{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:35:22Z","timestamp":1793118922145,"version":"4.5.0"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Learning and Memory"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.nlm.2020.107282","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T02:44:35Z","timestamp":1596077075000},"page":"107282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Exposure to elevated embryonic kynurenine in rats: Sex-dependent learning and memory impairments in adult offspring"],"prefix":"10.1016","volume":"174","author":[{"given":"Silas A.","family":"Buck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa M.","family":"Baratta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Pocivavsek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nlm.2020.107282_b0005","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/archpsyc.60.6.565","article-title":"Sex differences in the risk of schizophrenia: Evidence from meta-analysis","volume":"60","author":"Aleman","year":"2003","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.nlm.2020.107282_b0010","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuroscience.2013.01.063","article-title":"Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: Reversal with galantamine","volume":"238","author":"Alexander","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.nlm.2020.107282_b0015","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00213-011-2539-2","article-title":"Acute elevations of brain kynurenic acid impair cognitive flexibility: Normalization by the alpha7 positive modulator galantamine","volume":"220","author":"Alexander","year":"2012","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nlm.2020.107282_b0020","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/sj.npp.1300394","article-title":"Spatial memory deficits induced by perinatal treatment of rats with PCP and reversal effect of D-serine","volume":"29","author":"Andersen","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nlm.2020.107282_b0025","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/schbul\/sbu009","article-title":"Hippocampal volume is reduced in schizophrenia and schizoaffective disorder but not in psychotic bipolar I disorder demonstrated by both manual tracing and automated parcellation (FreeSurfer)","volume":"41","author":"Arnold","year":"2015","journal-title":"Schizophrenia Bulletin"},{"key":"10.1016\/j.nlm.2020.107282_b0030","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/gbb.12038","article-title":"Sensorimotor gating and spatial learning in alpha7-nicotinic receptor knockout mice","volume":"12","author":"Azzopardi","year":"2013","journal-title":"Genes, Brain and Behaviour"},{"key":"10.1016\/j.nlm.2020.107282_b0035","doi-asserted-by":"crossref","first-page":"6963","DOI":"10.1038\/s41598-018-25288-w","article-title":"Sex differences in hippocampal memory and kynurenic acid formation following acute sleep deprivation in rats","volume":"8","author":"Baratta","year":"2018","journal-title":"Scientific Reports"},{"key":"10.1016\/j.nlm.2020.107282_b0040","doi-asserted-by":"crossref","first-page":"100204","DOI":"10.1016\/j.ynstr.2019.100204","article-title":"Acute sleep deprivation during pregnancy in rats: Rapid elevation of placental and fetal inflammation and kynurenic acid","volume":"12","author":"Baratta","year":"2020","journal-title":"Neurobiology of Stress"},{"key":"10.1016\/j.nlm.2020.107282_b0045","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1037\/h0077579","article-title":"Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat","volume":"93","author":"Barnes","year":"1979","journal-title":"Journal of Comparative and Physiological Psychology"},{"key":"10.1016\/j.nlm.2020.107282_b0050","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ynstr.2017.04.001","article-title":"Early life stress leads to developmental and sex selective effects on performance in a novel object placement task","volume":"7","author":"Bath","year":"2017","journal-title":"Neurobiology of Stress"},{"key":"10.1016\/j.nlm.2020.107282_b0055","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0166-2236(97)01147-8","article-title":"GABAA, NMDA and AMPA receptors: A developmentally regulated 'menage a trois'","volume":"20","author":"Ben-Ari","year":"1997","journal-title":"Trends in Neurosciences"},{"key":"10.1016\/j.nlm.2020.107282_b0060","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neuroscience.2016.05.041","article-title":"The impact of biological sex and sex hormones on cognition in a rat model of early, pre-motor Parkinson's disease","volume":"345","author":"Betancourt","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.nlm.2020.107282_b0065","article-title":"Molecular alterations in the medial temporal lobe in schizophrenia","author":"Bobilev","year":"2019","journal-title":"Schizophrenia Research"},{"key":"10.1016\/j.nlm.2020.107282_b0070","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1176\/appi.ajp.2009.09030361","article-title":"Prenatal infection and schizophrenia: A review of epidemiologic and translational studies","volume":"167","author":"Brown","year":"2010","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.nlm.2020.107282_b0075","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1365-2826.2010.01969.x","article-title":"Prenatal social stress in the rat programmes neuroendocrine and behavioural responses to stress in the adult offspring: Sex-specific effects","volume":"22","author":"Brunton","year":"2010","journal-title":"Journal of Neuroendocrinology"},{"key":"10.1016\/j.nlm.2020.107282_b0080","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fnbeh.2019.00008","article-title":"A Specific role of hippocampal NMDA receptors and arc protein in rapid encoding of novel environmental representations and a more general long-term consolidation function","volume":"13","author":"Bye","year":"2019","journal-title":"Frontiers in Behavioral Neuroscience"},{"key":"10.1016\/j.nlm.2020.107282_b0085","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0393-19.2019","article-title":"Does prenatal exposure to maternal inflammation causes sex differences in schizophrenia-related behavioral outcomes in adult rats?","volume":"6","author":"Carney","year":"2019","journal-title":"eNeuro"},{"key":"10.1016\/j.nlm.2020.107282_b0090","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0920-9964(98)00070-X","article-title":"Differences in distribution of ages of onset in males and females with schizophrenia","volume":"33","author":"Castle","year":"1998","journal-title":"Schizophrenia Research"},{"key":"10.1016\/j.nlm.2020.107282_b0095","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bbr.2009.03.013","article-title":"L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning","volume":"201","author":"Chess","year":"2009","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.nlm.2020.107282_b0100","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/schbul\/sbl033","article-title":"Elevations of endogenous kynurenic acid produce spatial working memory deficits","volume":"33","author":"Chess","year":"2007","journal-title":"Schizophrenia Bulletin"},{"key":"10.1016\/j.nlm.2020.107282_b0105","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.pnpbp.2018.09.011","article-title":"Maternal immune activation in rats blunts brain cytokine and kynurenine pathway responses to a second immune challenge in early adulthood","volume":"89","author":"Clark","year":"2019","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10.1016\/j.nlm.2020.107282_b0110","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neulet.2006.09.061","article-title":"Antisense knockdown of the rat alpha7 nicotinic acetylcholine receptor produces spatial memory impairment","volume":"410","author":"Curzon","year":"2006","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.nlm.2020.107282_b0115","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/schbul\/sbm164","article-title":"The concept of progressive brain change in schizophrenia: Implications for understanding schizophrenia","volume":"34","author":"DeLisi","year":"2008","journal-title":"Schizophrenia Bulletin"},{"key":"10.1016\/j.nlm.2020.107282_b0120","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pharmthera.2009.02.003","article-title":"The dynamic effects of nicotine on the developing brain","volume":"122","author":"Dwyer","year":"2009","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.nlm.2020.107282_b0125","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0304-3940(01)02242-X","article-title":"Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia","volume":"313","author":"Erhardt","year":"2001","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.nlm.2020.107282_b0130","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.biopsych.2004.06.006","article-title":"Endogenous kynurenic acid disrupts prepulse inhibition","volume":"56","author":"Erhardt","year":"2004","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.nlm.2020.107282_b0135","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1046\/j.0022-3042.2001.00714.x","article-title":"The alpha7 nicotinic receptors in human fetal brain and spinal cord","volume":"80","author":"Falk","year":"2002","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.nlm.2020.107282_b0140","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bbr.2007.01.009","article-title":"Effects of intra-accumbens NMDA and AMPA receptor antagonists on short-term spatial learning in the Morris water maze task","volume":"179","author":"Ferretti","year":"2007","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.nlm.2020.107282_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2013.01.031","article-title":"Prenatal inhibition of the tryptophan-kynurenine pathway alters synaptic plasticity and protein expression in the rat hippocampus","volume":"1504","author":"Forrest","year":"2013","journal-title":"Brain Research"},{"key":"10.1016\/j.nlm.2020.107282_b0150","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuroscience.2013.09.034","article-title":"Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway","volume":"254","author":"Forrest","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.nlm.2020.107282_b0155","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuroscience.2015.09.022","article-title":"Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine","volume":"310","author":"Forrest","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.nlm.2020.107282_b0160","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1111\/j.1471-4159.1991.tb03460.x","article-title":"Blood-brain barrier transport of kynurenines: Implications for brain synthesis and metabolism","volume":"56","author":"Fukui","year":"1991","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.nlm.2020.107282_b0165","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1471-4159.1978.tb07815.x","article-title":"Synthesis and metabolism of L-kynurenine in rat brain","volume":"30","author":"Gal","year":"1978","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.nlm.2020.107282_b0170","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1159\/000481168","article-title":"Prenatal dynamics of kynurenine pathway metabolism in mice: Focus on kynurenic acid","volume":"39","author":"Goeden","year":"2017","journal-title":"Developmental Neuroscience"},{"key":"10.1016\/j.nlm.2020.107282_b0175","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1046\/j.1471-4159.1997.69010290.x","article-title":"Brain-specific modulation of kynurenic acid synthesis in the rat","volume":"69","author":"Gramsbergen","year":"1997","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.nlm.2020.107282_b0180","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/glia.20432","article-title":"Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry","volume":"55","author":"Guidetti","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.nlm.2020.107282_b0185","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/(SICI)1097-4547(19971101)50:3<457::AID-JNR12>3.0.CO;2-3","article-title":"Characterization of rat brain kynurenine aminotransferases I and II","volume":"50","author":"Guidetti","year":"1997","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.nlm.2020.107282_b0190","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00213-017-4780-9","article-title":"Prenatal kynurenine treatment in rats causes schizophrenia-like broad monitoring deficits in adulthood","volume":"235","author":"Hahn","year":"2018","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nlm.2020.107282_b0195","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fpsyt.2011.00021","article-title":"Litter gender composition and sex affect maternal behavior and DNA methylation levels of the oprm1 gene in rat offspring","volume":"2","author":"Hao","year":"2011","journal-title":"Frontiers in Psychiatry"},{"key":"10.1016\/j.nlm.2020.107282_b0200","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/1137","article-title":"Impaired recruitment of the hippocampus during conscious recollection in schizophrenia","volume":"1","author":"Heckers","year":"1998","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.nlm.2020.107282_b0205","doi-asserted-by":"crossref","first-page":"9639","DOI":"10.1073\/pnas.1401203111","article-title":"Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction","volume":"111","author":"Howerton","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.nlm.2020.107282_b0210","doi-asserted-by":"crossref","first-page":"5169","DOI":"10.1073\/pnas.1300065110","article-title":"O-GlcNAc transferase (OGT) as a placental biomarker of maternal stress and reprogramming of CNS gene transcription in development","volume":"110","author":"Howerton","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.nlm.2020.107282_b0215","first-page":"1","article-title":"Male fetus susceptibility to maternal inflammation: C-reactive protein and brain development","author":"Hunter","year":"2019","journal-title":"Psychological Medicine"},{"key":"10.1016\/j.nlm.2020.107282_b0220","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/cercor\/bht246","article-title":"Developmental expression of N-methyl-D-aspartate (NMDA) receptor subunits in human white and gray matter: Potential mechanism of increased vulnerability in the immature brain","volume":"25","author":"Jantzie","year":"2015","journal-title":"Cerebral Cortex"},{"key":"10.1016\/j.nlm.2020.107282_b0225","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.schres.2010.03.011","article-title":"Disturbed sexual dimorphism of brain activation during mental rotation in schizophrenia","volume":"122","author":"Jimenez","year":"2010","journal-title":"Schizophrenia Research"},{"key":"10.1016\/j.nlm.2020.107282_b0230","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/j.1476-5381.2011.01386.x","article-title":"Animal models of schizophrenia","volume":"164","author":"Jones","year":"2011","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.nlm.2020.107282_b0235","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3389\/fpsyg.2013.00547","article-title":"Sex, symptom, and premorbid social functioning associated with perceptual organization dysfunction in schizophrenia","volume":"4","author":"Joseph","year":"2013","journal-title":"Frontiers in Psychology"},{"key":"10.1016\/j.nlm.2020.107282_b0240","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1111\/ejn.12535","article-title":"Prenatal inhibition of the kynurenine pathway leads to structural changes in the hippocampus of adult rat offspring","volume":"39","author":"Khalil","year":"2014","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2020.107282_b0245","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.mehy.2009.09.040","article-title":"A unifying hypothesis of schizophrenia: Abnormal immune system development may help explain roles of prenatal hazards, post-pubertal onset, stress, genes, climate, infections, and brain dysfunction","volume":"74","author":"Kinney","year":"2010","journal-title":"Medical Hypotheses"},{"key":"10.1016\/j.nlm.2020.107282_b0250","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ijdevneu.2014.03.010","article-title":"Litter and sex effects on maternal behavior and DNA methylation of the Nr3c1 exon 17 promoter gene in hippocampus and cerebellum","volume":"36","author":"Kosten","year":"2014","journal-title":"International Journal of Developmental Neuroscience"},{"key":"10.1016\/j.nlm.2020.107282_b0255","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.neubiorev.2016.06.029","article-title":"A systematic review comparing sex differences in cognitive function in schizophrenia and in rodent models for schizophrenia, implications for improved therapeutic strategies","volume":"68","author":"Leger","year":"2016","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"10.1016\/j.nlm.2020.107282_b0260","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/ajcn\/24.6.659","article-title":"Quantitative aspects of tryptophan metabolism in humans and other species: A review","volume":"24","author":"Leklem","year":"1971","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.nlm.2020.107282_b0265","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00213-005-0164-7","article-title":"Nicotinic effects on cognitive function: Behavioral characterization, pharmacological specification, and anatomic localization","volume":"184","author":"Levin","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nlm.2020.107282_b0270","unstructured":"Lewis, A. M., Wagner, N. T. J., Rentschler, K. M., Buck, S. A., Baratta, A. M., Beggiato, S., \u2026 & Pocivavsek, A. (2019). Differential impact of light or dark phase kynurenine challenge in male and female rats: Biochemical alterations and disruptions in sleep-wake behavior. Program No. 502.09. Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience."},{"key":"10.1016\/j.nlm.2020.107282_b0275","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1176\/appi.ajp.2014.14010123","article-title":"Synaptic proteins in the hippocampus indicative of increased neuronal activity in CA3 in schizophrenia","volume":"172","author":"Li","year":"2015","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.nlm.2020.107282_b0280","first-page":"201","article-title":"Involvement of hippocampal NMDA and AMPA receptors in acquisition, formation and retrieval","volume":"37","author":"Liang","year":"1994","journal-title":"Chinese Journal of Physiology"},{"key":"10.1016\/j.nlm.2020.107282_b0285","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0006-3223(01)01067-8","article-title":"Longitudinal study of brain morphology in first episode schizophrenia","volume":"49","author":"Lieberman","year":"2001","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.nlm.2020.107282_b0290","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/schbul\/sbq086","article-title":"Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia","volume":"38","author":"Linderholm","year":"2012","journal-title":"Schizophrenia Bulletin"},{"key":"10.1016\/j.nlm.2020.107282_b0295","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.yhbeh.2014.06.006","article-title":"Assessment of the effects of sex and sex hormones on spatial cognition in adult rats using the Barnes maze","volume":"66","author":"Locklear","year":"2014","journal-title":"Hormones and Behavior"},{"key":"10.1016\/j.nlm.2020.107282_b0300","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s12640-018-9901-7","article-title":"Phencyclidine and scopolamine for modeling Amnesia in rodents: direct comparison with the use of barnes maze test and contextual fear conditioning test in mice","volume":"34","author":"Malikowska-Racia","year":"2018","journal-title":"Neurotoxicity Research"},{"key":"10.1016\/j.nlm.2020.107282_b0305","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neubiorev.2015.10.013","article-title":"Sex\/gender differences in the brain and cognition in schizophrenia","volume":"67","author":"Mendrek","year":"2016","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"10.1016\/j.nlm.2020.107282_b0310","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.pneurobio.2009.10.018","article-title":"Epidemiology-driven neurodevelopmental animal models of schizophrenia","volume":"90","author":"Meyer","year":"2010","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.nlm.2020.107282_b0315","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.brainres.2005.12.056","article-title":"Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder","volume":"1073\u20131074","author":"Miller","year":"2006","journal-title":"Brain Research"},{"key":"10.1016\/j.nlm.2020.107282_b0320","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.physbeh.2007.01.017","article-title":"Early prenatal stress impact on coping strategies and learning performance is sex dependent","volume":"91","author":"Mueller","year":"2007","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.nlm.2020.107282_b0325","doi-asserted-by":"crossref","first-page":"9055","DOI":"10.1523\/JNEUROSCI.1424-08.2008","article-title":"Sex-specific programming of offspring emotionality after stress early in pregnancy","volume":"28","author":"Mueller","year":"2008","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2020.107282_b0330","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.schres.2005.07.013","article-title":"Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia","volume":"80","author":"Nilsson","year":"2005","journal-title":"Schizophrenia Research"},{"key":"10.1016\/j.nlm.2020.107282_b0335","first-page":"1","article-title":"Assessment of prenatal kynurenine metabolism using tissue slices: focus on the neosynthesis of kynurenic acid in mice","author":"Notarangelo","year":"2019","journal-title":"Developmental Neuroscience"},{"key":"10.1016\/j.nlm.2020.107282_b0340","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.neuropharm.2016.03.001","article-title":"Elevated kynurenine pathway metabolism during neurodevelopment: Implications for brain and behavior","volume":"112","author":"Notarangelo","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nlm.2020.107282_b0345","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1159\/000455228","article-title":"Restraint stress during pregnancy rapidly raises kynurenic acid levels in mouse placenta and fetal brain","volume":"38","author":"Notarangelo","year":"2016","journal-title":"Developmental Neuroscience"},{"key":"10.1016\/j.nlm.2020.107282_b0350","first-page":"1","article-title":"Kynurenine pathway as a new target of cognitive impairment induced by lead toxicity during the lactation","volume":"10","author":"Ortega","year":"2020","journal-title":"Scientific Reports"},{"key":"10.1016\/j.nlm.2020.107282_b0355","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1101\/lm.5.4.302","article-title":"Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: A behavioral characterization of Acra7-deficient mice","volume":"5","author":"Paylor","year":"1998","journal-title":"Learning & Memory"},{"key":"10.1016\/j.nlm.2020.107282_b0360","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuropharm.2014.10.017","article-title":"Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: Implications for schizophrenia","volume":"90","author":"Pershing","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.nlm.2020.107282_b0365","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1007\/s00213-016-4404-9","article-title":"Prenatal kynurenine exposure in rats: Age-dependent changes in NMDA receptor expression and conditioned fear responding","volume":"233","author":"Pershing","year":"2016","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nlm.2020.107282_b0370","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1093\/schbul\/sbw221","article-title":"Kynurenic acid in schizophrenia: A systematic review and meta-analysis","volume":"43","author":"Plitman","year":"2017","journal-title":"Schizophrenia Bulletin"},{"key":"10.1016\/j.nlm.2020.107282_b0375","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsx141","article-title":"Acute kynurenine challenge disrupts sleep-wake architecture and impairs contextual memory in adult rats","volume":"40","author":"Pocivavsek","year":"2017","journal-title":"Sleep"},{"key":"10.1016\/j.nlm.2020.107282_b0380","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hipo.23040","article-title":"Inhibition of kynurenine aminotransferase II attenuates hippocampus-dependent memory deficit in adult rats treated prenatally with kynurenine","volume":"29","author":"Pocivavsek","year":"2019","journal-title":"Hippocampus"},{"key":"10.1016\/j.nlm.2020.107282_b0385","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1007\/s00213-014-3452-2","article-title":"Continuous kynurenine administration during the prenatal period, but not during adolescence, causes learning and memory deficits in adult rats","volume":"231","author":"Pocivavsek","year":"2014","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.nlm.2020.107282_b0390","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1038\/npp.2011.127","article-title":"Fluctuations in endogenous kynurenic acid control hippocampal glutamate and memory","volume":"36","author":"Pocivavsek","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nlm.2020.107282_b0395","unstructured":"Rentschler, K., Baratta, A. M., Ditty, A. L., Lewis, A. M., Wagner, N. T. J., Wright, C. J., \u2026 Pocivavsek, A. (2019) An experimental system of prenatal kynurenine elevations: distinct sex-dependent alterations in brain kynurenic acid and sleep disturbances in adulthood. Program No. 502.10. Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience."},{"key":"10.1016\/j.nlm.2020.107282_b0400","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tips.2006.01.009","article-title":"Behavioural pharmacology: 40+ years of progress, with a focus on glutamate receptors and cognition","volume":"27","author":"Robbins","year":"2006","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.nlm.2020.107282_b0405","first-page":"e51194","article-title":"Barnes maze testing strategies with small and large rodent models","author":"Rosenfeld","year":"2014","journal-title":"Journal of Visualized Experiments"},{"key":"10.1016\/j.nlm.2020.107282_b0410","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.yhbeh.2004.09.010","article-title":"Gender-specific effects of prenatal stress on emotional reactivity and stress physiology of goat kids","volume":"47","author":"Roussel","year":"2005","journal-title":"Hormones and Behavior"},{"key":"10.1016\/j.nlm.2020.107282_b0415","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1093\/schbul\/sbq112","article-title":"Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia","volume":"37","author":"Sathyasaikumar","year":"2011","journal-title":"Schizophrenia Bulletin"},{"key":"10.1016\/j.nlm.2020.107282_b0420","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrn3257","article-title":"Kynurenines in the mammalian brain: When physiology meets pathology","volume":"13","author":"Schwarcz","year":"2012","journal-title":"Nature Reviews Neuroscience"},{"key":"10.1016\/j.nlm.2020.107282_b0425","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0006-3223(01)01078-2","article-title":"Increased cortical kynurenate content in schizophrenia","volume":"50","author":"Schwarcz","year":"2001","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.nlm.2020.107282_b0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-019-0378-9","article-title":"Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls","volume":"9","author":"Sellgren","year":"2019","journal-title":"Translational Psychiatry"},{"key":"10.1016\/j.nlm.2020.107282_b0435","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/sj.npp.1300188","article-title":"Micromolar brain levels of kynurenic acid are associated with a disruption of auditory sensory gating in the rat","volume":"28","author":"Shepard","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nlm.2020.107282_b0440","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.bbr.2011.12.036","article-title":"An investigation of whether there are sex differences in certain behavioural and neurochemical parameters in the rat","volume":"229","author":"Simpson","year":"2012","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.nlm.2020.107282_b0445","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1192\/bjp.188.6.510","article-title":"Brain volume in first-episode schizophrenia: Systematic review and meta-analysis of magnetic resonance imaging studies","volume":"188","author":"Steen","year":"2006","journal-title":"British Journal of Psychiatry"},{"key":"10.1016\/j.nlm.2020.107282_b0450","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1176\/appi.ajp.2010.09081187","article-title":"The hippocampal formation in schizophrenia","volume":"167","author":"Tamminga","year":"2010","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.nlm.2020.107282_b0455","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuroscience.2011.08.038","article-title":"Glutamate and nicotinic receptor interactions in working memory: Importance for the cognitive impairment of schizophrenia","volume":"195","author":"Timofeeva","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.nlm.2020.107282_b0460","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1192\/bjp.172.4.324","article-title":"Prenatal exposure to maternal stress and subsequent schizophrenia. The May 1940 invasion of The Netherlands","volume":"172","author":"van Os","year":"1998","journal-title":"British Journal of Psychiatry"},{"key":"10.1016\/j.nlm.2020.107282_b0465","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3389\/fnmol.2018.00197","article-title":"Sex differences in psychiatric disease: A focus on the glutamate system","volume":"11","author":"Wickens","year":"2018","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"10.1016\/j.nlm.2020.107282_b0470","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41386-018-0208-4","article-title":"Sex differences in hippocampal cognition and neurogenesis","volume":"44","author":"Yagi","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nlm.2020.107282_b0475","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3389\/fnbeh.2019.00128","article-title":"Gender differences in large-scale and small-scale spatial ability: A systematic review based on behavioral and neuroimaging research","volume":"13","author":"Yuan","year":"2019","journal-title":"Frontiers in Behavioral Neuroscience"},{"key":"10.1016\/j.nlm.2020.107282_b0480","doi-asserted-by":"crossref","first-page":"e0188273","DOI":"10.1371\/journal.pone.0188273","article-title":"Sepsis-induced selective loss of NMDA receptors modulates hippocampal neuropathology in surviving septic mice","volume":"12","author":"Zhang","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nlm.2020.107282_b0485","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002170","article-title":"Prenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats","volume":"3","author":"Zuena","year":"2008","journal-title":"PLoS ONE"}],"container-title":["Neurobiology of Learning and Memory"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107474272030126X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107474272030126X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:37:33Z","timestamp":1761032253000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107474272030126X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":97,"alternative-id":["S107474272030126X"],"URL":"https:\/\/doi.org\/10.1016\/j.nlm.2020.107282","relation":{},"ISSN":["1074-7427"],"issn-type":[{"value":"1074-7427","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to elevated embryonic kynurenine in rats: Sex-dependent learning and memory impairments in adult offspring","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Learning and Memory","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nlm.2020.107282","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107282"}}