{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:13:59Z","timestamp":1790680439995,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Brain Research Program, Hungary","award":["KTIA_NAP_13-1-2013-0001"],"award-info":[{"award-number":["KTIA_NAP_13-1-2013-0001"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","neuropeptidesjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropeptides"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.npep.2017.02.079","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T16:10:55Z","timestamp":1486743055000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Evidence for a novel, neurohumoral antinociceptive mechanism mediated by peripheral capsaicin-sensitive nociceptors in conscious rats"],"prefix":"10.1016","volume":"62","author":[{"given":"G\u00e1bor","family":"Peth\u0151","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kata","family":"B\u00f6lcskei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2724-0891","authenticated-orcid":false,"given":"R\u00e9ka","family":"F\u00fcredi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1lint","family":"Botz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ter\u00e9z","family":"Bagoly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Pint\u00e9r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"Szolcs\u00e1nyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.npep.2017.02.079_bb0005","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.neuroscience.2012.08.056","article-title":"Intra-axonal calcium changes after axotomy in wild-type and slow Wallerian degeneration axons","volume":"225","author":"Adalbert","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.npep.2017.02.079_bb0010","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/S0896-6273(04)00150-3","article-title":"Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin","volume":"41","author":"Bandell","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.npep.2017.02.079_bb0015","first-page":"E1","article-title":"Peptide transport systems for opiates across the blood-brain barrier","volume":"259","author":"Banks","year":"1990","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.npep.2017.02.079_bb0020","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.ejphar.2007.01.097","article-title":"Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: a novel rat thermal hyperalgesia model","volume":"564","author":"B\u00f6lcskei","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.npep.2017.02.079_bb0025","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.ejpain.2009.08.005","article-title":"Antinociceptive desensitizing actions of TRPV1 receptor agonists capsaicin, resiniferatoxin and N-oleoyldopamine as measured by determination of the noxious heat and cold thresholds in the rat","volume":"14","author":"B\u00f6lcskei","year":"2010","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.npep.2017.02.079_bb0030","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1002\/art.38772","article-title":"Differential regulatory role of pituitary adenylate cyclase-activating polypeptide in the serum-transfer arthritis model","volume":"66","author":"Botz","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.npep.2017.02.079_bb0035","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1213\/00000539-198503000-00019","article-title":"Counter-irritation reduces pain during cutaneous needle insertion","volume":"64","author":"Bourke","year":"1985","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.npep.2017.02.079_bb0040","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/0304-3959(95)01441-1","article-title":"Characterization of a rat model of incisional pain","volume":"64","author":"Brennan","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.npep.2017.02.079_bb0045","doi-asserted-by":"publisher","first-page":"3403","DOI":"10.1113\/jphysiol.2013.269654","article-title":"Nociceptive primary afferents: they have a mind of their own","volume":"592","author":"Carlton","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.npep.2017.02.079_bb0050","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0304-3940(96)13304-8","article-title":"Immunohistochemical localization of enkephalin in peripheral sensory axons in the rat","volume":"221","author":"Carlton","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.npep.2017.02.079_bb0055","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0304-3959(00)00407-3","article-title":"Somatostatin receptors on peripheral primary afferent terminals: inhibition of sensitized nociceptors","volume":"90","author":"Carlton","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.npep.2017.02.079_bb0060","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1523\/JNEUROSCI.21-11-04042.2001","article-title":"Tonic control of peripheral cutaneous nociceptors by somatostatin receptors","volume":"21","author":"Carlton","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.npep.2017.02.079_bb0065","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S0306-4522(03)00337-3","article-title":"A role for peripheral somatostatin receptors in counter-irritation-induced analgesia","volume":"120","author":"Carlton","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.npep.2017.02.079_bb0070","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.npep.2017.02.079_bb0075","doi-asserted-by":"publisher","first-page":"13699","DOI":"10.1523\/JNEUROSCI.2867-10.2010","article-title":"Attenuation of activity in an endogenous analgesia circuit by ongoing pain in the rat","volume":"30","author":"Ferrari","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.npep.2017.02.079_bb0080","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ejphar.2008.12.035","article-title":"Effects of analgesics on the plantar incision-induced drop of the noxious heat threshold measured with an increasing-temperature water bath in the rat","volume":"605","author":"F\u00fcredi","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.npep.2017.02.079_bb0085","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1172\/JCI101190","article-title":"Studies on the relief of pain by counterirritation","volume":"20","author":"Gammon","year":"1941","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.npep.2017.02.079_bb0090","doi-asserted-by":"crossref","first-page":"7175","DOI":"10.1523\/JNEUROSCI.19-16-07175.1999","article-title":"Pain-induced analgesia mediated by mesolimbic reward circuits","volume":"19","author":"Gear","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.npep.2017.02.079_bb0095","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/BF02243002","article-title":"Counter irritation test in primary fibromyalgia","volume":"13","author":"Guieu","year":"1994","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.npep.2017.02.079_bb0100","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.brainres.2008.06.111","article-title":"Somatostatin inhibits activation of dorsal cutaneous primary afferents induced by antidromic stimulation of primary afferents from an adjacent thoracic segment in the rat","volume":"1229","author":"Guo","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.npep.2017.02.079_bb0105","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1136\/gut.35.3_Suppl.S1","article-title":"Somatostatin and somatostatin analogues: pharmacokinetics and pharmacodynamic effects","volume":"35","author":"Harris","year":"1994","journal-title":"Gut"},{"key":"10.1016\/j.npep.2017.02.079_bb0110","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0304-3940(99)00936-2","article-title":"Anti-nociceptive effect induced by somatostatin released from sensory nerve terminals and by synthetic somatostatin analogues in the rat","volume":"278","author":"Helyes","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.npep.2017.02.079_bb0115","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1016\/S0024-3205(03)00651-9","article-title":"Inhibitory effect of anandamide on resiniferatoxin-induced sensory neuropeptide release in vivo and neuropathic hyperalgesia in the rat","volume":"73","author":"Helyes","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.npep.2017.02.079_bb0120","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1002\/art.20184","article-title":"Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat","volume":"50","author":"Helyes","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.npep.2017.02.079_bb0125","doi-asserted-by":"publisher","first-page":"13088","DOI":"10.1073\/pnas.0900681106","article-title":"Impaired defense mechanism against inflammation, hyperalgesia, and airway hyperreactivity in somatostatin 4 receptor gene-deleted mice","volume":"106","author":"Helyes","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.npep.2017.02.079_bb0130","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S0304-3959(97)00124-3","article-title":"Inhibitory effect of somatostatin on the mechanosensitivity of articular afferents in normal and inflamed knee joints of the rat","volume":"73","author":"Heppelmann","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.npep.2017.02.079_bb0135","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0306-4522(76)90008-7","article-title":"Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat","volume":"1","author":"H\u00f6kfelt","year":"1976","journal-title":"Neuroscience"},{"key":"10.1016\/j.npep.2017.02.079_bb0140","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.npep.2014.10.001","article-title":"Analgesic topical capsaicinoid therapy increases somatostatin-like immunoreactivity in the human plasma","volume":"48","author":"Horv\u00e1th","year":"2014","journal-title":"Neuropeptides"},{"key":"10.1016\/j.npep.2017.02.079_bb0145","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/j.1476-5381.1967.tb01984.x","article-title":"Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin","volume":"31","author":"Jancs\u00f3","year":"1967","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.npep.2017.02.079_bb0150","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0306-4522(95)00334-F","article-title":"Coexpression of preprotachykinin-A, alpha-calcitonin gene-related peptide, somatostatin, and neurotrophin receptor family messenger RNAs in rat dorsal root ganglion neurons","volume":"70","author":"Kashiba","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.npep.2017.02.079_bb0155","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1021\/mp8001649","article-title":"Stabilization of indocyanine green by encapsulation within micellar systems","volume":"6","author":"Kirchherr","year":"2009","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.npep.2017.02.079_bb0160","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0079-6123(08)61790-2","article-title":"Neuropeptides in morphologically and functionally identified primary afferent neurons in dorsal root ganglia: substance P, CGRP and somatostatin","volume":"104","author":"Lawson","year":"1995","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.npep.2017.02.079_bb0165","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S0079-6123(08)61099-7","article-title":"Peptides and cutaneous polymodal nociceptor neurones","volume":"113","author":"Lawson","year":"1996","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.npep.2017.02.079_bb0170","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0165-0173(02)00186-8","article-title":"The whole body receptive field of dorsal horn multireceptive neurones","volume":"40","author":"Le Bars","year":"2002","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.npep.2017.02.079_bb0175","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0301-0082(94)E0017-B","article-title":"Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves","volume":"45","author":"Maggi","year":"1995","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.npep.2017.02.079_bb0180","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S1471-4892(02)00007-3","article-title":"GDNF and somatostatin in sensory neurones","volume":"3","author":"Malcangio","year":"2003","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.npep.2017.02.079_bb0185","first-page":"233","article-title":"Somatostatin treatment for pain in rheumatoid arthritis: a double blind versus placebo study in knee involvement","volume":"16","author":"Matucci-Cerinic","year":"1998","journal-title":"Med. Sci. Res."},{"key":"10.1016\/j.npep.2017.02.079_bb0190","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1016\/0024-3205(83)90352-1","article-title":"Minireview. Peptides and the blood-brain barrier","volume":"32","author":"Meisenberg","year":"1983","journal-title":"Life Sci."},{"key":"10.1016\/j.npep.2017.02.079_bb0195","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/0304-3959(75)90073-1","article-title":"Prolonged relief of pain by brief, intense transcutaneous somatic stimulation","volume":"1","author":"Melzack","year":"1975","journal-title":"Pain"},{"key":"10.1016\/j.npep.2017.02.079_bb0200","first-page":"313","article-title":"Development of somatostatin radioimmunoassay for the measurement of plasma and tissue contents of hormone","volume":"84","author":"N\u00e9meth","year":"1996","journal-title":"Acta Physiol. Hung."},{"key":"10.1016\/j.npep.2017.02.079_bb0205","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0014-2999(98)00216-7","article-title":"Inhibition of nociceptin on sensory neuropeptide release and mast cell-mediated plasma extravasation in rats","volume":"347","author":"N\u00e9meth","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.npep.2017.02.079_bb0210","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1124\/pr.113.008268","article-title":"Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine","volume":"66","author":"Nilius","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.npep.2017.02.079_bb0215","doi-asserted-by":"publisher","first-page":"3779","DOI":"10.1172\/JCI43766","article-title":"Central modulation of pain","volume":"120","author":"Ossipov","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.npep.2017.02.079_bb0220","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0006-8993(00)02077-1","article-title":"The pain inhibiting pain effect: an electrophysiological study in humans","volume":"862","author":"Reinert","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.npep.2017.02.079_bb0225","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1097\/00000542-200108000-00036","article-title":"Opioid peptide-expressing leukocytes: identification, recruitment, and simultaneously increasing inhibition of inflammatory pain","volume":"95","author":"Rittner","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1016\/j.npep.2017.02.079_bb0230","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1096\/fj.06-6077fje","article-title":"Pain control by CXCR2 ligands through Ca2+-regulated release of opioid peptides from polymorphonuclear cells","volume":"20","author":"Rittner","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.npep.2017.02.079_bb0235","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1093\/brain\/110.6.1497","article-title":"An electrophysiological investigation into the pain-relieving effects of heterotopic nociceptive stimuli. Probable involvement of a supraspinal loop","volume":"110","author":"Roby-Brami","year":"1987","journal-title":"Brain"},{"key":"10.1016\/j.npep.2017.02.079_bb0240","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1111\/j.1460-9568.2004.03284.x","article-title":"Co-localization of endomorphin-2 and substance P in primary afferent nociceptors and effects of injury: a light and electron microscopic study in the rat","volume":"19","author":"Sanderson Nydahl","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.npep.2017.02.079_bb0245","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/0304-3959(90)91074-S","article-title":"A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury","volume":"43","author":"Seltzer","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.npep.2017.02.079_bb0250","first-page":"79","article-title":"Intra-articular injection of somatostatin in knee osteoarthritis: clinical results and IGF-1 serum levels","volume":"14","author":"Silveri","year":"1994","journal-title":"Int. J. Clin. Pharmacol. Res."},{"key":"10.1016\/j.npep.2017.02.079_bb0255","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.pain.2010.11.018","article-title":"Treating pain with pain: supraspinal mechanisms of endogenous analgesia elicited by heterotopic noxious conditioning stimulation","volume":"152","author":"Sprenger","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.npep.2017.02.079_bb0260","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.brainresrev.2008.12.017","article-title":"Peripheral mechanisms of pain and analgesia","volume":"60","author":"Stein","year":"2009","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.npep.2017.02.079_bb0265","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","article-title":"ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures","volume":"112","author":"Story","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.npep.2017.02.079_bb0270","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/S0079-6123(08)61097-3","article-title":"Capsaicin-sensitive sensory nerve terminals with local and systemic efferent functions: facts and scopes of an unorthodox neuroregulatory mechanism","volume":"113","author":"Szolcs\u00e1nyi","year":"1996","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.npep.2017.02.079_bb0275","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1517\/14728222.2013.772580","article-title":"Transient receptor potential vanilloid 1 as a therapeutic target in analgesia","volume":"17","author":"Szolcs\u00e1nyi","year":"2013","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.npep.2017.02.079_bb0280","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1038\/sj.bjp.0701685","article-title":"Release of somatostatin and its role in the mediation of the anti-inflammatory effect induced by antidromic stimulation of sensory fibres of rat sciatic nerve","volume":"123","author":"Szolcs\u00e1nyi","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.npep.2017.02.079_bb0285","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1038\/sj.bjp.0702144","article-title":"Systemic anti-inflammatory effect induced by counter-irritation through a local release of somatostatin from nociceptors","volume":"125","author":"Szolcs\u00e1nyi","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.npep.2017.02.079_bb0290","series-title":"Hyperalgesia: molecular mechanisms and clinical implications, Progress in Pain Research and Management","first-page":"113","article-title":"Sensocrine function of capsaicin-sensitive nociceptors mediated by somatostatin regulates against inflammation and hyperalgesia","volume":"30","author":"Szolcs\u00e1nyi","year":"2004"},{"key":"10.1016\/j.npep.2017.02.079_bb0295","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.2174\/156802611796904852","article-title":"Inhibition of the function of TRPV1-expressing nociceptive sensory neurons by somatostatin 4 receptor agonism: mechanism and therapeutical implications","volume":"11","author":"Szolcs\u00e1nyi","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.npep.2017.02.079_bb0300","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s00726-005-0289-3","article-title":"Strategies to improve plasma half life time of peptide and protein drugs","volume":"30","author":"Werle","year":"2006","journal-title":"Amino Acids"},{"key":"10.1016\/j.npep.2017.02.079_bb0305","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s002210050637","article-title":"Dorsal root potentials and dorsal root reflexes: a double-edged sword","volume":"124","author":"Willis","year":"1999","journal-title":"Exp. Brain Res."}],"container-title":["Neuropeptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417916300464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417916300464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T11:15:45Z","timestamp":1568805345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143417916300464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":61,"alternative-id":["S0143417916300464"],"URL":"https:\/\/doi.org\/10.1016\/j.npep.2017.02.079","relation":{},"ISSN":["0143-4179"],"issn-type":[{"value":"0143-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence for a novel, neurohumoral antinociceptive mechanism mediated by peripheral capsaicin-sensitive nociceptors in conscious rats","name":"articletitle","label":"Article Title"},{"value":"Neuropeptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.npep.2017.02.079","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}