{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:09:40Z","timestamp":1791284980674,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuromuscular Disorders"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.nmd.2011.10.012","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T21:06:42Z","timestamp":1321045602000},"page":"277-285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Transgenic inactivation of murine myostatin does not decrease the severity of disease in a model of Spinal Muscular Atrophy"],"prefix":"10.1016","volume":"22","author":[{"given":"Hansj\u00f6rg","family":"Rindt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desire M.","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer M.","family":"Vale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Krogman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Ferrill F.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian L.","family":"Lorson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nmd.2011.10.012_b0005","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a Spinal Muscular Atrophy-determining gene","volume":"80","author":"Lefebvre","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.nmd.2011.10.012_b0010","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1093\/hmg\/ddm379","article-title":"Neuronal SMN expression corrects Spinal Muscular Atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect","volume":"17","author":"Gavrilina","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nmd.2011.10.012_b0015","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/hmg\/ddn426","article-title":"Delivery of recombinant follistatin lessens disease severity in a mouse model of Spinal Muscular Atrophy","volume":"18","author":"Rose","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nmd.2011.10.012_b0020","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1083\/jcb.200407021","article-title":"Muscle expression of a local IGF-1 isoform protects motor neurons in an ALS mouse model","volume":"168","author":"Dobrowolny","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1016\/j.nmd.2011.10.012_b0025","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/387083a0","article-title":"Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member","volume":"387","author":"McPherron","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.nmd.2011.10.012_b0030","doi-asserted-by":"crossref","first-page":"12457","DOI":"10.1073\/pnas.94.23.12457","article-title":"Double muscling in cattle due to mutations in the myostatin gene","volume":"94","author":"McPherron","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nmd.2011.10.012_b0035","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1056\/NEJMoa040933","article-title":"Myostatin mutation associated with gross muscle hypertrophy in a child","volume":"350","author":"Schuelke","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nmd.2011.10.012_b0040","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1371\/journal.pgen.0030079","article-title":"A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs","volume":"3","author":"Mosher","year":"2007","journal-title":"PLoS Genet"},{"key":"10.1016\/j.nmd.2011.10.012_b0045","first-page":"487","article-title":"Targeting myostatin for therapies against muscle-wasting disorders","volume":"11","author":"Tsuchida","year":"2008","journal-title":"Curr Opin Drug Discov Devel"},{"key":"10.1016\/j.nmd.2011.10.012_b0050","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1038\/sj.onc.1201807","article-title":"FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders","volume":"16","author":"Hayette","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.nmd.2011.10.012_b0055","doi-asserted-by":"crossref","first-page":"40788","DOI":"10.1074\/jbc.M006114200","article-title":"Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-beta family","volume":"275","author":"Tsuchida","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nmd.2011.10.012_b0060","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1210\/me.2002-0366","article-title":"Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains","volume":"17","author":"Hill","year":"2003","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.nmd.2011.10.012_b0065","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/ana.10385","article-title":"Loss of myostatin attenuates severity of muscular dystrophy in mdx mice","volume":"52","author":"Wagner","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nmd.2011.10.012_b0070","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.nbd.2006.05.009","article-title":"Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis","volume":"23","author":"Holzbaur","year":"2006","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.nmd.2011.10.012_b0075","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1093\/hmg\/ddp253","article-title":"Inhibition of myostatin does not ameliorate disease features of severe Spinal Muscular Atrophy mice","volume":"18","author":"Sumner","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nmd.2011.10.012_b0080","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/hmg\/ddi078","article-title":"SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with Spinal Muscular Atrophy and associates with full-length SMN","volume":"14","author":"Le","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nmd.2011.10.012_b0085","doi-asserted-by":"crossref","first-page":"9920","DOI":"10.1073\/pnas.94.18.9920","article-title":"Inactivation of the survival motor neuron gene, a candidate gene for human Spinal Muscular Atrophy, leads to massive cell death in early mouse embryos","volume":"94","author":"Schrank","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nmd.2011.10.012_b0235","doi-asserted-by":"crossref","first-page":"52,54","DOI":"10.2144\/00291bm09","article-title":"Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT)","volume":"29","author":"Truett","year":"2000","journal-title":"Biotechniques"},{"key":"10.1016\/j.nmd.2011.10.012_b0095","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1210\/me.2010-0127","article-title":"Regulation of muscle mass by follistatin and activins","volume":"24","author":"Lee","year":"2010","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.nmd.2011.10.012_b0100","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1093\/hmg\/ddn156","article-title":"Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of Spinal Muscular Atrophy","volume":"17","author":"Kariya","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nmd.2011.10.012_b0105","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1210\/en.2010-0488","article-title":"Endocrine actions of myostatin: systemic regulation of the IGF and IGF binding protein axis","volume":"152","author":"Williams","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.nmd.2011.10.012_b0110","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1172\/JCI29562","article-title":"Trichostatin A increases SMN expression and survival in a mouse model of Spinal Muscular Atrophy","volume":"117","author":"Avila","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nmd.2011.10.012_b0115","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.nbd.2007.04.009","article-title":"Abnormal motor phenotype in the SMNDelta7 mouse model of Spinal Muscular Atrophy","volume":"27","author":"Butchbach","year":"2007","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.nmd.2011.10.012_b0120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.expneurol.2008.02.025","article-title":"Identification of a battery of tests for drug candidate evaluation in the SMNDelta7 neonate model of Spinal Muscular Atrophy","volume":"212","author":"El-Khodor","year":"2008","journal-title":"Exp Neurol"},{"key":"10.1016\/j.nmd.2011.10.012_b0125","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ceb.2009.02.004","article-title":"The role of RNP biogenesis in Spinal Muscular Atrophy","volume":"21","author":"Chari","year":"2009","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.nmd.2011.10.012_b0130","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrn2670","article-title":"Spinal Muscular Atrophy: why do low levels of survival motor neuron protein make motor neurons sick?","volume":"10","author":"Burghes","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.nmd.2011.10.012_b0135","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1093\/hmg\/ddq329","article-title":"Cardiac defects contribute to the pathology of Spinal Muscular Atrophy models","volume":"19","author":"Shababi","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nmd.2011.10.012_b0140","doi-asserted-by":"crossref","unstructured":"Bevan AK, Hutchinson KR, Foust KD, et al. Early heart failure in the SMNDelta7 model of Spinal Muscular Atrophy and correction by postnatal scAAV9-SMN delivery. Hum Mol Genet 2010; 19:3895\u2013905.","DOI":"10.1093\/hmg\/ddq300"},{"key":"10.1016\/j.nmd.2011.10.012_b0145","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1093\/hmg\/ddq330","article-title":"Arrhythmia and cardiac defects are a feature of Spinal Muscular Atrophy model mice","volume":"19","author":"Heier","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nmd.2011.10.012_b0150","doi-asserted-by":"crossref","unstructured":"Wishart TM, Huang JP, Murray LM, et al. SMN deficiency disrupts brain development in a mouse model of severe Spinal Muscular Atrophy. Hum Mol Genet 2010;19:4216\u201328.","DOI":"10.1093\/hmg\/ddq340"},{"key":"10.1016\/j.nmd.2011.10.012_b0155","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/S0140-6736(08)60921-6","article-title":"Spinal Muscular Atrophy","volume":"371","author":"Lunn","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.nmd.2011.10.012_b0160","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1093\/hmg\/ddq021","article-title":"Rho-kinase inactivation prolongs survival of an intermediate SMA mouse model","volume":"19","author":"Bowerman","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nmd.2011.10.012_b0165","doi-asserted-by":"crossref","first-page":"10337","DOI":"10.1073\/pnas.1104928108","article-title":"Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits","volume":"108","author":"Akten","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nmd.2011.10.012_b0170","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.bbrc.2009.11.148","article-title":"Effect of diet on the survival and phenotype of a mouse model for Spinal Muscular Atrophy","volume":"391","author":"Butchbach","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.nmd.2011.10.012_b0175","doi-asserted-by":"crossref","first-page":"7615","DOI":"10.1523\/JNEUROSCI.1245-05.2005","article-title":"Regular exercise prolongs survival in a type 2 Spinal Muscular Atrophy model mouse","volume":"25","author":"Grondard","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.nmd.2011.10.012_b0180","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1152\/japplphysiol.01091.2007","article-title":"Transforming growth factor-beta and myostatin signaling in skeletal muscle","volume":"104","author":"Kollias","year":"2008","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.nmd.2011.10.012_b0185","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1093\/hmg\/ddr067","article-title":"Increased IGF-1 in muscle modulates the phenotype of severe SMA mice","volume":"20","author":"Bosch-Marce","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nmd.2011.10.012_b0190","doi-asserted-by":"crossref","first-page":"18117","DOI":"10.1073\/pnas.0505996102","article-title":"Regulation of muscle growth by multiple ligands signaling through activin type II receptors","volume":"102","author":"Lee","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nmd.2011.10.012_b0195","doi-asserted-by":"crossref","first-page":"7230","DOI":"10.1128\/MCB.23.20.7230-7242.2003","article-title":"Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis","volume":"23","author":"Rebbapragada","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.nmd.2011.10.012_b0200","doi-asserted-by":"crossref","first-page":"e789","DOI":"10.1371\/journal.pone.0000789","article-title":"Quadrupling muscle mass in mice by targeting TGF-beta signaling pathways","volume":"2","author":"Lee","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nmd.2011.10.012_b0240","article-title":"Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice","author":"Nakatani","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.nmd.2011.10.012_b0210","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1089\/hum.2007.159","article-title":"Myostatin propeptide gene delivery by adeno-associated virus serotype 8 vectors enhances muscle growth and ameliorates dystrophic phenotypes in mdx mice","volume":"19","author":"Qiao","year":"2008","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.nmd.2011.10.012_b0215","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0002-9440(10)62271-7","article-title":"Elimination of myostatin does not combat muscular dystrophy in dy mice but increases postnatal lethality","volume":"166","author":"Li","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.nmd.2011.10.012_b0220","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.2353\/ajpath.2006.051316","article-title":"Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy","volume":"168","author":"Parsons","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.nmd.2011.10.012_b0225","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/mus.20920","article-title":"Myostatin blockade improves function but not histopathology in a murine model of limb-girdle muscular dystrophy 2C","volume":"37","author":"Bogdanovich","year":"2008","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nmd.2011.10.012_b0230","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1089\/rej.2010.1065","article-title":"Altered primary and secondary myogenesis in the myostatin-null mouse","volume":"13","author":"Matsakas","year":"2010","journal-title":"Rejuvenation Res"}],"container-title":["Neuromuscular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960896611013708?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960896611013708?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:59:55Z","timestamp":1760774395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960896611013708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0960896611013708"],"URL":"https:\/\/doi.org\/10.1016\/j.nmd.2011.10.012","relation":{},"ISSN":["0960-8966"],"issn-type":[{"value":"0960-8966","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transgenic inactivation of murine myostatin does not decrease the severity of disease in a model of Spinal Muscular Atrophy","name":"articletitle","label":"Article Title"},{"value":"Neuromuscular Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nmd.2011.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}