{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:46:21Z","timestamp":1787165181493,"version":"build-2736575974"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004695","name":"University of KwaZulu-Natal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Learning and Memory"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.nlm.2022.107611","type":"journal-article","created":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T11:21:29Z","timestamp":1647084089000},"page":"107611","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Trauma-like exposure alters neuronal apoptosis, Bin1, Fkbp5 and NR2B expression in an amyloid-beta (1\u201342) rat model of Alzheimer's disease"],"prefix":"10.1016","volume":"190","author":[{"given":"Oluwaseun Samuel","family":"Faborode","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"Dalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa Vuyisile","family":"Mabandla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.nlm.2022.107611_b0010","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1073\/pnas.1114198109","article-title":"Novelty exposure overcomes foot shock-induced spatial-memory impairment by processes of synaptic-tagging in rats","volume":"109","author":"Almaguer-Melian","year":"2012","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.nlm.2022.107611_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2019.170102","article-title":"Anxiolytic impact of Apelin-13 in a rat model of Alzheimer\u2019s disease: Involvement of glucocorticoid receptor and FKBP5","volume":"118","author":"Aminyavari","year":"2019","journal-title":"Peptides"},{"issue":"12","key":"10.1016\/j.nlm.2022.107611_b0020","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA118.006379","article-title":"Reduction of the expression of the late-onset Alzheimer\u2019s disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model","volume":"294","author":"Andrew","year":"2019","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"10.1016\/j.nlm.2022.107611_b0025","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: Neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cognitive Processing"},{"issue":"AUG.","key":"10.1016\/j.nlm.2022.107611_b0030","article-title":"Differential cortical c-Fos and Zif-268 expression after object and spatial memory processing in a standard or episodic-like object recognition task","author":"Barbosa","year":"2013","journal-title":"Frontiers in Behavioral Neuroscience"},{"issue":"SUPPL. 1","key":"10.1016\/j.nlm.2022.107611_b0035","article-title":"The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders","volume":"34","author":"Binder","year":"2009","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.nlm.2022.107611_b0040","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0242-18.2019","article-title":"The disease-associated chaperone FKBP51 impairs cognitive function by accelerating AMPA receptor recycling","volume":"6","author":"Blair","year":"2019","journal-title":"ENeuro"},{"issue":"10","key":"10.1016\/j.nlm.2022.107611_b0045","doi-asserted-by":"crossref","DOI":"10.1172\/JCI69003","article-title":"Accelerated neurodegeneration through chaperone-mediated oligomerization of tau","volume":"123","author":"Blair","year":"2013","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.nlm.2022.107611_b0050","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neubiorev.2016.08.023","article-title":"Understanding posttraumatic stress disorder through fear conditioning, extinction and reconsolidation","volume":"71","author":"Careaga","year":"2016","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"10.1016\/j.nlm.2022.107611_b0055","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.3836-11.2011","article-title":"Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy","author":"Carroll","year":"2011","journal-title":"Journal of Neuroscience"},{"issue":"2","key":"10.1016\/j.nlm.2022.107611_b0060","doi-asserted-by":"crossref","DOI":"10.1002\/syn.22134","article-title":"Synapse impairment associated with enhanced apoptosis in post-traumatic stress disorder","volume":"74","author":"Chen","year":"2020","journal-title":"Synapse (New York, N. Y.)"},{"issue":"10","key":"10.1016\/j.nlm.2022.107611_b0065","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103082","article-title":"Neuronal cell death mechanisms in major neurodegenerative diseases","volume":"19","author":"Chi","year":"2018","journal-title":"International Journal of Molecular Sciences"},{"issue":"1738","key":"10.1016\/j.nlm.2022.107611_b0070","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2016.0532","article-title":"Hsp90 and FKBP51: Complex regulators of psychiatric diseases","volume":"373","author":"Criado-Marrero","year":"2018","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"issue":"3","key":"10.1016\/j.nlm.2022.107611_b0075","article-title":"Brain corticosteroid receptor balance in health and disease*","volume":"19","author":"de Kloet","year":"1998","journal-title":"Endocrine Reviews"},{"issue":"10","key":"10.1016\/j.nlm.2022.107611_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.02.026","article-title":"Neuronal BIN1 regulates presynaptic neurotransmitter release and memory consolidation","volume":"30","author":"De Rossi","year":"2020","journal-title":"Cell Reports"},{"issue":"5","key":"10.1016\/j.nlm.2022.107611_b0085","doi-asserted-by":"crossref","DOI":"10.1002\/ana.410270502","article-title":"Synapse loss in frontal cortex biopsies in Alzheimer\u2019s disease: Correlation with cognitive severity","volume":"27","author":"DeKosky","year":"1990","journal-title":"Annals of Neurology"},{"issue":"5","key":"10.1016\/j.nlm.2022.107611_b0090","doi-asserted-by":"crossref","DOI":"10.1007\/s10571-015-0156-z","article-title":"Protective effects of baicalin on A\u03b21\u201342-induced learning and memory deficit, oxidative stress, and apoptosis in rat","volume":"35","author":"Ding","year":"2015","journal-title":"Cellular and Molecular Neurobiology"},{"key":"10.1016\/j.nlm.2022.107611_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105170","article-title":"Exposure to footshock stress downregulates antioxidant genes and increases neuronal apoptosis in an A\u03b2(1\u201342) rat model of Alzheimer\u2019s disease","volume":"150","author":"Faborode","year":"2021","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.nlm.2022.107611_b0100","article-title":"Inescapable footshocks induce molecular changes in the prefrontal cortex of rats in an amyloid-beta-42 model of Alzheimer\u2019s disease","volume":"113679","author":"Faborode","year":"2021","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.nlm.2022.107611_b0105","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/978-1-4939-7571-6_25","article-title":"An animal model of alzheimer disease based on the intrahippocampal injection of amyloid \u03b2-peptide (1\u201342)","volume":"1727","author":"Facchinetti","year":"2018","journal-title":"Methods in Molecular Biology"},{"issue":"3","key":"10.1016\/j.nlm.2022.107611_b0110","doi-asserted-by":"crossref","DOI":"10.3233\/JAD-170702","article-title":"Role of genetics and epigenetics in the pathogenesis of Alzheimer\u2019s disease and frontotemporal dementia","volume":"62","author":"Fenoglio","year":"2018","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"10.1016\/j.nlm.2022.107611_b0115","article-title":"Glutamate and GABA imbalance promotes neuronal apoptosis in hippocampus after stress","volume":"20","author":"Gao","year":"2014","journal-title":"Medical Science Monitor"},{"issue":"2","key":"10.1016\/j.nlm.2022.107611_b0120","doi-asserted-by":"crossref","DOI":"10.1001\/archpsyc.63.2.168","article-title":"Role of genes and environments for explaining Alzheimer disease","volume":"63","author":"Gatz","year":"2006","journal-title":"Archives of General Psychiatry"},{"issue":"10","key":"10.1016\/j.nlm.2022.107611_b0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078806","article-title":"BIN1 is decreased in sporadic but not familial Alzheimer\u2019s disease or in aging","volume":"8","author":"Glennon","year":"2013","journal-title":"PLoS ONE"},{"issue":"3 SUPPL.","key":"10.1016\/j.nlm.2022.107611_b0130","first-page":"S155","article-title":"Stress, PTSD, and dementia","volume":"10","author":"Greenberg","year":"2014","journal-title":"Alzheimer\u2019s and Dementia"},{"issue":"4","key":"10.1016\/j.nlm.2022.107611_b0135","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.3892\/mmr.2017.7203","article-title":"Amyloid \u03b2-42 induces neuronal apoptosis by targeting mitochondria","volume":"16","author":"Han","year":"2017","journal-title":"Molecular Medicine Reports"},{"issue":"10","key":"10.1016\/j.nlm.2022.107611_b0140","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer\u2019s disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nature Genetics"},{"issue":"6286","key":"10.1016\/j.nlm.2022.107611_b0145","doi-asserted-by":"crossref","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.nlm.2022.107611_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2009.07.010","article-title":"The interaction between acute oligomer A\u03b21-40 and stress severely impaired spatial learning and memory","volume":"93","author":"Huang","year":"2010","journal-title":"Neurobiology of Learning and Memory"},{"issue":"3","key":"10.1016\/j.nlm.2022.107611_b0155","doi-asserted-by":"crossref","DOI":"10.1038\/s41386-018-0261-z","article-title":"Correction: ApoE2 Exaggerates PTSD-related behavioral, cognitive, and neuroendocrine alterations","volume":"44","author":"Johnson","year":"2019","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"10.1016\/j.nlm.2022.107611_b0160","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1523\/JNEUROSCI.3333-14.2015","article-title":"Posttraumatic stress disorder-like induction elevates \u03b2-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses","volume":"35","author":"Justice","year":"2015","journal-title":"Journal of Neuroscience"},{"issue":"2","key":"10.1016\/j.nlm.2022.107611_b0165","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/01616412.2018.1544745","article-title":"Time-dependent effect of oligomeric amyloid-\u03b2 (1\u201342)-induced hippocampal neurodegeneration in rat model of Alzheimer\u2019s disease","volume":"41","author":"Karthick","year":"2019","journal-title":"Neurological Research"},{"issue":"14","key":"10.1016\/j.nlm.2022.107611_b0170","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.21-14-05222.2001","article-title":"Amygdala is critical for stress-induced modulation of hippocampal long-term potentiation and learning","volume":"21","author":"Kim","year":"2001","journal-title":"Journal of Neuroscience"},{"issue":"12","key":"10.1016\/j.nlm.2022.107611_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/S0166-2236(98)01322-8","article-title":"Stress: Metaplastic effects in the hippocampus","volume":"21","author":"Kim","year":"1998","journal-title":"Trends in Neurosciences"},{"key":"10.1016\/j.nlm.2022.107611_b0180","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.220","article-title":"Mature neurons: equipped for survival","volume":"4","author":"Kole","year":"2013","journal-title":"Cell Death & Disease"},{"issue":"12","key":"10.1016\/j.nlm.2022.107611_b0185","doi-asserted-by":"crossref","DOI":"10.18632\/aging.101136","article-title":"Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex","volume":"8","author":"Koukouli","year":"2016","journal-title":"Aging"},{"issue":"1\u20133","key":"10.1016\/j.nlm.2022.107611_b0190","article-title":"Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo","volume":"649","author":"Li","year":"2010","journal-title":"European Journal of Pharmacology"},{"issue":"3","key":"10.1016\/j.nlm.2022.107611_b0195","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10571-016-0386-8","article-title":"Autophagy and Alzheimer\u2019s disease","volume":"37","author":"Li","year":"2017","journal-title":"Cellular and Molecular Neurobiology"},{"issue":"7","key":"10.1016\/j.nlm.2022.107611_b0200","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0006-3223(98)00246-7","article-title":"Brain activation in PTSD in response to trauma-related stimuli","volume":"45","author":"Liberzon","year":"1999","journal-title":"Biological Psychiatry"},{"issue":"10","key":"10.1016\/j.nlm.2022.107611_b0205","doi-asserted-by":"crossref","first-page":"951","DOI":"10.2174\/1567205012666151027124938","article-title":"Neurodegeneration in amygdala precedes hippocampus in the APPswe\/ PS1dE9 mouse model of Alzheimer\u2019s disease","volume":"12","author":"Lin","year":"2015","journal-title":"Current Alzheimer Research"},{"key":"10.1016\/j.nlm.2022.107611_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2014.12.005","article-title":"Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer\u2019s disease (APP\/PS1) transgenic mice","volume":"118","author":"Lin","year":"2015","journal-title":"Neurobiology of Learning and Memory"},{"issue":"FEB","key":"10.1016\/j.nlm.2022.107611_b0215","article-title":"The role of NMDA receptors in Alzheimer\u2019s disease","volume":"13","author":"Liu","year":"2019","journal-title":"Frontiers in Neuroscience"},{"issue":"4","key":"10.1016\/j.nlm.2022.107611_b0220","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"2","key":"10.1016\/j.nlm.2022.107611_b0225","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1021\/acschemneuro.6b00374","article-title":"Neurocytometry: Flow cytometric sorting of specific neuronal populations from human and rodent brain","volume":"8","author":"Martin","year":"2017","journal-title":"ACS Chemical Neuroscience"},{"issue":"8","key":"10.1016\/j.nlm.2022.107611_b0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220125","article-title":"Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo","volume":"14","author":"McAvoy","year":"2019","journal-title":"PLoS ONE"},{"issue":"3","key":"10.1016\/j.nlm.2022.107611_b0235","doi-asserted-by":"crossref","DOI":"10.1152\/physrev.00041.2006","article-title":"Physiology and neurobiology of stress and adaptation: Central role of the brain","volume":"87","author":"McEwen","year":"2007","journal-title":"Physiological Reviews"},{"issue":"1","key":"10.1016\/j.nlm.2022.107611_b0240","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-35725-5","article-title":"Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling","volume":"8","author":"Minnella","year":"2018","journal-title":"Scientific Reports"},{"issue":"14","key":"10.1016\/j.nlm.2022.107611_b0245","first-page":"2948","article-title":"BIN1 regulates BACE1 intracellular trafficking and amyloid-\u03b2 production","volume":"25","author":"Miyagawa","year":"2016","journal-title":"Human Molecular Genetics"},{"issue":"4","key":"10.1016\/j.nlm.2022.107611_b0250","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2990.2011.01181.x","article-title":"The three new pathways leading to Alzheimer\u2019s disease","volume":"37","author":"Morgan","year":"2011","journal-title":"Neuropathology and Applied Neurobiology"},{"issue":"1","key":"10.1016\/j.nlm.2022.107611_b0255","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"Journal of Neuroscience Methods"},{"issue":"7","key":"10.1016\/j.nlm.2022.107611_b0260","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006338","article-title":"Neurotoxicity of amyloid \u03b2-protein: Synaptic and network dysfunction","volume":"2","author":"Mucke","year":"2012","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"10.1016\/j.nlm.2022.107611_b0265","series-title":"The rat brain in stereotaxic coordinates: Hard cover edition","author":"Paxinos","year":"2007"},{"issue":"7636","key":"10.1016\/j.nlm.2022.107611_b0270","doi-asserted-by":"crossref","DOI":"10.1038\/nature20814","article-title":"Structural variation in amyloid-\u03b2 fibrils from Alzheimer\u2019s disease clinical subtypes","volume":"541","author":"Qiang","year":"2017","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.nlm.2022.107611_b0275","article-title":"Research paper: Stress-induced spatial memory deficit reversed by basolateral amygdala NMDA receptor inhibition in male wistar rats","volume":"11","author":"Rafia","year":"2020","journal-title":"Basic and Clinical Neuroscience"},{"key":"10.1016\/j.nlm.2022.107611_b0280","article-title":"Stress-enhanced fear learning, a robust rodent model of post-traumatic stress disorder","volume":"140","author":"Rajbhandari","year":"2018","journal-title":"Journal of Visualized Experiments"},{"issue":"4","key":"10.1016\/j.nlm.2022.107611_b0285","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4161\/auto.5778","article-title":"Apoptosis meets autophagy-like cell death in the ischemic penumbra: Two sides of the same coin?","volume":"4","author":"Rami","year":"2008","journal-title":"Autophagy"},{"issue":"9","key":"10.1016\/j.nlm.2022.107611_b0290","doi-asserted-by":"crossref","DOI":"10.1002\/bies.201600050","article-title":"FK506 binding protein 51 integrates pathways of adaptation: FKBP51 shapes the reactivity to environmental change","volume":"38","author":"Rein","year":"2016","journal-title":"BioEssays"},{"issue":"3","key":"10.1016\/j.nlm.2022.107611_b0295","doi-asserted-by":"crossref","DOI":"10.1006\/nlme.2002.4080","article-title":"Stress and memory: Opposing effects of glucocorticoids on memory consolidation and memory retrieval","volume":"78","author":"Roozendaal","year":"2002","journal-title":"Neurobiology of Learning and Memory"},{"issue":"3","key":"10.1016\/j.nlm.2022.107611_b0300","article-title":"The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: Dependence on the basolateral amygdala","volume":"100","author":"Roozendaal","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"10.1016\/j.nlm.2022.107611_b0305","doi-asserted-by":"crossref","DOI":"10.1037\/0735-7044.110.5.1074","article-title":"Basolateral amygdala lesions block glucocorticoid-induced modulation of memory for spatial learning","volume":"110","author":"Roozendaal","year":"1996","journal-title":"Behavioral Neuroscience"},{"issue":"1","key":"10.1016\/j.nlm.2022.107611_b0310","doi-asserted-by":"crossref","DOI":"10.1159\/000464422","article-title":"Molecular pathogenesis of alzheimer\u2019s disease: An update","volume":"24","author":"Sanabria-Castro","year":"2017","journal-title":"Annals of Neurosciences"},{"issue":"1","key":"10.1016\/j.nlm.2022.107611_b0315","doi-asserted-by":"crossref","DOI":"10.3109\/10253899609001092","article-title":"Stress, glucocorticoids, and damage to the nervous system: The current state of confusion","volume":"1","author":"Sapolsky","year":"1996","journal-title":"Stress"},{"issue":"11","key":"10.1016\/j.nlm.2022.107611_b0320","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.5345-07.2008","article-title":"Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons","volume":"28","author":"Schneider","year":"2008","journal-title":"Journal of Neuroscience"},{"issue":"9","key":"10.1016\/j.nlm.2022.107611_b0325","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-019-0407-3","article-title":"A novel role for the late-onset Alzheimer\u2019s disease (LOAD)-associated protein Bin1 in regulating postsynaptic trafficking and glutamatergic signaling","volume":"25","author":"Sch\u00fcrmann","year":"2020","journal-title":"Molecular Psychiatry"},{"issue":"9","key":"10.1016\/j.nlm.2022.107611_b0330","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.376","article-title":"Palmitoylethanolamide controls reactive gliosis and exerts neuroprotective functions in a rat model of Alzheimer\u2019s disease","volume":"5","author":"Scuderi","year":"2014","journal-title":"Cell Death and Disease"},{"issue":"2\u20133","key":"10.1016\/j.nlm.2022.107611_b0335","article-title":"Systemic inflammation induces apoptosis with variable vulnerability of different brain regions","volume":"30","author":"Semmler","year":"2005","journal-title":"Journal of Chemical Neuroanatomy"},{"key":"10.1016\/j.nlm.2022.107611_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2020.107187","article-title":"Memory decline correlates with increased plasma cytokines in amyloid-beta (1\u201342) rat model of Alzheimer\u2019s disease","volume":"169","author":"Shallie","year":"2020","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.nlm.2022.107611_b0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.112795","article-title":"Amyloid-beta (1\u201342) lesion of CA1 rat dorsal hippocampus reduces contextual fear memory and increases expression of microglial genes regulating neuroinflammation","author":"Shallie","year":"2020","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.nlm.2022.107611_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104636","article-title":"4,5 caffeoylquinic acid and scutellarin, identified by integrated metabolomics and proteomics approach as the active ingredients of Dengzhan Shengmai, act against chronic cerebral hypoperfusion by regulating glutamatergic and GABAergic synapses","volume":"152","author":"Sheng","year":"2020","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.nlm.2022.107611_b0355","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3389\/fncel.2014.00373","article-title":"De-regulation of gene expression and alternative splicing affects distinct cellular pathways in the aging hippocampus","volume":"8","author":"Stilling","year":"2014","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"12","key":"10.1016\/j.nlm.2022.107611_b0360","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A\u03b2-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"issue":"JAN","key":"10.1016\/j.nlm.2022.107611_b0365","article-title":"A review of adversity, the amygdala and the hippocampus: A consideration of developmental timing","volume":"3","author":"Tottenham","year":"2010","journal-title":"Frontiers in Human Neuroscience"},{"key":"10.1016\/j.nlm.2022.107611_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/S0079-6123(07)67003-4","article-title":"Amygdala modulation of memory-related processes in the hippocampus: Potential relevance to PTSD","volume":"167","author":"Tsoory","year":"2007","journal-title":"Progress in Brain Research"},{"key":"10.1016\/j.nlm.2022.107611_b0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2018.11.002","article-title":"Chemogenetic inactivation of the dorsal hippocampus and medial prefrontal cortex, individually and concurrently, impairs object recognition and spatial memory consolidation in female mice","volume":"156","author":"Tuscher","year":"2018","journal-title":"Neurobiology of Learning and Memory"},{"issue":"3","key":"10.1016\/j.nlm.2022.107611_b0380","doi-asserted-by":"crossref","DOI":"10.1017\/S1461145707008139","article-title":"Stress hormones and post-traumatic stress disorder in civilian trauma victims: A longitudinal study. Part II: The adrenergic response","volume":"11","author":"Videlock","year":"2008","journal-title":"International Journal of Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/j.nlm.2022.107611_b0385","doi-asserted-by":"crossref","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: Procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nature Protocols"},{"issue":"3","key":"10.1016\/j.nlm.2022.107611_b0390","article-title":"Neuronal apoptosis and expressions of Caspase-9 in hippocampus and amygdala of PTSD rats and their significances","volume":"39","author":"Wang","year":"2013","journal-title":"Journal of Jilin University Medicine Edition"},{"issue":"4","key":"10.1016\/j.nlm.2022.107611_b0395","doi-asserted-by":"crossref","DOI":"10.1007\/s12031-016-0755-2","article-title":"Role of the endoplasmic reticulum pathway in the medial prefrontal cortex in post-traumatic stress disorder model rats","volume":"59","author":"Wen","year":"2016","journal-title":"Journal of Molecular Neuroscience"},{"issue":"6","key":"10.1016\/j.nlm.2022.107611_b0400","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1001\/archgenpsychiatry.2010.61","article-title":"Posttraumatic stress disorder and risk of dementia among US veterans","volume":"67","author":"Yaffe","year":"2010","journal-title":"Archives of General Psychiatry"},{"issue":"9","key":"10.1016\/j.nlm.2022.107611_b0405","doi-asserted-by":"crossref","DOI":"10.1038\/sj.npp.1301605","article-title":"Effects of single prolonged stress and D-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD","volume":"33","author":"Yamamoto","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nlm.2022.107611_b0410","doi-asserted-by":"crossref","DOI":"10.1111\/j.1749-6632.2009.04979.x","article-title":"Status of glucocorticoid alterations in post-traumatic stress disorder","volume":"1179","author":"Yehuda","year":"2009","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.nlm.2022.107611_b0415","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.psychres.2018.03.037","article-title":"The effects of early trauma and the FKBP5 gene on PTSD and the HPA axis in a clinical sample of Gulf War veterans","volume":"270","author":"Young","year":"2018","journal-title":"Psychiatry Research"},{"issue":"2","key":"10.1016\/j.nlm.2022.107611_b0420","doi-asserted-by":"crossref","DOI":"10.1007\/s12192-014-0550-3","article-title":"Collaboration of geldanamycin-activated P70S6K and Hsp70 against beta-amyloid-induced hippocampal apoptosis: An approach to long-term memory and learning","volume":"20","author":"Zare","year":"2015","journal-title":"Cell Stress and Chaperones"},{"issue":"6","key":"10.1016\/j.nlm.2022.107611_b0425","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131525","article-title":"Curcumin improves amyloid \u03b2-peptide (1\u201342) induced spatial memory deficits through BDNF-ERK signaling pathway","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS ONE"},{"issue":"7","key":"10.1016\/j.nlm.2022.107611_b0430","doi-asserted-by":"crossref","DOI":"10.1007\/s10072-016-2546-5","article-title":"Dysfunction of NMDA receptors in Alzheimer\u2019s disease","volume":"37","author":"Zhang","year":"2016","journal-title":"Neurological Sciences"},{"issue":"1","key":"10.1016\/j.nlm.2022.107611_b0435","doi-asserted-by":"crossref","DOI":"10.1186\/s40246-021-00307-6","article-title":"Convergent lines of evidence support BIN1 as a risk gene of Alzheimer\u2019s disease","volume":"15","author":"Zhu","year":"2021","journal-title":"Human Genomics"}],"container-title":["Neurobiology of Learning and Memory"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742722000351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742722000351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:40:24Z","timestamp":1761032424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074742722000351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":86,"alternative-id":["S1074742722000351"],"URL":"https:\/\/doi.org\/10.1016\/j.nlm.2022.107611","relation":{},"ISSN":["1074-7427"],"issn-type":[{"value":"1074-7427","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trauma-like exposure alters neuronal apoptosis, Bin1, Fkbp5 and NR2B expression in an amyloid-beta (1\u201342) rat model of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Learning and Memory","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nlm.2022.107611","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107611"}}