{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:48:19Z","timestamp":1773211699199,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropeptides"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.npep.2008.02.002","type":"journal-article","created":{"date-parts":[[2008,3,25]],"date-time":"2008-03-25T00:20:12Z","timestamp":1206404412000},"page":"293-299","source":"Crossref","is-referenced-by-count":15,"title":["Effects of fluoxetine administration on hypothalamic melanocortin system in obese Zucker rats"],"prefix":"10.1016","volume":"42","author":[{"given":"I.","family":"Churruca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.P.","family":"Portillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Casis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.T.","family":"Macarulla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Echevarr\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.npep.2008.02.002_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/nrc.10030","article-title":"Selective serotonin reuptake inhibitors alter NPY immunostaining in the rat hypothalamus","volume":"30","author":"Acebes","year":"2002","journal-title":"Neurosci. Res. Commun."},{"key":"10.1016\/j.npep.2008.02.002_bib2","first-page":"1182","article-title":"Differential effects of melanocortin peptides on neural melanocortin receptors","volume":"46","author":"Adan","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.npep.2008.02.002_bib3","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.2042-7158.1992.tb05500.x","article-title":"Anorectic activity of fluoxetine and norfluoxetine in mice, rats and guinea pigs","volume":"44","author":"Anelli","year":"1992","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.npep.2008.02.002_bib4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.nutr.20.1.105","article-title":"Regulation of metabolism and body fat mass by leptin","volume":"20","author":"Baile","year":"2000","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.npep.2008.02.002_bib29","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/0028-3908(84)90098-4","article-title":"Serotonin and appetite","volume":"23","author":"Blundell","year":"1984","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.npep.2008.02.002_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.peptides.2005.02.029","article-title":"The melanocortin system and energy balance","volume":"27","author":"Butler","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.npep.2008.02.002_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.regpep.2006.11.012","article-title":"Selective serotonin reuptake inhibitor (fluoxetine) decreases the effects of ghrelin on memory retention and food intake","volume":"140","author":"Carlini","year":"2007","journal-title":"Regul. Peptides"},{"key":"10.1016\/j.npep.2008.02.002_bib7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1043-2760(99)00153-8","article-title":"The central melanocortin system and energy homeostasis","volume":"10","author":"Cone","year":"1999","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.npep.2008.02.002_bib8","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nn1455","article-title":"Anatomy and regulation of the central melanocortin system","volume":"8","author":"Cone","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.npep.2008.02.002_bib9","first-page":"67","article-title":"High-fat feeding reduced muscle uncoupling protein 3 expression in rats","volume":"55","author":"Corbalan","year":"1999","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.npep.2008.02.002_bib10","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0006-8993(96)00329-0","article-title":"Increased feeding and neuropeptide Y (NPY) but not NPY mRNA levels in the hypothalamus of the rat following central administration of the serotonin synthesis inhibitor p-chlorophenylalanine","volume":"724","author":"Dryden","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.npep.2008.02.002_bib11","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/(SICI)1096-9861(19981228)402:4<442::AID-CNE2>3.0.CO;2-R","article-title":"Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area","volume":"402","author":"Elias","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.npep.2008.02.002_bib12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0896-6273(00)81084-3","article-title":"From lesions to leptin: hypothalamic control of food intake and body weight","volume":"22","author":"Elmquist","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.npep.2008.02.002_bib13","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/oby.2002.72","article-title":"Effects of fluoxetine administration on neuropeptide Y and orexins in obese Zucker rat hypothalamus","volume":"10","author":"Guti\u00e9rrez","year":"2002","journal-title":"Obes. Res."},{"issue":"2","key":"10.1016\/j.npep.2008.02.002_bib14","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2337\/diabetes.48.2.267","article-title":"Altered energy balance causes selective changes in melanocortin-4 (MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding","volume":"48","author":"Harrold","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.npep.2008.02.002_bib15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0169-328X(91)90080-H","article-title":"Monoaminergic regulation of pro-opioiomelanocortin messenger RNA concentrations in primary cell cultures of rat hypothalamus","volume":"9","author":"L\u2019H\u00e9reault","year":"1991","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.npep.2008.02.002_bib16","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0091-3057(90)90556-W","article-title":"Medium hypothalamic nuclei mediate serotonin\u2019s inhibitory effect on feeding behaviour","volume":"37","author":"Leibowitz","year":"1990","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.npep.2008.02.002_bib17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/5070","article-title":"Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides","volume":"21","author":"Marsh","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.npep.2008.02.002_bib18","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1210\/me.8.10.1298","article-title":"Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain","volume":"8","author":"Mountjoy","year":"1994","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.npep.2008.02.002_bib19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1046\/j.1365-2265.2003.01839.x","article-title":"Appetite regulation: from the gut to the hypothalamus","volume":"60","author":"Neary","year":"2004","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.npep.2008.02.002_bib20","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.bbrc.2006.01.021","article-title":"A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice","volume":"341","author":"Nonogaki","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.npep.2008.02.002_bib21","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1017\/S1461145706007206","article-title":"Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors","volume":"10","author":"Nonogaki","year":"2007","journal-title":"Int. J. Neuropsychopharmacol"},{"key":"10.1016\/j.npep.2008.02.002_bib22","doi-asserted-by":"crossref","first-page":"R1775","DOI":"10.1152\/ajpregu.00527.2006","article-title":"Milnacipran, a serotonin and norepinephrine reuptake inhibitor, induces appetite-suppressing effects without inducing hypothalamic stress responses in mice","volume":"292","author":"Nonogaki","year":"2007","journal-title":"Am. J .Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.npep.2008.02.002_bib23","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1986"},{"key":"10.1016\/j.npep.2008.02.002_bib25","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.npep.2008.02.002_bib24","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1210\/en.2002-220931","article-title":"Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization","volume":"144","author":"Shinyama","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.npep.2008.02.002_bib26","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0014-2999(00)00538-0","article-title":"Role of melanocortins in the central control of feeding","volume":"405","author":"Vergoni","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.npep.2008.02.002_bib27","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/BF02244365","article-title":"Effect of hypothalamic and peripheral fluoxetine injection on natural pattern of macronutrient intake in the rat","volume":"105","author":"Weiss","year":"1991","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.npep.2008.02.002_bib28","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0031-9384(01)00612-6","article-title":"The hypothalamus and the control of energy homeostasis. Different circuits, different purposes","volume":"74","author":"Williams","year":"2001","journal-title":"Physiol. Behav."}],"container-title":["Neuropeptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417908000267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417908000267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T06:52:33Z","timestamp":1557384753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143417908000267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0143417908000267"],"URL":"https:\/\/doi.org\/10.1016\/j.npep.2008.02.002","relation":{},"ISSN":["0143-4179"],"issn-type":[{"value":"0143-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}