{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:25:03Z","timestamp":1767626703916,"version":"3.44.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","award":["BFU2007-64130\/BFI"],"award-info":[{"award-number":["BFU2007-64130\/BFI"]}],"id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["BFU2009-12284\/BFI","PIM2010ERN-00577\/NEUCONNECT"],"award-info":[{"award-number":["BFU2009-12284\/BFI","PIM2010ERN-00577\/NEUCONNECT"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropeptides"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.npep.2011.10.002","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T12:46:17Z","timestamp":1321015577000},"page":"29-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Altered expression of neuropeptides in the primary somatosensory cortex of the Down syndrome model Ts65Dn"],"prefix":"10.1016","volume":"46","author":[{"given":"Samuel","family":"Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Gilabert-Juan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Miguel","family":"Blasco-Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Crespo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"N\u00e1cher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Varea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.npep.2011.10.002_b0005","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ana.410200413","article-title":"Dendritic atrophy in children with Down\u2019s syndrome","volume":"20","author":"Becker","year":"1986","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.npep.2011.10.002_b0010","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/cne.20337","article-title":"Synaptic structural abnormalities in the Ts65Dn mouse model of Down syndrome","volume":"480","author":"Belichenko","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.npep.2011.10.002_b0015","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/cne.21433","article-title":"Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationship","volume":"504","author":"Belichenko","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.npep.2011.10.002_b0020","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/cne.21895","article-title":"Excitatory-inhibitory relationship in the fascia dentate in the Ts65Dn mouse model of Down syndrome","volume":"512","author":"Belichenko","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.npep.2011.10.002_b0025","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0304-3940(96)12318-1","article-title":"Distribution of parvalbumin immunoreactivity in the neocortex of hypothyroid adult rats","volume":"204","author":"Berbel","year":"1996","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.npep.2011.10.002_b0030","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF03160106","article-title":"Neuropeptide Y immunoreactive neurons in murine trisomy 16 cortical cultures. Plasticity of expression and differentiation","volume":"22","author":"Caserta","year":"1994","journal-title":"Mol. Chem. Neuropathol."},{"issue":"3","key":"10.1016\/j.npep.2011.10.002_b0035","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0169-328X(90)90037-E","article-title":"Increased number of somatostatin-immunoreactive neurons in primary cultures of trisomy 15 mouse neocortex","volume":"7","author":"Caserta","year":"1990","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"10","key":"10.1016\/j.npep.2011.10.002_b0040","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1523\/JNEUROSCI.17-10-03894.1997","article-title":"Molecular and physiological diversity of cortical nonpyramidal cells","volume":"17","author":"Cauli","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.npep.2011.10.002_b0045","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nn.2600","article-title":"Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome","volume":"13","author":"Chakrabarti","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.npep.2011.10.002_b0050","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/0306-4522(85)90260-X","article-title":"The anatomy of neuropeptide-Y-containing neurons in the rat brain","volume":"15","author":"Chronwall","year":"1985","journal-title":"Neuroscience"},{"key":"10.1016\/j.npep.2011.10.002_b0055","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0031-9384(99)00178-X","article-title":"Motor dysfunction in a mouse model for Down syndrome","volume":"68","author":"Costa","year":"1999","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.npep.2011.10.002_b0060","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0006-8993(90)91253-D","article-title":"Neuropeptide Y innervations of ACTH-immunoreactive neurons in the arcuate nucleus of rats: a correlated light and electron microscopic double immunolabeling study","volume":"506","author":"Csiffary","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.npep.2011.10.002_b0065","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/cercor\/13.7.758","article-title":"Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment","volume":"13","author":"Dierssen","year":"2003","journal-title":"Cereb. Cortex"},{"issue":"Suppl 2","key":"10.1016\/j.npep.2011.10.002_b0070","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1601-183X.2006.00224.x","article-title":"Dendritic pathology in mental retardation from molecular genetics to neurobiology","volume":"5","author":"Dierssen","year":"2006","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.npep.2011.10.002_b0075","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0361-9230(01)00530-5","article-title":"Synaptic pathology in the anterior cingulated cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, Gap-43 and the complexins","volume":"55","author":"Eastwood","year":"2001","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.npep.2011.10.002_b0080","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0304-3940(95)12052-6","article-title":"A behavioural assessment of Ts65Dn mice: a putative Down syndrome model","volume":"199","author":"Escorihuela","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.npep.2011.10.002_b0085","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-3940(98)00317-6","article-title":"Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome","volume":"247","author":"Escorihuela","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.npep.2011.10.002_b0090","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nn1860","article-title":"Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome","volume":"10","author":"Fern\u00e1ndez","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.npep.2011.10.002_b0095","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.1460-9568.2003.03096.x","article-title":"Diversity beyond variance: modulation of firing rates and network coherence by GABAergic subpopulations","volume":"19","author":"Foldy","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.npep.2011.10.002_b0100","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/0165-3806(90)90120-N","article-title":"Developmental expression of somatostatin in mouse brain. I. Immunocytochemical studies","volume":"53","author":"Forloni","year":"1990","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.npep.2011.10.002_b0105","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0378-1119(03)00769-8","article-title":"Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions","volume":"318","author":"Gardiner","year":"2003","journal-title":"Gene"},{"key":"10.1016\/j.npep.2011.10.002_b0110","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0387-7604(01)00239-X","article-title":"Seizure frequencey and characteristics in children with Down syndrome","volume":"23","author":"Goldberg-stern","year":"2001","journal-title":"Brain Dev."},{"key":"10.1016\/j.npep.2011.10.002_b0115","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0014-4886(03)00164-X","article-title":"Vasoactive intestinal peptide in the brain of a mouse model for Down syndrome","volume":"183","author":"Hill","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.npep.2011.10.002_b0120","doi-asserted-by":"crossref","first-page":"13333","DOI":"10.1073\/pnas.93.23.13333","article-title":"Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome","volume":"96","author":"Holtzman","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.npep.2011.10.002_b0125","first-page":"121","article-title":"Epilepsy in Down Syndrome- prevalence in three age groups","volume":"5","author":"Johannsen","year":"1996","journal-title":"Seizure"},{"key":"10.1016\/j.npep.2011.10.002_b0130","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/cercor\/10.10.981","article-title":"Dendritic anomalies in disorders associated with mental retardation","volume":"10","author":"Kaufmann","year":"2000","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.npep.2011.10.002_b0135","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0006-8993(00)01984-3","article-title":"Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice","volume":"858","author":"Kurt","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.npep.2011.10.002_b0140","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/cne.901670105","article-title":"Pyramidal cell abnormalities in the motor cortex of a child with Down\u2019s syndrome. A Golgi study","volume":"167","author":"Mar\u00edn-Padilla","year":"1976","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.npep.2011.10.002_b0145","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nrn1519","article-title":"Interneurons of the neocortical inhibitory system","volume":"5","author":"Markram","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.npep.2011.10.002_b0150","first-page":"14","article-title":"Contributo allo studio della corteccia cerebral, ed all\u2019origine central dei nervi","volume":"1","author":"Martinotti","year":"1889","journal-title":"Ann. Freniatr Sci. affini"},{"key":"10.1016\/j.npep.2011.10.002_b0155","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1177\/38.6.2110586","article-title":"Quantitative immunohistochemistry of synaptophysin in human neocortex: an alternative method to estimate density of presynaptic terminals in paraffin sections","volume":"38","author":"Masliah","year":"1990","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.npep.2011.10.002_b0160","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0891-0618(96)00211-6","article-title":"Distribution of cholecystokinin immunoreactivity in the BALB\/c mouse forebrain: an immunocytochemical study","volume":"12","author":"Meziane","year":"1997","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.npep.2011.10.002_b0165","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00702-010-0376-9","article-title":"Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down\u2019s s\u00edndrome","volume":"117","author":"P\u00e9rez-Cremades","year":"2010","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.npep.2011.10.002_b0170","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1059-1311(05)80079-2","article-title":"Epilepsy and associated effects on adaptive behaviour in adults with Down syndrome","volume":"4","author":"Prasher","year":"1995","journal-title":"Seizure"},{"key":"10.1016\/j.npep.2011.10.002_b0175","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1001\/archneur.1991.00530150088024","article-title":"Seizure disorders in Down syndrome","volume":"48","author":"Pueschel","year":"1991","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.npep.2011.10.002_b0180","first-page":"3","article-title":"Sur la structure de l\u2019ecorce cerebrale de quelques mammiferes","volume":"7","author":"Ram\u00f3n y Cajal","year":"1891","journal-title":"Cellule"},{"key":"10.1016\/j.npep.2011.10.002_b0185","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ng1095-177","article-title":"A mouse model for Down syndrome exhibits learning and behaviour deficits","volume":"11","author":"Reeves","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.npep.2011.10.002_b0190","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0006-8993(92)91439-L","article-title":"Immunohistochemical markers in the rat cortex: co-localization of calretinin and calbindin-D28k with neuropeptides and GABA","volume":"587","author":"Rogers","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.npep.2011.10.002_b0195","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0140-6736(03)12987-X","article-title":"Down\u2019s syndrome","volume":"361","author":"Roizen","year":"2003","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.npep.2011.10.002_b0200","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1534\/genetics.105.050898","article-title":"Perinatal loss of Ts65Dn Down syndrome mice","volume":"172","author":"Roper","year":"2006","journal-title":"Genetics"},{"issue":"3","key":"10.1016\/j.npep.2011.10.002_b0205","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1385\/JMN:30:3:329","article-title":"Neonatal mice of the down syndrome model, Ts65Dn exhibit upregulated VIP measures and reduced responsiveness of cortical astrocytes to VIP stimulation","volume":"30","author":"Sahir","year":"2006","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.npep.2011.10.002_b0210","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0006-8993(90)91764-8","article-title":"Neocortical VIP neurons are increased in the hemisphere containing focal cerebrocortical microdysgenesis in New Zealand Black mice","volume":"532","author":"Sherman","year":"1990","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.npep.2011.10.002_b0215","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuropharm.2005.02.012","article-title":"Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome","volume":"49","author":"Siarey","year":"2005","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.npep.2011.10.002_b0220","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1111\/j.1471-4159.2006.03971.x","article-title":"Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome","volume":"98","author":"Siarey","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.npep.2011.10.002_b0225","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0006-8993(80)90263-2","article-title":"Vasoactive intestinal polypeptide (VIP) in mouse and rat brain: an immunocytochemical study","volume":"186","author":"Sims","year":"1980","journal-title":"Brain Res."},{"key":"10.1016\/j.npep.2011.10.002_b0230","first-page":"12","article-title":"Epilepys in Down syndrome. Clinical aspects and possible mechanisms","volume":"98 Suppl","author":"Stafstrom","year":"1993","journal-title":"Am J. Ment. Retard."},{"key":"10.1016\/j.npep.2011.10.002_b0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(81)90314-0","article-title":"Abnormal neuronal development in the visual cortex of the human fetus and infant with down\u2019s syndrome. A quantitative and qualitative Golgi study","volume":"225","author":"Takashima","year":"1981","journal-title":"Brain Res."},{"key":"10.1016\/j.npep.2011.10.002_b0240","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0387-7604(89)80082-8","article-title":"Dendrites, dementia and the Down syndrome","volume":"11","author":"Takashima","year":"1989","journal-title":"Brain Dev."},{"key":"10.1016\/j.npep.2011.10.002_b0245","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0887-8994(02)00380-6","article-title":"Perinatal growth of prefrontal layer III pyramids in Down syndrome","volume":"27","author":"Vuksic","year":"2002","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.npep.2011.10.002_b0250","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1113\/jphysiol.2004.073353","article-title":"Anatomical, physiological and molecular properties of Martinotti cells in the somatosensory cortex of the juvenile rat","volume":"561.1","author":"Wang","year":"2004","journal-title":"J. Physiol."}],"container-title":["Neuropeptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417911000904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417911000904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T20:36:17Z","timestamp":1758918977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143417911000904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0143417911000904"],"URL":"https:\/\/doi.org\/10.1016\/j.npep.2011.10.002","relation":{},"ISSN":["0143-4179"],"issn-type":[{"type":"print","value":"0143-4179"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered expression of neuropeptides in the primary somatosensory cortex of the Down syndrome model Ts65Dn","name":"articletitle","label":"Article Title"},{"value":"Neuropeptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.npep.2011.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}