{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:50:53Z","timestamp":1772999453558,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropeptides"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1016\/j.npep.2005.03.005","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T07:44:59Z","timestamp":1115883899000},"page":"419-426","source":"Crossref","is-referenced-by-count":31,"title":["Protective effect of colostrinin on neuroblastoma cell survival is due to reduced aggregation of \u03b2-amyloid"],"prefix":"10.1016","volume":"39","author":[{"given":"David","family":"Schuster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anitha","family":"Rajendran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sek Wen","family":"Hui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Nicotera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thamarapu","family":"Srikrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian L.","family":"Kruzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.npep.2005.03.005_bib1","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.peptides.2003.08.005","article-title":"The neuroprotective peptide NAP inhibits the aggregation of the beta-amyloid peptide","volume":"24","author":"Ashur-Fabian","year":"2003","journal-title":"Peptides"},{"key":"10.1016\/j.npep.2005.03.005_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3233\/JAD-2004-6103","article-title":"Colostrinin (a naturally occurring proline-rich, polypeptide mixture) in the treatment of Alzhemier\u2019s disease","volume":"6","author":"Bilikiewicz","year":"2004","journal-title":"J. Alz. Dis."},{"key":"10.1016\/j.npep.2005.03.005_bib3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1385\/JMN:20:2:125","article-title":"Modulation of 4HNE-mediated signaling by proline-rich peptides from ovine colostrum","volume":"20","author":"Boldogh","year":"2003","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.npep.2005.03.005_bib4","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1124\/jpet.103.063891","article-title":"Protective peptides that are orally active and mechanistically nonchiral","volume":"09","author":"Brenneman","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.npep.2005.03.005_bib5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1056\/NEJMra040223","article-title":"Alzheimer\u2019s disease","volume":"351","author":"Cummings","year":"2004","journal-title":"New Eng. J. Med."},{"issue":"27","key":"10.1016\/j.npep.2005.03.005_bib6","doi-asserted-by":"crossref","first-page":"28531","DOI":"10.1074\/jbc.M403197200","article-title":"A femtomolar acting octapeptide interacts with tubulin and protects astrocytes against zinc intoxication","volume":"279","author":"Divinski","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.npep.2005.03.005_bib7","doi-asserted-by":"crossref","first-page":"10032","DOI":"10.1073\/pnas.1630428100","article-title":"Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer\u2019s disease","volume":"100","author":"Gamblin","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.npep.2005.03.005_bib8","first-page":"2230","article-title":"Alzheimer\u2019s disease","volume":"40","author":"Gilman","year":"1996","journal-title":"Perspect. Biol. Med."},{"key":"10.1016\/j.npep.2005.03.005_bib9","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1073\/pnas.1834302100","article-title":"Alzheimer\u2019s disease-affected brain: presence of oligomeric A\u03b2 ligands (ADDLs) suggests a molecular basis for reversible memory loss","volume":"100","author":"Gong","year":"2003","journal-title":"PNAS"},{"key":"10.1016\/j.npep.2005.03.005_bib10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: progress and problems on the road to therapy","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.npep.2005.03.005_bib11","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/S1357-2725(03)00169-9","article-title":"Amyloidosis: new strategies for treatment","volume":"35","author":"Hirschfield","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.npep.2005.03.005_bib12","first-page":"275","article-title":"Proline-rich polypeptide (PRP) \u2013 an immunomodulatory peptide from ovine colostrum","volume":"41","author":"Janusz","year":"1993","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"},{"issue":"2","key":"10.1016\/j.npep.2005.03.005_bib13","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0014-5793(74)80529-6","article-title":"Isolation and characterization of a proline-rich polypeptide from ovine colostrums","volume":"49","author":"Janusz","year":"1974","journal-title":"FEBS Lett."},{"key":"10.1016\/j.npep.2005.03.005_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1042\/bj1990009","article-title":"Chemical and physical characterization of a proline-rich polypeptide from sheep colostrum","volume":"199","author":"Janusz","year":"1981","journal-title":"Biochem. J."},{"issue":"3","key":"10.1016\/j.npep.2005.03.005_bib15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1385\/JMN:17:3:379","article-title":"Towards an understanding of biological role of colostrinin peptides","volume":"17","author":"Kruzel","year":"2001","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.npep.2005.03.005_bib16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1023\/B:JOPC.0000020079.76155.9d","article-title":"The alcohol-induced conformational changes in casein micells: new challenges for the purification of colostrinin","volume":"23","author":"Kruzel","year":"2004","journal-title":"Protein J."},{"key":"10.1016\/j.npep.2005.03.005_bib17","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1161\/01.STR.0000014207.05597.D7","article-title":"NAP, a fentomolar-acting peptide, protects the brain against ischemic injury by reducing apoptotic death","volume":"33","author":"Leker","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.npep.2005.03.005_bib18","first-page":"377","article-title":"Colostrinin: a proline-rich polypeptide (PRP) complex isolated from ovine colostrum for treatment of Alzheimer\u2019s disease. A double-blind, placebo-controlled study","volume":"47","author":"Leszek","year":"1999","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"},{"issue":"10","key":"10.1016\/j.npep.2005.03.005_bib19","first-page":"PI93","article-title":"Colostrinin proline-rich polypeptide complex from ovine colostrum \u2013 a long-term study of its efficacy in Alzheimer\u2019s disease","volume":"8","author":"Leszek","year":"2002","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.npep.2005.03.005_bib20","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/S1357-2725(03)00133-X","article-title":"Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer\u2019s disease","volume":"35","author":"Ling","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.npep.2005.03.005_bib21","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1006\/bbrc.2002.6514","article-title":"Poly- l-lysine dissolves fibrillar aggregation of the Alzheimer \u03b2-amyloid peptide in vitro","volume":"291","author":"Nguyen","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.npep.2005.03.005_bib22","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1126\/science.1105850","article-title":"Self-propagating molecular-level polymorphism in Ahzheimer\u2019s \u03b2-amyloid fibrils","volume":"307","author":"Petkova","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.npep.2005.03.005_bib23","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1056\/NEJMoa013128","article-title":"Memantine in moderate- to-severe Alzhemier\u2019s disease","volume":"348","author":"Reisberg","year":"2003","journal-title":"New Eng. J. Med."},{"key":"10.1016\/j.npep.2005.03.005_bib24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1042\/0264-6021:3490299","article-title":"Oligomerization of \u03b2-amyloid of the Alzheimer\u2019s and the Dutch-cerebral-hemorrhage types","volume":"349","author":"Sian","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.npep.2005.03.005_bib25","first-page":"67","article-title":"Induction of cell prolipheration and cytokines by colostrinin and component proline-rich peptides in human peripheral blood leukocytes","volume":"4","author":"Stanton","year":"2001","journal-title":"Psychogeriat. Annuals"},{"key":"10.1016\/j.npep.2005.03.005_bib26","first-page":"191","article-title":"The effect of a proline-rich polypeptide (PRP) on the humoral immune response. I. Distinct effect of PRP n the T cell properties of mouse glass-nonadherent (NAT) and glass-adherent (GAT) thymocytes in thymectomized mice","volume":"32","author":"Zimecki","year":"1984","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"}],"container-title":["Neuropeptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417905000454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417905000454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T18:25:34Z","timestamp":1550600734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143417905000454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0143417905000454"],"URL":"https:\/\/doi.org\/10.1016\/j.npep.2005.03.005","relation":{},"ISSN":["0143-4179"],"issn-type":[{"value":"0143-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}