{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:21:35Z","timestamp":1782256895793,"version":"3.54.5"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuromuscular Disorders"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.nmd.2021.02.007","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T09:38:46Z","timestamp":1613381926000},"page":"371-384","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Importance of immunohistochemical evaluation of developmentally regulated myosin heavy chains in human muscle biopsies"],"prefix":"10.1016","volume":"31","author":[{"given":"C.A.","family":"Sewry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Phadke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nmd.2021.02.007_bib0001","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/292805a0","article-title":"Pinset-H\u00e4rst\u00f6m I. Three myosin heavy-chain isozymes appear sequentially in rat muscle development","volume":"292","author":"Whalen","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.nmd.2021.02.007_bib0002","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13395-015-0046-6","article-title":"Developmental myosins: expression patterns and functional significance","volume":"5","author":"Schiaffino","year":"2015","journal-title":"Skelet Muscle"},{"key":"10.1016\/j.nmd.2021.02.007_bib0003","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1152\/physrev.00031.2010","article-title":"Fibre types in mammalian skeletal muscles","volume":"91","author":"Schiaffino","year":"2011","journal-title":"Physiol Rev"},{"key":"10.1016\/j.nmd.2021.02.007_bib0004","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1001\/archneur.65.8.1083","article-title":"Embryonic myosin heavy-chain mutations cause distal arthrogryposis and developmental myosin myopathy that persists postnatally","volume":"65","author":"Tajsharghi","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.nmd.2021.02.007_bib0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00401-012-1024-2","article-title":"Myosinopathies: pathology and mechanisms","volume":"125","author":"Tajsharghi","year":"2013","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.nmd.2021.02.007_bib0006","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.aanat.2016.02.007","article-title":"Expression and identification of 10 sarcomeric MyHC isoforms in human skeletal muscles of different embryological origin. Diversity and similarity in mammalian species","volume":"207","author":"Mascarello","year":"2016","journal-title":"Ann Anat"},{"key":"10.1016\/j.nmd.2021.02.007_bib0007","doi-asserted-by":"crossref","first-page":"906","DOI":"10.2174\/138161210790883453","article-title":"Basic mechanisms and clinical implications","volume":"16","author":"Ciciliot","year":"2010","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.nmd.2021.02.007_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0012-1606(88)90183-2","article-title":"Embryonic and neonatal myosin heavy chain in denervated and paralyzed rat skeletal muscle","volume":"127","author":"Schiaffino","year":"1988","journal-title":"Dev Biol"},{"key":"10.1016\/j.nmd.2021.02.007_bib0009","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1432-1033.1990.tb19379.x","article-title":"Myosin heavy chain isoform composition in striated muscle after denervation and self-reinnervation","volume":"193","author":"Jakubiec-Puka","year":"1990","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.nmd.2021.02.007_bib0010","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1152\/jappl.2000.89.3.1106","article-title":"Denervation alters myosin heavy chain expression and contractility of developing rat diaphragm muscle","volume":"89","author":"Sieck","year":"2000","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.nmd.2021.02.007_bib0011","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/ar.a.20218","article-title":"Adult and developmental myosin heavy chain isoforms in soleus muscle of aging Fischer Brown Norway rat","volume":"286","author":"Snow","year":"2005","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"10.1016\/j.nmd.2021.02.007_bib0012","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.biocel.2014.09.010","article-title":"The need to more precisely define aspects of skeletal muscle regeneration","volume":"56","author":"Grounds","year":"2014","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.nmd.2021.02.007_bib0013","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1083\/jcb.92.2.471","article-title":"Distribution and properties of myosin isozymes in developing avian and mammalian skeletal muscle fibres","volume":"92","author":"Gauthier","year":"1982","journal-title":"J Cell Biol"},{"key":"10.1016\/j.nmd.2021.02.007_bib0014","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/ar.1092360315","article-title":"Development of innervation of skeletal muscle fibres in man: relation to acetylcholine receptors","volume":"236","author":"Hesselmans","year":"1993","journal-title":"Anat Rec"},{"key":"10.1016\/j.nmd.2021.02.007_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0925-4773(91)90036-6","article-title":"Immunocytochemical characterisation of two generations of fibres during the development of the human quadriceps muscle","volume":"35","author":"Barbet","year":"1991","journal-title":"Mech Dev"},{"key":"10.1016\/j.nmd.2021.02.007_bib0016","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0022-510X(87)90181-X","article-title":"Primary, secondary and tertiary myotubes in developing skeletal muscle: a new approach to the analysis of human myogenesis","volume":"81","author":"Draeger","year":"1987","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.nmd.2021.02.007_bib0017","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0022-510X(89)90076-2","article-title":"Immunocytochemical demonstration of myosin heavy chain expression in human muscle","volume":"91","author":"Ecob-Prince","year":"1989","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.nmd.2021.02.007_bib0018","series-title":"Muscle biopsy; a practical approach","author":"Dubowitz","year":"2021"},{"key":"10.1016\/j.nmd.2021.02.007_bib0019","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0960-8966(91)90004-C","article-title":"Myosin isoform transitions and physiological properties of regenerated and re-innervated soleus muscles of the rat","volume":"1","author":"Davis","year":"1991","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2021.02.007_bib0020","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/mus.23946","article-title":"Absence of developmental and unconventional myosin heavy chain in human suprahyoid muscles","volume":"49","author":"Luo","year":"2014","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nmd.2021.02.007_bib0021","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/mus.26638","article-title":"Molecular indicators of denervation in aging human skeletal muscle","volume":"60","author":"Soendenbroe","year":"2019","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nmd.2021.02.007_bib0022","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040893","article-title":"Key components of human myofibre denervation and neuromuscular junction stability are modulated by age and exercise","volume":"9","author":"Soendenbroe","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.nmd.2021.02.007_bib0023","series-title":"Current concepts in childhood spinal muscular atrophy","first-page":"57","article-title":"Contribution of immunocytochemistry to the pathogenesis of spinal muscular atrophy","author":"Sewry","year":"1989"},{"key":"10.1016\/j.nmd.2021.02.007_bib0024","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0022-510X(81)90018-6","article-title":"Embryonic and foetal myosins in human skeletal muscle. The presence of foetal myosins in duchenne muscular dystrophy and infantile spinal muscular atrophy","volume":"52","author":"Fitzsimons","year":"1981","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.nmd.2021.02.007_bib0025","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0022-510X(92)90103-R","article-title":"Evolution of muscle specific proteins in Werdnig-Hoffman's disease","volume":"109","author":"Soussi-Yanicostas","year":"1992","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.nmd.2021.02.007_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0012-1606(88)90183-2","article-title":"Embryonic and neonatal myosin heavy chain in denervated and paralyzed rat skeletal muscle","volume":"127","author":"Schiaffino","year":"1988","journal-title":"Dev Biol"},{"key":"10.1016\/j.nmd.2021.02.007_bib0027","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00401-010-0637-6","article-title":"Differences in aberrant expression and splicing of sarcomeric proteins in the myotonic dystrophies DM1 and DM2","volume":"119","author":"Vihola","year":"2010","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.nmd.2021.02.007_bib0028","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1177\/147323001103900205","article-title":"The study of myogenin expression in denervated human skeletal muscles","volume":"39","author":"Chen","year":"2011","journal-title":"J Int Med Res"},{"key":"10.1016\/j.nmd.2021.02.007_bib0029","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/aja.1001980307","article-title":"Differential expression of muscle regulatory factor genes in normal and denervated adult rat hindlimb muscles","volume":"198","author":"Voytik","year":"1993","journal-title":"Dev Dyn"},{"key":"10.1016\/j.nmd.2021.02.007_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10974-019-09511-3","article-title":"The role of satellite and other functional cell types in muscle repair and regeneration","volume":"40","author":"Chen","year":"2019","journal-title":"J Muscle Res Cell Motil"},{"key":"10.1016\/j.nmd.2021.02.007_bib0031","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fphys.2014.00099","article-title":"Skeletal muscle wasting with disuse atrophy is multi-dimensional: the response and interaction of myonuclei, satellite cells and signaling pathways","volume":"5","author":"Brooks","year":"2014","journal-title":"Front Physiol"},{"key":"10.1016\/j.nmd.2021.02.007_bib0032","doi-asserted-by":"crossref","first-page":"432","DOI":"10.2741\/3253","article-title":"Response and adaptation of skeletal muscle to denervation stress: the role of apoptosis in muscle loss","volume":"14","author":"Siu","year":"2009","journal-title":"Front Biosci (Landmark Ed)"},{"key":"10.1016\/j.nmd.2021.02.007_bib0033","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10974-015-9439-8","article-title":"Skeletal muscle atrophy: disease-induced mechanisms may mask disuse atrophy","volume":"36","author":"Malavaki","year":"2015","journal-title":"J Muscle Res Cell Motil"},{"key":"10.1016\/j.nmd.2021.02.007_bib0034","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0960-8966(94)90045-0","article-title":"Experimental regeneration in canine muscular dystrophy\u20132. Expression of myosin heavy chain isoforms","volume":"4","author":"Wilson","year":"1994","journal-title":"Neuromuscul Disord"}],"container-title":["Neuromuscular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960896621000353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960896621000353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:10:12Z","timestamp":1760775012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960896621000353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0960896621000353"],"URL":"https:\/\/doi.org\/10.1016\/j.nmd.2021.02.007","relation":{},"ISSN":["0960-8966"],"issn-type":[{"value":"0960-8966","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Importance of immunohistochemical evaluation of developmentally regulated myosin heavy chains in human muscle biopsies","name":"articletitle","label":"Article Title"},{"value":"Neuromuscular Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nmd.2021.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}