{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:40:24Z","timestamp":1789764024444,"version":"4.0.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"CureDuchenne Foundation"},{"name":"OSU\/NCH Center for Neuromuscular Health and Disease"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuromuscular Disorders"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.nmd.2015.08.005","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T15:07:39Z","timestamp":1439305659000},"page":"827-834","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["The first exon duplication mouse model of Duchenne muscular dystrophy: A tool for therapeutic development"],"prefix":"10.1016","volume":"25","author":[{"given":"Adeline","family":"Vulin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5892-3639","authenticated-orcid":false,"given":"Nicolas","family":"Wein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabatha R.","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Rutherford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Findlay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline A.","family":"Yurkoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuuki","family":"Kaminoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Flanigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nmd.2015.08.005_bib0010","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/ajmg.a.30617","article-title":"Improved molecular diagnosis of dystrophinopathies in an unselected clinical cohort","volume":"134","author":"Dent","year":"2005","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.nmd.2015.08.005_bib0015","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/mus.20586","article-title":"Entries in the Leiden Duchenne muscular dystrophy mutation database: an overview of mutation types and paradoxical cases that confirm the reading-frame rule","volume":"34","author":"Aartsma-Rus","year":"2006","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nmd.2015.08.005_bib0020","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/humu.22758","article-title":"The TREAT-NMD DMD Global Database: analysis of more than 7,000 Duchenne muscular dystrophy mutations","volume":"36","author":"Bladen","year":"2015","journal-title":"Hum Mutat"},{"key":"10.1016\/j.nmd.2015.08.005_bib0025","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1002\/humu.21114","article-title":"Mutational spectrum of DMD mutations in dystrophinopathy patients: application of modern diagnostic techniques to a large cohort","volume":"30","author":"Flanigan","year":"2009","journal-title":"Hum Mutat"},{"key":"10.1016\/j.nmd.2015.08.005_bib0030","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1073\/pnas.86.4.1292","article-title":"Recovery of induced mutations for X chromosome-linked muscular dystrophy in mice","volume":"86","author":"Chapman","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nmd.2015.08.005_bib0035","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1093\/hmg\/5.8.1149","article-title":"Differential expression of dystrophin isoforms in strains of mdx mice with different mutations","volume":"5","author":"Im","year":"1996","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nmd.2015.08.005_bib0040","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0888-7543(92)90210-J","article-title":"An error in dystrophin mRNA processing in golden retriever muscular dystrophy, an animal homologue of Duchenne muscular dystrophy","volume":"13","author":"Sharp","year":"1992","journal-title":"Genomics"},{"key":"10.1016\/j.nmd.2015.08.005_bib0045","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/humu.20367","article-title":"Duplications in the DMD gene","volume":"27","author":"White","year":"2006","journal-title":"Hum Mutat"},{"key":"10.1016\/j.nmd.2015.08.005_bib0050","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1093\/intimm\/5.8.957","article-title":"Targeted disruption of the MHC class II Aa gene in C57BL\/6 mice","volume":"5","author":"Kontgen","year":"1993","journal-title":"Int Immunol"},{"key":"10.1016\/j.nmd.2015.08.005_bib0055","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/nm.3628","article-title":"Translation from a DMD exon 5 IRES results in a functional dystrophin isoform that attenuates dystrophinopathy in humans and mice","volume":"20","author":"Wein","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.nmd.2015.08.005_bib0060","doi-asserted-by":"crossref","first-page":"RRN1276","DOI":"10.1371\/currents.RRN1276","article-title":"The different impact of a high fat diet on dystrophic mdx and control C57Bl\/10 mice","volume":"3","author":"Radley-Crabb","year":"2011","journal-title":"PLoS Curr"},{"key":"10.1016\/j.nmd.2015.08.005_bib0065","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1056\/NEJMoa1011367","article-title":"Systemic administration of PRO051 in Duchenne's muscular dystrophy","volume":"364","author":"Goemans","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nmd.2015.08.005_bib0070","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/ana.23982","article-title":"Eteplirsen for the treatment of Duchenne muscular dystrophy","volume":"74","author":"Mendell","year":"2013","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nmd.2015.08.005_bib0075","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.nmd.2010.01.013","article-title":"Becker muscular dystrophy patients with deletions around exon 51; a promising outlook for exon skipping therapy in Duchenne patients","volume":"20","author":"Helderman-van den Enden","year":"2010","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2015.08.005_bib0080","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2350-8-43","article-title":"Antisense-induced exon skipping for duplications in Duchenne muscular dystrophy","volume":"8","author":"Aartsma-Rus","year":"2007","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.nmd.2015.08.005_bib0085","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.nmd.2010.07.276","article-title":"Personalized exon skipping strategies to address clustered non-deletion dystrophin mutations","volume":"20","author":"Forrest","year":"2010","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2015.08.005_bib0090","doi-asserted-by":"crossref","first-page":"e155","DOI":"10.1038\/mtna.2014.8","article-title":"Targeted exon skipping to correct exon duplications in the dystrophin gene","volume":"3","author":"Greer","year":"2014","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.nmd.2015.08.005_bib0095","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0960-8966(95)00001-4","article-title":"How does dystrophin deficiency lead to muscle degeneration? \u2013 evidence from the mdx mouse","volume":"5","author":"McArdle","year":"1995","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2015.08.005_bib0100","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.nmd.2012.11.012","article-title":"Becker muscular dystrophy with widespread muscle hypertrophy and a non-sense mutation of exon 2","volume":"23","author":"Flanigan","year":"2013","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2015.08.005_bib0105","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.nmd.2009.08.010","article-title":"DMD Trp3X nonsense mutation associated with a founder effect in North American families with mild Becker muscular dystrophy","volume":"19","author":"Flanigan","year":"2009","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2015.08.005_bib0110","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/humu.20913","article-title":"DMD exon 1 truncating point mutations: amelioration of phenotype by alternative translation initiation in exon 6","volume":"30","author":"Gurvich","year":"2009","journal-title":"Hum Mutat"},{"key":"10.1016\/j.nmd.2015.08.005_bib0115","doi-asserted-by":"crossref","first-page":"42ra54","DOI":"10.1126\/scitranslmed.3000692","article-title":"A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy","volume":"2","author":"Chandrasekharan","year":"2010","journal-title":"Sci Transl Med"}],"container-title":["Neuromuscular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960896615006951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960896615006951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:03:51Z","timestamp":1760774631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960896615006951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0960896615006951"],"URL":"https:\/\/doi.org\/10.1016\/j.nmd.2015.08.005","relation":{},"ISSN":["0960-8966"],"issn-type":[{"value":"0960-8966","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The first exon duplication mouse model of Duchenne muscular dystrophy: A tool for therapeutic development","name":"articletitle","label":"Article Title"},{"value":"Neuromuscular Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nmd.2015.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}