{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:30:46Z","timestamp":1786995046697,"version":"build-2736575974"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropeptides"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.npep.2022.102295","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T06:21:34Z","timestamp":1665728494000},"page":"102295","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Melittin ameliorates motor function and prevents autophagy-induced cell death and astrogliosis in rat models of cerebellar ataxia induced by 3-acetylpyridine"],"prefix":"10.1016","volume":"96","author":[{"given":"Zahra","family":"Aghighi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynab","family":"Ghorbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meysam Hassani","family":"Moghaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mobina","family":"Fathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad-Amin","family":"Abdollahifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoureh","family":"Soleimani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Karimzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homa","family":"Rasoolijazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Aliaghaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.npep.2022.102295_bb0005","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3389\/fphar.2014.00196","article-title":"Glutathione: new roles in redox signaling for an old antioxidant","volume":"5","author":"Aquilano","year":"2014","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.npep.2022.102295_bb0010","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1517\/14728214.2015.990373","article-title":"Emerging drugs for the treatment of acne","volume":"20","author":"Aslam","year":"2015","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"10.1016\/j.npep.2022.102295_bb0015","first-page":"33","article-title":"Melittin, An active ingredient of honeybee venom (Apis mellifera), as a potent inhibitor of tumor growth in mice","volume":"6","author":"Attia","year":"2009","journal-title":"Egypt. J. Nat. Toxins"},{"issue":"8","key":"10.1016\/j.npep.2022.102295_bb0020","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1016\/j.bbagen.2013.04.006","article-title":"Punctum on two different transcription factors regulated by PGC-1\u03b1: Nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2","volume":"1830","author":"Baldelli","year":"2013","journal-title":"Biochim. Biophys. Acta (BBA)"},{"issue":"5\u20136","key":"10.1016\/j.npep.2022.102295_bb0025","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1159\/000111432","article-title":"Glutathione protects astrocytes from peroxynitrite-mediated mitochondrial damage: implications for neuronal\/astrocytic trafficking and neurodegeneration","volume":"18","author":"Barker","year":"1996","journal-title":"Dev. Neurosci."},{"issue":"5","key":"10.1016\/j.npep.2022.102295_bb0030","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1046\/j.1471-4159.1995.64051965.x","article-title":"Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture","volume":"64","author":"Bola\u00f1os","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.npep.2022.102295_bb0035","series-title":"Inflammatory Response Leads to Neuronal Death in Human Post-Mortem Cerebral Cortex in Patients with COVID-19. ACS Chem Neurosci","author":"Boroujeni","year":"2021"},{"issue":"1","key":"10.1016\/j.npep.2022.102295_bb0040","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/(SICI)1098-1136(20000101)29:1<98::AID-GLIA10>3.0.CO;2-B","article-title":"Induction of nitric oxide synthesis lowers intracellular glutathione in microglia of primary glial cultures","volume":"29","author":"Chatterjee","year":"2000","journal-title":"Glia."},{"issue":"9","key":"10.1016\/j.npep.2022.102295_bb0045","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1074\/jbc.271.9.4573","article-title":"Molecular Ordering of the Cell Death Pathway: Bcl-2 AND Bcl-xL Function upstream of the CED-3-like apoptotic proteases (\u2217)","volume":"271","author":"Chinnaiyan","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.npep.2022.102295_bb0050","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0361-9230(02)00785-2","article-title":"Disruption of astroglial interlaminar processes in Alzheimer\u2019s disease","volume":"58","author":"Colombo","year":"2002","journal-title":"Brain Res. Bull."},{"issue":"1","key":"10.1016\/j.npep.2022.102295_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-01747-8","article-title":"Characterizing microglia activation: a spatial statistics approach to maximize information extraction","volume":"7","author":"Davis","year":"2017","journal-title":"Sci. Rep."},{"issue":"1\u20133","key":"10.1016\/j.npep.2022.102295_bb0060","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ejphar.2009.04.044","article-title":"Intrathecal administration of clonidine attenuates spinal neuroimmune activation in a rat model of neuropathic pain with existing hyperalgesia","volume":"614","author":"Feng","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.npep.2022.102295_bb0065","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.toxicon.2021.11.008","article-title":"Melittin administration ameliorates motor function, prevents apoptotic cell death and protects Purkinje neurons in the rat model of cerebellar ataxia induced by 3-Acetylpyridine","volume":"205","author":"Ghorbani","year":"2022","journal-title":"Toxicon"},{"issue":"8","key":"10.1016\/j.npep.2022.102295_bb0070","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0166-2236(96)10046-1","article-title":"Control of gap-junctional communication in astrocytic networks","volume":"19","author":"Giaume","year":"1996","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.npep.2022.102295_bb0075","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrn2757","article-title":"Astroglial networks: a step further in neuroglial and gliovascular interactions","volume":"11","author":"Giaume","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.npep.2022.102295_bb0080","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrm1072","article-title":"Beyond the gap: functions of unpaired connexon channels","volume":"4","author":"Goodenough","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.npep.2022.102295_bb0085","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/5692","article-title":"Microdomains for neuron\u2013glia interaction: parallel fiber signaling to Bergmann glial cells","volume":"2","author":"Grosche","year":"1999","journal-title":"Nat. Neurosci."},{"issue":"6","key":"10.1016\/j.npep.2022.102295_bb0090","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0959-440X(00)00146-9","article-title":"Caspases: key players in programmed cell death","volume":"10","author":"Gr\u00fctter","year":"2000","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.npep.2022.102295_bb0095","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12974-015-0344-2","article-title":"Bee venom ameliorates lipopolysaccharide-induced memory loss by preventing NF-kappaB pathway","volume":"12","author":"Gu","year":"2015","journal-title":"J. Neuroinflammation"},{"issue":"12","key":"10.1016\/j.npep.2022.102295_bb0100","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1523\/JNEUROSCI.11-12-03783.1991","article-title":"Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion","volume":"11","author":"Haass","year":"1991","journal-title":"J. Neurosci."},{"issue":"35","key":"10.1016\/j.npep.2022.102295_bb0105","doi-asserted-by":"crossref","first-page":"220","DOI":"10.4103\/0973-1296.113271","article-title":"Effects of honeybee (Apis mellifera) venom on keratinocyte migration in vitro","volume":"9","author":"Han","year":"2013","journal-title":"Pharmacogn. Mag."},{"issue":"1","key":"10.1016\/j.npep.2022.102295_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-14-286","article-title":"Neuroprotective effects of melittin on hydrogen peroxide-induced apoptotic cell death in neuroblastoma SH-SY5Y cells","volume":"14","author":"Han","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.npep.2022.102295_bb0115","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fnana.2015.00032","article-title":"Inflammation in Parkinson\u2019s disease: role of glucocorticoids","volume":"9","author":"Herrero","year":"2015","journal-title":"Front. Neuroanat."},{"issue":"4","key":"10.1016\/j.npep.2022.102295_bb0120","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/01.all.0000173784.81024.7a","article-title":"Are regulatory T cells the target of venom immunotherapy?","volume":"5","author":"Jutel","year":"2005","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.npep.2022.102295_bb0125","first-page":"295","article-title":"Effect of honey bee venom on Lewis rats with experimental allergic encephalomyelitis as regards changes of GABA and glutamate","volume":"7","author":"Karimi","year":"2011","journal-title":"J. Am. Sci."},{"issue":"2","key":"10.1016\/j.npep.2022.102295_bb0130","first-page":"671","article-title":"Effect of honey bee venom on lewis rats with experimental allergic encephalomyelitis, a model for multiple sclerosis","volume":"11","author":"Karimi","year":"2012","journal-title":"Iran. J. Pharmaceut. Res. IJPR"},{"issue":"13","key":"10.1016\/j.npep.2022.102295_bb0135","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1038\/sj.onc.1205187","article-title":"Gap junction intercellular communication propagates cell death in cancerous cells","volume":"21","author":"Krutovskikh","year":"2002","journal-title":"Oncogene."},{"issue":"2","key":"10.1016\/j.npep.2022.102295_bb0140","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0024-3205(02)01617-X","article-title":"The water-soluble fraction of bee venom produces antinociceptive and anti-inflammatory effects on rheumatoid arthritis in rats","volume":"71","author":"Kwon","year":"2002","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.npep.2022.102295_bb0145","doi-asserted-by":"crossref","DOI":"10.4314\/tjpr.v9i1.52104","article-title":"Study of the molecular mechanism of anti-inflammatory activity of bee venom in lipopolysaccharide stimulated RAW 264.7 macrophages","volume":"9","author":"Lam","year":"2010","journal-title":"Trop. J. Pharm. Res."},{"issue":"12","key":"10.1016\/j.npep.2022.102295_bb0150","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1002\/cyto.a.20954","article-title":"Automated Sholl analysis of digitized neuronal morphology at multiple scales: whole cell Sholl analysis versus Sholl analysis of arbor subregions","volume":"77","author":"Langhammer","year":"2010","journal-title":"Cytometry Part A"},{"issue":"2","key":"10.1016\/j.npep.2022.102295_bb0155","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s12311-008-0019-y","article-title":"Spinocerebellar ataxia 2 (SCA2)","volume":"7","author":"Lastres-Becker","year":"2008","journal-title":"Cerebellum"},{"issue":"5","key":"10.1016\/j.npep.2022.102295_bb0160","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3390\/molecules21050616","article-title":"Anti-inflammatory applications of melittin, a major component of bee venom: Detailed mechanism of action and adverse effects","volume":"21","author":"Lee","year":"2016","journal-title":"Molecules."},{"issue":"03","key":"10.1016\/j.npep.2022.102295_bb0165","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1142\/S0192415X04002016","article-title":"Anti-inflammatory effect of bee venom on type II collagen-induced arthritis","volume":"32","author":"Lee","year":"2004","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.npep.2022.102295_bb0170","first-page":"2","article-title":"An overview of bee venom acupuncture in the treatment of arthritis","author":"Lee","year":"2005","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"4","key":"10.1016\/j.npep.2022.102295_bb0175","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jpain.2007.11.012","article-title":"Bee venom acupuncture for musculoskeletal pain: a review","volume":"9","author":"Lee","year":"2008","journal-title":"J. Pain"},{"key":"10.1016\/j.npep.2022.102295_bb0180","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1742-2094-8-132","article-title":"Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal on amyloid-\u03b2 generation and inflammatory reactions via inhibition of NF-\u03baB and STAT3 activation in cultured astrocytes and microglial BV-2 cells","volume":"8","author":"Lee","year":"2011","journal-title":"J. Neuroinflammation"},{"issue":"2","key":"10.1016\/j.npep.2022.102295_bb0185","first-page":"931","article-title":"The anti-tumour effect of Mel and its role in autophagy in human hepatocellular carcinoma cells","volume":"11","author":"Lv","year":"2019","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.npep.2022.102295_bb0190","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1471-4159.1994.62010045.x","article-title":"Vitamin E, ascorbate, glutathione, glutathicne disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain","volume":"62","author":"Makar","year":"1994","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.npep.2022.102295_bb0195","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/WCO.0b013e32832b9897","article-title":"Cerebellar ataxias","volume":"22","author":"Manto","year":"2009","journal-title":"Curr. Opin. Neurol."},{"issue":"1","key":"10.1016\/j.npep.2022.102295_bb0200","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1523\/JNEUROSCI.15-01-00152.1995","article-title":"Beta 2-adrenergic receptors are expressed by glia in vivo in the normal and injured central nervous system in the rat, rabbit, and human","volume":"15","author":"Mantyh","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.npep.2022.102295_bb0205","series-title":"Nearest Neighbor Distances Calculation with ImageJ","author":"Mao","year":"2016"},{"issue":"3","key":"10.1016\/j.npep.2022.102295_bb0210","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuropharm.2007.05.002","article-title":"Venom therapy in multiple sclerosis","volume":"53","author":"Mirshafiey","year":"2007","journal-title":"Neuropharmacology."},{"key":"10.1016\/j.npep.2022.102295_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2021.147444","article-title":"Elderberry diet ameliorates motor function and prevents oxidative stress-induced cell death in rat models of Huntington disease","volume":"1762","author":"Moghaddam","year":"2021","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.npep.2022.102295_bb0220","doi-asserted-by":"crossref","first-page":"194","DOI":"10.5603\/FM.a2017.0091","article-title":"Evaluation of the spatial arrangement of Purkinje cells in ataxic rat\u2019s cerebellum after Sertoli cells transplantation","volume":"77","author":"Mohammadi","year":"2018","journal-title":"Folia Morphol. (Warsz)"},{"key":"10.1016\/j.npep.2022.102295_bb0225","first-page":"2278","article-title":"Studies on bee venom and its medical uses","volume":"1","author":"Mohammed","year":"2012","journal-title":"Int. J. Adv. Res. Tech."},{"issue":"4","key":"10.1016\/j.npep.2022.102295_bb0230","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.3390\/toxins7041126","article-title":"Three valuable peptides from bee and wasp venoms for therapeutic and biotechnological use: melittin, apamin and mastoparan","volume":"7","author":"Moreno","year":"2015","journal-title":"Toxins."},{"issue":"3","key":"10.1016\/j.npep.2022.102295_bb0235","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.neuron.2009.03.019","article-title":"Motor behavior activates Bergmann glial networks","volume":"62","author":"Nimmerjahn","year":"2009","journal-title":"Neuron."},{"issue":"1\u20132","key":"10.1016\/j.npep.2022.102295_bb0240","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/15419060802014164","article-title":"Connexin43 mimetic peptides reduce swelling, astrogliosis, and neuronal cell death after spinal cord injury","volume":"15","author":"O\u2019Carroll","year":"2008","journal-title":"Cell Commun. Adhes."},{"issue":"11","key":"10.1016\/j.npep.2022.102295_bb0245","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1258\/ebm.2011.011127","article-title":"Melittin attenuates liver injury in thioacetamide-treated mice through modulating inflammation and fibrogenesis","volume":"236","author":"Park","year":"2011","journal-title":"Exp. Biol. Med."},{"issue":"6","key":"10.1016\/j.npep.2022.102295_bb0250","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.neuron.2014.04.038","article-title":"Norepinephrine controls astroglial responsiveness to local circuit activity","volume":"82","author":"Paukert","year":"2014","journal-title":"Neuron."},{"issue":"6","key":"10.1016\/j.npep.2022.102295_bb0255","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jpain.2004.05.003","article-title":"Acupoint stimulation with diluted bee venom (apipuncture) alleviates thermal hyperalgesia in a rodent neuropathic pain model: involvement of spinal alpha2-adrenoceptors","volume":"5","author":"Roh","year":"2004","journal-title":"J. Pain"},{"key":"10.1016\/j.npep.2022.102295_bb0260","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.pneurobio.2015.04.003","article-title":"Astrocyte physiopathology: at the crossroads of intercellular networking, inflammation and cell death","volume":"130","author":"Rossi","year":"2015","journal-title":"Prog. Neurobiol."},{"issue":"4","key":"10.1016\/j.npep.2022.102295_bb0265","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.tins.2014.02.008","article-title":"Diversity of astroglial functions alludes to subcellular specialisation","volume":"37","author":"Rusakov","year":"2014","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.npep.2022.102295_bb0270","first-page":"103","article-title":"HPLC study of chemical composition of honeybee (Apis mellifera L.) venom","volume":"48","author":"Rybak-Chmielewska","year":"2004","journal-title":"J. Apicult. Sci."},{"issue":"1","key":"10.1016\/j.npep.2022.102295_bb0275","first-page":"111","article-title":"Toxic effects and safety of bee venom protein [Melittin] in mice: Search for natural vaccine adjuvants","volume":"3","author":"Saeed","year":"2017","journal-title":"J. Nat. Products Resour."},{"key":"10.1016\/j.npep.2022.102295_bb0280","first-page":"135","article-title":"Bee venom: physico-chemical properties. Biological and pharmacological effects. Use in medical practice. Theoretical and practical basics of apitherapy (Russian)","author":"Savilov","year":"2010","journal-title":"Roszdrav."},{"issue":"4","key":"10.1016\/j.npep.2022.102295_bb0285","first-page":"531","article-title":"Surface complexity of human neocortical astrocytic cells: changes with development, aging, and dementia","volume":"36","author":"Senitz","year":"1995","journal-title":"J. Hirnforsch."},{"issue":"2","key":"10.1016\/j.npep.2022.102295_bb0290","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.pharmthera.2007.04.004","article-title":"Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds","volume":"115","author":"Son","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.npep.2022.102295_bb0295","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/363801","article-title":"Effects of bee venom injections at acupoints on neurologic dysfunction induced by thoracolumbar intervertebral disc disorders in canines: a randomized, controlled prospective study","volume":"2015","author":"Tsai","year":"2015","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.npep.2022.102295_bb0300","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0014-4886(91)90115-S","article-title":"Astrocyte hypertrophy in the Alzheimer\u2019s disease hippocampal formation","volume":"112","author":"Vijayan","year":"1991","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/j.npep.2022.102295_bb0305","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrn3725","article-title":"Astrocyte Ca2+ signalling: an unexpected complexity","volume":"15","author":"Volterra","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.npep.2022.102295_bb0310","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neuro.2016.11.010","article-title":"3-Acetylpyridine neurotoxicity in mice","volume":"58","author":"Wecker","year":"2017","journal-title":"Neurotoxicology."},{"issue":"3","key":"10.1016\/j.npep.2022.102295_bb0315","first-page":"53","article-title":"Efficacy of apitox (bee venom) for osteoarthritis: a randomized active-controlled trial","volume":"7","author":"Won","year":"2000","journal-title":"J. Am. Apither. Soc."},{"key":"10.1016\/j.npep.2022.102295_bb0320","doi-asserted-by":"crossref","first-page":"S213","DOI":"10.1016\/S1353-8020(11)70066-9","article-title":"Fluoxetine protects neurons against microglial activation-mediated neurotoxicity","volume":"18","author":"Zhang","year":"2012","journal-title":"Parkinsonism Relat. Disord."}],"container-title":["Neuropeptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417922000701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417922000701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T20:39:43Z","timestamp":1758919183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143417922000701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":64,"alternative-id":["S0143417922000701"],"URL":"https:\/\/doi.org\/10.1016\/j.npep.2022.102295","relation":{},"ISSN":["0143-4179"],"issn-type":[{"value":"0143-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melittin ameliorates motor function and prevents autophagy-induced cell death and astrogliosis in rat models of cerebellar ataxia induced by 3-acetylpyridine","name":"articletitle","label":"Article Title"},{"value":"Neuropeptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.npep.2022.102295","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102295"}}