{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:17:45Z","timestamp":1770063465332,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Science, Sports, and Culture of Japan","doi-asserted-by":"crossref","award":["26292165"],"award-info":[{"award-number":["26292165"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Science, Sports, and Culture of Japan","doi-asserted-by":"crossref","award":["16H05043"],"award-info":[{"award-number":["16H05043"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"AMED-CREST","award":["15gm0610016h0102"],"award-info":[{"award-number":["15gm0610016h0102"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","neuropeptidesjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropeptides"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.npep.2017.04.005","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T11:16:30Z","timestamp":1492082190000},"page":"21-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Neuropeptide S increases motor activity and thermogenesis in the rat through sympathetic activation"],"prefix":"10.1016","volume":"65","author":[{"given":"Takuya","family":"Ensho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"92","key":"10.1016\/j.npep.2017.04.005_bb0005","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1152\/japplphysiol.00994.2001","article-title":"Uncoupling proteins and thermoregulation","volume":"1985","author":"Argyropoulos","year":"2002","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.npep.2017.04.005_bb0010","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1111\/j.1530-0277.2008.00713.x","article-title":"The effects of neuropeptide S on ethanol drinking and other related behaviors in alcohol-preferring and -nonpreferring rats","volume":"32","author":"Badia-Elder","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.npep.2017.04.005_bb0015","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.bbrc.2005.05.029","article-title":"Peptide S is a novel potent inhibitor of voluntary and fast-induced food intake in rats","volume":"332","author":"Beck","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.npep.2017.04.005_bb0020","first-page":"R321","article-title":"Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism","volume":"260","author":"Billington","year":"1991","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.npep.2017.04.005_bb0025","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1002\/cne.22606","article-title":"Anatomical characterization of the neuropeptide S system in the mouse brain by in situ hybridization and immunohistochemistry","volume":"519","author":"Clark","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.npep.2017.04.005_bb0030","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0196-9781(95)00020-K","article-title":"Dissociated feeding and hypothermic effects of neuropeptide Y in the paraventricular and perifornical hypothalamus","volume":"16","author":"Currie","year":"1995","journal-title":"Peptides"},{"key":"10.1016\/j.npep.2017.04.005_bb0035","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4306\/pi.2008.5.4.203","article-title":"Peripheral amino acid levels in schizophrenia and antipsychotic treatment","volume":"5","author":"De Luca","year":"2008","journal-title":"Psychiatry Investig."},{"key":"10.1016\/j.npep.2017.04.005_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2009.07.024","article-title":"Behavioral phenotyping of neuropeptide S receptor knockout mice","volume":"205","author":"Duangdao","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.npep.2017.04.005_bb0045","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1111\/j.1460-9568.2009.06948.x","article-title":"The paraventricular nucleus of the hypothalamus is a neuroanatomical substrate for the inhibition of palatable food intake by neuropeptide S","volume":"30","author":"Fedeli","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.npep.2017.04.005_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2010.09.022","article-title":"Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response","volume":"217","author":"Fendt","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.npep.2017.04.005_bb0055","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.bbrc.2012.10.137","article-title":"Central and peripheral des-acyl ghrelin regulates body temperature in rats","volume":"430","author":"Inoue","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.npep.2017.04.005_bb0060","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.neuron.2008.07.002","article-title":"Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala","volume":"59","author":"J\u00fcngling","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.npep.2017.04.005_bb0065","doi-asserted-by":"crossref","first-page":"19567","DOI":"10.1073\/pnas.1004100107","article-title":"Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system","volume":"107","author":"Kallupi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.npep.2017.04.005_bb0070","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.neuron.2004.08.007","article-title":"Neuropeptide S: a novel activating anxiolytic?","volume":"43","author":"Koob","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.npep.2017.04.005_bb0075","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1210\/endo.143.1.8561","article-title":"Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers","volume":"143","author":"Lawrence","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.npep.2017.04.005_bb0080","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00213-008-1080-4","article-title":"Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders","volume":"197","author":"Leonard","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.npep.2017.04.005_bb0085","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1002\/cne.22603","article-title":"Molecular fingerprint of neuropeptide S-producing neurons in the mouse brain","volume":"519","author":"Liu","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.npep.2017.04.005_bb0090","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.neuropharm.2011.08.016","article-title":"Nasal application of neuropeptide S reduces anxiety and prolongs memory in rats: social versus non-social effects","volume":"62","author":"Lukas","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.npep.2017.04.005_bb0095","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.autneu.2012.05.003","article-title":"Enhanced parasympathetic activity of sportive women is paradoxically associated to enhanced resting energy expenditure","volume":"169","author":"Messina","year":"2012","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.npep.2017.04.005_bb0100","doi-asserted-by":"crossref","first-page":"639280","DOI":"10.1155\/2013\/639280","article-title":"Autonomic nervous system in the control of energy balance and body weight: personal contributions","volume":"2013","author":"Messina","year":"2013","journal-title":"Neurol. Res. Int."},{"key":"10.1016\/j.npep.2017.04.005_bb0105","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fncir.2016.00066","article-title":"Role of the orexin system on the hypothalamus-pituitary-thyroid Axis","volume":"10","author":"Messina","year":"2016","journal-title":"Front Neural Circuits"},{"key":"10.1016\/j.npep.2017.04.005_bb0110","doi-asserted-by":"crossref","DOI":"10.5812\/asjsm.26841","article-title":"Parachute jumping induces more sympathetic activation than cortisol secretion in first-time parachutists","volume":"7","author":"Messina","year":"2016","journal-title":"Asian J. Sports Med."},{"key":"10.1016\/j.npep.2017.04.005_bb0115","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1515\/jbcpp-2015-0133","article-title":"Exercise increases the level of plasma orexin A in humans","volume":"27","author":"Messina","year":"2016","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.npep.2017.04.005_bb0120","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.peptides.2010.02.006","article-title":"Microinjection of neuropeptide S into the rat ventral tegmental area induces hyperactivity and increases extracellular levels of dopamine metabolites in the nucleus accumbens shell","volume":"31","author":"Mochizuki","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.npep.2017.04.005_bb0125","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.npep.2006.07.003","article-title":"Quetiapine lowers sympathetic and hyperthermic reactions due to cerebral injection of orexin A","volume":"40","author":"Monda","year":"2006","journal-title":"Neuropeptides"},{"key":"10.1016\/j.npep.2017.04.005_bb0130","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1210\/en.2003-0536","article-title":"A role for neuropeptide W in the regulation of feeding behavior","volume":"144","author":"Mondal","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.npep.2017.04.005_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2016.01.155","article-title":"Involvement of endogenous neuromedin U and neuromedin S in thermoregulation","author":"Nakahara","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.npep.2017.04.005_bb0140","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1006\/bbrc.2000.3669","article-title":"Central effects of neuromedin U in the regulation of energy homeostasis","volume":"277","author":"Nakazato","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.npep.2017.04.005_bb0145","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1385\/ENDO:30:1:75","article-title":"Centrally administered neuropeptide S activates orexin-containing neurons in the hypothalamus and stimulates feeding in rats","volume":"30","author":"Niimi","year":"2006","journal-title":"Endocrine"},{"key":"10.1016\/j.npep.2017.04.005_bb0150","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neulet.2014.08.031","article-title":"Endogenous neuropeptide S tone influences sleep-wake rhythm in rats","volume":"581","author":"Oishi","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.npep.2017.04.005_bb0155","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/npp.2010.207","article-title":"Neuropeptide S enhances memory during the consolidation phase and interacts with noradrenergic systems in the brain","volume":"36","author":"Okamura","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.npep.2017.04.005_bb0160","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1523\/JNEUROSCI.5256-08.2009","article-title":"Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice","volume":"29","author":"Pa\u00f1eda","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.npep.2017.04.005_bb0165","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1476-5381.2009.00163.x","article-title":"Neuropeptide S selectively inhibits the release of 5-HT and noradrenaline from mouse frontal cortex nerve endings","volume":"157","author":"Raiteri","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.npep.2017.04.005_bb0170","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.peptides.2007.01.008","article-title":"Phylogenetic appearance of neuropeptide S precursor proteins in tetrapods","volume":"28","author":"Reinscheid","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.npep.2017.04.005_bb0175","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.1113\/JP272971","article-title":"The complementary and divergent roles of uncoupling proteins 1 and 3 in thermoregulation","volume":"594","author":"Riley","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.npep.2017.04.005_bb0180","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/bjp.2008.96","article-title":"Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice","volume":"154","author":"Rizzi","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.npep.2017.04.005_bb0185","doi-asserted-by":"crossref","first-page":"20809","DOI":"10.1074\/jbc.M601846200","article-title":"Structure-activity studies on neuropeptide S: identification of the amino acid residues crucial for receptor activation","volume":"281","author":"Roth","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.npep.2017.04.005_bb0190","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1210\/en.2005-1280","article-title":"Neuropeptide S stimulates the hypothalamo-pituitary-adrenal axis and inhibits food intake","volume":"147","author":"Smith","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.npep.2017.04.005_bb0195","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1172\/JCI62595","article-title":"NPs \u2013 heart hormones that regulate brown fat?","volume":"122","author":"Whittle","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.npep.2017.04.005_bb0200","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.neuron.2004.08.005","article-title":"Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects","volume":"43","author":"Xu","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.npep.2017.04.005_bb0205","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/cne.21159","article-title":"Distribution of neuropeptide S receptor mRNA and neurochemical characteristics of neuropeptide S-expressing neurons in the rat brain","volume":"500","author":"Xu","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.npep.2017.04.005_bb0210","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/WNR.0b013e328339b5f9","article-title":"Neuropeptide S mitigates spatial memory impairment induced by rapid eye movement sleep deprivation in rats","volume":"21","author":"Zhao","year":"2010","journal-title":"Neuroreport"},{"key":"10.1016\/j.npep.2017.04.005_bb0215","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.neuroscience.2012.01.022","article-title":"Neuropeptide S promotes wakefulness through activation of the posterior hypothalamic histaminergic and orexinergic neurons","volume":"207","author":"Zhao","year":"2012","journal-title":"Neuroscience"}],"container-title":["Neuropeptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417917300100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417917300100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T18:55:56Z","timestamp":1535914556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143417917300100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":43,"alternative-id":["S0143417917300100"],"URL":"https:\/\/doi.org\/10.1016\/j.npep.2017.04.005","relation":{},"ISSN":["0143-4179"],"issn-type":[{"value":"0143-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuropeptide S increases motor activity and thermogenesis in the rat through sympathetic activation","name":"articletitle","label":"Article Title"},{"value":"Neuropeptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.npep.2017.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}