{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:29:56Z","timestamp":1787812196081,"version":"build-2784847793"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuromuscular Disorders"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.nmd.2022.09.010","type":"journal-article","created":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T09:54:39Z","timestamp":1664704479000},"page":"24-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Quantitative vs qualitative muscle MRI: Imaging biomarker in patients with Oculopharyngeal Muscular Dystrophy (OPMD)"],"prefix":"10.1016","volume":"33","author":[{"given":"Gerd","family":"Melkus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos L.","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5269-1710","authenticated-orcid":false,"given":"Ian C.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kawan S.","family":"Rakhra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre R.","family":"Bourque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Breiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Zwicker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanns","family":"Lochm\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Brais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0187-2199","authenticated-orcid":false,"given":"Jodi","family":"Warman-Chardon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nmd.2022.09.010_bib0001","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/ng0298-164","article-title":"Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy","volume":"18","author":"Brais","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.nmd.2022.09.010_bib0002","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/mus.26888","article-title":"A study of impairments in oculopharyngeal muscular dystrophy","volume":"62","author":"Brisson","year":"2020","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nmd.2022.09.010_bib0003","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1212\/WNL.55.9.1267","article-title":"Oculopharyngeal MD among Bukhara Jews is due to a founder (GCG)9 mutation in the PABP2 gene","volume":"55","author":"Blumen","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.nmd.2022.09.010_bib0004","first-page":"376","article-title":"[Haplotype Analysis of Oculopharyngeal Muscular Dystrophy (OPMD) Locus in Yakutia]","volume":"52","author":"Marusin","year":"2016","journal-title":"Genetika"},{"key":"10.1016\/j.nmd.2022.09.010_bib0005","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1001\/jama.286.19.2437","article-title":"Oculopharyngeal muscular dystrophy in Hispanic New Mexicans","volume":"286","author":"Becher","year":"2001","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.nmd.2022.09.010_bib0006","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1111\/ene.15252","article-title":"Clinical and genetic features of a large homogeneous cohort of oculopharyngeal muscular dystrophy patients from the Canary Islands","volume":"29","author":"Alonso-Perez","year":"2022","journal-title":"Eur J Neurol"},{"issue":"1","key":"10.1016\/j.nmd.2022.09.010_bib0007","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/S0960-8966(97)00074-6","article-title":"Andre Barbeau and the oculopharyngeal muscular dystrophy in French Canada and North America","volume":"7","author":"Bouchard","year":"1997","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2022.09.010_bib0008","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/mus.20726","article-title":"Variability of the recessive oculopharyngeal muscular dystrophy phenotype","volume":"35","author":"Semmler","year":"2007","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nmd.2022.09.010_bib0009","unstructured":"Trollet C., Boulinguiez A., Roth F., Stojkovic T., Butler-Browne G., Evangelista T., et\u00a0al. Oculopharyngeal muscular dystrophy. In: Adam M P, et\u00a0al. editor GeneReviews((R)). Seattle (WA), 1993."},{"key":"10.1016\/j.nmd.2022.09.010_bib0010","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/ana.25804","article-title":"MRI in neuromuscular diseases: an emerging diagnostic tool and biomarker for prognosis and efficacy","volume":"88","author":"Dahlqvist","year":"2020","journal-title":"Ann Neurol"},{"issue":"15","key":"10.1016\/j.nmd.2022.09.010_bib0011","doi-asserted-by":"crossref","first-page":"e1475","DOI":"10.1212\/WNL.0000000000012640","article-title":"Longitudinal assessment of strength, functional capacity, oropharyngeal function, and quality of life in oculopharyngeal muscular dystrophy","volume":"97","author":"Kroon","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.nmd.2022.09.010_bib0012","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1007\/s00415-011-6393-2","article-title":"Quantitative MRI can detect subclinical disease progression in muscular dystrophy","volume":"259","author":"Fischmann","year":"2012","journal-title":"J Neurol"},{"key":"10.1016\/j.nmd.2022.09.010_bib0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00223-019-00545-w","article-title":"Assessment of muscle function and physical performance in daily clinical practice : a position paper endorsed by the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)","volume":"105","author":"Beaudart","year":"2019","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.nmd.2022.09.010_bib0014","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1136\/thx.39.11.818","article-title":"Effect of encouragement on walking test performance","volume":"39","author":"Guyatt","year":"1984","journal-title":"Thorax"},{"key":"10.1016\/j.nmd.2022.09.010_bib0015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/13682820701234444","article-title":"Reliability of speech diadochokinetic test measurement","volume":"43","author":"Gadesmann","year":"2008","journal-title":"Int J Lang Commun Disord"},{"key":"10.1016\/j.nmd.2022.09.010_bib0016","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nrd.2017.70","article-title":"How much do clinical trials cost?","volume":"16","author":"Martin","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.nmd.2022.09.010_bib0017","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.omtn.2019.02.003","article-title":"RNA-Based Therapy Utilizing Oculopharyngeal Muscular Dystrophy Transcript Knockdown and Replacement","volume":"15","author":"Abu-Baker","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.nmd.2022.09.010_bib0018","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.omtn.2021.02.017","article-title":"BB-301: a silence and replace AAV-based vector for the treatment of oculopharyngeal muscular dystrophy","volume":"24","author":"Strings-Ufombah","year":"2021","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.nmd.2022.09.010_bib0019","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1055\/s-0037-1604111","article-title":"The Role of Muscle Imaging in the Diagnosis and Assessment of Children with Genetic Muscle Disease","volume":"48","author":"Warman Chardon","year":"2017","journal-title":"Neuropediatrics"},{"issue":"2","key":"10.1016\/j.nmd.2022.09.010_bib0020","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1016\/j.nmd.2012.08.002","article-title":"TREAT-NMD workshop: pattern recognition in genetic muscle diseases using muscle MRI: 25-26 February 2011","volume":"22","author":"Straub","year":"2012","journal-title":"Rome, Italy. Neuromusc Disord : NMD"},{"issue":"5","key":"10.1016\/j.nmd.2022.09.010_bib0021","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/cge.13935","article-title":"Whole genome sequencing reveals biallelic PLA2G6 mutations in siblings with cerebellar atrophy and cap myopathy","volume":"99","author":"McMillan","year":"2021","journal-title":"Clin Genet"},{"key":"10.1016\/j.nmd.2022.09.010_bib0022","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/ana.25685","article-title":"Novel Recessive TNNT1 Congenital Core-Rod Myopathy in French Canadians","volume":"87","author":"Pellerin","year":"2020","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nmd.2022.09.010_bib0023","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.nmd.2019.08.011","article-title":"MYO-MRI diagnostic protocols in genetic myopathies","volume":"29","author":"Warman Chardon","year":"2019","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2022.09.010_bib0024","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1053\/ejpn.2002.0617","article-title":"A short protocol for muscle MRI in children with muscular dystrophies","volume":"6","author":"Mercuri","year":"2002","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.nmd.2022.09.010_bib0025","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S1058-2746(03)00211-8","article-title":"Influence of cuff muscle fatty degeneration on anatomic and functional outcomes after simple suture of full-thickness tears","volume":"12","author":"Goutallier","year":"2003","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.nmd.2022.09.010_bib0026","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1136\/jnnp-2018-319578","article-title":"Muscle MRI in a large cohort of patients with oculopharyngeal muscular dystrophy","volume":"90","author":"Alonso-Jimenez","year":"2019","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.nmd.2022.09.010_bib0027","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1007\/s00415-017-8547-3","article-title":"Quantifying fat replacement of muscle by quantitative MRI in muscular dystrophy","volume":"264","author":"Burakiewicz","year":"2017","journal-title":"J Neurol"},{"key":"10.1016\/j.nmd.2022.09.010_bib0028","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1007\/s00415-018-9037-y","article-title":"Quantitative muscle MRI and ultrasound for facioscapulohumeral muscular dystrophy: complementary imaging biomarkers","volume":"265","author":"Mul","year":"2018","journal-title":"J Neurol"},{"key":"10.1016\/j.nmd.2022.09.010_bib0029","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3233\/JND-200543","article-title":"Correlation Between Quantitative MRI and Muscle Histopathology in Muscle Biopsies from Healthy Controls and Patients with IBM, FSHD and OPMD","volume":"7","author":"Lassche","year":"2020","journal-title":"J Neuromuscul Dis"},{"key":"10.1016\/j.nmd.2022.09.010_bib0030","first-page":"2838","article-title":"Medical Research Council: nerve Injuries Research Committee. His Majesty's Stationery Office: 1942; pp. 48 (iii) and 74 figures and 7 diagrams; with aids to the examination of the peripheral nervous system","volume":"133","year":"2010","journal-title":"By Michael O'Brien for the Guarantors of Brain"},{"key":"10.1016\/j.nmd.2022.09.010_bib0031","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.neuroimage.2006.01.015","article-title":"User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability","volume":"31","author":"Yushkevich","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.nmd.2022.09.010_bib0032","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"10.1016\/j.nmd.2022.09.010_bib0033","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1213\/ANE.0000000000002864","article-title":"Correlation Coefficients: appropriate Use and Interpretation","volume":"126","author":"Schober","year":"2018","journal-title":"Anesth Analg"},{"key":"10.1016\/j.nmd.2022.09.010_bib0034","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.nmd.2017.09.010","article-title":"Involvement of pelvic girdle and proximal leg muscles in early oculopharyngeal muscular dystrophy","volume":"27","author":"van der Sluijs","year":"2017","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.nmd.2022.09.010_bib0035","doi-asserted-by":"crossref","first-page":"e4119","DOI":"10.1002\/nbm.4119","article-title":"Multi-center evaluation of stability and reproducibility of quantitative MRI measures in healthy calf muscles","volume":"32","author":"Schlaffke","year":"2019","journal-title":"NMR Biomed"},{"key":"10.1016\/j.nmd.2022.09.010_bib0036","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00247-005-1413-y","article-title":"Obesity and fat quantification in lean tissues using three-point Dixon MR imaging","volume":"35","author":"Kovanlikaya","year":"2005","journal-title":"Pediatr Radiol"},{"key":"10.1016\/j.nmd.2022.09.010_bib0037","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/sj.ijo.0801733","article-title":"Fat content in individual muscle fibers of lean and obese subjects","volume":"25","author":"Malenfant","year":"2001","journal-title":"Int J Obes Relat Metab Disord"},{"issue":"17","key":"10.1016\/j.nmd.2022.09.010_bib0038","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176059","article-title":"Age-Associated Salivary MicroRNA Biomarkers for Oculopharyngeal Muscular Dystrophy","volume":"21","author":"Raz","year":"2020","journal-title":"Int J Mol Sci"}],"container-title":["Neuromuscular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960896622006940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960896622006940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:13:04Z","timestamp":1760775184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960896622006940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S0960896622006940"],"URL":"https:\/\/doi.org\/10.1016\/j.nmd.2022.09.010","relation":{},"ISSN":["0960-8966"],"issn-type":[{"value":"0960-8966","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative vs qualitative muscle MRI: Imaging biomarker in patients with Oculopharyngeal Muscular Dystrophy (OPMD)","name":"articletitle","label":"Article Title"},{"value":"Neuromuscular Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nmd.2022.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}