{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:10:48Z","timestamp":1791364248676,"version":"4.3.1"},"reference-count":129,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Learning and Memory"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.nlm.2022.107656","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T19:34:02Z","timestamp":1656790442000},"page":"107656","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Brain derived neurotrophic factor in perioperative neurocognitive disorders: Current evidence and future directions"],"prefix":"10.1016","volume":"193","author":[{"given":"Nikolaj","family":"Travica","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajara","family":"Aslam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"O'Neil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa M.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Gamage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Walder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe S.J.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Segasby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Marx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nlm.2022.107656_b0005","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/ACO.0000000000000812","article-title":"Postoperative neurocognitive disorders","volume":"33","author":"Olotu","year":"2020","journal-title":"Current Opinion in Anesthesiology"},{"key":"10.1016\/j.nlm.2022.107656_b0010","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.bja.2019.07.004","article-title":"State of the clinical science of perioperative brain health: Report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018","volume":"123","author":"Mahanna-Gabrielli","year":"2019","journal-title":"British journal of anaesthesia"},{"key":"10.1016\/j.nlm.2022.107656_b0015","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1097\/ALN.0000000000002334","article-title":"Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery\u20142018","volume":"129","author":"Evered","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1016\/j.nlm.2022.107656_b0020","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1213\/ANE.0000000000003514","article-title":"Postoperative cognitive dysfunction and noncardiac surgery","volume":"127","author":"Evered","year":"2018","journal-title":"Anesthesia & Analgesia"},{"key":"10.1016\/j.nlm.2022.107656_b0025","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/aas.12724","article-title":"Post-operative cognitive dysfunction at 3 months in adults after non-cardiac surgery: A qualitative systematic review","volume":"60","author":"Paredes","year":"2016","journal-title":"Acta Anaesthesiologica Scandinavica"},{"key":"10.1016\/j.nlm.2022.107656_b0030","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3109\/00207454.2013.833919","article-title":"Postoperative cognitive dysfunction, Alzheimer's disease, and anesthesia","volume":"124","author":"Arora","year":"2014","journal-title":"International Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2019.110791","article-title":"The potential mechanism of postoperative cognitive dysfunction in older people","volume":"130","author":"Lin","year":"2020","journal-title":"Experimental gerontology"},{"key":"10.1016\/j.nlm.2022.107656_b0040","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.12659\/MSM.892485","article-title":"Postoperative cognitive dysfunction: Current developments in mechanism and prevention","volume":"20","author":"Wang","year":"2014","journal-title":"Medical Science Monitor: International medical journal of experimental and clinical research"},{"key":"10.1016\/j.nlm.2022.107656_b0045","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/j.1399-6576.2010.02268.x","article-title":"New insights into the pathophysiology of postoperative cognitive dysfunction","volume":"54","author":"Krenk","year":"2010","journal-title":"Acta Anaesthesiologica Scandinavica"},{"key":"10.1016\/j.nlm.2022.107656_b0050","doi-asserted-by":"crossref","first-page":"i115","DOI":"10.1093\/bja\/aex354","article-title":"Postoperative cognitive dysfunction and dementia: What we need to know and do","volume":"119","author":"Needham","year":"2017","journal-title":"BJA: British Journal of Anaesthesia"},{"key":"10.1016\/j.nlm.2022.107656_b0055","doi-asserted-by":"crossref","unstructured":"Safavynia SA, Goldstein PA. The role of neuroinflammation in postoperative cognitive dysfunction: moving from hypothesis to treatment. Frontiers in psychiatry 2019:752.","DOI":"10.3389\/fpsyt.2018.00752"},{"key":"10.1016\/j.nlm.2022.107656_b0060","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fnagi.2015.00112","article-title":"Biomarkers of postoperative delirium and cognitive dysfunction","volume":"7","author":"Androsova","year":"2015","journal-title":"Frontiers in aging neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0065","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/ALN.0000000000000953","article-title":"Cerebrospinal fluid biomarker for Alzheimer disease predicts postoperative cognitive dysfunction","volume":"124","author":"Evered","year":"2016","journal-title":"Anesthesiology"},{"key":"10.1016\/j.nlm.2022.107656_b0070","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/sj.npp.1301571","article-title":"Interaction between BDNF and serotonin: Role in mood disorders","volume":"33","author":"Martinowich","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nlm.2022.107656_b0075","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.5114\/aoms.2015.56342","article-title":"Brain-derived neurotrophic factor and its clinical implications","volume":"11","author":"Bathina","year":"2015","journal-title":"Archives of medical science: AMS"},{"key":"10.1016\/j.nlm.2022.107656_b0080","doi-asserted-by":"crossref","first-page":"12764","DOI":"10.1523\/JNEUROSCI.3566-09.2009","article-title":"New insights in the biology of BDNF synthesis and release: Implications in CNS function","volume":"29","author":"Greenberg","year":"2009","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0085","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/378192a0","article-title":"Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo","volume":"378","author":"Cohen-Cory","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.nlm.2022.107656_b0090","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrn3650","article-title":"Branch management: Mechanisms of axon branching in the developing vertebrate CNS","volume":"15","author":"Kalil","year":"2014","journal-title":"Nature Reviews Neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0095","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fnsyn.2014.00005","article-title":"The BDNF effects on dendritic spines of mature hippocampal neurons depend on neuronal activity","volume":"6","author":"Kellner","year":"2014","journal-title":"Frontiers in synaptic neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0100","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s12035-009-8050-7","article-title":"Activity-dependent dendritic release of BDNF and biological consequences","volume":"39","author":"Kuczewski","year":"2009","journal-title":"Molecular neurobiology"},{"key":"10.1016\/j.nlm.2022.107656_b0105","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10571-017-0510-4","article-title":"BDNF: A key factor with multipotent impact on brain signaling and synaptic plasticity","volume":"38","author":"Kowia\u0144ski","year":"2018","journal-title":"Cellular and molecular neurobiology"},{"key":"10.1016\/j.nlm.2022.107656_b0110","first-page":"1","article-title":"A simple role for BDNF in learning and memory?","volume":"3","author":"Cunha","year":"2010","journal-title":"Frontiers in molecular neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0115","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3389\/fncel.2019.00363","article-title":"Brain-derived neurotrophic factor: A key molecule for memory in the healthy and the pathological brain","volume":"13","author":"Miranda","year":"2019","journal-title":"Frontiers in cellular neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0120","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/nrn2738","article-title":"TrkB signalling pathways in LTP and learning","volume":"10","author":"Minichiello","year":"2009","journal-title":"Nature Reviews Neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0125","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0896-6273(02)00942-X","article-title":"Mechanism of TrkB-mediated hippocampal long-term potentiation","volume":"36","author":"Minichiello","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.nlm.2022.107656_b0130","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.nlm.2007.08.018","article-title":"BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?","volume":"89","author":"Lu","year":"2008","journal-title":"Neurobiology of learning and memory"},{"key":"10.1016\/j.nlm.2022.107656_b0135","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0301-0082(00)00014-9","article-title":"Brain-derived neurotrophic factor in the control human brain, and in Alzheimer\u2019s disease and Parkinson\u2019s disease","volume":"63","author":"Murer","year":"2001","journal-title":"Progress in neurobiology"},{"key":"10.1016\/j.nlm.2022.107656_b0140","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.neuron.2008.09.024","article-title":"A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition","volume":"60","author":"Hong","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.nlm.2022.107656_b0145","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fnins.2018.00052","article-title":"Exercise-mediated neurogenesis in the hippocampus via BDNF","volume":"12","author":"Liu","year":"2018","journal-title":"Frontiers in neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0150","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4306\/pi.2010.7.4.231","article-title":"The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment","volume":"7","author":"Lee","year":"2010","journal-title":"Psychiatry investigation"},{"key":"10.1016\/j.nlm.2022.107656_b0155","article-title":"The neurotrophic and neuroprotective effects of psychotropic agents","author":"Hunsberger","year":"2022","journal-title":"Dialogues in clinical neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0160","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2592319","article-title":"Chronic mild stress modulates activity-dependent transcription of BDNF in rat hippocampal slices","volume":"2016","author":"Molteni","year":"2016","journal-title":"Neural plasticity"},{"key":"10.1016\/j.nlm.2022.107656_b0165","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.yfrne.2006.09.004","article-title":"Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: Complexity of steroid hormone-growth factor interactions in the adult CNS","volume":"27","author":"Scharfman","year":"2006","journal-title":"Frontiers in neuroendocrinology"},{"key":"10.1016\/j.nlm.2022.107656_b0170","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuroscience.2012.10.019","article-title":"Interactions between estradiol, BDNF and dendritic spines in promoting memory","volume":"239","author":"Luine","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-45976-5","article-title":"Associations between serum and plasma brain-derived neurotrophic factor and influence of storage time and centrifugation strategy","volume":"9","author":"Gejl","year":"2019","journal-title":"Scientific reports"},{"key":"10.1016\/j.nlm.2022.107656_b0180","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/S1461145710000738","article-title":"Blood BDNF concentrations reflect brain-tissue BDNF levels across species","volume":"14","author":"Klein","year":"2011","journal-title":"International Journal of Neuropsychopharmacology"},{"key":"10.1016\/j.nlm.2022.107656_b0185","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1055\/s-0029-1224162","article-title":"Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats","volume":"42","author":"Sartorius","year":"2009","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.nlm.2022.107656_b0190","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1177\/1073858407302725","article-title":"Brain plasticity mechanisms and memory: A party of four","volume":"13","author":"Bruel-Jungerman","year":"2007","journal-title":"The Neuroscientist"},{"key":"10.1016\/j.nlm.2022.107656_b0195","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/bja\/aex041","article-title":"Predicting postoperative brain function from the blood: Is there a role for biomarkers?","volume":"119","author":"Vutskits","year":"2017","journal-title":"BJA: British Journal of Anaesthesia"},{"key":"10.1016\/j.nlm.2022.107656_b0200","first-page":"1132","article-title":"Dynamic association of plasma brain-derived neurotrophic factor, neuron-specific enolase, and S100\u03b2with delirium in critically ill patients","author":"Hui","year":"2018","journal-title":"Chinese Journal of Emergency Medicine"},{"key":"10.1016\/j.nlm.2022.107656_b0205","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jcrc.2019.12.010","article-title":"Association of neuronal repair biomarkers with delirium among survivors of critical illness","volume":"56","author":"Hayhurst","year":"2020","journal-title":"Journal of critical care"},{"key":"10.1016\/j.nlm.2022.107656_b0210","doi-asserted-by":"crossref","unstructured":"Williams J, Finn K, Melvin V, Meagher D, McCarthy G, Adamis D. The Association of serum levels of brain-derived neurotrophic factor with the occurrence of and recovery from delirium in older medical inpatients. BioMed research international 2017;2017.","DOI":"10.1155\/2017\/5271395"},{"key":"10.1016\/j.nlm.2022.107656_b0215","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jcrc.2010.10.006","article-title":"Brain-derived neurotrophic factor and neuron-specific enolase, but not S100\u03b2, levels are associated to the occurrence of delirium in intensive care unit patients","volume":"26","author":"Grandi","year":"2011","journal-title":"Journal of critical care"},{"key":"10.1016\/j.nlm.2022.107656_b0220","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/sj.mp.4001957","article-title":"Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories","volume":"12","author":"Heldt","year":"2007","journal-title":"Molecular psychiatry"},{"key":"10.1016\/j.nlm.2022.107656_b0225","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.neuron.2006.11.025","article-title":"Persistence of long-term memory storage requires a late protein synthesis-and BDNF-dependent phase in the hippocampus","volume":"53","author":"Bekinschtein","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.nlm.2022.107656_b0230","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0006-8993(98)00993-7","article-title":"Expression of BDNF and trkB as a function of age and cognitive performance","volume":"812","author":"Croll","year":"1998","journal-title":"Brain research"},{"key":"10.1016\/j.nlm.2022.107656_b0235","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1006\/exnr.1999.7109","article-title":"Brain-derived neurotrophic factor improves long-term potentiation and cognitive functions after transient forebrain ischemia in the rat","volume":"159","author":"Kiprianova","year":"1999","journal-title":"Experimental neurology"},{"key":"10.1016\/j.nlm.2022.107656_b0240","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1017\/S1461145710001008","article-title":"Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients","volume":"14","author":"Laske","year":"2011","journal-title":"International Journal of Neuropsychopharmacology"},{"key":"10.1016\/j.nlm.2022.107656_b0245","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fnagi.2014.00069","article-title":"A large, cross-sectional observational study of serum BDNF, cognitive function, and mild cognitive impairment in the elderly","volume":"6","author":"Shimada","year":"2014","journal-title":"Frontiers in aging neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0250","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.nlm.2008.07.014","article-title":"BDNF is a novel marker of cognitive function in ageing women: The DR\u2019s EXTRA Study","volume":"90","author":"Komulainen","year":"2008","journal-title":"Neurobiology of learning and memory"},{"key":"10.1016\/j.nlm.2022.107656_b0255","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1177\/0891988708316860","article-title":"Serum brain-derived neurotrophic factor is associated with cognitive function in healthy older adults","volume":"21","author":"Gunstad","year":"2008","journal-title":"Journal of geriatric psychiatry and neurology"},{"key":"10.1016\/j.nlm.2022.107656_b0260","doi-asserted-by":"crossref","first-page":"5368","DOI":"10.1523\/JNEUROSCI.6251-09.2010","article-title":"Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume","volume":"30","author":"Erickson","year":"2010","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0265","article-title":"Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects","volume":"4","author":"Li","year":"2009","journal-title":"PloS one"},{"key":"10.1016\/j.nlm.2022.107656_b0270","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3233\/JAD-160593","article-title":"BDNF responses in healthy older persons to 35 minutes of physical exercise, cognitive training, and mindfulness: Associations with working memory function","volume":"55","author":"H\u00e5kansson","year":"2017","journal-title":"Journal of Alzheimer's Disease"},{"key":"10.1016\/j.nlm.2022.107656_b0275","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.physbeh.2011.06.005","article-title":"Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males","volume":"104","author":"Griffin","year":"2011","journal-title":"Physiology & behavior"},{"key":"10.1016\/j.nlm.2022.107656_b0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091339","article-title":"The associations between serum brain-derived neurotrophic factor, potential confounders, and cognitive decline: A longitudinal study","volume":"9","author":"Nettiksimmons","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nlm.2022.107656_b0285","doi-asserted-by":"crossref","unstructured":"Ng TKS, Ho CSH, Tam WWS, Kua EH, Ho RC-M. Decreased serum brain-derived neurotrophic factor (BDNF) levels in patients with Alzheimer\u2019s disease (AD): a systematic review and meta-analysis. International journal of molecular sciences 2019;20:257.","DOI":"10.3390\/ijms20020257"},{"key":"10.1016\/j.nlm.2022.107656_b0290","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.parkreldis.2016.05.023","article-title":"Low BDNF is associated with cognitive impairments in patients with Parkinson\u2019s disease","volume":"29","author":"Wang","year":"2016","journal-title":"Parkinsonism & related disorders"},{"key":"10.1016\/j.nlm.2022.107656_b0295","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/ajmg.b.30501","article-title":"Low brain-derived neurotrophic factor (BDNF) levels in serum of Huntington's disease patients","volume":"144","author":"Ciammola","year":"2007","journal-title":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"},{"key":"10.1016\/j.nlm.2022.107656_b0300","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neulet.2005.12.085","article-title":"Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes","volume":"398","author":"Cunha","year":"2006","journal-title":"Neuroscience letters"},{"key":"10.1016\/j.nlm.2022.107656_b0305","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/j.1471-4159.2005.03135.x","article-title":"Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease","volume":"93","author":"Peng","year":"2005","journal-title":"Journal of neurochemistry"},{"key":"10.1016\/j.nlm.2022.107656_b0310","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainresrev.2008.07.007","article-title":"New insights into brain BDNF function in normal aging and Alzheimer disease","volume":"59","author":"Tapia-Arancibia","year":"2008","journal-title":"Brain research reviews"},{"key":"10.1016\/j.nlm.2022.107656_b0315","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.bbi.2014.02.002","article-title":"Postoperative cognitive dysfunction: Involvement of neuroinflammation and neuronal functioning","volume":"38","author":"Hovens","year":"2014","journal-title":"Brain, behavior, and immunity"},{"key":"10.1016\/j.nlm.2022.107656_b0320","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neulet.2018.03.043","article-title":"Dexmedetomidine promotes the recovery of neurogenesis in aged mouse with postoperative cognitive dysfunction","volume":"677","author":"Wang","year":"2018","journal-title":"Neuroscience letters"},{"key":"10.1016\/j.nlm.2022.107656_b0325","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3389\/fnmol.2019.00246","article-title":"Histone H3K9 trimethylation downregulates the expression of brain-derived neurotrophic factor in the dorsal hippocampus and impairs memory formation during anaesthesia and surgery","volume":"12","author":"Wu","year":"2019","journal-title":"Frontiers in molecular neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0330","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s12035-014-8659-z","article-title":"Epigenetic enhancement of brain-derived neurotrophic factor signaling pathway improves cognitive impairments induced by isoflurane exposure in aged rats","volume":"50","author":"Ji","year":"2014","journal-title":"Molecular neurobiology"},{"key":"10.1016\/j.nlm.2022.107656_b0335","first-page":"6","article-title":"Effect of minor surgery under propofol anaesthesia on brain BDNF and cognition","volume":"13","author":"Rafiq","year":"2018","journal-title":"Pakistan Journal of Neurological Sciences (PJNS)"},{"key":"10.1016\/j.nlm.2022.107656_b0340","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3892\/etm.2014.1769","article-title":"Emulsified isoflurane anesthesia decreases brain-derived neurotrophic factor expression and induces cognitive dysfunction in adult rats","volume":"8","author":"Zhang","year":"2014","journal-title":"Experimental and therapeutic medicine"},{"key":"10.1016\/j.nlm.2022.107656_b0345","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neuroscience.2011.05.073","article-title":"Peripheral orthopaedic surgery down-regulates hippocampal brain-derived neurotrophic factor and impairs remote memory in mouse","volume":"190","author":"Fidalgo","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0350","first-page":"123","article-title":"Finding the Effect of Minor Surgery Under Propofol Anaesthesia on Brain BDNF in Pakistan","volume":"12","author":"Pasha","year":"2021","journal-title":"Systematic Reviews in Pharmacology"},{"key":"10.1016\/j.nlm.2022.107656_b0355","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s11064-007-9586-4","article-title":"Plasma concentrations of brain-derived neurotrophic factor in patients undergoing minor surgery: A randomized controlled trial","volume":"33","author":"Vutskits","year":"2008","journal-title":"Neurochemical research"},{"key":"10.1016\/j.nlm.2022.107656_b0360","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.clinbiochem.2012.02.025","article-title":"Plasma concentrations but not serum concentrations of brain-derived neurotrophic factor are related to pro-inflammatory cytokines in patients undergoing major abdominal surgery","volume":"45","author":"Chimienti","year":"2012","journal-title":"Clinical biochemistry"},{"key":"10.1016\/j.nlm.2022.107656_b0365","first-page":"495","article-title":"Breast cancer surgery decreases serum brain-derived neurotrophic factor concentrations in middle aged women: Relationship to the serum c-reactive protein concentration","volume":"70","author":"Zoladz","year":"2019","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.nlm.2022.107656_b0370","first-page":"3886","article-title":"Effect of different anesthesia techniques on the serum brain-derived neurotrophic factor (BDNF) levels","volume":"19","author":"Ozer","year":"2015","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"10.1016\/j.nlm.2022.107656_b0375","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bbi.2016.02.003","article-title":"Postoperative cognitive dysfunction and neuroinflammation; cardiac surgery and abdominal surgery are not the same","volume":"54","author":"Hovens","year":"2016","journal-title":"Brain, behavior, and immunity"},{"key":"10.1016\/j.nlm.2022.107656_b0380","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/cns.12368","article-title":"Surgical stress induces brain-derived neurotrophic factor reduction and postoperative cognitive dysfunction via glucocorticoid receptor phosphorylation in aged mice","volume":"21","author":"Tian","year":"2015","journal-title":"CNS neuroscience & therapeutics"},{"key":"10.1016\/j.nlm.2022.107656_b0385","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bbi.2015.08.002","article-title":"NADPH oxidase 2-derived reactive oxygen species in the hippocampus might contribute to microglial activation in postoperative cognitive dysfunction in aged mice","volume":"51","author":"Qiu","year":"2016","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/j.nlm.2022.107656_b0390","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.intimp.2016.12.003","article-title":"PPAR\u03b3 activation ameliorates postoperative cognitive decline probably through suppressing hippocampal neuroinflammation in aged mice","volume":"43","author":"Zhang","year":"2017","journal-title":"International immunopharmacology"},{"key":"10.1016\/j.nlm.2022.107656_b0395","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/bja\/aex103","article-title":"Association of intraoperative changes in brain-derived neurotrophic factor and postoperative delirium in older adults","volume":"119","author":"Wyrobek","year":"2017","journal-title":"BJA: British Journal of Anaesthesia"},{"key":"10.1016\/j.nlm.2022.107656_b0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclinane.2021.110235","article-title":"Decreased brain-derived neurotrophic factor levels may predict early perioperative neurocognitive disorder in patients undergoing coronary artery bypass surgery: A prospective observational pilot study","volume":"71","author":"Miniksar","year":"2021","journal-title":"Journal of Clinical Anesthesia"},{"key":"10.1016\/j.nlm.2022.107656_b0405","first-page":"231","volume":"31","author":"Zhang","year":"2015","journal-title":"Differential expressions of serum cytokines in cognitive dysfunction patients after colorectal surgery. Xi bao yu fen zi mian yi xue za zhi= Chinese journal of cellular and molecular immunology"},{"key":"10.1016\/j.nlm.2022.107656_b0410","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s00540-012-1506-3","article-title":"Changes in plasma and cerebrospinal fluid biomarkers in aged patients with early postoperative cognitive dysfunction following total hip-replacement surgery","volume":"27","author":"Ji","year":"2013","journal-title":"Journal of anesthesia"},{"key":"10.1016\/j.nlm.2022.107656_b0415","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s12035-014-9013-1","article-title":"Enriched environment attenuates surgery-induced impairment of learning, memory, and neurogenesis possibly by preserving BDNF expression","volume":"53","author":"Fan","year":"2016","journal-title":"Molecular neurobiology"},{"key":"10.1016\/j.nlm.2022.107656_b0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.134785","article-title":"Sevoflurane anesthesia-mediated oxidative stress and cognitive impairment in hippocampal neurons of old rats can be ameliorated by expression of brain derived neurotrophic factor","volume":"721","author":"Xu","year":"2020","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.nlm.2022.107656_b0425","doi-asserted-by":"crossref","unstructured":"Xue Z, Shui M, Lin X, et al. Role of BDNF\/ProBDNF Imbalance in Postoperative Cognitive Dysfunction by Modulating Synaptic Plasticity in Aged Mice. Frontiers in Aging Neuroscience 2022;14.","DOI":"10.3389\/fnagi.2022.780972"},{"key":"10.1016\/j.nlm.2022.107656_b0430","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrn1726","article-title":"The yin and yang of neurotrophin action","volume":"6","author":"Lu","year":"2005","journal-title":"Nature Reviews Neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0435","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.celrep.2014.03.040","article-title":"proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus","volume":"7","author":"Yang","year":"2014","journal-title":"Cell reports"},{"key":"10.1016\/j.nlm.2022.107656_b0440","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fnagi.2017.00284","article-title":"Increased hippocampal ProBDNF contributes to memory impairments in aged mice","volume":"9","author":"Buhusi","year":"2017","journal-title":"Frontiers in aging neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0445","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1089\/rej.2008.0791","article-title":"Effect of aging on brain-derived neurotrophic factor, proBDNF, and their receptors in the hippocampus of Lou\/C rats","volume":"11","author":"Silhol","year":"2008","journal-title":"Rejuvenation research"},{"key":"10.1016\/j.nlm.2022.107656_b0450","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1800","article-title":"Association between BDNF rs6265 polymorphisms and postoperative cognitive dysfunction in Chinese Han Population","volume":"10","author":"Xie","year":"2020","journal-title":"Brain and Behavior"},{"key":"10.1016\/j.nlm.2022.107656_b0455","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/mp.2015.27","article-title":"The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: Progress and controversy","volume":"20","author":"Notaras","year":"2015","journal-title":"Molecular psychiatry"},{"key":"10.1016\/j.nlm.2022.107656_b0460","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1016\/j.neubiorev.2012.07.002","article-title":"Effect of BDNF val66met polymorphism on declarative memory and its neural substrate: A meta-analysis","volume":"36","author":"Kambeitz","year":"2012","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"10.1016\/j.nlm.2022.107656_b0465","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1523\/JNEUROSCI.0348-04.2004","article-title":"Variant brain-derived neurotrophic factor (BDNF)(Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons","volume":"24","author":"Chen","year":"2004","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0470","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","article-title":"The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function","volume":"112","author":"Egan","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.nlm.2022.107656_b0475","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3389\/fncel.2018.00396","article-title":"Tacrine (10)-hupyridone prevents post-operative cognitive dysfunction via the activation of BDNF pathway and the inhibition of AChE in aged mice","volume":"12","author":"Chen","year":"2018","journal-title":"Frontiers in cellular neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0480","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/ntr\/ntx157","article-title":"Nicotine-induced neuroprotection against cognitive dysfunction after partial hepatectomy involves activation of BDNF\/TrkB signaling pathway and inhibition of NF-\u03baB signaling pathway in aged rats","volume":"20","author":"Wei","year":"2018","journal-title":"Nicotine and Tobacco Research"},{"key":"10.1016\/j.nlm.2022.107656_b0485","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s11011-017-9970-y","article-title":"Curcumin attenuates surgery-induced cognitive dysfunction in aged mice","volume":"32","author":"Wu","year":"2017","journal-title":"Metabolic brain disease"},{"key":"10.1016\/j.nlm.2022.107656_b0490","doi-asserted-by":"crossref","unstructured":"Tang X, Zhao Y, Zhou Z, et al. Resveratrol mitigates sevoflurane-induced neurotoxicity by the SIRT1-dependent regulation of BDNF expression in developing mice. Oxidative medicine and cellular longevity 2020;2020.","DOI":"10.1155\/2020\/9018624"},{"key":"10.1016\/j.nlm.2022.107656_b0495","doi-asserted-by":"crossref","unstructured":"Zhong J, Li J, Ni C, Zuo Z. Amantadine alleviates postoperative cognitive dysfunction possibly by preserving neurotrophic factor expression and dendritic arborization in the hippocampus of old rodents. Frontiers in Aging Neuroscience 2020;12.","DOI":"10.3389\/fnagi.2020.605330"},{"key":"10.1016\/j.nlm.2022.107656_b0500","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/EJA.0b013e328331a3d5","article-title":"Amitriptyline rather than lornoxicam ameliorates neuropathic pain-induced deficits in abilities of spatial learning and memory","volume":"27","author":"Hu","year":"2010","journal-title":"European Journal of Anaesthesiology (EJA)"},{"key":"10.1016\/j.nlm.2022.107656_b0505","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fnbeh.2018.00135","article-title":"Is environmental enrichment ready for clinical application in human post-stroke rehabilitation?","volume":"12","author":"McDonald","year":"2018","journal-title":"Frontiers in behavioral neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0510","doi-asserted-by":"crossref","first-page":"7215","DOI":"10.1523\/JNEUROSCI.2045-04.2004","article-title":"Brain-derived neurotrophic factor induces hyperexcitable reentrant circuits in the dentate gyrus","volume":"24","author":"Koyama","year":"2004","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0515","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/S0306-4522(99)00296-1","article-title":"Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex","volume":"93","author":"Croll","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0520","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022863","article-title":"Glutamatergic mechanisms associated with seizures and epilepsy","volume":"5","author":"Barker-Haliski","year":"2015","journal-title":"Cold Spring Harbor perspectives in medicine"},{"key":"10.1016\/j.nlm.2022.107656_b0525","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/ALN.0000000000002729","article-title":"Postoperative delirium and postoperative cognitive dysfunction: Overlap and divergence","volume":"131","author":"Daiello","year":"2019","journal-title":"Anesthesiology"},{"key":"10.1016\/j.nlm.2022.107656_b0530","first-page":"24","article-title":"Cognitive impairment and BDNF serum levels","volume":"51","author":"Siuda","year":"2017","journal-title":"Polish Journal of Neurology and Neurosurgery"},{"key":"10.1016\/j.nlm.2022.107656_b0535","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/jne.12324","article-title":"Involvement of Endogenous Brain-Derived Neurotrophic Factor in Hypothalamic-Pituitary-Adrenal Axis Activity","volume":"27","author":"Naert","year":"2015","journal-title":"Journal of neuroendocrinology"},{"key":"10.1016\/j.nlm.2022.107656_b0540","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1007\/s00540-013-1633-5","article-title":"Early postoperative cognitive dysfunction is associated with higher cortisol levels in aged patients following hip fracture surgery","volume":"27","author":"Ji","year":"2013","journal-title":"Journal of anesthesia"},{"key":"10.1016\/j.nlm.2022.107656_b0545","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neubiorev.2017.11.011","article-title":"Post-operative cognitive dysfunction: An exploration of the inflammatory hypothesis and novel therapies","volume":"84","author":"Skvarc","year":"2018","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"10.1016\/j.nlm.2022.107656_b0550","first-page":"1","article-title":"Effects of nutritional interventions on BDNF concentrations in humans: A systematic review","author":"Gravesteijn","year":"2021","journal-title":"Nutritional Neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0555","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.3389\/fpsyg.2020.02209","article-title":"The Effect of Mindfulness-Based Intervention on Brain-Derived Neurotrophic Factor (BDNF): A Systematic Review and Meta-Analysis of Controlled Trials","volume":"11","author":"Gomutbutra","year":"2020","journal-title":"Frontiers in psychology"},{"key":"10.1016\/j.nlm.2022.107656_b0560","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neurobiolaging.2004.03.002","article-title":"The impact of age, weight and gender on BDNF levels in human platelets and plasma","volume":"26","author":"Lommatzsch","year":"2005","journal-title":"Neurobiology of aging"},{"key":"10.1016\/j.nlm.2022.107656_b0565","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00125-006-0537-4","article-title":"Brain-derived neurotrophic factor (BDNF) and type 2 diabetes","volume":"50","author":"Krabbe","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.nlm.2022.107656_b0570","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s11011-017-9997-0","article-title":"The interrelationship of metabolic syndrome and neurodegenerative diseases with focus on brain-derived neurotrophic factor (BDNF): Kill two birds with one stone","volume":"32","author":"Motamedi","year":"2017","journal-title":"Metabolic brain disease"},{"key":"10.1016\/j.nlm.2022.107656_b0575","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/dmrr.2786","article-title":"Obesity and post-operative cognitive dysfunction: A systematic review and meta-analysis","volume":"32","author":"Feinkohl","year":"2016","journal-title":"Diabetes\/metabolism research and reviews"},{"key":"10.1016\/j.nlm.2022.107656_b0580","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.2884","article-title":"Diabetes is associated with risk of postoperative cognitive dysfunction: A meta-analysis","volume":"33","author":"Feinkohl","year":"2017","journal-title":"Diabetes\/metabolism research and reviews"},{"key":"10.1016\/j.nlm.2022.107656_b0585","first-page":"18","article-title":"Predictors of cognitive dysfunction after major noncardiac surgery","volume":"108","author":"Monk","year":"2008","journal-title":"The Journal of the American Society of Anesthesiologists"},{"key":"10.1016\/j.nlm.2022.107656_b0590","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1177\/1545968315586465","article-title":"Brain-Derived Neurotrophic Factor (BDNF) in traumatic brain injury\u2013related mortality: Interrelationships between genetics and acute systemic and central nervous system BDNF profiles","volume":"30","author":"Failla","year":"2016","journal-title":"Neurorehabilitation and neural repair"},{"key":"10.1016\/j.nlm.2022.107656_b0595","doi-asserted-by":"crossref","first-page":"204","DOI":"10.59566\/IJBS.2008.4204","article-title":"Increase in levels of BDNF is associated with inflammation and oxidative stress during cardiopulmonary bypass","volume":"4","author":"Amoureux","year":"2008","journal-title":"International journal of biomedical science: IJBS"},{"key":"10.1016\/j.nlm.2022.107656_b0600","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.ne.19.030196.001445","article-title":"Physiology of the neurotrophins","volume":"19","author":"Lewin","year":"1996","journal-title":"Annual review of neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0605","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.neurobiolaging.2007.02.027","article-title":"Interleukin-1\u03b2 impairs brain derived neurotrophic factor-induced signal transduction","volume":"29","author":"Tong","year":"2008","journal-title":"Neurobiology of aging"},{"key":"10.1016\/j.nlm.2022.107656_b0610","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2021.155556","article-title":"Relationship between cytokines and brain-derived neurotrophic factor (BDNF) in trajectories of cancer-related cognitive impairment","volume":"144","author":"Yap","year":"2021","journal-title":"Cytokine"},{"key":"10.1016\/j.nlm.2022.107656_b0615","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1055\/s-0037-1613072","article-title":"Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation","volume":"87","author":"Fujimura","year":"2002","journal-title":"Thrombosis and haemostasis"},{"key":"10.1016\/j.nlm.2022.107656_b0620","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuroscience.2013.01.074","article-title":"Stress effects on BDNF expression: Effects of age, sex, and form of stress","volume":"239","author":"Bath","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.nlm.2022.107656_b0625","article-title":"Brain derived neurotrophic factor deficiency exacerbates inflammation-induced anhedonia in mice","volume":"105404","author":"Parrott","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.nlm.2022.107656_b0630","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1007\/s12035-018-1283-6","article-title":"Brain-derived neurotrophic factor in brain disorders: Focus on neuroinflammation","volume":"56","author":"Giacobbo","year":"2019","journal-title":"Molecular neurobiology"},{"key":"10.1016\/j.nlm.2022.107656_b0635","doi-asserted-by":"crossref","first-page":"R262","DOI":"10.1016\/j.cub.2005.03.023","article-title":"Neurotrophins: A ticket to ride for BDNF","volume":"15","author":"Thomas","year":"2005","journal-title":"Current Biology"},{"key":"10.1016\/j.nlm.2022.107656_b0640","doi-asserted-by":"crossref","unstructured":"Seo E-H, Piao L, Park H-J, et al. Impact of general anaesthesia on endoplasmic reticulum stress: propofol vs. isoflurane. International journal of medical sciences 2019;16:1287.","DOI":"10.7150\/ijms.36265"},{"key":"10.1016\/j.nlm.2022.107656_b0645","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.brainresbull.2020.11.005","article-title":"Proteolytic cleavage of proBDNF to mBDNF in neuropsychiatric and neurodegenerative diseases","volume":"166","author":"Wang","year":"2021","journal-title":"Brain Research Bulletin"}],"container-title":["Neurobiology of Learning and Memory"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742722000806?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074742722000806?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:42:31Z","timestamp":1761032551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074742722000806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":129,"alternative-id":["S1074742722000806"],"URL":"https:\/\/doi.org\/10.1016\/j.nlm.2022.107656","relation":{},"ISSN":["1074-7427"],"issn-type":[{"value":"1074-7427","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain derived neurotrophic factor in perioperative neurocognitive disorders: Current evidence and future directions","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Learning and Memory","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nlm.2022.107656","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107656"}}