{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:51:05Z","timestamp":1793987465670,"version":"4.8.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"am","delay-in-days":320,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32MH122092"],"award-info":[{"award-number":["F32MH122092"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH069558"],"award-info":[{"award-number":["MH069558"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH109484"],"award-info":[{"award-number":["MH109484"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH118237"],"award-info":[{"award-number":["MH118237"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001065","name":"Nathan Cummings Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Learning and Memory"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.nlm.2022.107626","type":"journal-article","created":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T17:34:46Z","timestamp":1652031286000},"page":"107626","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Isolation driven changes in Iba1-positive microglial morphology are associated with social recognition memory in adults and adolescents"],"prefix":"10.1016","volume":"192","author":[{"given":"Nicole C.","family":"Ferrara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Trask","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallika","family":"Padival","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred J.","family":"Helmstetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Amiel","family":"Rosenkranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.nlm.2022.107626_b0010","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.cell.2018.04.004","article-title":"Corticoamygdala transfer of socially derived information gates observational learning","volume":"173","author":"Allsop","year":"2018","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.nlm.2022.107626_b0015","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1523\/JNEUROSCI.3097-16.2017","article-title":"Optogenetic examination of prefrontal-amygdala synaptic development","volume":"37","author":"Arruda-Carvalho","year":"2017","journal-title":"Journal of Neuroscience"},{"issue":"1","key":"10.1016\/j.nlm.2022.107626_b0020","first-page":"195","article-title":"Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function","volume":"33","author":"Boelen","year":"2012","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.nlm.2022.107626_b0025","doi-asserted-by":"crossref","unstructured":"Carvalho-Paulo, D., Bento Torres Neto, J., de Oliveira, T. C. G., de Sousa, A. A., dos Reis, R. R., dos Santos, Z. A., ... , Pican\u00e7o Diniz, C. W. (2021). Microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states. Frontiers in immunology, 12, 2330.","DOI":"10.3389\/fimmu.2021.683026"},{"issue":"14","key":"10.1016\/j.nlm.2022.107626_b0030","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1002\/cne.22359","article-title":"Prefrontal cortical inputs to the basal amygdala undergo pruning during late adolescence in the rat","volume":"518","author":"Cressman","year":"2010","journal-title":"Journal of Comparative Neurology"},{"issue":"2\u20133","key":"10.1016\/j.nlm.2022.107626_b0035","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.physbeh.2003.08.003","article-title":"Novel-object place conditioning in adolescent and adult male and female rats: Effects of social isolation","volume":"80","author":"Douglas","year":"2003","journal-title":"Physiology & Behavior"},{"issue":"3","key":"10.1016\/j.nlm.2022.107626_b0040","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/dev.20025","article-title":"Rewarding properties of social interactions in adolescent and adult male and female rats: Impact of social versus isolate housing of subjects and partners","volume":"45","author":"Douglas","year":"2004","journal-title":"Developmental Psychobiology: The Journal of the International Society for Developmental Psychobiology"},{"issue":"2","key":"10.1016\/j.nlm.2022.107626_b0050","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.neuron.2014.02.040","article-title":"CSF1 receptor signaling is necessary for microglia viability, which unmasks a cell that rapidly repopulates the microglia-depleted adult brain","volume":"82","author":"Elmore","year":"2014","journal-title":"Neuron"},{"issue":"8","key":"10.1016\/j.nlm.2022.107626_b0055","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.3390\/ijms21083008","article-title":"Fear learning enhances prefrontal cortical suppression of auditory thalamic inputs to the amygdala in adults, but not adolescents","volume":"21","author":"Ferrara","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"45","key":"10.1016\/j.nlm.2022.107626_b0060","doi-asserted-by":"crossref","first-page":"9308","DOI":"10.1523\/JNEUROSCI.1414-21.2021","article-title":"Developmental shifts in amygdala activity during a high social drive state","volume":"41","author":"Ferrara","year":"2021","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2022.107626_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2021.01.021","article-title":"Maturation of amygdala inputs regulate shifts in social and fear behaviors: A substrate for developmental effects of stress","author":"Ferrara","year":"2021","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"10.1016\/j.nlm.2022.107626_b0070","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.brainres.2014.10.037","article-title":"Effects of prefrontal cortex and hippocampal NMDA NR1-subunit deletion on complex cognitive and social behaviors","volume":"1600","author":"Finlay","year":"2015","journal-title":"Brain Research"},{"issue":"3","key":"10.1016\/j.nlm.2022.107626_bib276","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1530\/JOE-11-0206","article-title":"The transformation of hormonal stress responses throughout puberty and adolescence","volume":"210","author":"Folib","year":"2011","journal-title":"Journal of Endocrinology"},{"issue":"1","key":"10.1016\/j.nlm.2022.107626_b0080","doi-asserted-by":"crossref","first-page":"e15973","DOI":"10.1371\/journal.pone.0015973","article-title":"Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission","volume":"6","author":"Fontainhas","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.nlm.2022.107626_b0085","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.conb.2017.10.007","article-title":"Environment matters: Microglia function and dysfunction in a changing world","volume":"47","author":"Hanamsagar","year":"2017","journal-title":"Current Opinion in Neurobiology"},{"issue":"2","key":"10.1016\/j.nlm.2022.107626_b0090","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/glia.10161","article-title":"Microglia as a source and target of cytokines","volume":"40","author":"Hanisch","year":"2002","journal-title":"Glia"},{"issue":"2","key":"10.1016\/j.nlm.2022.107626_bib274","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3758\/BRM.41.2.472","article-title":"CowLog: Open-source software for coding behaviors from digital video","volume":"41","author":"H\u00e4nninen","year":"2009","journal-title":"Behavior research methods"},{"issue":"6","key":"10.1016\/j.nlm.2022.107626_b0095","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/cercor\/bhr229","article-title":"Evidence that microglia mediate the neurobiological effects of chronic psychological stress on the medial prefrontal cortex","volume":"22","author":"Hinwood","year":"2012","journal-title":"Cerebral Cortex"},{"issue":"2","key":"10.1016\/j.nlm.2022.107626_b0100","doi-asserted-by":"crossref","first-page":"107899","DOI":"10.1016\/j.celrep.2020.107899","article-title":"Social behavior is modulated by valence-encoding mPFC-amygdala sub-circuitry","volume":"32","author":"Huang","year":"2020","journal-title":"Cell Reports"},{"issue":"1","key":"10.1016\/j.nlm.2022.107626_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-328X(98)00040-0","article-title":"Microglia-specific localisation of a novel calcium binding protein, Iba1","volume":"57","author":"Ito","year":"1998","journal-title":"Molecular Brain Research"},{"issue":"4","key":"10.1016\/j.nlm.2022.107626_b0110","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nn.2504","article-title":"Observational fear learning involves affective pain system and Ca v 1.2 Ca 2+ channels in ACC","volume":"13","author":"Jeon","year":"2010","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.nlm.2022.107626_b0115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fncel.2013.00003","article-title":"Quantitating the subtleties of microglial morphology with fractal analysis","volume":"7","author":"Karperien","year":"2013","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"2","key":"10.1016\/j.nlm.2022.107626_b0120","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.bbr.2010.09.007","article-title":"Adolescent social isolation changes social recognition in adult mice","volume":"216","author":"Kercmar","year":"2011","journal-title":"Behavioural Brain Research"},{"issue":"11","key":"10.1016\/j.nlm.2022.107626_b0125","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/mp.2016.103","article-title":"Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects","volume":"22","author":"Kim","year":"2017","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.nlm.2022.107626_b0130","doi-asserted-by":"crossref","first-page":"e64567","DOI":"10.7554\/eLife.64567","article-title":"Linking mPFC circuit maturation to the developmental regulation of emotional memory and cognitive flexibility","volume":"10","author":"Klune","year":"2021","journal-title":"Elife"},{"issue":"19","key":"10.1016\/j.nlm.2022.107626_b0135","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.3390\/molecules26195984","article-title":"Cannabinoid receptor 2 alters social memory and microglial activity in an age-dependent manner","volume":"26","author":"Komorowska-M\u00fcller","year":"2021","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.nlm.2022.107626_b0140","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/syn.21716","article-title":"Dendritic remodeling in the adolescent medial prefrontal cortex and the basolateral amygdala of male and female rats","volume":"68","author":"Koss","year":"2014","journal-title":"Synapse"},{"issue":"1","key":"10.1016\/j.nlm.2022.107626_b0145","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1037\/h0033328","article-title":"Long- and short-term social deprivation and sociability in rats","volume":"81","author":"Latane","year":"1972","journal-title":"Journal of Comparative and Physiological Psychology"},{"key":"10.1016\/j.nlm.2022.107626_b0150","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.nlm.2015.07.002","article-title":"The effects of acute social isolation on long-term social recognition memory","volume":"124","author":"Leser","year":"2015","journal-title":"Neurobiology of Learning and Memory"},{"issue":"1","key":"10.1016\/j.nlm.2022.107626_b0155","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.14016","article-title":"Neural mechanisms of social homeostasis","volume":"1457","author":"Matthews","year":"2019","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"1","key":"10.1016\/j.nlm.2022.107626_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-13581-z","article-title":"Quantitative microglia analyses reveal diverse morphologic responses in the rat cortex after diffuse brain injury","volume":"7","author":"Morrison","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.nlm.2022.107626_b0165","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.bbi.2019.11.023","article-title":"Repeated stress induces a pro-inflammatory state, increases amygdala neuronal and microglial activation, and causes anxiety in adult male rats","volume":"84","author":"Munshi","year":"2020","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/j.nlm.2022.107626_bib273","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroscience.2018.08.017","article-title":"Effects of peripheral immune challenge on in vivo firing of basolateral amygdala neurons in adult male rats","volume":"390","author":"Munshi","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.nlm.2022.107626_b0170","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.bbr.2016.09.006","article-title":"Microglia depletion in early life programs persistent changes in social, mood-related, and locomotor behavior in male and female rats","volume":"316","author":"Nelson","year":"2017","journal-title":"Behavioural Brain Research"},{"issue":"5","key":"10.1016\/j.nlm.2022.107626_b0175","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.celrep.2018.06.113","article-title":"Colony-stimulating factor 1 receptor (CSF1R) regulates microglia density and distribution, but not microglia differentiation in vivo","volume":"24","author":"Oosterhof","year":"2018","journal-title":"Cell Reports"},{"issue":"7","key":"10.1016\/j.nlm.2022.107626_b0180","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nn.2341","article-title":"Adenosine A 2A receptor mediates microglial process retraction","volume":"12","author":"Orr","year":"2009","journal-title":"Nature Neuroscience"},{"issue":"17","key":"10.1016\/j.nlm.2022.107626_b0185","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1242\/jcs.113.17.3073","article-title":"Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages\/microglia","volume":"113","author":"Ohsawa","year":"2000","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.nlm.2022.107626_bib275","article-title":"The rat brain in stereotaxic coordinates: hard cover edition","author":"Paxinos","year":"2007","journal-title":"Elsevier"},{"issue":"3","key":"10.1016\/j.nlm.2022.107626_bib271","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/dev.420230303","article-title":"Differential rates of attack, defense, and counterattack during the developmental decrease in play fighting by male and female rats","volume":"23","author":"Pellis","year":"1990","journal-title":"The Journal of the International Society for Developmental Psychobiology"},{"issue":"1","key":"10.1016\/j.nlm.2022.107626_b0190","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1677\/joe.1.06972","article-title":"Adrenarche in the rat","volume":"191","author":"Pignatelli","year":"2006","journal-title":"Journal of Endocrinology"},{"issue":"11","key":"10.1016\/j.nlm.2022.107626_b0195","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.2174\/13894501113149990208","article-title":"Acute and chronic stress-induced disturbances of microglial plasticity, phenotype and function","volume":"14","author":"Rohan Walker","year":"2013","journal-title":"Current Drug Targets"},{"issue":"2","key":"10.1016\/j.nlm.2022.107626_b0200","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1006\/bbrc.2001.5388","article-title":"Iba1 is an actin-cross-linking protein in macrophages\/microglia","volume":"286","author":"Sasaki","year":"2001","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"1","key":"10.1016\/j.nlm.2022.107626_bib272","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00441-013-1581-2","article-title":"Adolescence as a vulnerable period to alter rodent behavior","volume":"354","author":"Schneider","year":"2013","journal-title":"Cell and tissue research"},{"issue":"1","key":"10.1016\/j.nlm.2022.107626_b0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-35649-0","article-title":"Limited prefrontal cortical regulation over the basolateral amygdala in adolescent rats","volume":"8","author":"Selleck","year":"2018","journal-title":"Scientific Reports"},{"issue":"5","key":"10.1016\/j.nlm.2022.107626_b0210","doi-asserted-by":"crossref","first-page":"e65085","DOI":"10.1371\/journal.pone.0065085","article-title":"Rapid and reversible impairments of short-and long-term social recognition memory are caused by acute isolation of adult rats via distinct mechanisms","volume":"8","author":"Shahar-Gold","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.nlm.2022.107626_b0215","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bbi.2015.09.001","article-title":"Dynamic microglial modulation of spatial learning and social behavior","volume":"55","author":"Torres","year":"2016","journal-title":"Brain, Behavior, and Immunity"},{"issue":"3","key":"10.1016\/j.nlm.2022.107626_b0220","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nn.4481","article-title":"An intra-amygdala circuit specifically regulates social fear learning","volume":"20","author":"Twining","year":"2017","journal-title":"Nature Neuroscience"},{"issue":"7","key":"10.1016\/j.nlm.2022.107626_b0225","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/dev.21064","article-title":"Social context induces two unique patterns of c-Fos expression in adolescent and adult rats","volume":"55","author":"Varlinskaya","year":"2013","journal-title":"Developmental Psychobiology"},{"issue":"6056","key":"10.1016\/j.nlm.2022.107626_b0230","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1126\/science.1209951","article-title":"Bidirectional control of social hierarchy by synaptic efficacy in medial prefrontal cortex","volume":"334","author":"Wang","year":"2011","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.nlm.2022.107626_b0235","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00429-011-0355-4","article-title":"Differential neuronal changes in medial prefrontal cortex, basolateral amygdala and nucleus accumbens after postweaning social isolation","volume":"217","author":"Wang","year":"2012","journal-title":"Brain Structure and Function"},{"issue":"9","key":"10.1016\/j.nlm.2022.107626_b0240","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.psyneuen.2012.02.003","article-title":"Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice","volume":"37","author":"Wohleb","year":"2012","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"10.1016\/j.nlm.2022.107626_b0245","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00429-012-0446-x","article-title":"Differential distribution and activation of microglia in the brain of male C57BL\/6J mice","volume":"218","author":"Yang","year":"2013","journal-title":"Brain Structure and Function"},{"key":"10.1016\/j.nlm.2022.107626_b0250","doi-asserted-by":"crossref","unstructured":"Young, K., & Morrison, H. (2018). Quantifying microglia morphology from photomicrographs of immunohistochemistry prepared tissue using ImageJ. Journal of Visualized Experiments: JoVE, (136).","DOI":"10.3791\/57648-v"},{"key":"10.1016\/j.nlm.2022.107626_b0255","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.bbr.2012.12.050","article-title":"Post-weaning social isolation impairs observational fear conditioning","volume":"242","author":"Yusufishaq","year":"2013","journal-title":"Behavioural Brain Research"},{"issue":"3","key":"10.1016\/j.nlm.2022.107626_b0260","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nn.3641","article-title":"Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior","volume":"17","author":"Zhan","year":"2014","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.nlm.2022.107626_b0265","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bbi.2019.02.010","article-title":"Deficiencies of microglia and TNF\u03b1 in the mPFC-mediated cognitive inflexibility induced by social stress during adolescence","volume":"79","author":"Zhang","year":"2019","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/j.nlm.2022.107626_b0270","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbi.2014.01.017","article-title":"Neonatal intrahippocampal injection of lipopolysaccharide induces deficits in social behavior and prepulse inhibition and microglial activation in rats: Implication for a new schizophrenia animal model","volume":"38","author":"Zhu","year":"2014","journal-title":"Brain, Behavior, and Immunity"}],"container-title":["Neurobiology of Learning and Memory"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742722000508?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742722000508?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:40:18Z","timestamp":1761032418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074742722000508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":57,"alternative-id":["S1074742722000508"],"URL":"https:\/\/doi.org\/10.1016\/j.nlm.2022.107626","relation":{},"ISSN":["1074-7427"],"issn-type":[{"value":"1074-7427","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isolation driven changes in Iba1-positive microglial morphology are associated with social recognition memory in adults and adolescents","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Learning and Memory","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nlm.2022.107626","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107626"}}