","journal-title":"International Journal of Neuropsychopharmcology."},{"key":"10.1016\/j.nlm.2019.107034_b0460","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fnmol.2017.00095","article-title":"A novel long non-coding RNA, durga modulates dendrite density and expression of kalirin in zebrafish","volume":"10","author":"Sarangdhar","year":"2017","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"10.1016\/j.nlm.2019.107034_b0465","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1471-2164-8-74","article-title":"The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function","volume":"8","author":"Scheele","year":"2007","journal-title":"BMC Genomics"},{"key":"10.1016\/j.nlm.2019.107034_b0470","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1176\/appi.ajp.160.8.1516","article-title":"Untreated depression and hippocampal volume loss","volume":"160","author":"Sheline","year":"2003","journal-title":"American Journal of Psychiatry"},{"issue":"3","key":"10.1016\/j.nlm.2019.107034_b0475","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003517","article-title":"Long non-coding RNA and alternative splicing modulations in Parkinson's leukocytes identified by RNA sequencing","volume":"10","author":"Soreq","year":"2014","journal-title":"PLoS Computational Biology"},{"issue":"12","key":"10.1016\/j.nlm.2019.107034_b0480","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.biopsych.2015.02.004","article-title":"Long noncoding RNA-directed epigenetic regulation of gene expression is associated with anxiety-like behavior in mice","volume":"78","author":"Spadaro","year":"2015","journal-title":"Biological Psychiatry"},{"issue":"1","key":"10.1016\/j.nlm.2019.107034_b0485","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkp841","article-title":"Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents","volume":"38","author":"Stein","year":"2009","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.nlm.2019.107034_b0490","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.biopsych.2005.10.005","article-title":"Synaptic plasticity and disconnection in schizophrenia","volume":"59","author":"Stephan","year":"2006","journal-title":"Biological Psychiatry"},{"issue":"1","key":"10.1016\/j.nlm.2019.107034_b0495","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nbt.3055","article-title":"In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9","volume":"33","author":"Swiech","year":"2015","journal-title":"Nature Biotechnology"},{"issue":"3","key":"10.1016\/j.nlm.2019.107034_b0500","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/bies.20544","article-title":"The relationship between non-protein-coding DNA and eukaryotic complexity","volume":"29","author":"Taft","year":"2007","journal-title":"BioEssays"},{"key":"10.1016\/j.nlm.2019.107034_b0505","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fncel.2017.00124","article-title":"The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons","volume":"11","author":"Tan","year":"2017","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"6","key":"10.1016\/j.nlm.2019.107034_b0510","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1073\/pnas.88.6.2093","article-title":"Dendritic location of neural BC1 RNA","volume":"88","author":"Tiedge","year":"1991","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.nlm.2019.107034_b0515","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ebiom.2018.07.022","article-title":"The long noncoding RNA landscape in amygdala tissues from schizophrenia patients","volume":"34","author":"Tian","year":"2018","journal-title":"EBioMedicine"},{"issue":"6","key":"10.1016\/j.nlm.2019.107034_b0520","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.molcel.2010.08.011","article-title":"The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation","volume":"39","author":"Tripathi","year":"2010","journal-title":"Molecular Cell"},{"key":"10.1016\/j.nlm.2019.107034_b0525","doi-asserted-by":"crossref","DOI":"10.1101\/gr.218149.116","article-title":"Transposable elements are the primary source of novelty in primate gene regulation","author":"Trizzino","year":"2017","journal-title":"Genome Research"},{"issue":"10","key":"10.1016\/j.nlm.2019.107034_b0530","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nrg.2016.85","article-title":"Evolution to the rescue: Using comparative genomics to understand long non-coding RNAs","volume":"17","author":"Ulitsky","year":"2016","journal-title":"Nature Reviews Genetics"},{"issue":"5","key":"10.1016\/j.nlm.2019.107034_b0535","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nn.3996","article-title":"A coding-independent function of an alternative Ube3a transcript during neuronal development","volume":"18","author":"Valluy","year":"2015","journal-title":"Nature Neuroscience"},{"issue":"9","key":"10.1016\/j.nlm.2019.107034_b0540","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.tig.2014.07.001","article-title":"Ten years of next-generation sequencing technology","volume":"30","author":"Van Dijk","year":"2014","journal-title":"Trends in Genetics"},{"issue":"4","key":"10.1016\/j.nlm.2019.107034_b0545","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/embj.201386225","article-title":"The long non-coding RNA Paupar regulates the expression of both local and distal genes","volume":"33","author":"Vance","year":"2014","journal-title":"The EMBO Journal"},{"issue":"9","key":"10.1016\/j.nlm.2019.107034_b0550","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1101\/lm.026492.112","article-title":"MicroRNAs in learning, memory, and neurological diseases","volume":"19","author":"Wang","year":"2012","journal-title":"Learning & Memory"},{"issue":"39","key":"10.1016\/j.nlm.2019.107034_b0555","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1159\/000447799","article-title":"Sulforaphane prevents neuronal apoptosis and memory impairment in diabetic rats","volume":"2016","author":"Wang","year":"2016","journal-title":"Cellular Physiology and Biochemistry"},{"key":"10.1016\/j.nlm.2019.107034_b0560","doi-asserted-by":"crossref","first-page":"24449","DOI":"10.18632\/oncotarget.15511","article-title":"The long noncoding RNA HOTAIR promotes Parkinso\u0144s disease by upregulating LRRK2 expression","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"issue":"6420","key":"10.1016\/j.nlm.2019.107034_b0565","doi-asserted-by":"crossref","first-page":"8464","DOI":"10.1126\/science.aat8464","article-title":"Comprehensive functional genomic resource and integrative model for the human brain","volume":"362","author":"Wang","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.nlm.2019.107034_b0570","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.1002\/jcb.26769","article-title":"Down-regulated long non-coding RNA ANRIL restores the learning and memory abilities and rescues hippocampal pyramidal neurons from apoptosis in streptozotocin-induced diabetic rats via the NF-kB signaling pathway","volume":"119","author":"Wen","year":"2018","journal-title":"Journal of Cellular Biochemistry"},{"issue":"4","key":"10.1016\/j.nlm.2019.107034_b0575","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.bbrc.2017.12.149","article-title":"LncRNA NEAT1 promotes autophagy in MPTP-induced Parkinson's disease through stabilizing PINK1 protein","volume":"496","author":"Yan","year":"2018","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.nlm.2019.107034_b0580","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1007\/s12035-016-0038-5","article-title":"Distinct Hippocampal expression profiles of long non-coding RNAs in a Alzheimer\u2019s disease model","volume":"54","author":"Yang","year":"2017","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.nlm.2019.107034_b0585","first-page":"1091","article-title":"Crosstalk between Meg3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN\/PI3K\/AKT pathway","volume":"8","author":"Yang","year":"2016","journal-title":"American Journal of Translational Research"},{"key":"10.1016\/j.nlm.2019.107034_b0590","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.brainres.2011.07.011","article-title":"Diabetes impairs learning performance and affects the mitochondrial function of hippocampal pyramidal neuros","volume":"1411","author":"Ye","year":"2011","journal-title":"Brain Research"},{"issue":"2","key":"10.1016\/j.nlm.2019.107034_b0595","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.molcel.2012.07.033","article-title":"Long noncoding RNAs with snoRNA ends","volume":"48","author":"Yin","year":"2012","journal-title":"Molecular Cell"},{"issue":"3","key":"10.1016\/j.nlm.2019.107034_b0600","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0092-8674(03)00079-5","article-title":"The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses","volume":"112","author":"Zalfa","year":"2003","journal-title":"Cell"},{"issue":"39","key":"10.1016\/j.nlm.2019.107034_b0605","doi-asserted-by":"crossref","first-page":"33403","DOI":"10.1074\/jbc.M504286200","article-title":"Fragile X mental retardation protein (FMRP) binds specifically to the brain cytoplasmic RNAs BC1\/BC200 via a novel RNA-binding motif","volume":"280","author":"Zalfa","year":"2005","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.nlm.2019.107034_b0610","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.biopha.2016.06.017","article-title":"Beta-asarone protects against MPTP-induced Parkinson\u2019s disease via regulating long non-coding RNA MALAT1 and inhibiting \u03b1-synuclein protein expression","volume":"83","author":"Zhang","year":"2016","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.nlm.2019.107034_b0615","first-page":"1","article-title":"Silencing of long noncoding RNA SOX21-AS1 relieves neuronal oxidative stress injury in mice with alzheimer\u2019s disease by upregulating FZD3\/5 via the Wnt signaling pathway","author":"Zhang","year":"2018","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.nlm.2019.107034_b9090","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41398-018-0267-7","article-title":"Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides","volume":"2","author":"Zhou","year":"2018","journal-title":"Translational Psychiatry"},{"key":"10.1016\/j.nlm.2019.107034_b9091","article-title":"Analysis of long noncoding RNAs highlights region-specific altered expression patterns and diagnostic roles in Alzheimer's disease","author":"Zhou","year":"2018","journal-title":"Briefings in Bioinformatics"}],"container-title":["Neurobiology of Learning and Memory"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742719301017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742719301017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:33:40Z","timestamp":1761032020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074742719301017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":127,"alternative-id":["S1074742719301017"],"URL":"https:\/\/doi.org\/10.1016\/j.nlm.2019.107034","relation":{},"ISSN":["1074-7427"],"issn-type":[{"value":"1074-7427","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging roles for long noncoding RNAs in learning, memory and associated disorders","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Learning and Memory","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nlm.2019.107034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107034"}}