{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:27:03Z","timestamp":1794007623537,"version":"4.8.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropeptides"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.npep.2021.102180","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T00:11:00Z","timestamp":1625875860000},"page":"102180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Onion component, isoalliin, stimulates feeding and activates the arcuate nucleus neuropeptide Y, ghrelin- and Ninjin'yoeito-responsive neurons"],"prefix":"10.1016","volume":"89","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusaku","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakhat","family":"Yermek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey W.G.","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Seino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Yada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.npep.2021.102180_bb0005","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nn.2739","article-title":"AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training","volume":"14","author":"Aponte","year":"2011","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.npep.2021.102180_bb0010","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2503\/hortj.OKD-066","article-title":"Comparative study on phytochemical variations in Japanese F1 varieties of bulb onions and south-east Asian shallot landraces","volume":"87","author":"Ariyanti","year":"2018","journal-title":"Horticult. J."},{"key":"10.1016\/j.npep.2021.102180_bb0015","first-page":"634","article-title":"Therapeutic values of onion (Allium cepa L.) and garlic (Allium sativum L.)","volume":"34","author":"Augusti","year":"1996","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.npep.2021.102180_bb0020","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/scientificamerican0385-114","article-title":"The chemistry of garlic and onions","volume":"252","author":"Block","year":"1985","journal-title":"Sci.Am."},{"issue":"15","key":"10.1016\/j.npep.2021.102180_bb0025","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1007\/s00018-013-1550-7","article-title":"Neuronal calcium signaling: function and dysfunction","volume":"71","author":"Brini","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.npep.2021.102180_bb0030","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/ijc.2910440409","article-title":"A case-control study of gastric cancer and diet in Italy","volume":"44","author":"Buiatti","year":"1989","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.npep.2021.102180_bb0035","series-title":"A Quick Reference of Herbal Medicine","article-title":"Phytotherapy","author":"Capasso","year":"2003"},{"key":"10.1016\/j.npep.2021.102180_bb0040","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4239\/wjd.v5.i3.328","article-title":"Interrelationships between ghrelin, insulin and glucose homeostasis: physiological relevance","volume":"5","author":"Chabot","year":"2014","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.npep.2021.102180_bb0045","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1038\/srep04517","article-title":"A key role for neuropeptide y in lifespan extension and cancer suppression via dietary restriction","volume":"4","author":"Chiba","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.npep.2021.102180_bb0050","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1021\/jf020396t","article-title":"Chemical composition of shallot (Allium ascalonicum Hort.)","volume":"50","author":"Fattorusso","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.npep.2021.102180_bb0055","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF00442819","article-title":"Attenuation of anorexia induced by heat or surgery during sustained administration of ginsenoside Rg1into rat third ventricle","volume":"99","author":"Fujimoto","year":"1989","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.npep.2021.102180_bb0060","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.npep.2019.03.001","article-title":"Ninjin-yoeito activates ghrelin-responsive and unresponsive NPY neurons in the arcuate nucleus and counteracts cisplatin-induced anorexia","volume":"75","author":"Goswami","year":"2019","journal-title":"Neuropeptides."},{"key":"10.1016\/j.npep.2021.102180_bb0065","doi-asserted-by":"crossref","unstructured":"Goswami, C., Dezaki, K., Wang, L., Inui, A., Seino, Y., Yada, T., 2020. ninjin'yoeito targets distinct Ca2+ channels to activate ghrelin-responsive vs. unresponsive NPY neurons in the arcuate nucleus. Front. Nutrition. 7, 104.","DOI":"10.3389\/fnut.2020.00104"},{"key":"10.1016\/j.npep.2021.102180_bb0070","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/nn1548","article-title":"Agouti-related peptide-expressing neurons are mandatory for feeding","volume":"8","author":"Gropp","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.npep.2021.102180_bb0075","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.cmet.2012.04.019","article-title":"Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet","volume":"15","author":"Hatori","year":"2012","journal-title":"Cell Metab."},{"issue":"51","key":"10.1016\/j.npep.2021.102180_bb0080","doi-asserted-by":"crossref","first-page":"19564","DOI":"10.1073\/pnas.0609598103","article-title":"TRP channel activation by reversible covalent modification","volume":"103","author":"Hinman","year":"2006","journal-title":"PNAS."},{"issue":"8","key":"10.1016\/j.npep.2021.102180_bb0085","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1089\/acm.2020.0083","article-title":"Usefulness of Ninjin\u2019yoeito for chronic obstructive pulmonary disease patients with frailty","volume":"26","author":"Hirai","year":"2020","journal-title":"J. Altern. Complement. Med."},{"key":"10.1016\/j.npep.2021.102180_bb0090","doi-asserted-by":"crossref","first-page":"4785","DOI":"10.1002\/cncr.27430","article-title":"Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients: a prospective, randomized, placebo-controlled phase 2 study","volume":"118","author":"Hiura","year":"2012","journal-title":"Cancer."},{"key":"10.1016\/j.npep.2021.102180_bb0095","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41467-017-02488-y","article-title":"GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose","volume":"9","author":"Iwasaki","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.npep.2021.102180_bb0100","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.npep.2012.09.004","article-title":"Arcuate NPY neurons sense and integrate peripheral metabolic signals to control feeding","volume":"46","author":"Kohno","year":"2012","journal-title":"Neuropeptides."},{"key":"10.1016\/j.npep.2021.102180_bb0105","doi-asserted-by":"crossref","first-page":"948","DOI":"10.2337\/diabetes.52.4.948","article-title":"Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin","volume":"52","author":"Kohno","year":"2003","journal-title":"Diabetes."},{"key":"10.1016\/j.npep.2021.102180_bb0110","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1210\/en.2006-1240","article-title":"Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway","volume":"148","author":"Kohno","year":"2007","journal-title":"Endocrinology."},{"key":"10.1016\/j.npep.2021.102180_bb0115","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neulet.2011.05.060","article-title":"AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats","volume":"499","author":"Kohno","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.npep.2021.102180_bb0120","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cmet.2007.09.006","article-title":"High-fat diet disrupts behavioral and molecular circadian rhythms in mice","volume":"6","author":"Kohsaka","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.npep.2021.102180_bb0125","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1172\/JCI46229","article-title":"Rapid, reversible activation of AgRP neurons drives feeding behavior in mice","volume":"121","author":"Krashes","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.npep.2021.102180_bb0130","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3390\/nu8020069","article-title":"Anorexia of aging: risk factors, consequences, and potential treatments","volume":"8","author":"Landi","year":"2016","journal-title":"Nutrients."},{"key":"10.1016\/j.npep.2021.102180_bb0135","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.chroma.2005.12.016","article-title":"The analysis of onion and garlic","volume":"1112","author":"Lanzotti","year":"2006","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.npep.2021.102180_bb0140","series-title":"In: Phytomedicines of Europe, American Chemical Society Symp. Ser","first-page":"176","volume":"691","author":"Lawson","year":"1998"},{"key":"10.1016\/j.npep.2021.102180_bb0145","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1126\/science.1115524","article-title":"NPY\/AgRP neurons are essentials for feeding in adult mice but can be ablated in neonates","volume":"310","author":"Luquet","year":"2005","journal-title":"Science."},{"key":"10.1016\/j.npep.2021.102180_bb0150","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fendo.2013.00015","article-title":"Ghrelin: central and peripheral implications in anorexia nervosa","volume":"4","author":"M\u00e9quinion","year":"2013","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.npep.2021.102180_bb0155","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/appe.1997.0134","article-title":"Circadian rhythms in the Zucker obese rat: assessment and intervention","volume":"30","author":"Mistlberger","year":"1998","journal-title":"Appetite"},{"key":"10.1016\/j.npep.2021.102180_bb0160","first-page":"27","article-title":"Pathophysiology of the anorexia of aging","volume":"16","author":"Morley","year":"2013","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care."},{"key":"10.1016\/j.npep.2021.102180_bb0165","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35051587","article-title":"A role for ghrelin in the central regulation of feeding","volume":"409","author":"Nakazato","year":"2001","journal-title":"Nature."},{"key":"10.1016\/j.npep.2021.102180_bb0170","first-page":"404","article-title":"Memoire sur la fermentation appel\u00e9e lactique","volume":"52","author":"Pasteur","year":"1858","journal-title":"Ann. Chim. Phys. Ser."},{"key":"10.1016\/j.npep.2021.102180_bb0175","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/978-3-030-12457-1_22","article-title":"Calcium signaling and gene expression","volume":"1131","author":"Puri","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.npep.2021.102180_bb0180","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.fct.2010.10.019","article-title":"Effects of Korean ginseng root extract on cisplatin-induced emesis in a rat-pica model","volume":"49","author":"Raghavendran","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.npep.2021.102180_bb0185","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature."},{"key":"10.1016\/j.npep.2021.102180_bb0190","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0031-9422(00)90878-1","article-title":"Enzymatic conversion of trans-(+)-S-1-propenyl-l-cysteine S-oxide to the bitter and odor-bearing components of onion","volume":"7","author":"Schwimmer","year":"1968","journal-title":"Phytochemistry"},{"key":"10.1016\/j.npep.2021.102180_bb0195","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0076-6879(71)17084-X","article-title":"[199] S-alkyl-l-cysteine sulfoxide lyase [Allium cepa (Onion)]","volume":"17B","author":"Schwimmer","year":"1971","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.npep.2021.102180_bb0200","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s11418-015-0921-9","article-title":"Ninjin\u2019yoeito and ginseng extract prevent oxaliplatin-induced neurodegeneration in PC12 cells","volume":"69","author":"Suzuki","year":"2015","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.npep.2021.102180_bb0205","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.3892\/ol.2017.5937","article-title":"Japanese Kampo medicine ninjin\u2019yoeito synergistically enhances tumor vaccine effects mediated by CD8+ T cells","volume":"13","author":"Takaku","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.npep.2021.102180_bb0210","first-page":"779","article-title":"A certain step of proteolytic processing of proopiomelanocortin occurs during the transition between two distinct stages of secretory granule maturation in rat anterior pituitary corticotrophs","volume":"131","author":"Tanaka","year":"1992","journal-title":"Endocrinology."},{"key":"10.1016\/j.npep.2021.102180_bb0215","doi-asserted-by":"crossref","first-page":"12419","DOI":"10.1523\/JNEUROSCI.3412-08.2008","article-title":"Novel leptin-regulated genes revealed by transcriptional profiling of the hypothalamic paraventricular nucleus","volume":"28","author":"Tung","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.npep.2021.102180_bb0220","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1271\/bbb.58.108","article-title":"Composition of sulfur-containing components in onion and their flavor characters","volume":"58","author":"Ueda","year":"1994","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.npep.2021.102180_bb0225","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3389\/fnut.2018.00126","article-title":"Herbal medicine Ninjin\u2019yoeito in the treatment of sarcopenia and frailty","volume":"5","author":"Uto","year":"2018","journal-title":"Front. Nutrition."},{"key":"10.1016\/j.npep.2021.102180_bb0230","first-page":"331","article-title":"Goals for nutrition in the year 2000","volume":"49","author":"Willett","year":"1999","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.npep.2021.102180_bb0235","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ejphar.2010.11.042","article-title":"Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network","volume":"660","author":"Williams","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.npep.2021.102180_bb0240","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0196-9781(93)90035-F","article-title":"Pituitary adenylate cyclase activating polypeptide (PACAP) increases cytosolic-free calcium concentration in folliculo-stellate cells and somatotropes of rat pituitary","volume":"14","author":"Yada","year":"1993","journal-title":"Peptides."},{"issue":"2","key":"10.1016\/j.npep.2021.102180_bb0245","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/S0021-9258(17)42256-3","article-title":"Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells","volume":"269","author":"Yada","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.npep.2021.102180_bb0250","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.2174\/138161212803216898","article-title":"Neurohormones, rikkunshito and hypothalamic neurons interactively control appetite and anorexia","volume":"18","author":"Yada","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.npep.2021.102180_bb0255","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.phymed.2007.08.006","article-title":"Effect of Ninjin-yoei-to (Rensheng-Yangrong-tang) on olfactory behavior after olfactory nerve transection","volume":"15","author":"Yamasaki","year":"2008","journal-title":"Phytomedicine."},{"key":"10.1016\/j.npep.2021.102180_bb0260","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.2174\/138161212803216988","article-title":"The role of NPY and ghrelin in anorexia nervosa","volume":"18","author":"Zhang","year":"2012","journal-title":"Curr. Pharm. Des."}],"container-title":["Neuropeptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417921000664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417921000664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T20:38:36Z","timestamp":1758919116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143417921000664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":52,"alternative-id":["S0143417921000664"],"URL":"https:\/\/doi.org\/10.1016\/j.npep.2021.102180","relation":{},"ISSN":["0143-4179"],"issn-type":[{"value":"0143-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Onion component, isoalliin, stimulates feeding and activates the arcuate nucleus neuropeptide Y, ghrelin- and Ninjin'yoeito-responsive neurons","name":"articletitle","label":"Article Title"},{"value":"Neuropeptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.npep.2021.102180","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102180"}}