{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:08:15Z","timestamp":1790701695897,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuromuscular Disorders"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.nmd.2019.10.008","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T20:03:26Z","timestamp":1572897806000},"page":"5-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Long-term data with idebenone on respiratory function outcomes in patients with Duchenne muscular dystrophy"],"prefix":"10.1016","volume":"30","author":[{"given":"Laurent","family":"Servais","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara S.M.","family":"Straathof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Schara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Leinonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4672-8825","authenticated-orcid":false,"given":"Shabir","family":"Hasham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"De Waele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Gordish-Dressman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig M.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar H.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Voit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Mercuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar M.","family":"Buyse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nmd.2019.10.008_bib0001","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1474-4422(09)70271-6","article-title":"Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, pharmacological and psychosocial management","volume":"9","author":"Bushby","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.nmd.2019.10.008_bib0002","first-page":"121","article-title":"Improvement of survival in Duchenne muscular dystrophy: retrospective analysis of 835 patients","volume":"31","author":"Passamano","year":"2012","journal-title":"Acta Myol"},{"key":"10.1016\/j.nmd.2019.10.008_bib0003","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1474-4422(18)30025-5","article-title":"Diagnosis and management of Duchenne muscular dystrophy, part 2: respiratory, cardiac, bone health, and orthopaedic management","volume":"17","author":"Birnkrant","year":"2018","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.nmd.2019.10.008_bib0004","article-title":"Clinical pulmonary function testing in Duchenne muscular dystrophy","author":"Mayer","year":"2018","journal-title":"Paediatr Respir Rev"},{"key":"10.1016\/j.nmd.2019.10.008_bib0005","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1164\/rccm.201703-0507WS","article-title":"Pulmonary endpoints in Duchenne muscular dystrophy: a workshop summary","volume":"196","author":"Finder","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.nmd.2019.10.008_bib0006","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.nmd.2018.07.004","article-title":"Longitudinal pulmonary function testing outcome measures in Duchenne muscular dystrophy: long-term natural history with and without glucocorticoids","volume":"28","author":"McDonald","year":"2018","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2019.10.008_bib0007","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/ppul.23172","article-title":"Characterization of pulmonary function in Duchenne muscular dystrophy","volume":"50","author":"Mayer","year":"2015","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.nmd.2019.10.008_bib0008","first-page":"35","article-title":"Advances in pulmonary care in Duchenne muscular dystrophy","volume":"13","author":"Mayer","year":"2017","journal-title":"US Neurol"},{"key":"10.1016\/j.nmd.2019.10.008_bib0009","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01418-2017","article-title":"Evolution of respiratory function in Duchenne muscular dystrophy from childhood to adulthood","volume":"51","author":"LoMauro","year":"2018","journal-title":"Eur Respir J"},{"key":"10.1016\/j.nmd.2019.10.008_bib0010","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.nmd.2019.02.002","article-title":"Respiratory and upper limb function as outcome measures in ambulant and non-ambulant subjects with Duchenne muscular dystrophy: a prospective multicentre study","volume":"29","author":"Ricotti","year":"2019","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2019.10.008_bib0011","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.nmd.2018.08.005","article-title":"Breathe Duchenne: what natural history studies tell us about the progression of pulmonary morbidity in DMD","volume":"28","author":"Mayer","year":"2018","journal-title":"Neuromuscul Disord"},{"issue":"2","key":"10.1016\/j.nmd.2019.10.008_bib0012","doi-asserted-by":"crossref","first-page":"189","DOI":"10.17925\/ENR.2015.10.02.189","article-title":"Idebenone as a novel therapeutic approach for Duchenne muscular dystrophy","volume":"10","author":"Buyse","year":"2015","journal-title":"Eur Neurol Rev"},{"key":"10.1016\/j.nmd.2019.10.008_bib0013","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/eurheartj\/ehn406","article-title":"Long-term blinded placebo-controlled study of SNT-MC17\/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance","volume":"30","author":"Buyse","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.nmd.2019.10.008_bib0014","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.nmd.2011.02.016","article-title":"Idebenone as a novel, therapeutic approach for duchenne muscular dystrophy: results from a 12 month, double-blind, randomized placebo-controlled trial","volume":"21","author":"Buyse","year":"2011","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2019.10.008_bib0015","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/ppul.22688","article-title":"Effects of glucocorticoids and idebenone on respiratory function in patients with Duchenne muscular dystrophy","volume":"48","author":"Buyse","year":"2013","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.nmd.2019.10.008_bib0016","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/S0140-6736(15)60025-3","article-title":"Efficacy of idebenone on respiratory function in patients with Duchenne muscular dystrophy not using glucocorticoids (DELOS): a double-blind randomised placebo-controlled phase 3 trial","volume":"385","author":"Buyse","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.nmd.2019.10.008_bib0017","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.nmd.2016.12.014","article-title":"Characterization of pulmonary function in 10\u201318 year old patients with Duchenne muscular dystrophy","volume":"27","author":"Meier","year":"2017","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2019.10.008_bib0018","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/ppul.23547","article-title":"Treatment effect of idebenone on inspiratory function in patients with Duchenne muscular dystrophy","volume":"52","author":"Buyse","year":"2017","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.nmd.2019.10.008_bib0019","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3233\/JND-170245","article-title":"Efficacy of idebenone to preserve respiratory function above clinically meaningful thresholds for forced vital capacity (FVC) in patients with Duchenne muscular dystrophy","volume":"4","author":"Mayer","year":"2017","journal-title":"J Neuromuscul Dis"},{"key":"10.1016\/j.nmd.2019.10.008_bib0020","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3233\/JND-180338","article-title":"Home-based monitoring of pulmonary function in patients with Duchenne muscular dystrophy","volume":"5","author":"Buyse","year":"2018","journal-title":"J Neuromuscul Dis"},{"key":"10.1016\/j.nmd.2019.10.008_bib0021","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.nmd.2016.05.008","article-title":"Idebenone reduces respiratory complications in patients with Duchenne muscular dystrophy","volume":"26","author":"McDonald","year":"2016","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2019.10.008_bib0022","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/mus.23807","article-title":"The cooperative international neuromuscular research group Duchenne natural history study\u2013a longitudinal investigation in the era of glucocorticoid therapy: design of protocol and the methods used","volume":"48","author":"McDonald","year":"2013","journal-title":"Muscle Nerve"},{"issue":"9","key":"10.1016\/j.nmd.2019.10.008_bib0023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0161955","article-title":"Long-term efficacy, safety, and pharmacokinetics of drisapersen in Duchenne muscular dystrophy: results from an open-label extension study","volume":"11","author":"Goemans","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.nmd.2019.10.008_bib0024","doi-asserted-by":"crossref","first-page":"e2146","DOI":"10.1212\/WNL.0000000000005680","article-title":"Eteplirsen treatment for Duchenne muscular dystrophy: exon skipping and dystrophin production","volume":"90","author":"Charleston","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.nmd.2019.10.008_bib0025","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/cpt.1086","article-title":"Real-World evidence: what it is and what it can tell us according to the international society for pharmacoepidemiology (ISPE) comparative effectiveness research (CER) special interest group (SIG)","volume":"104","author":"Yuan","year":"2018","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.nmd.2019.10.008_bib0026","unstructured":"Criteria for rating therapeutic and diagnostic studies: https:\/\/www.neurology.org\/sites\/default\/files\/ifa\/loe.pdf."},{"key":"10.1016\/j.nmd.2019.10.008_bib0027","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/mus.25411","article-title":"Patient-centered benefit-risk assessment in Duchenne muscular dystrophy","volume":"55","author":"Hollin","year":"2017","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nmd.2019.10.008_bib0028","doi-asserted-by":"crossref","DOI":"10.1007\/s11136-018-1891-7","article-title":"Engaging patients and caregivers in prioritizing symptoms impacting quality of life for Duchenne and Becker muscular dystrophy","author":"Hollin","year":"2018","journal-title":"Qual. Life Res"},{"key":"10.1016\/j.nmd.2019.10.008_bib0029","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11325-015-1196-9","article-title":"Sleep quality of mother-caregivers of Duchenne muscular dystrophy patients","volume":"20","author":"Nozoe","year":"2016","journal-title":"Sleep Breath"},{"key":"10.1016\/j.nmd.2019.10.008_bib0030","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/PHM.0000000000000228","article-title":"Cost and physician effort analysis of invasive vs. noninvasive respiratory management of Duchenne muscular dystrophy","volume":"94","author":"Bach","year":"2015","journal-title":"Am J Phys Med Rehabil"}],"container-title":["Neuromuscular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960896619311642?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960896619311642?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:09:00Z","timestamp":1760774940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960896619311642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0960896619311642"],"URL":"https:\/\/doi.org\/10.1016\/j.nmd.2019.10.008","relation":{},"ISSN":["0960-8966"],"issn-type":[{"value":"0960-8966","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term data with idebenone on respiratory function outcomes in patients with Duchenne muscular dystrophy","name":"articletitle","label":"Article Title"},{"value":"Neuromuscular Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nmd.2019.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}