{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:23:45Z","timestamp":1790573025576,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21NS096936"],"award-info":[{"award-number":["R21NS096936"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T32AG049688"],"award-info":[{"award-number":["T32AG049688"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Learning and Memory"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.nlm.2021.107505","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T02:44:50Z","timestamp":1629427490000},"page":"107505","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Effects of nicotinic antagonists on working memory performance in young rhesus monkeys"],"prefix":"10.1016","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5479-609X","authenticated-orcid":false,"given":"Nicholas A.","family":"Upright","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G.","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nlm.2021.107505_b0005","doi-asserted-by":"crossref","unstructured":"Akaike, A., & Izumi, Y. (2018). Overview. In A. Akaike, S. Shimohama, & Y. Misu (Eds.), Nicotinic Acetylcholine Receptor Signaling in Neuroprotection (pp. 1\u201315). Springer Singapore. Doi: 10.1007\/978-981-10-8488-1_1.","DOI":"10.1007\/978-981-10-8488-1_1"},{"issue":"1","key":"10.1016\/j.nlm.2021.107505_b0010","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1152\/physrev.00015.2008","article-title":"Mammalian nicotinic acetylcholine receptors: From structure to function","volume":"89","author":"Albuquerque","year":"2009","journal-title":"Physiological Reviews"},{"issue":"4","key":"10.1016\/j.nlm.2021.107505_b0015","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.48","article-title":"Methyllycaconitine- and scopolamine-induced cognitive dysfunction: Differential reversal effect by cognition-enhancing drugs","volume":"2","author":"Andriambeloson","year":"2014","journal-title":"Pharmacology Research & Perspectives"},{"issue":"16","key":"10.1016\/j.nlm.2021.107505_b0020","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1517\/14656560903329102","article-title":"Mecamylamine \u2013 a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders","volume":"10","author":"Bacher","year":"2009","journal-title":"Expert Opinion on Pharmacotherapy"},{"issue":"3","key":"10.1016\/j.nlm.2021.107505_b0025","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0166-4328(86)90225-1","article-title":"Visual recognition impairment follows ventromedial but not dorsolateral prefrontal lesions in monkeys","volume":"20","author":"Bachevalier","year":"1986","journal-title":"Behavioural Brain Research"},{"issue":"4558","key":"10.1016\/j.nlm.2021.107505_b0030","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.7046051","article-title":"The cholinergic hypothesis of geriatric memory dysfunction","volume":"217","author":"Bartus","year":"1982","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.nlm.2021.107505_b0035","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/00008877-199911000-00015","article-title":"Differential improvement in memory-related task performance with nicotine by aged male and female rhesus monkeys","volume":"10","author":"Buccafusco","year":"1999","journal-title":"Behavioural Pharmacology"},{"issue":"7","key":"10.1016\/j.nlm.2021.107505_b0040","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.bcp.2009.06.102","article-title":"A reversible model of the cognitive impairment associated with schizophrenia in monkeys: Potential therapeutic effects of two nicotinic acetylcholine receptor agonists","volume":"78","author":"Buccafusco","year":"2009","journal-title":"Biochemical Pharmacology"},{"issue":"10","key":"10.1016\/j.nlm.2021.107505_b0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047484","article-title":"Muscarinic and nicotinic modulation of thalamo-prefrontal cortex synaptic pasticity in vivo","volume":"7","author":"Bueno-Junior","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.nlm.2021.107505_b0050","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuropharm.2012.10.019","article-title":"Positive allosteric modulator of alpha 7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates","volume":"67","author":"Callahan","year":"2013","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.nlm.2021.107505_b0055","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.biopsych.2010.08.006","article-title":"Immediate and sustained improvements in working memory after selective stimulation of \u03b17 nicotinic acetylcholine receptors","volume":"69","author":"Castner","year":"2011","journal-title":"Biological Psychiatry"},{"issue":"1","key":"10.1016\/j.nlm.2021.107505_b0060","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0022-3565(24)36376-1","article-title":"Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h\u03b12\u03b22, h\u03b12\u03b24, h\u03b13\u03b22, h\u03b13\u03b24, h\u03b14\u03b22, h\u03b14\u03b24 and h\u03b17 expressed in Xenopus Oocytes","volume":"280","author":"Chavez-Noriega","year":"1997","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"1","key":"10.1016\/j.nlm.2021.107505_b0065","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0306-4522(00)00071-3","article-title":"Nicotine binding in human striatum: Elevation in schizophrenia and reductions in dementia with Lewy bodies, Parkinson\u2019s disease and Alzheimer\u2019s disease and in relation to neuroleptic medication","volume":"98","author":"Court","year":"2000","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/j.nlm.2021.107505_b0070","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/nn.2971","article-title":"Cholinergic modulation of a specific memory function of prefrontal cortex","volume":"14","author":"Croxson","year":"2011","journal-title":"Nature Neuroscience"},{"issue":"3","key":"10.1016\/j.nlm.2021.107505_b0075","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1124\/jpet.112.193078","article-title":"Pharmacologic characterization of a nicotine-discriminative stimulus in Rhesus Monkeys","volume":"341","author":"Cunningham","year":"2012","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"4","key":"10.1016\/j.nlm.2021.107505_b0080","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/FBP.0000000000000054","article-title":"The discriminative stimulus effects of mecamylamine in nicotine-treated and untreated rhesus monkeys","volume":"25","author":"Cunningham","year":"2014","journal-title":"Behavioural Pharmacology"},{"key":"10.1016\/j.nlm.2021.107505_b9010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.pbb.2019.02.002","article-title":"Discriminative stimulus effects of mecamylamine and nicotine in rhesus monkeys: Central and peripheral mechanisms","volume":"179","author":"Cunningham","year":"2019","journal-title":"Pharmacology Biochemistry and Behavior"},{"issue":"3","key":"10.1016\/j.nlm.2021.107505_b0085","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1152\/jn.2000.83.3.1536","article-title":"Local infusion of scopolamine into intraparietal cortex slows covert orienting in Rhesus Monkeys","volume":"83","author":"Davidson","year":"2000","journal-title":"Journal of Neurophysiology"},{"issue":"3","key":"10.1016\/j.nlm.2021.107505_b0090","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0024-3205(88)90318-9","article-title":"Nicotine enhances delayed matching-to-sample performance by primates","volume":"43","author":"Elrod","year":"1988","journal-title":"Life Sciences"},{"issue":"4","key":"10.1016\/j.nlm.2021.107505_b0095","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0306-4522(97)00224-8","article-title":"Nicotinic antagonist administration into the ventral hippocampus and spatial working memory in rats","volume":"81","author":"Felix","year":"1997","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.nlm.2021.107505_b0100","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00213-004-1794-x","article-title":"Cholinergic targets for cognitive enhancement in schizophrenia: Focus on cholinesterase inhibitors and muscarinic agonists","volume":"174","author":"Friedman","year":"2004","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.nlm.2021.107505_b0105","article-title":"Involvement of nicotinic receptors in working memory function","author":"Galvin","year":"2020","journal-title":"Springer, Berlin Heidelberg."},{"key":"10.1016\/j.nlm.2021.107505_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2020.02.030","article-title":"Muscarinic M1 receptors modulate working memory performance and activity via KCNQ potassium channels in the primate prefrontal cortex","author":"Galvin","year":"2020","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.nlm.2021.107505_b0115","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.pbb.2005.04.010","article-title":"Muscarinic and nicotinic receptor modulation of object and spatial -back working memory in humans","volume":"81","author":"Green","year":"2005","journal-title":"Pharmacology Biochemistry and Behavior"},{"issue":"2","key":"10.1016\/j.nlm.2021.107505_b0120","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00213-002-1005-6","article-title":"Nicotine-induced enhancement of attention in the five-choice serial reaction time task: The influence of task demands","volume":"162","author":"Hahn","year":"2002","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.nlm.2021.107505_b0125","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00213-011-2258-8","article-title":"Selective nicotinic receptor antagonists: Effects on attention and nicotine-induced attentional enhancement","volume":"217","author":"Hahn","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.nlm.2021.107505_b0130","unstructured":"Hartig, F. (2019). DHARMa: Residual Diagnostics for Hierarchical (Multi-Level \/ Mixed) Regression Models (R package version 0.2.6) [Computer software]. https:\/\/CRAN.R-project.org."},{"issue":"3","key":"10.1016\/j.nlm.2021.107505_b0135","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/ntr\/nty116","article-title":"Nicotinic acetylcholine receptor agonists for the treatment of Alzheimer\u2019s dementia: An update","volume":"21","author":"Hoskin","year":"2019","journal-title":"Nicotine & Tobacco Research"},{"issue":"2","key":"10.1016\/j.nlm.2021.107505_b0140","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00213-004-1804-z","article-title":"Effects of nicotine and mecamylamine on cognition in rhesus monkeys","volume":"175","author":"Katner","year":"2004","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.nlm.2021.107505_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.tins.2020.06.001","article-title":"Do nicotinic receptors modulate high-order cognitive processing?","author":"Koukouli","year":"2020","journal-title":"Trends in Neurosciences"},{"issue":"13","key":"10.1016\/j.nlm.2021.107505_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v082.i13","article-title":"lmerTest Package: Tests in Linear Mixed Effects Models","volume":"82","author":"Kuznetsova","year":"2017","journal-title":"Journal of Statistical Software"},{"key":"10.1016\/j.nlm.2021.107505_b0155","unstructured":"Lenth, R. (2019). emmeans: Estimated Marginal Means, aka Least-Squares Means (R package version 1.3.4) [Computer software]. https:\/\/CRAN.R-project.org\/package=emmeans."},{"issue":"3","key":"10.1016\/j.nlm.2021.107505_b0160","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s002130050667","article-title":"Nicotinic acetylcholine involvement in cognitive function in animals","volume":"138","author":"Levin","year":"1998","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.nlm.2021.107505_b0165","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neuropharm.2018.04.026","article-title":"Intermittent stimulation in the nucleus basalis of meynert improves sustained attention in rhesus monkeys","volume":"137","author":"Liu","year":"2018","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.nlm.2021.107505_b0170","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1152\/jn.00380.2016","article-title":"Human parietal cortex lesions impact the precision of spatial working memory","volume":"116","author":"Mackey","year":"2016","journal-title":"Journal of Neurophysiology"},{"issue":"49","key":"10.1016\/j.nlm.2021.107505_b0175","doi-asserted-by":"crossref","first-page":"16064","DOI":"10.1523\/JNEUROSCI.2454-15.2015","article-title":"Muscarinic attenuation of mnemonic rule representation in macaque dorsolateral prefrontal cortex during a pro- and anti-saccade task","volume":"35","author":"Major","year":"2015","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2021.107505_b0180","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuropharm.2016.12.003","article-title":"The discriminative stimulus effects of i.v. nicotine in rhesus monkeys: Pharmacokinetics and apparent pA2 analysis with dihydro-\u03b2-erythroidine","volume":"116","author":"Moerke","year":"2017","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.nlm.2021.107505_b0185","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.3233\/JAD-170591","article-title":"In vivo Depiction of \u03b17 Nicotinic Receptor Loss for Cognitive Decline in Alzheimer\u2019s Disease","volume":"61","author":"Nakaizumi","year":"2018","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"3","key":"10.1016\/j.nlm.2021.107505_b0190","doi-asserted-by":"crossref","first-page":"206","DOI":"10.2165\/00002512-199711030-00005","article-title":"Nicotinic system involvement in Alzheimer\u2019s and Parkinson\u2019s Diseases","volume":"11","author":"Newhouse","year":"1997","journal-title":"Drugs & Aging"},{"issue":"5","key":"10.1016\/j.nlm.2021.107505_b0195","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00213-015-4174-9","article-title":"Attenuation in rats of impairments of memory by scopolamine, a muscarinic receptor antagonist, by mecamylamine, a nicotinic receptor antagonist","volume":"233","author":"Newman","year":"2016","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.nlm.2021.107505_b0200","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0091-3057(93)90091-7","article-title":"Blockade of hippocampal nicotinic receptors impairs working memory but not reference memory in rats","volume":"45","author":"Ohno","year":"1993","journal-title":"Pharmacology Biochemistry and Behavior"},{"issue":"10","key":"10.1016\/j.nlm.2021.107505_b0205","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1093\/brain\/awt195","article-title":"Alterations in \u03b14\u03b22 nicotinic receptors in cognitive decline in Alzheimer\u2019s aetiopathology","volume":"136","author":"Okada","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.nlm.2021.107505_b0210","doi-asserted-by":"crossref","DOI":"10.1177\/0269881121991570","article-title":"Contrasting effects of the \u03b17 nicotinic receptor antagonist methyllycaconitine in different rat models of heroin reinstatement","author":"Palandri","year":"2021","journal-title":"Journal of Psychopharmacology"},{"issue":"2","key":"10.1016\/j.nlm.2021.107505_b0215","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0022-3565(24)29581-1","article-title":"Analysis of Mecamylamine Stereoisomers on Human Nicotinic Receptor Subtypes","volume":"297","author":"Papke","year":"2001","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"6","key":"10.1016\/j.nlm.2021.107505_b0220","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.neuron.2013.01.038","article-title":"Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition","volume":"77","author":"Parnaudeau","year":"2013","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.nlm.2021.107505_b0225","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuron.2012.08.036","article-title":"Acetylcholine as a neuromodulator: Cholinergic signaling shapes nervous system function and behavior","volume":"76","author":"Picciotto","year":"2012","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.nlm.2021.107505_b0230","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/neu.10102","article-title":"Nicotinic receptors in aging and dementia","volume":"53","author":"Picciotto","year":"2002","journal-title":"Journal of Neurobiology"},{"issue":"1","key":"10.1016\/j.nlm.2021.107505_b0235","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/1096-9861(20000911)425:1<58::AID-CNE6>3.0.CO;2-X","article-title":"Localization of nicotinic receptor subunit mRNAs in monkey brain by in situ hybridization","volume":"425","author":"Quik","year":"2000","journal-title":"Journal of Comparative Neurology"},{"key":"10.1016\/j.nlm.2021.107505_b0240","unstructured":"R Core Team. (2018). R: A language and environment for statistical computing. https:\/\/www.R-project.org\/."},{"issue":"6","key":"10.1016\/j.nlm.2021.107505_b0245","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1093\/brain\/awy099","article-title":"Cognitive correlates of \u03b14\u03b22 nicotinic acetylcholine receptors in mild Alzheimer\u2019s dementia","volume":"141","author":"Sabri","year":"2018","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.nlm.2021.107505_b0250","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1177\/026988110401800403","article-title":"Nicotinic receptor mechanisms and cognition in normal states and neuropsychiatric disorders","volume":"18","author":"Sacco","year":"2004","journal-title":"Journal of Psychopharmacology"},{"issue":"1","key":"10.1016\/j.nlm.2021.107505_b0255","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrn1588","article-title":"Choline transporters, cholinergic transmission and cognition","volume":"6","author":"Sarter","year":"2005","journal-title":"Nature Reviews Neuroscience"},{"issue":"2","key":"10.1016\/j.nlm.2021.107505_b0260","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0022-3565(24)34957-2","article-title":"Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys","volume":"290","author":"Schneider","year":"1999","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"21","key":"10.1016\/j.nlm.2021.107505_b0265","doi-asserted-by":"crossref","first-page":"5366","DOI":"10.1523\/JNEUROSCI.0364-17.2017","article-title":"Nicotinic \u03b14\u03b22 cholinergic receptor influences on dorsolateral prefrontal cortical neuronal firing during a working memory task","volume":"37","author":"Sun","year":"2017","journal-title":"The Journal of Neuroscience"},{"issue":"3","key":"10.1016\/j.nlm.2021.107505_b0270","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/ntr\/nty166","article-title":"Nicotinic acetylcholine receptor ligands, cognitive function, and preclinical approaches to drug discovery","volume":"21","author":"Terry","year":"2019","journal-title":"Nicotine & Tobacco Research"},{"key":"10.1016\/j.nlm.2021.107505_b0275","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/(SICI)1098-2299(199907)47:3<127::AID-DDR3>3.0.CO;2-#","article-title":"Dose-specific improvements in memory-related task performance by rats and aged monkeys administered the nicotinic-cholinergic antagonist mecamylamine","volume":"47","author":"Terry","year":"1999","journal-title":"Drug Development Research"},{"issue":"3","key":"10.1016\/j.nlm.2021.107505_b0280","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/ntr\/nty034","article-title":"Alpha7 nicotinic receptors as therapeutic targets in schizophrenia","volume":"21","author":"Tregellas","year":"2019","journal-title":"Nicotine & Tobacco Research"},{"key":"10.1016\/j.nlm.2021.107505_b0285","doi-asserted-by":"crossref","DOI":"10.3389\/fncir.2021.648624","article-title":"Neuromodulation of persistent activity and working memory circuitry in primate prefrontal cortex by muscarinic receptors","volume":"15","author":"Vijayraghavan","year":"2021","journal-title":"Frontiers in Neural Circuits"},{"issue":"2","key":"10.1016\/j.nlm.2021.107505_b0290","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1124\/jpet.118.248070","article-title":"Involvement of nicotinic receptor subtypes in the behavioral effects of nicotinic drugs in squirrel monkeys","volume":"366","author":"Withey","year":"2018","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"29","key":"10.1016\/j.nlm.2021.107505_b0295","doi-asserted-by":"crossref","first-page":"12078","DOI":"10.1073\/pnas.1307849110","article-title":"Nicotinic 7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex","volume":"110","author":"Yang","year":"2013","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"4","key":"10.1016\/j.nlm.2021.107505_b0300","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0149-2918(01)80059-X","article-title":"Mecamylamine: New therapeutic uses and toxicity\/risk profile","volume":"23","author":"Young","year":"2001","journal-title":"Clinical Therapeutics"},{"key":"10.1016\/j.nlm.2021.107505_b0305","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.neuropharm.2014.11.003","article-title":"Diversity of native nicotinic receptor subtypes in mammalian brain","volume":"96","author":"Zoli","year":"2015","journal-title":"Neuropharmacology"}],"container-title":["Neurobiology of Learning and Memory"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742721001271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742721001271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:40:33Z","timestamp":1761032433000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074742721001271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":62,"alternative-id":["S1074742721001271"],"URL":"https:\/\/doi.org\/10.1016\/j.nlm.2021.107505","relation":{},"ISSN":["1074-7427"],"issn-type":[{"value":"1074-7427","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of nicotinic antagonists on working memory performance in young rhesus monkeys","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Learning and Memory","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nlm.2021.107505","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107505"}}