{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:18:14Z","timestamp":1760833094957,"version":"build-2065373602"},"reference-count":44,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuromuscular Disorders"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.nmd.2004.04.006","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T16:23:03Z","timestamp":1086798183000},"page":"405-416","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse"],"prefix":"10.1016","volume":"14","author":[{"given":"Annamaria","family":"De Luca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabata","family":"Pierno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Liantonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Desaphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fedele","family":"Natuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Paola","family":"Didonna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ermanno","family":"Ferrannini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Jockusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Franchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Lentini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filomena","family":"Corbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Tortorella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Conte Camerino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nmd.2004.04.006_BIB1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0166-2236(96)81859-5","article-title":"Ion-channel defects and aberrant excitability in myotonia and periodic paralysis","volume":"19","author":"Cannon","year":"1996","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.nmd.2004.04.006_BIB2","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s00415-002-0871-5","article-title":"Skeletal muscle channelopathies","volume":"249","author":"Jurkat-Rott","year":"2002","journal-title":"J Neurol"},{"key":"10.1016\/j.nmd.2004.04.006_BIB3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11910-002-0055-9","article-title":"Periodic paralysis: understanding channelopathies","volume":"2","author":"Lehmann-Horn","year":"2002","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.1016\/j.nmd.2004.04.006_BIB4","series-title":"The non-dystrophic myotonias","first-page":"1291","author":"R\u00fcdel","year":"1994"},{"key":"10.1016\/j.nmd.2004.04.006_BIB5","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1152\/physrev.00029.2001","article-title":"Molecular structure and physiological function of chloride channels","volume":"82","author":"Jentsch","year":"2002","journal-title":"Physiol Rev"},{"key":"10.1016\/j.nmd.2004.04.006_BIB6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0002-9343(98)00123-5","article-title":"The familial periodic paralyses and non-dystrophic myotonias","volume":"104","author":"Ptacek","year":"1998","journal-title":"Am J Med"},{"key":"10.1016\/j.nmd.2004.04.006_BIB7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2165\/00003088-199937050-00002","article-title":"Clinical pharmacokinetics of mexiletine","volume":"37","author":"Labb\u00e8","year":"1999","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.nmd.2004.04.006_BIB8","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/0002-8703(84)90175-3","article-title":"Pharmacology, electrophysiology, and pharmacokinetics of mexiletine","volume":"107","author":"Woosley","year":"1984","journal-title":"Am Heart J"},{"key":"10.1016\/j.nmd.2004.04.006_BIB9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1056\/NEJM198607033150107","article-title":"Drug therapy. Tocainide","volume":"315","author":"Roden","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nmd.2004.04.006_BIB10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/0470846682.ch14","article-title":"Molecular mechanisms of gating and drug block of sodium channels","volume":"241","author":"Catterall","year":"2002","journal-title":"Novartis Found Symp"},{"key":"10.1016\/j.nmd.2004.04.006_BIB11","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1085\/jgp.69.4.497","article-title":"Local anesthetics: hydrophilic and hydrophobic pathways for the drug\u2013receptor reaction","volume":"69","author":"Hille","year":"1977","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.nmd.2004.04.006_BIB12","doi-asserted-by":"crossref","first-page":"9270","DOI":"10.1073\/pnas.93.17.9270","article-title":"Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels","volume":"93","author":"Ragsdale","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nmd.2004.04.006_BIB13","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/PL00005118","article-title":"Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide","volume":"356","author":"De Luca","year":"1997","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.nmd.2004.04.006_BIB14","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0026-895X(24)23198-9","article-title":"Molecular determinants of mexiletine structure for potent and use-dependent block of skeletal muscle sodium channels","volume":"57","author":"De Luca","year":"2000","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.nmd.2004.04.006_BIB15","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/354304a0","article-title":"Inactivation of muscle chloride channel by transposon insertion in myotonic mice","volume":"354","author":"Steinmeyer","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.nmd.2004.04.006_BIB16","doi-asserted-by":"crossref","first-page":"5963","DOI":"10.1016\/S0021-9258(17)37556-7","article-title":"Nonsense and missense mutations in the muscular chloride channel gene Clc-1 of myotonic mice","volume":"269","author":"Gronemeier","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nmd.2004.04.006_BIB17","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/mus.880110505","article-title":"The myotonic mouse mutant ADR: electrophysiology of the muscle fiber","volume":"11","author":"Mehrke","year":"1988","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nmd.2004.04.006_BIB18","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/mus.880110504","article-title":"The myotonic mouse mutant ADR: physiological and histochemical properties of muscle","volume":"11","author":"Reininghaus","year":"1988","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nmd.2004.04.006_BIB19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0022-3565(24)36782-5","article-title":"Evaluation of the antimyotonic activity of mexiletine and some new analogs on sodium currents of single muscle fibers and on the abnormal excitability of the myotonic ADR mouse","volume":"282","author":"De Luca","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.nmd.2004.04.006_BIB20","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/sj.bjp.0704366","article-title":"Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo","volume":"134","author":"Talon","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.nmd.2004.04.006_BIB21","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0960-8966(99)00101-7","article-title":"Antimyotonic effects of tocainide enantiomers on skeletal muscle fibers of congenitally myotonic goats","volume":"10","author":"Conte Camerino","year":"2000","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2004.04.006_BIB22","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/BF00372958","article-title":"Chloride channel regulation in the skeletal muscle of normal and myotonic goats","volume":"417","author":"Bryant","year":"1991","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1016\/j.nmd.2004.04.006_BIB23","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1113\/jphysiol.1974.sp010620","article-title":"On the repetitive discharge in myotonic muscle fibres","volume":"240","author":"Adrian","year":"1974","journal-title":"J Physiol (London)"},{"key":"10.1016\/j.nmd.2004.04.006_BIB24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0022-3565(25)30836-0","article-title":"The mechanism of action of dantrolene sodium","volume":"201","author":"Morgan","year":"1977","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.nmd.2004.04.006_BIB25","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/sj.bjp.0702901","article-title":"Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na+ channels in a model of myotonia induced by ATX","volume":"128","author":"Desaphy","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.nmd.2004.04.006_BIB26","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/chir.530060713","article-title":"Stereospecific synthesis and absolute configuration of mexiletine","volume":"6","author":"Franchini","year":"1994","journal-title":"Chirality"},{"key":"10.1016\/j.nmd.2004.04.006_BIB27","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/(SICI)1520-636X(2000)12:3<103::AID-CHIR1>3.0.CO;2-X","article-title":"Facile entry to (\u2212)-(R)- and (+)-(S)-mexiletine","volume":"12","author":"Carocci","year":"2000","journal-title":"Chirality"},{"key":"10.1016\/j.nmd.2004.04.006_BIB28","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1021\/jm000931l","article-title":"Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na+ channels with increased potency and improved use-dependent activity","volume":"43","author":"Franchini","year":"2000","journal-title":"J Med Chem"},{"year":"1979","author":"Tallarida","series-title":"Manual of pharmacological calculations","key":"10.1016\/j.nmd.2004.04.006_BIB29"},{"key":"10.1016\/j.nmd.2004.04.006_BIB30","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/mus.880170710","article-title":"Paramyotonia congenita: abnormal short exercise test, and improvement after mexiletine therapy","volume":"17","author":"Jackson","year":"1994","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nmd.2004.04.006_BIB31","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1067\/mcp.2000.108023","article-title":"Pharmacokinetic and pharmacodynamic interaction between mexiletine and propafenone in human beings","volume":"68","author":"Labbe'","year":"2000","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.nmd.2004.04.006_BIB32","first-page":"274","article-title":"Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms","volume":"29","author":"Honma","year":"2001","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.nmd.2004.04.006_BIB33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/med.2610120202","article-title":"Potassium channel activator drugs: mechanism of action, pharmacological properties, and therapeutic potential","volume":"12","author":"Longman","year":"1992","journal-title":"Med Res Rev"},{"key":"10.1016\/j.nmd.2004.04.006_BIB34","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1476-5381.1995.tb16342.x","article-title":"Mexiletine-induced shortening of the action potential duration of ventricular muscles by activation of ATP-sensitive K+ channels","volume":"115","author":"Sato","year":"1995","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.nmd.2004.04.006_BIB35","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/sj.bjp.0702117","article-title":"Effects of mexiletine on ATP-sensitive K+ channel of rat skeletal muscle fibres: a state dependent mechanism of action","volume":"125","author":"Tricarico","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.nmd.2004.04.006_BIB36","first-page":"47","article-title":"Methods of blood collection in the mouse","volume":"29","author":"Hoff","year":"2000","journal-title":"Lab Animal"},{"key":"10.1016\/j.nmd.2004.04.006_BIB37","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s00210-002-0669-0","article-title":"Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile","volume":"367","author":"De Luca","year":"2003","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.nmd.2004.04.006_BIB38","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/ana.10603","article-title":"Antiepileptic drugs as a possible neuroprotective strategy in brain ischemia","volume":"53","author":"Calabresi","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nmd.2004.04.006_BIB39","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0090-9556(25)07144-2","article-title":"Meta-hydroxymexiletine, a new metabolite of mexiletine. Isolation, characterization, and species differences in its formation","volume":"19","author":"Grech-Belanger","year":"1991","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.nmd.2004.04.006_BIB40","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/S0090-9556(25)08789-6","article-title":"Isolation and structural characterization by spectroscopic methods of two glucuronide metabolites of mexiletine after N-oxidation and deamination","volume":"20","author":"Turgeon","year":"1992","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.nmd.2004.04.006_BIB41","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/chir.10307","article-title":"Stereospecific synthesis of \u2018para-Hydroxymexiletine\u2019 and sodium channel blocking activity evaluation","volume":"16","author":"Catalano","year":"2004","journal-title":"Chirality"},{"key":"10.1016\/j.nmd.2004.04.006_BIB42","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1212\/WNL.57.10.1849","article-title":"Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative","volume":"57","author":"Desaphy","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.nmd.2004.04.006_BIB43","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1113\/jphysiol.2001.012541","article-title":"Mexiletine block of disease-associated mutations in S6 segments of the human skeletal muscle Na+ channel","volume":"537","author":"Takahashi","year":"2001","journal-title":"J Physiol"},{"key":"10.1016\/j.nmd.2004.04.006_BIB44","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0960-8966(99)00060-7","article-title":"Different effects of mexiletine on two mutant sodium channels causing paramyotonia congenita and hyperkalemic periodic paralysis","volume":"10","author":"Weckbecker","year":"2000","journal-title":"Neuromuscul Disord"}],"container-title":["Neuromuscular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096089660400121X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096089660400121X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:52:22Z","timestamp":1760773942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096089660400121X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S096089660400121X"],"URL":"https:\/\/doi.org\/10.1016\/j.nmd.2004.04.006","relation":{},"ISSN":["0960-8966"],"issn-type":[{"type":"print","value":"0960-8966"}],"subject":[],"published":{"date-parts":[[2004,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse","name":"articletitle","label":"Article Title"},{"value":"Neuromuscular Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nmd.2004.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}