{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:34:45Z","timestamp":1777883685351,"version":"3.51.4"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011724","name":"Muscular Dystrophy UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011724","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["32ER30_173672"],"award-info":[{"award-number":["32ER30_173672"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010767","name":"Stiftung f\u00fcr die Erforschung der Muskelkrankheiten","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009358","name":"Duchenne Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009358","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007423","name":"Duchenne Parent Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","nmd-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuromuscular Disorders"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.nmd.2026.106366","type":"journal-article","created":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T06:26:48Z","timestamp":1769927208000},"page":"106366","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Safety and Efficacy of Tamoxifen in Patients with Duchenne muscular dystrophy: open Label Extension of TAMDMD Trial"],"prefix":"10.1016","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6037-7295","authenticated-orcid":false,"given":"Ga\u00ebtan","family":"Zwingli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niveditha","family":"Putananickal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Rubino\u2013Nacht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Schaedelin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helge","family":"Amthor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2013Marie","family":"Childs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Deconinck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iain","family":"Horrocks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia","family":"Houwen\u2013van Opstal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Laugel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Lopez Lobato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Nascimento Osorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Schara\u2013Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Spinty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpad","family":"von Moers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Hafner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier M.","family":"Dorchies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0707-9201","authenticated-orcid":false,"given":"Dirk","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina C.","family":"Henzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.nmd.2026.106366_bib0001","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/ana.23528","article-title":"Evidence-based path to newborn screening for duchenne muscular dystrophy","volume":"71","author":"Mendell","year":"2012","journal-title":"Ann Neurol"},{"issue":"1","key":"10.1016\/j.nmd.2026.106366_bib0002","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13023-021-01862-w","article-title":"The clinical course of duchenne muscular dystrophy in the corticosteroid treatment era: a systematic literature review","volume":"16","author":"Szabo","year":"2021","journal-title":"Orphanet J Rare Dis"},{"issue":"4","key":"10.1016\/j.nmd.2026.106366_bib0003","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2533\/chimia.2018.238","article-title":"Repurposing the selective oestrogen receptor modulator Tamoxifen for the treatment of Duchenne muscular dystrophy","volume":"72","author":"Gayi","year":"2018","journal-title":"Chim (Aarau)"},{"issue":"2","key":"10.1016\/j.nmd.2026.106366_bib0004","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ajpath.2012.10.018","article-title":"The anticancer drug tamoxifen counteracts the pathology in a mouse model of duchenne muscular dystrophy","volume":"182","author":"Dorchies","year":"2013","journal-title":"Am J Pathol"},{"issue":"11","key":"10.1016\/j.nmd.2026.106366_bib0005","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/0006-2952(94)90073-6","article-title":"Tamoxifen and hydroxytamoxifen as intramembraneous inhibitors of lipid peroxidation. Evidence for peroxyl radical scavenging activity","volume":"47","author":"Cust\u00f3dio","year":"1994","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1016\/j.nmd.2026.106366_bib0006","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/taap.1998.8510","article-title":"Tamoxifen inhibits induction of the mitochondrial permeability transition by Ca2+ and inorganic phosphate","volume":"152","author":"Custodio","year":"1998","journal-title":"Toxicol Appl Pharmacol"},{"issue":"4\u20136","key":"10.1016\/j.nmd.2026.106366_bib0007","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/0960-0760(91)90292-D","article-title":"Tamoxifen and oestrogen both protect the rat muscle against physiological damage","volume":"40","author":"Koot","year":"1991","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"2","key":"10.1016\/j.nmd.2026.106366_bib0008","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1006\/jsre.2001.6350","article-title":"Tamoxifen decreases fibroblast function and downregulates TGF(beta2) in dupuytren's affected palmar fascia","volume":"103","author":"Kuhn","year":"2002","journal-title":"J Surg Res"},{"issue":"3","key":"10.1016\/j.nmd.2026.106366_bib0009","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/01.sap.0000199155.73000.2f","article-title":"Down-regulating causes of fibrosis with tamoxifen: a possible cellular\/molecular approach to treat rhinophyma","volume":"56","author":"Payne","year":"2006","journal-title":"Ann Plast Surg"},{"issue":"7","key":"10.1016\/j.nmd.2026.106366_bib0010","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/sj.bjp.0706265","article-title":"Modulation of mitochondrial Ca(2+) uptake by estrogen receptor agonists and antagonists","volume":"145","author":"Lobat\u00f3n","year":"2005","journal-title":"Br J Pharmacol"},{"issue":"10","key":"10.1016\/j.nmd.2026.106366_bib0011","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S1474-4422(23)00285-5","article-title":"Safety and efficacy of tamoxifen in boys with duchenne muscular dystrophy (TAMDMD): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial","volume":"22","author":"Henzi","year":"2023","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.nmd.2026.106366_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.nmd.2025.105275","article-title":"Safety and efficacy of tamoxifen in non-ambulant patients with Duchenne muscular dystrophy: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial (TAMDMD Group B)","volume":"47","author":"Henzi","year":"2025","journal-title":"Neuromuscul Disord"},{"issue":"3","key":"10.1016\/j.nmd.2026.106366_bib0013","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1001\/jama.2021.9941","article-title":"Guidelines for reporting trial protocols and completed trials modified due to the COVID-19 pandemic and other extenuating circumstances: the conserve 2021 statement","volume":"326","author":"Orkin","year":"2021","journal-title":"Jama"},{"issue":"1","key":"10.1016\/j.nmd.2026.106366_bib0014","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1186\/s13063-019-3740-6","article-title":"Tamoxifen in Duchenne muscular dystrophy (TAMDMD): study protocol for a multicenter, randomized, placebo-controlled, double-blind phase 3 trial","volume":"20","author":"Nagy","year":"2019","journal-title":"Trials"},{"issue":"2","key":"10.1016\/j.nmd.2026.106366_bib0015","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/dmcn.13590","article-title":"Corticosteroids in duchenne muscular dystrophy: impact on the motor function measure sensitivity to change and implications for clinical trials","volume":"60","author":"Schreiber","year":"2018","journal-title":"Dev Med Child Neurol"},{"issue":"1","key":"10.1016\/j.nmd.2026.106366_bib0016","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1469-8749.2009.03316.x","article-title":"Monitoring changes and predicting loss of ambulation in duchenne muscular dystrophy with the Motor Function Measure","volume":"52","author":"Vuillerot","year":"2010","journal-title":"Dev Med Child Neurol"},{"issue":"1","key":"10.1016\/j.nmd.2026.106366_bib0017","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1530\/JOE-16-0070","article-title":"Plasma steroid-binding proteins: primary gatekeepers of steroid hormone action","volume":"230","author":"Hammond","year":"2016","journal-title":"J Endocrinol"}],"container-title":["Neuromuscular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960896626000349?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960896626000349?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:54:36Z","timestamp":1777600476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960896626000349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":17,"alternative-id":["S0960896626000349"],"URL":"https:\/\/doi.org\/10.1016\/j.nmd.2026.106366","relation":{},"ISSN":["0960-8966"],"issn-type":[{"value":"0960-8966","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and Efficacy of Tamoxifen in Patients with Duchenne muscular dystrophy: open Label Extension of TAMDMD Trial","name":"articletitle","label":"Article Title"},{"value":"Neuromuscular Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nmd.2026.106366","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106366"}}