{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:24:44Z","timestamp":1791059084090,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuromuscular Disorders"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.nmd.2006.03.003","type":"journal-article","created":{"date-parts":[[2006,4,19]],"date-time":"2006-04-19T13:42:54Z","timestamp":1145454174000},"page":"337-346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Differential calcineurin signalling activity and regeneration efficacy in diaphragm and limb muscles of dystrophic mdx mice"],"prefix":"10.1016","volume":"16","author":[{"given":"Nicole","family":"Stupka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda J.","family":"Michell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce E.","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon S.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nmd.2006.03.003_bib1","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1002\/mus.1192","article-title":"The dystrophin\u2013glycoprotein complex, cellular signalling, and the regulation of cell survival in the muscular dystrophies","volume":"24","author":"Rando","year":"2001","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nmd.2006.03.003_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1023\/A:1006812004945","article-title":"The molecular basis for activity-induced injury in Duchenne muscular dystrophy","volume":"176","author":"Petrof","year":"1998","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.nmd.2006.03.003_bib3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/153537020422900608","article-title":"Altered activity of signaling pathways in diaphragm and tibialis anterios muscle of dystrophic mice","volume":"229","author":"Lang","year":"2004","journal-title":"Exp Biol Med"},{"key":"10.1016\/j.nmd.2006.03.003_bib4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1469-7793.2001.00591.x","article-title":"Force and power output of fast and slow skeletal muscles from mdx mice 6\u201328 month old","volume":"535","author":"Lynch","year":"2001","journal-title":"J Physiol"},{"key":"10.1016\/j.nmd.2006.03.003_bib5","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/mus.880151008","article-title":"Differential expression of muscular dystrophy in diaphragm versus hindlimb muscles of mdx mice","volume":"15","author":"Dupont-Versteegden","year":"1992","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nmd.2006.03.003_bib6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0960-8966(93)90098-5","article-title":"Morphometric analysis of mdx diaphragm muscle fibers. Comparison with hindlimb muscles","volume":"3","author":"Louboutin","year":"1993","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2006.03.003_bib7","doi-asserted-by":"crossref","first-page":"C834","DOI":"10.1152\/ajpcell.1993.265.3.C834","article-title":"Adaptations in myosin heavy chain expression and contractile function in dystrophic mouse diaphragm","volume":"265","author":"Petrof","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1016\/j.nmd.2006.03.003_bib8","doi-asserted-by":"crossref","first-page":"C2063","DOI":"10.1152\/ajpcell.1997.272.6.C2063","article-title":"Contractile properties of diaphragm muscle segments from old mdx and old transgenic mdx mice","volume":"272","author":"Lynch","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.nmd.2006.03.003_bib9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1152\/japplphysiol.00689.2002","article-title":"Inspiratory loading does not accelerate dystrophy in mdx mouse diaphragm: implications for regeneration therapy","volume":"94","author":"Krupnick","year":"2003","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.nmd.2006.03.003_bib10","first-page":"R961","article-title":"Regenerative capacity of the dystrophic (mdx) diaphragm after induced injury","volume":"287","author":"Matecki","year":"2004","journal-title":"Am J Physiol"},{"key":"10.1016\/j.nmd.2006.03.003_bib11","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1002\/(SICI)1097-4598(199809)21:9<1153::AID-MUS6>3.0.CO;2-6","article-title":"Dystrophy and myogenesis in mdx diaphragm muscle","volume":"21","author":"Anderson","year":"1998","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nmd.2006.03.003_bib12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/dvdy.20602","article-title":"Satellite cells from dystrophic (mdx) mice display accelerated differentiation in primary cultures and in isolated myofibres","volume":"235","author":"Yablonka-Reuveni","year":"2005","journal-title":"Dev Dyn"},{"key":"10.1016\/j.nmd.2006.03.003_bib13","doi-asserted-by":"crossref","first-page":"15817","DOI":"10.1016\/S0021-9258(18)47660-0","article-title":"Expression of the Duchenne's muscular dystrophy gene in cultured muscle cells","volume":"262","author":"Lev","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nmd.2006.03.003_bib14","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1152\/physrev.2000.80.4.1483","article-title":"Calcineurin: form and function","volume":"80","author":"Rusnak","year":"2000","journal-title":"Physiol Rev"},{"key":"10.1016\/j.nmd.2006.03.003_bib15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00401-005-1049-x","article-title":"Cyclosporine A treatment upregulates Id1 and Smad3 expression and delays skeletal muscle regeneration","volume":"110","author":"Sakuma","year":"2005","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.nmd.2006.03.003_bib16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00401-002-0647-0","article-title":"Calcineurin is a potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2","volume":"105","author":"Sakuma","year":"2003","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.nmd.2006.03.003_bib17","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1091\/mbc.9.10.2905","article-title":"Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells","volume":"9","author":"Abbott","year":"1998","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.nmd.2006.03.003_bib18","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/(SICI)1521-1878(200006)22:6<510::AID-BIES4>3.0.CO;2-1","article-title":"Remodeling muscles with calcineurin","volume":"22","author":"Olson","year":"2000","journal-title":"BioEssays"},{"key":"10.1016\/j.nmd.2006.03.003_bib19","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1083\/jcb.149.3.657","article-title":"Calcineurin activity is required for the initiation of skeletal muscle differentiation","volume":"149","author":"Friday","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1016\/j.nmd.2006.03.003_bib20","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00401-003-0807-x","article-title":"The calcineurin signal transduction pathway is essential for successful muscle regeneration in mdx dystrophic mice","volume":"107","author":"Stupka","year":"2004","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.nmd.2006.03.003_bib21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0002-9440(10)62270-5","article-title":"A multidisciplinary evaluation of the effectiveness of cyclosporine A in dystrophic mdx mice","volume":"166","author":"De Luca","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.nmd.2006.03.003_bib22","doi-asserted-by":"crossref","first-page":"E46","DOI":"10.1038\/ncb0302-e46a","article-title":"Calcineurin and skeletal muscle growth (letter to the editor)","volume":"4","author":"Dunn","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.nmd.2006.03.003_bib23","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1212\/WNL.39.12.1610","article-title":"Elevated calmodulin levels and reduced calmodulin-stimulated calcium-ATPase in Duchenne progressive muscular dystrophy","volume":"39","author":"Niebroj-Dobosz","year":"1989","journal-title":"Neurology"},{"key":"10.1016\/j.nmd.2006.03.003_bib24","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.2173137","article-title":"Increased activity of calcium leak channels in myotubes of Duchenne human and mdx mouse origin","volume":"250","author":"Fong","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.nmd.2006.03.003_bib25","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1021\/bi00016a030","article-title":"Characterization of the recombinant C-terminal domain of dystrophin: phosphorylation by calmodulin-dependent protein kinase II and dephosphorylation by type 2B protein phophastase","volume":"34","author":"Walsh","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.nmd.2006.03.003_bib26","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1139\/o96-047","article-title":"Phosphorylation of the carboxyl-terminal region of dystrophin","volume":"74","author":"Michalak","year":"1996","journal-title":"Biochem Cell Biol"},{"key":"10.1016\/j.nmd.2006.03.003_bib27","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/hmg\/ddh033","article-title":"Temporal gene expression profiling of dystrophin-deficient (mdx) mouse diaphragm identifies conserved and muscle-group specific mechanisms in the pathogenesis of muscular dystrophy","volume":"13","author":"Porter","year":"2004","journal-title":"Hum Mol Gen"},{"key":"10.1016\/j.nmd.2006.03.003_bib28","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/S0960-9822(01)00397-9","article-title":"Activation of JNK1 contributes to dystrophic muscle pathogenesis","volume":"11","author":"Kolodziejzyk","year":"2001","journal-title":"Curr Biol"},{"key":"10.1016\/j.nmd.2006.03.003_bib29","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1152\/physrev.00019.2003","article-title":"Cellular and molecular regeneration of muscle regeneration","volume":"84","author":"Charg\u00e9","year":"2003","journal-title":"Physiol Rev"},{"key":"10.1016\/j.nmd.2006.03.003_bib30","first-page":"R961","article-title":"Regenerative capacity of the dystrophic (mdx) diaphragm after induced injury","volume":"287","author":"Matecki","year":"2004","journal-title":"Am J Physiol"},{"key":"10.1016\/j.nmd.2006.03.003_bib31","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1083\/jcb.141.4.943","article-title":"Myosin heavy chains IIa and IId are functionally distinct in the mouse","volume":"141","author":"Sartorius","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1016\/j.nmd.2006.03.003_bib32","first-page":"R1256","article-title":"Skeletal muscle calcineurin: influence of phenotype, adaptation, and atrophy","volume":"280","author":"Spangenburg","year":"2001","journal-title":"Am J Physiol"},{"key":"10.1016\/j.nmd.2006.03.003_bib33","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1073\/pnas.89.9.3686","article-title":"Calcineurin phosphatase activityin T lymphocytesis inhibited by FK506 and cyclosporin A","volume":"89","author":"Fruman","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nmd.2006.03.003_bib34","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1042\/bj3200879","article-title":"Competitive inhibition of calcineurin phosphatase by its autoinhibitory domain","volume":"320","author":"Sagoo","year":"1996","journal-title":"Biochem J"},{"key":"10.1016\/j.nmd.2006.03.003_bib35","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/S0021-9258(19)39919-3","article-title":"Identification of an autoinhibitory domain in calcineurin","volume":"265","author":"Hashimoto","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nmd.2006.03.003_bib36","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1074\/jbc.270.1.340","article-title":"Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin: role of the autoinhibitory domain","volume":"270","author":"Perrino","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nmd.2006.03.003_bib37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/hmg\/ddh037","article-title":"Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice","volume":"13","author":"Chakkalakal","year":"2004","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nmd.2006.03.003_bib38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1083\/jcb.200105110","article-title":"A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice","volume":"155","author":"Wehling","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1016\/j.nmd.2006.03.003_bib39","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1083\/jcb.151.3.663","article-title":"Matching for calcineurin activity to upstream effectors is critical for skeletal muscle fiber growth","volume":"151","author":"Dunn","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1016\/j.nmd.2006.03.003_bib40","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev.immunol.15.1.707","article-title":"Transcription factors of the NFAT family: regulation and function","volume":"15","author":"Rao","year":"1997","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.nmd.2006.03.003_bib41","doi-asserted-by":"crossref","first-page":"C593","DOI":"10.1152\/ajpcell.00346.2004","article-title":"Static stretch promotes in calcineurin and p38 dependent manner MEF2A nuclear translocation and expression of neonatal myosin heavy chain in C2C12 myocytes","volume":"288","author":"Rauch","year":"2004","journal-title":"Am J Physiol"},{"key":"10.1016\/j.nmd.2006.03.003_bib42","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1091\/mbc.02-02-0016","article-title":"p38 Mitogen-activated protein kinase-, calcium-calmodulin-dependent protein kinase-, and calcineurin-mediated signaling pathways transcriptionally regulate myogenin expression","volume":"13","author":"Xu","year":"2002","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.nmd.2006.03.003_bib43","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000075028","article-title":"Forming a multinucleated cell: molecules that regulate myoblast fusion","volume":"176","author":"Horsely","year":"2004","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.nmd.2006.03.003_bib44","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1083\/jcb.145.3.633","article-title":"Myogenin induces a shift of enzyme activity in muscles of transgenic mice","volume":"145","author":"Hughes","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1016\/j.nmd.2006.03.003_bib45","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0955-0674(99)00036-8","article-title":"MEF2: a transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation","volume":"11","author":"Naya","year":"1999","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.nmd.2006.03.003_bib46","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0165-6147(02)02111-9","article-title":"Calcineurin signaling and neural control of skeletal muscle fiber type and size","volume":"23","author":"Schiaffino","year":"2002","journal-title":"Trends Pharm Sci"},{"key":"10.1016\/j.nmd.2006.03.003_bib47","doi-asserted-by":"crossref","first-page":"C984","DOI":"10.1152\/ajpcell.00483.2001","article-title":"Calcineurin differentially regulates maintenance and growth of phenotypically distinct muscles","volume":"282","author":"Mitchell","year":"2002","journal-title":"Am J Physiol"},{"key":"10.1016\/j.nmd.2006.03.003_bib48","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0022-510X(92)90171-G","article-title":"Calcium, calmodulin and 3\u2032,5\u2032-cyclic nucleotide phosphodiesterase activity in human muscular dystrophy","volume":"109","author":"Mishra","year":"1992","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.nmd.2006.03.003_bib49","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/383434a0","article-title":"Superoxide dismutase protects calcineurin from inactivation","volume":"383","author":"Wang","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.nmd.2006.03.003_bib50","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0960-8966(97)00096-5","article-title":"Oxidative stress as a potential pathogenic mechanism in an animal model of Duchenne muscular dystrophy","volume":"7","author":"Ragusa","year":"1997","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2006.03.003_bib51","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0022-510X(96)00066-4","article-title":"Extraocular, limb and diaphragm muscle group-specfic antioxidant enzyme activity patterns in control and mdx mice","volume":"139","author":"Ragusa","year":"1996","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.nmd.2006.03.003_bib52","first-page":"1937","article-title":"Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin\/NFAT pathway","volume":"18","author":"St.-Pierre","year":"2005","journal-title":"Fed Am Soc Exp Biol J"},{"key":"10.1016\/j.nmd.2006.03.003_bib53","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cardiores.2004.01.021","article-title":"Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs","volume":"63","author":"Molkentin","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.nmd.2006.03.003_bib54","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0092-8674(03)00319-2","article-title":"IL-4 acts a myoblast recruitment factor during mammalian muscle growth","volume":"113","author":"Horsely","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.nmd.2006.03.003_bib55","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000075028","article-title":"Forming a multinucleated cell: molecules that regulate myoblast fusion","volume":"176","author":"Horsely","year":"2004","journal-title":"Cells Tissues Organs"}],"container-title":["Neuromuscular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960896606000630?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960896606000630?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:54:14Z","timestamp":1760774054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960896606000630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0960896606000630"],"URL":"https:\/\/doi.org\/10.1016\/j.nmd.2006.03.003","relation":{},"ISSN":["0960-8966"],"issn-type":[{"value":"0960-8966","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential calcineurin signalling activity and regeneration efficacy in diaphragm and limb muscles of dystrophic mdx mice","name":"articletitle","label":"Article Title"},{"value":"Neuromuscular Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nmd.2006.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}