{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:00:36Z","timestamp":1761490836948,"version":"3.37.3"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"President's Faculty Research & Development Grant","award":["335435"],"award-info":[{"award-number":["335435"]}]},{"DOI":"10.13039\/100009846","name":"Nova Southeastern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009846","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropeptides"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.npep.2019.101958","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T15:04:17Z","timestamp":1564153457000},"page":"101958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Angiotensin II induces cyclooxygenase 2 expression in rat astrocytes via the angiotensin type 1 receptor"],"prefix":"10.1016","volume":"77","author":[{"given":"Ann Tenneil","family":"O'Connor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle A.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.npep.2019.101958_bb0005","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3109\/10799893.2013.876041","article-title":"p38 mitogen-activated protein kinase is stimulated by both angiotensin II and angiotensin III in cultured rat astrocytes","volume":"34","author":"Alanazi","year":"2014","journal-title":"J. Recept. Signal Transduct. Res."},{"issue":"1","key":"10.1016\/j.npep.2019.101958_bb0010","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1124\/jpet.106.115287","article-title":"Losartan reduces the increased participation of cyclooxygenase-2-derived products in vascular responses of hypertensive rats","volume":"321","author":"\u00c1lvarez","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"10.1016\/j.npep.2019.101958_bb0015","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1210\/endo-124-6-3125","article-title":"Interleukin-1 beta increases prostaglandin e2 in rat astrocyte cultures: modulatory effect of neuropeptides","volume":"124","author":"Arimura","year":"1989","journal-title":"Endocrinology"},{"issue":"15","key":"10.1016\/j.npep.2019.101958_bb0020","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases","volume":"336","author":"Barnes","year":"1997","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.npep.2019.101958_bb0025","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/HJH.0b013e328317a730","article-title":"p38 MAPK contributes to angiotensin II-induced COX-2 expression in aortic fibroblasts from normotensive and hypertensive rats","volume":"27","author":"Beltr\u00e1n","year":"2009","journal-title":"J. Hypertens."},{"issue":"7","key":"10.1016\/j.npep.2019.101958_bb0030","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.biocel.2003.08.006","article-title":"Prostanoids and prostanoid receptors in signal transduction","volume":"36","author":"Bos","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.npep.2019.101958_bb0035","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.neuron.2013.10.044","article-title":"The cerebellum and cognitive function: 25 years of insight from anatomy and neuroimaging","volume":"80","author":"Buckner","year":"2013","journal-title":"Neuron"},{"issue":"7","key":"10.1016\/j.npep.2019.101958_bb0040","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1172\/JCI5505","article-title":"Angiotensin II attenuates renal cortical cyclooxygenase-2 expression","volume":"103","author":"Cheng","year":"1999","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.npep.2019.101958_bb0045","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.npep.2011.07.002","article-title":"Angiotensin III stimulates ERK1\/2 mitogen-activated protein kinases and astrocyte growth in cultured rat astrocytes","volume":"45","author":"Clark","year":"2011","journal-title":"Neuropeptides"},{"issue":"1\u20132","key":"10.1016\/j.npep.2019.101958_bb0050","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.autneu.2009.02.003","article-title":"Central sympathetic overactivity: maladies and mechanisms","volume":"148","author":"Fisher","year":"2009","journal-title":"Autonom. Neurosci."},{"issue":"9","key":"10.1016\/j.npep.2019.101958_bb0055","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1074\/jbc.M111.327874","article-title":"Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes","volume":"287","author":"Font-Nieves","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.npep.2019.101958_bb0060","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/FJC.0b013e318157f72d","article-title":"COX-2 inhibitors and cardiovascular risk","volume":"50","author":"Funk","year":"2007","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.npep.2019.101958_bb0065","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1155\/2018\/7902081","article-title":"Interactions between the cyclooxygenase metabolic pathway and the renin-angiotensin-aldosterone systems: their effect on cardiovascular risk, from theory to the clinical practice","volume":"2018","author":"Gawrys","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.npep.2019.101958_bb0070","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/9550","article-title":"Inducible cyclooxygenase may have anti-inflammatory properties","volume":"5","author":"Gilroy","year":"1999","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.npep.2019.101958_bb0075","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1227\/01.NEU.0000154060.14900.8F","article-title":"Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury","volume":"56","author":"Gopez","year":"2005","journal-title":"Neurosurgery"},{"issue":"4","key":"10.1016\/j.npep.2019.101958_bb0080","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4330\/wjc.v7.i4.204","article-title":"Autonomic and endocrine control of cardiovascular function","volume":"7","author":"Gordan","year":"2015","journal-title":"World J. Cardiol."},{"key":"10.1016\/j.npep.2019.101958_bb0085","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.mce.2016.08.013","article-title":"Angiotensin II induces interleukin-6 expression in astrocytes: role of reactive oxygen species and NF-kappaB","volume":"437","author":"Gowrisankar","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"issue":"4","key":"10.1016\/j.npep.2019.101958_bb0090","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1046\/j.1365-201X.2003.01101.x","article-title":"Interactions between COX-2 and the renin\u2013angiotensin system in the kidney","volume":"177","author":"Harris","year":"2003","journal-title":"Acta Physiol. Scand."},{"issue":"4","key":"10.1016\/j.npep.2019.101958_bb0095","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/jnc.13776","article-title":"Heterologous regulation of the cannabinoid type 1 receptor by angiotensin II in astrocytes of spontaneously hypertensive rats","volume":"139","author":"Haspula","year":"2016","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.npep.2019.101958_bb0100","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1124\/jpet.118.248831","article-title":"Molecular basis of the brain renin angiotensin system in cardiovascular and neurologic disorders: uncovering a key role for the astroglial angiotensin type 1 receptor AT1R","volume":"366","author":"Haspula","year":"2018","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.npep.2019.101958_bb0105","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.autneu.2018.01.002","article-title":"Neuroinflammation and sympathetic overactivity: mechanisms and implications in hypertension","volume":"210","author":"Haspula","year":"2018","journal-title":"Auton. Neurosci."},{"issue":"2","key":"10.1016\/j.npep.2019.101958_bb0110","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1124\/jpet.102.037705","article-title":"Angiotensin II increases expression of cyclooxygenase-2: implications for the function of vascular smooth muscle cells","volume":"303","author":"Hu","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.npep.2019.101958_bb0115","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.npep.2014.04.001","article-title":"Angiotensin II inhibits uptake of transferrin-bound iron but not non-transferrin-bound iron by cultured astrocytes","volume":"48","author":"Huang","year":"2014","journal-title":"Neuropeptides"},{"issue":"5","key":"10.1016\/j.npep.2019.101958_bb0120","first-page":"R1000","article-title":"Characterization of angiotensin receptors mediating prostaglandin synthesis in C6 glioma cells","volume":"260","author":"Jaiswal","year":"1991","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"issue":"6 Pt 2","key":"10.1016\/j.npep.2019.101958_bb0125","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.HYP.21.6.900","article-title":"Alterations in prostaglandin production in spontaneously hypertensive rat smooth muscle cells","volume":"21","author":"Jaiswal","year":"1993","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.npep.2019.101958_bb0130","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/1570159X11311020007","article-title":"ACE2-Ang-(1-7)-mas axis in brain: a potential target for prevention and treatment of ischemic stroke","volume":"11","author":"Jiang","year":"2013","journal-title":"Curr. Neuropharmacol."},{"issue":"6","key":"10.1016\/j.npep.2019.101958_bb0135","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/01.HYP.1.6.598","article-title":"Sympathetic nerve activity and blood pressure in normotensive backcross rats genetically related to the spontaneously hypertensive rat","volume":"1","author":"Judy","year":"1979","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.npep.2019.101958_bb0140","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1046\/j.1365-2044.2000.01271.x","article-title":"Cyclo-oxygenase isoenzymes: physiological and pharmacological role","volume":"55","author":"Kam","year":"2000","journal-title":"Anaesthesia"},{"issue":"2","key":"10.1016\/j.npep.2019.101958_bb0145","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1073\/pnas.1517642113","article-title":"Systematic study of constitutive cyclooxygenase-2 expression: role of NF-\u03baB and NFAT transcriptional pathways","volume":"113","author":"Kirkby","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.npep.2019.101958_bb0150","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1084\/jem.187.4.517","article-title":"Compensatory prostaglandin E<sub>2<\/sub> biosynthesis in cyclooxygenase 1 or 2 null cells","volume":"187","author":"Kirtikara","year":"1998","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.npep.2019.101958_bb0155","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1016\/S0021-9258(18)53338-X","article-title":"Expression of the protein product of the prostaglandin synthase-2\/TIS10 gene in mitogen-stimulated Swiss 3T3 cells","volume":"268","author":"Kujubu","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.npep.2019.101958_bb0160","first-page":"277","article-title":"Arterial pressure development in neonatal and young spontaneously hypertensive rats","volume":"14","author":"Lais","year":"1977","journal-title":"Blood Vessels"},{"issue":"2","key":"10.1016\/j.npep.2019.101958_bb0165","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000330805","article-title":"JNK\/ERK\/FAK mediate promigratory actions of basic fibroblast growth factor in astrocytes via CCL2 and COX2","volume":"20","author":"Lichtenstein","year":"2012","journal-title":"Neurosignals"},{"issue":"4","key":"10.1016\/j.npep.2019.101958_bb0170","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"2","key":"10.1016\/j.npep.2019.101958_bb0175","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1046\/j.1471-4159.1998.71020526.x","article-title":"Transforming growth factor beta1 regulates the expression of cyclooxygenase in cultured cortical astrocytes and neurons","volume":"71","author":"Luo","year":"1998","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.npep.2019.101958_bb0180","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3317\/jraas.2003.023","article-title":"Interaction between cyclooxygenase and the renin-angiotensin-aldosterone system: rationale and clinical relevance","volume":"4","author":"Meune","year":"2003","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"key":"10.1016\/j.npep.2019.101958_bb0185","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1253\/jcj.27.282","article-title":"Development of a strain of spontaneously hypertensive rats","volume":"27","author":"Okamoto","year":"1963","journal-title":"Jpn. Circ. J."},{"issue":"8","key":"10.1016\/j.npep.2019.101958_bb0190","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/00004872-198808000-00002","article-title":"Brain angiotensin in the developing spontaneously hypertensive rat","volume":"6","author":"Phillips","year":"1988","journal-title":"J. Hypertens."},{"issue":"42","key":"10.1016\/j.npep.2019.101958_bb0195","doi-asserted-by":"crossref","first-page":"38658","DOI":"10.1074\/jbc.M106599200","article-title":"Positive and negative regulation of NF-kappaB by COX-2: roles of different prostaglandins","volume":"276","author":"Poligone","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.npep.2019.101958_bb0200","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1172\/JCI0214752","article-title":"Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II","volume":"110","author":"Qi","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.npep.2019.101958_bb0205","doi-asserted-by":"crossref","first-page":"C364","DOI":"10.1152\/ajpcell.1984.247.5.C364","article-title":"Increased angiotensin II receptors in neuronal cultures from hypertensive rat brain","volume":"247","author":"Raizada","year":"1984","journal-title":"Am. J. Phys. Cell Phys."},{"issue":"5","key":"10.1016\/j.npep.2019.101958_bb0210","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","article-title":"Prostaglandins and inflammation","volume":"31","author":"Ricciotti","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.npep.2019.101958_bb0215","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1177\/1074248407301172","article-title":"The cycloxygenase 2 (COX-2) story: it\u2019s time to explain, not inflame","volume":"12","author":"Salinas","year":"2007","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.npep.2019.101958_bb0220","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1111\/j.1440-1681.2009.05234.x","article-title":"Brain cytokines as neuromodulators in cardiovascular control","volume":"37","author":"Shi","year":"2010","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"12","key":"10.1016\/j.npep.2019.101958_bb0225","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1002\/glia.23212","article-title":"Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury","volume":"65","author":"Shiow","year":"2017","journal-title":"Glia"},{"issue":"2","key":"10.1016\/j.npep.2019.101958_bb0230","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1074\/jbc.M408172200","article-title":"Angiotensin II and epidermal growth factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling pathways","volume":"280","author":"Slice","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.npep.2019.101958_bb0235","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: biology and pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol."},{"issue":"3","key":"10.1016\/j.npep.2019.101958_bb0240","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.bbi.2007.09.011","article-title":"Antiinflammatory and neuroprotective actions of COX2 inhibitors in the injured brain","volume":"22","author":"Strauss","year":"2008","journal-title":"Brain Behav. Immun."},{"issue":"8","key":"10.1016\/j.npep.2019.101958_bb0245","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1089\/089771500415436","article-title":"Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat","volume":"17","author":"Strauss","year":"2000","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.npep.2019.101958_bb0250","series-title":"Chapter 32 - Angiotensin-(1\u20137) and Cancer. The Protective Arm of the Renin Angiotensin System (RAS)","first-page":"225","author":"Tallant","year":"2015"},{"issue":"4","key":"10.1016\/j.npep.2019.101958_bb0255","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/(SICI)1098-1136(199704)19:4<333::AID-GLIA6>3.0.CO;2-Y","article-title":"Angiotensin II activates distinct signal transduction pathways in astrocytes isolated from neonatal rat brain","volume":"19","author":"Tallant","year":"1997","journal-title":"Glia"},{"key":"10.1016\/j.npep.2019.101958_bb0260","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-1-4899-1376-0_13","article-title":"Identification of AT1 receptors on cultured astrocytes","volume":"396","author":"Tallant","year":"1996","journal-title":"Adv. Exp. Med. Biol."},{"issue":"3","key":"10.1016\/j.npep.2019.101958_bb0265","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/01.HYP.34.3.503","article-title":"Inhibition of the renin-angiotensin system upregulates cyclooxygenase-2 expression in the macula densa","volume":"34","author":"Wolf","year":"1999","journal-title":"Hypertension"},{"issue":"10","key":"10.1016\/j.npep.2019.101958_bb0270","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/ajh.2012.67","article-title":"Distinct roles of central and peripheral prostaglandin E2 and EP subtypes in blood pressure regulation","volume":"25","author":"Yang","year":"2012","journal-title":"Am. J. Hypertens."}],"container-title":["Neuropeptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417919300800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417919300800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T21:59:59Z","timestamp":1610661599000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143417919300800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":54,"alternative-id":["S0143417919300800"],"URL":"https:\/\/doi.org\/10.1016\/j.npep.2019.101958","relation":{},"ISSN":["0143-4179"],"issn-type":[{"type":"print","value":"0143-4179"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiotensin II induces cyclooxygenase 2 expression in rat astrocytes via the angiotensin type 1 receptor","name":"articletitle","label":"Article Title"},{"value":"Neuropeptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.npep.2019.101958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101958"}}