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Neurol."},{"key":"10.1016\/j.npep.2007.01.003_bib79","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0306-4530(98)00085-7","article-title":"A determinant factor in the efficacy of GHRH administration in promoting sleep: high peak concentration versus recurrent increasing slopes","volume":"24","author":"Marshall","year":"1999","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.npep.2007.01.003_bib80","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/0140-6736(92)90571-J","article-title":"DQ rather than DR gene marks susceptibility to narcolepsy","volume":"339","author":"Matsuki","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.npep.2007.01.003_bib81","unstructured":"Mayer, G., Hellman, F., Leonhardt, E., Sommenschein, W., K.M.-E., 1994. Circadian temperature- and activity rhythms in unmedicated narcolepsy patients. J. 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J. Neurosci."},{"key":"10.1016\/j.npep.2007.01.003_bib88","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/BF01934026","article-title":"Transport of the synthetic peptide DSIP through the blood\u2013brain barrier in rabbit","volume":"33","author":"Monnier","year":"1977","journal-title":"Experientia"},{"issue":"2","key":"10.1016\/j.npep.2007.01.003_bib89","first-page":"105","article-title":"Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacs","volume":"7","author":"Monti","year":"1987","journal-title":"Int. J. Clin. Pharmacol. Res."},{"key":"10.1016\/j.npep.2007.01.003_bib90","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1176\/jnp.7.2.251","article-title":"Brain stem reticular formation and activation of the EEG. 1949","volume":"7","author":"Moruzzi","year":"1995","journal-title":"J. Neuropsychiatr. Clin. Neurosci."},{"key":"10.1016\/j.npep.2007.01.003_bib91","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0022-3956(98)00059-4","article-title":"Galanin has REM-sleep deprivation-like effects on the sleep EEG in healthy young men","volume":"33","author":"Murck","year":"1999","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.npep.2007.01.003_bib92","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0006-8993(00)02555-5","article-title":"Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system","volume":"873","author":"Nakamura","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.npep.2007.01.003_bib93","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0006-8993(99)01336-0","article-title":"Distribution of orexin neurons in the adult rat brain","volume":"827","author":"Nambu","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.npep.2007.01.003_bib94","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0301-0082(96)00070-6","article-title":"Pharmacological aspects of human and canine narcolepsy","volume":"52","author":"Nishino","year":"1997","journal-title":"Prog. 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Rev."},{"key":"10.1016\/j.npep.2007.01.003_bib97","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0140-6736(99)05582-8","article-title":"Hypocretin (orexin) deficiency in human narcolepsy","volume":"355","author":"Nishino","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.npep.2007.01.003_bib98","series-title":"Neurobiology of Mental Illness","first-page":"1160","article-title":"The neurobiology of sleep in relation to mental illness","author":"Nishino","year":"2004"},{"key":"10.1016\/j.npep.2007.01.003_bib99","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0168-0102(00)00195-4","article-title":"Is narcolepsy REM sleep disorder? Analysis of sleep abnormalities in narcoleptic Dobermans","volume":"38","author":"Nishino","year":"2000","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.npep.2007.01.003_bib100","first-page":"352","article-title":"TRH and its analogs significantly reduce canine cataplexy","volume":"24A","author":"Nishino","year":"1995","journal-title":"Sleep Res."},{"key":"10.1016\/j.npep.2007.01.003_bib101","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0304-3940(01)02270-4","article-title":"Decreased brain histamine contents in hypocretin\/orexin receptor-2 mutated narcoleptic dogs","volume":"313","author":"Nishino","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.npep.2007.01.003_bib102","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/ana.1130","article-title":"Low CSF hypocretin (orexin) and altered energy homeostasis in human narcolepsy","volume":"50","author":"Nishino","year":"2001","journal-title":"Ann. 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Dis."},{"key":"10.1016\/j.npep.2007.01.003_bib118","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1212\/WNL.57.12.2253","article-title":"CSF hypocretin\/orexin levels in narcolepsy and other neurological conditions","volume":"57","author":"Ripley","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.npep.2007.01.003_bib119","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0143-4179(82)90008-7","article-title":"Electroencephalographic analysis of the sleep-inducing actions of cholecystokinin","volume":"3","author":"Rojas-Ramirez","year":"1982","journal-title":"Neuropeptides"},{"key":"10.1016\/j.npep.2007.01.003_bib120","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/0031-9384(94)90382-4","article-title":"Hypothalamic injection of prolactin or its antibody alters the rat sleep\u2013wake cycle","volume":"55","author":"Roky","year":"1994","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.npep.2007.01.003_bib121","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1136\/jnnp.43.6.535","article-title":"Autonomic control of cardiovascular reflexes in Narcolepsy","volume":"43","author":"Sachs","year":"1980","journal-title":"J. Neurol. Neurosurg. 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Behav."},{"key":"10.1016\/j.npep.2007.01.003_bib136","series-title":"Neuropeptides: Regulators of Physiological Processes","author":"Strand","year":"1999"},{"key":"10.1016\/j.npep.2007.01.003_bib137","doi-asserted-by":"crossref","DOI":"10.1152\/ajpregu.00919.2005","article-title":"Central administration of neuropeptide Y induces wakefulness in rats","author":"Szentirmai","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.npep.2007.01.003_bib138","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0006-8993(86)91107-8","article-title":"Sleep-related neuronal discharge in the basal forebrain of cats","volume":"370","author":"Szymusiak","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.npep.2007.01.003_bib139","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0896-6273(00)00058-1","article-title":"Reduced number of hypocretin neurons in human narcolepsy","volume":"27","author":"Thannickal","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.npep.2007.01.003_bib140","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2202-4-19","article-title":"A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep","volume":"4","author":"Verret","year":"2003","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.npep.2007.01.003_bib141","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0278-5846(86)90060-6","article-title":"The effects of caerulein on nocturnal sleep","volume":"10","author":"Watanabe","year":"1986","journal-title":"Prog. 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