{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:25:56Z","timestamp":1763141156978,"version":"build-2065373602"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T00:00:00Z","timestamp":1552003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["New Microbes and New Infections"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.nmni.2019.100529","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T03:01:24Z","timestamp":1552532484000},"page":"100529","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["V348I mutation in UL23 gene of human herpesvirus 1 in a case of herpetic hepatitis and haemophagocytic lymphohistiocytosis"],"prefix":"10.1016","volume":"29","author":[{"given":"S.","family":"Corcione","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Sidoti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Mornese Pinna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bonetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Urbino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cavallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.G.","family":"De Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nmni.2019.100529_bib1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1086\/513646","article-title":"Fulminant hepatitis during herpes simplex virus infection in apparently immunocompetent adults: report of two cases and review of the literature","author":"Farr","year":"1997","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.nmni.2019.100529_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2017.01102","article-title":"How viruses contribute to the pathogenesis of hemophagocytic lymphohistiocytosis","volume":"8","author":"Brisse","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.nmni.2019.100529_bib3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0140-6736(00)61951-7","article-title":"Histiocytic medullary reticulosis","volume":"234","author":"Bodley","year":"1939","journal-title":"Lancet"},{"key":"10.1016\/j.nmni.2019.100529_bib4","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S0140-6736(13)61048-X","article-title":"Adult haemophagocytic syndrome","volume":"383","author":"Ramos-Casals","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.nmni.2019.100529_bib5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/ACI.0000000000000405","article-title":"Comparing hemophagocytic lymphohistiocytosis in pediatric and adult patients","volume":"17","author":"Wysocki","year":"2017","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.nmni.2019.100529_bib6","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/pbc.21039","article-title":"HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis Pediatr","volume":"48","author":"Henter","year":"2007","journal-title":"Blood Cancer"},{"key":"10.1016\/j.nmni.2019.100529_bib7","first-page":"69","article-title":"Hemophagocytic lymphohistiocytosis: review of etiologies and management","author":"George","year":"2014","journal-title":"J\u00a0Blood Med"},{"key":"10.1016\/j.nmni.2019.100529_bib8","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1086\/315696","article-title":"Genetic characterization of thymidine kinase from acyclovir-resistant and susceptible herpes simplex virus type 1 isolated from bone marrow transplant recipients","volume":"182","author":"Morfin","year":"2000","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.nmni.2019.100529_bib9","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1086\/315387","article-title":"Characterization of an acyclovir-resistant herpes simplex virus type 2 strain isolated from a premature neonate","volume":"181","author":"Oram","year":"2000","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.nmni.2019.100529_bib10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/(SICI)1096-9071(199810)56:2<151::AID-JMV9>3.0.CO;2-7","article-title":"Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: analysis of clinical isolates from herpetic keratitis patients and laboratory strains","volume":"56","author":"Kudo","year":"1998","journal-title":"J\u00a0Med Virol"},{"issue":"9","key":"10.1016\/j.nmni.2019.100529_bib11","doi-asserted-by":"crossref","first-page":"e0136825","DOI":"10.1371\/journal.pone.0136825","article-title":"Genotypic characterization of herpes simplex virus type 1 isolates in immunocompromised patients in Rio de Janeiro, Brazil","volume":"10","author":"Perse da Silva","year":"2015","journal-title":"PLoSOne"},{"key":"10.1016\/j.nmni.2019.100529_bib12","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.1128\/AAC.00259-10","article-title":"Differentiation between polymorphisms and resistance-associated mutations in human cytomegalovirus DNA polymerase","volume":"54","author":"Chevillotte","year":"2010","journal-title":"Antimicrob Ag Chemother"},{"key":"10.1016\/j.nmni.2019.100529_bib13","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/ped.12817","article-title":"Hemophagocytic lymphohistiocytosis caused by systemic herpes simplex virus type 1 infection: successful treatment with dexamethasone palmitate","volume":"58","author":"Otsubo","year":"2016","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.nmni.2019.100529_bib14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s15010-010-0037-9","article-title":"Hemophagocytic syndrome caused by primary herpes simplex virus 1 infection: report of a first case","volume":"38","author":"Cusini","year":"2010","journal-title":"Infection"},{"key":"10.1016\/j.nmni.2019.100529_bib15","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2016-218310","article-title":"Haemophagocytic lymphohistiocytosis associated with fulminant hepatitis and multiorgan failure following primary Epstein\u2013Barr virus and herpes simplex virus type 1 infection","author":"Honsig","year":"2017","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.nmni.2019.100529_bib16","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S0140-6736(13)61048-X","article-title":"Adult haemophagocytic syndrome","volume":"383","author":"Ramos-Casals","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.nmni.2019.100529_bib17","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.2169\/internalmedicine.8490-16","article-title":"Successful treatment of herpes simplex virus (HSV)-1-associated hemophagocytic lymphohistiocytosis (HLH) with acyclovir: a case report and literature review","author":"Yabushita","year":"2017","journal-title":"Intern Med"},{"key":"10.1016\/j.nmni.2019.100529_bib18","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.3389\/fimmu.2017.01902","article-title":"Epstein\u2013Barr virus and hemophagocytic lymphohistiocytosis","volume":"8","author":"Marsh","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.nmni.2019.100529_bib19","first-page":"42","article-title":"Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis","volume":"7","author":"Goudarzipour","year":"2013","journal-title":"Int J Hematol Oncol Stem Cell Res"},{"key":"10.1016\/j.nmni.2019.100529_bib20","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1182\/blood-2011-03-278127","article-title":"How I treat hemophagocytic lymphohistiocytosis","volume":"118","author":"Jordan","year":"2011","journal-title":"Blood"}],"container-title":["New Microbes and New Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2052297519300253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2052297519300253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T19:57:42Z","timestamp":1761854262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2052297519300253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":20,"alternative-id":["S2052297519300253"],"URL":"https:\/\/doi.org\/10.1016\/j.nmni.2019.100529","relation":{},"ISSN":["2052-2975"],"issn-type":[{"type":"print","value":"2052-2975"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"V348I mutation in UL23 gene of human herpesvirus 1 in a case of herpetic hepatitis and haemophagocytic lymphohistiocytosis","name":"articletitle","label":"Article Title"},{"value":"New Microbes and New Infections","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nmni.2019.100529","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100529"}}