{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:56:44Z","timestamp":1791111404337,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropeptides"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.npep.2007.08.002","type":"journal-article","created":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T07:31:00Z","timestamp":1191310260000},"page":"441-452","source":"Crossref","is-referenced-by-count":47,"title":["Opioids and migration, chemotaxis, invasion, and adhesion of human cancer cells"],"prefix":"10.1016","volume":"41","author":[{"given":"Ian S.","family":"Zagon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen A.","family":"Rahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia J.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.npep.2007.08.002_bib1","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1016\/S0022-5347(05)68157-8","article-title":"Human renal cell cancer proliferation in tissue culture is tonically inhibited by opioid growth factor","volume":"162","author":"Bisignani","year":"1999","journal-title":"J. Urol."},{"key":"10.1016\/j.npep.2007.08.002_bib2","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1067\/mva.2000.107763b","article-title":"Opioid growth factor modulates angiogenesis","volume":"32","author":"Blebea","year":"2000","journal-title":"J. Vascular Surg."},{"key":"10.1016\/j.npep.2007.08.002_bib3","unstructured":"Cheng, F., Zagon, I.S., Verderame, M.F., McLaughlin, P.J., in press. The OGF\u2013OGFr axis utilizes the p16 pathway to inhibit progression of human squamous cell carcinoma of the head and neck. Cancer Res."},{"key":"10.1016\/j.npep.2007.08.002_bib4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/glia.20262","article-title":"HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines","volume":"53","author":"El-Hage","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.npep.2007.08.002_bib5","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/0277-5379(88)90335-5","article-title":"Two new human tumor cell lines derived from squamous cell carcinomas of the tongue: establishment, characterization and response to cytotoxic treatment","volume":"24","author":"Gioanni","year":"1988","journal-title":"Eur. J. Cancer Clin. Oncol."},{"key":"10.1016\/j.npep.2007.08.002_bib6","series-title":"The Pharmacological Basis of Therapeutics","first-page":"69","article-title":"Opioid analgesics","author":"Gutstein","year":"2001"},{"key":"10.1016\/j.npep.2007.08.002_bib7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0304-3835(02)00360-9","article-title":"Potential ability of morphine to inhibit the adhesion, invasion and metastasis of metastatic colon 26-L5 carcinoma cells","volume":"187","author":"Harimaya","year":"2002","journal-title":"Cancer Lett."},{"key":"10.1016\/j.npep.2007.08.002_bib8","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1172\/JCI118171","article-title":"Enkephalins stimulate leukemia cell migration and surface expression of CD9","volume":"96","author":"Heagy","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.npep.2007.08.002_bib9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1177\/026988110001400307","article-title":"Morphine inhibits human microglial production of, and migration towards, RANTES","volume":"14","author":"Hu","year":"2000","journal-title":"J. Pyschopharmacol."},{"key":"10.1016\/j.npep.2007.08.002_bib10","first-page":"R115","article-title":"Identification and characterization of \u03b6-opioid receptor in human colon cancer","volume":"271","author":"Hytrek","year":"1996","journal-title":"Amer. J. Physiol."},{"key":"10.1016\/j.npep.2007.08.002_bib11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1089\/jop.2006.0111","article-title":"Topically applied naltrexone restores corneal reepithelialization in diabetic rats","volume":"23","author":"Klocek","year":"2007","journal-title":"J. Ocular Pharmacol. Therap."},{"key":"10.1016\/j.npep.2007.08.002_bib12","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1001\/archotol.1981.00790470051012","article-title":"Human squamous cell carcinoma","volume":"107","author":"Krause","year":"1981","journal-title":"Arch. Otolaryngol."},{"key":"10.1016\/j.npep.2007.08.002_bib13","first-page":"197","article-title":"Methods used for the study of opioid receptors","volume":"39","author":"Leslie","year":"1987","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.npep.2007.08.002_bib14","first-page":"991","article-title":"Regulation of human head and neck squamous cell carcinoma growth in tissue culture by opioid growth factor","volume":"14","author":"McLaughlin","year":"1999","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.npep.2007.08.002_bib15","first-page":"191","article-title":"The opioid growth factor receptor in human head and neck squamous cell carcinoma","volume":"5","author":"McLaughlin","year":"2000","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.npep.2007.08.002_bib16","first-page":"421","article-title":"Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neck","volume":"19","author":"McLaughlin","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.npep.2007.08.002_bib17","first-page":"373","article-title":"Human neuroblastoma cell growth in tissue culture is regulated by opioid growth factor","volume":"14","author":"McLaughlin","year":"1999","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.npep.2007.08.002_bib18","first-page":"1577","article-title":"Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor (OGFr)","volume":"28","author":"McLaughlin","year":"2006","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.npep.2007.08.002_bib19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0162-3109(99)00188-5","article-title":"Opioids suprress chemokine-mediated migration of monkey neutrophils and monocytes \u2013 an instant response","volume":"47","author":"Miyagi","year":"2000","journal-title":"Immunopharmacol."},{"key":"10.1016\/j.npep.2007.08.002_bib20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0304-3835(98)00186-4","article-title":"Effects of prostatic neuropeptides on invasion and migration of PC-3 prostate cancer cells","volume":"133","author":"Nagakawa","year":"1998","journal-title":"Cancer Lett."},{"key":"10.1016\/j.npep.2007.08.002_bib21","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.4049\/jimmunol.176.3.1675","article-title":"Opioids trigger \u03b15\u03b21 integrin-mediated monocyte adhesion","volume":"176","author":"Pello","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.npep.2007.08.002_bib22","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0143-4179(85)90029-0","article-title":"Opiate receptor-mediated chemotaxis of human monocytes","volume":"5","author":"Ruff","year":"1985","journal-title":"Neuropeptides"},{"key":"10.1016\/j.npep.2007.08.002_bib23","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev.iy.06.040188.001251","article-title":"Opioid peptides and opioid receptors in cells of the immune system","volume":"6","author":"Sibinga","year":"1988","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.npep.2007.08.002_bib24","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1159\/000188401","article-title":"Opioids modulate migration, spreading and adherence of mesangial cells","volume":"68","author":"Singhal","year":"1994","journal-title":"Nephron"},{"key":"10.1016\/j.npep.2007.08.002_bib25","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1046\/j.0022-202x.2001.01546.x","article-title":"Cell-density-regulated chemotactic responsiveness of keratinocytes in vitro","volume":"117","author":"Szabo","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.npep.2007.08.002_bib26","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1523\/JNEUROSCI.3170-04.2005","article-title":"Morphine-induced chemotaxis and brain-derived neurotrophic factor expression in microglia","volume":"25","author":"Takayama","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.npep.2007.08.002_bib27","first-page":"R511","article-title":"Opioid growth factor tonically inhibits human colon cancer cell proliferation in tissue culture","volume":"271","author":"Zagon","year":"1996","journal-title":"Amer. J. Physiol."},{"key":"10.1016\/j.npep.2007.08.002_bib28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0304-3835(96)04566-1","article-title":"Opioid growth factor (OGF) inhibits human pancreatic cancer transplanted into nude mice","volume":"112","author":"Zagon","year":"1997","journal-title":"Cancer Lett."},{"key":"10.1016\/j.npep.2007.08.002_bib29","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1126\/science.6867737","article-title":"Naltrexone modulates tumor response in mice with neuroblastoma","volume":"221","author":"Zagon","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.npep.2007.08.002_bib30","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0024-3205(84)90651-9","article-title":"Duration of opiate receptor blockade determines tumorigenic response in mice with neuroblastoma: A role for endogenous opioid systems in cancer","volume":"35","author":"Zagon","year":"1984","journal-title":"Life Sci."},{"key":"10.1016\/j.npep.2007.08.002_bib31","series-title":"Receptors in the Developing Nervous System","first-page":"39","article-title":"Opioid growth factor receptor in the developing nervous system","volume":"vol. 1","author":"Zagon","year":"1993"},{"key":"10.1016\/j.npep.2007.08.002_bib32","series-title":"Cytokines-Stress and Immunity","first-page":"245","article-title":"Opioid growth factor, [Met5]-enkephalin, and the etiology, pathogenesis, and treatment of gastrointestinal cancer","author":"Zagon","year":"1999"},{"key":"10.1016\/j.npep.2007.08.002_bib33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0143-4179(03)00007-6","article-title":"Opioids and the apoptotic pathway in human cancer cells","volume":"37","author":"Zagon","year":"2003","journal-title":"Neuropeptides"},{"key":"10.1016\/j.npep.2007.08.002_bib34","first-page":"1443","article-title":"Opioid growth factor (OGF) inhibits anchorage-independent growth in human cancer cells","volume":"24","author":"Zagon","year":"2004","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.npep.2007.08.002_bib35","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.npep.2005.07.001","article-title":"Opioids and differentiation in human cancer cells","volume":"39","author":"Zagon","year":"2005","journal-title":"Neuropeptides"},{"key":"10.1016\/j.npep.2007.08.002_bib36","first-page":"1053","article-title":"Opioid growth factor regulates the cell cycle of human neoplasias","volume":"17","author":"Zagon","year":"2000","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.npep.2007.08.002_bib37","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1001\/archopht.124.11.1620","article-title":"Regulation of corneal repair by particle-mediated gene transfer of opioid growth factor receptor complementary DNA","volume":"124","author":"Zagon","year":"2006","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.npep.2007.08.002_bib38","first-page":"R942","article-title":"Opioid growth factor modulates corneal epithelial growth in tissue culture","volume":"268","author":"Zagon","year":"1995","journal-title":"Amer. J. Physiol."},{"key":"10.1016\/j.npep.2007.08.002_bib39","first-page":"73","article-title":"Reepithelialization of the human cornea is regulated by endogenous opioids","volume":"41","author":"Zagon","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.npep.2007.08.002_bib40","first-page":"77","article-title":"Identification and characterization of opioid growth factor receptor in human pancreatic adenocarcinoma","volume":"5","author":"Zagon","year":"2000","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.npep.2007.08.002_bib41","first-page":"577","article-title":"Human pancreatic cancer cell proliferation in tissue culture is tonically inhibited by opioid growth factor","volume":"14","author":"Zagon","year":"1999","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.npep.2007.08.002_bib42","first-page":"775","article-title":"Overexpression of the opioid growth factor receptor potentiates growth inhibition in human pancreatic cancer","volume":"30","author":"Zagon","year":"2007","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.npep.2007.08.002_bib43","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0165-0173(01)00160-6","article-title":"The biology of the opioid growth factor (OGFr)","volume":"38","author":"Zagon","year":"2002","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.npep.2007.08.002_bib44","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0006-8993(99)01753-9","article-title":"Opioid growth factor and organ development in rat and human embryos","volume":"839","author":"Zagon","year":"2000","journal-title":"Brain Res."}],"container-title":["Neuropeptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417907000832?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417907000832?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T15:54:41Z","timestamp":1546530881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143417907000832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0143417907000832"],"URL":"https:\/\/doi.org\/10.1016\/j.npep.2007.08.002","relation":{},"ISSN":["0143-4179"],"issn-type":[{"value":"0143-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}