{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:12:03Z","timestamp":1778670723471,"version":"3.51.4"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["568713"],"award-info":[{"award-number":["568713"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001773","name":"University of New South Wales","doi-asserted-by":"publisher","award":["SIR30"],"award-info":[{"award-number":["SIR30"]}],"id":[{"id":"10.13039\/501100001773","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022513","name":"Tasmanian Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022513","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropeptides"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.npep.2023.102399","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T12:50:16Z","timestamp":1702385416000},"page":"102399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effects of somatostatin, a somatostatin agonist, and an antagonist, on a putative migraine trigger pathway"],"prefix":"10.1016","volume":"103","author":[{"given":"Geoffrey A.","family":"Lambert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro S.","family":"Zagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.npep.2023.102399_bb0005","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1177\/03331024211017884","article-title":"Targeting reactive nitroxidative species in preclinical models of migraine","volume":"41","author":"Akerman","year":"2021","journal-title":"Cephalalgia"},{"key":"10.1016\/j.npep.2023.102399_bb0010","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pain.2005.05.015","article-title":"Inhibition of nociceptive dural input in the trigeminal nucleus caudalis by somatostatin receptor blockade in the posterior hypothalamus","volume":"117","author":"Bartsch","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.npep.2023.102399_bb0015","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0006-8993(83)91292-1","article-title":"The periaqueductal gray-raphe magnus projection contains somatostatin, neurotensin and serotonin but not cholecystokinin","volume":"261","author":"Beitz","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/j.npep.2023.102399_bb0020","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/S0028-3908(99)00241-5","article-title":"5-HT1A and 5-HT1B\/1D receptors are involved in the modulation of the trigeminovascular system of the cat: a microiontophoretic study","volume":"39","author":"Boers","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.npep.2023.102399_bb0025","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1468-2982.2004.00636.x","article-title":"Naratriptan has a selective inhibitory effect on trigeminovascular neurones at central 5-HT1A and 5-HT1B\/1D receptors in the cat: implications for migraine therapy","volume":"24","author":"Boers","year":"2004","journal-title":"Cephalalgia"},{"key":"10.1016\/j.npep.2023.102399_bb0030","doi-asserted-by":"crossref","DOI":"10.1186\/s10194-019-1042-8","article-title":"Aura and Head pain: relationship and gaps in the translational models: official journal of the Italian Society for the Study of headaches","volume":"20","author":"Bolay","year":"2019","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.npep.2023.102399_bb0035","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/archneur.56.5.548","article-title":"Functional MRI-BOLD of visually triggered headache in patients with migraine","volume":"56","author":"Cao","year":"1999","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.npep.2023.102399_bb0040","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1212\/WNL.59.1.72","article-title":"Functional MRI-BOLD of brainstem structures during visually triggered migraine","volume":"59","author":"Cao","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.npep.2023.102399_bb0045","doi-asserted-by":"crossref","first-page":"17796","DOI":"10.1038\/s41598-018-35491-4","article-title":"Spike sorting based on shape, phase, and distribution features, and K-TOPS clustering with validity and error indices","volume":"8","author":"Caro-Mart\u00edn","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.npep.2023.102399_bb0050","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/sj.bjp.0705894","article-title":"Cellular actions of somatostatin on rat periaqueductal grey neurons in vitro: somatostatin actions in PAG","volume":"142","author":"Connor","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.npep.2023.102399_bb0055","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1046\/j.1468-2982.1998.1810659.x","article-title":"Differential effects of the 5HT1B\/1D receptor agonist naratriptan on trigeminal versus spinal nociceptive responses","volume":"18","author":"Cumberbatch","year":"1998","journal-title":"Cephalalgia."},{"key":"10.1016\/j.npep.2023.102399_bb0060","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S0028-3908(01)00190-3","article-title":"The role of 5-HT1B and 5-HT1D receptors in the selective inhibitory effect of naratriptan on trigeminovascular neurons","volume":"42","author":"Donaldson","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.npep.2023.102399_bb0065","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-1-4615-7886-4_10","article-title":"Immunocytochemical studies of somatostatin neurons in brain","volume":"188","author":"Elde","year":"1985","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.npep.2023.102399_bb0070","first-page":"201","article-title":"Brain systems for sensory modulation: understanding the neurobiology of the therapeutic process","volume":"2","author":"Fields","year":"1997","journal-title":"Mind\/Body Med."},{"key":"10.1016\/j.npep.2023.102399_bb0075","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1177\/0333102411410609","article-title":"Evaluation of cutaneous allodynia following induction of cortical spreading depression in freely moving rats","volume":"31","author":"Fioravanti","year":"2011","journal-title":"Cephalalgia"},{"key":"10.1016\/j.npep.2023.102399_bb0080","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1016\/j.pain.2007.10.014","article-title":"Studying sex and gender differences in pain and analgesia: a consensus report","volume":"132","author":"Greenspan","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.npep.2023.102399_bb0085","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(90)90071-M","article-title":"Fabrication of a metal-cored multi-barrelled microiontophoresis assembly","volume":"32","author":"Hellier","year":"1990","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.npep.2023.102399_bb0090","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0304-3940(95)11345-2","article-title":"Inhibition of spinal nociceptive neurons by microinjections of somatostatin into the nucleus raphe magnus and the midbrain periaqueductal gray of the anesthetized cat","volume":"187","author":"Helmchen","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.npep.2023.102399_bb0095","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1212\/WNL.0b013e31827f0f10","article-title":"Provocation of migraine with aura using natural trigger factors","volume":"80","author":"Hougaard","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.npep.2023.102399_bb0100","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0304-3959(90)90010-B","article-title":"Response properties of nociceptive and non-nociceptive neurons in the rat's trigeminal subnucleus caudalis (medullary dorsal horn) related to cutaneous and deep craniofacial afferent stimulation and modulation by diffuse noxious inhibitory controls","volume":"41","author":"Hu","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.npep.2023.102399_bb0105","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0896-6273(00)80984-8","article-title":"Early exploration of the visual cortex","volume":"20","author":"Hubel","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.npep.2023.102399_bb0110","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1111\/j.1526-4610.2007.00672.x","article-title":"The discovery of a new drug class for the acute treatment of migraine","volume":"47","author":"Humphrey","year":"2007","journal-title":"Headache"},{"key":"10.1016\/j.npep.2023.102399_bb0115","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0306-4522(03)00364-6","article-title":"The somatostatin sst2A receptor in the rat trigeminal ganglion","volume":"120","author":"Ichikawa","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.npep.2023.102399_bb0120","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0304-3959(97)00069-9","article-title":"Possible mechanism of c-fos expression in trigeminal nucleus caudalis following cortical spreading depression","volume":"72","author":"Ingvardsen","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.npep.2023.102399_bb0125","first-page":"266","article-title":"Reply to Moskowitz et al","volume":"76","author":"Ingvardsen","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.npep.2023.102399_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1990.tb31977.x","article-title":"Heteroreceptors, autoreceptors, and other terminal sites","volume":"604","author":"Kalsner","year":"1990","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.npep.2023.102399_bb0135","doi-asserted-by":"crossref","DOI":"10.1530\/ERC-22-0138","article-title":"A study of acromegaly-associated headache with somatostatin analgesia","author":"Kaniuka-Jakubowska","year":"2023","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.npep.2023.102399_bb0140","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/s41582-018-0098-4","article-title":"Biological insights from the premonitory symptoms of migraine","volume":"14","author":"Karsan","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.npep.2023.102399_bb0145","first-page":"996","article-title":"The migraine premonitory phase","volume":"24","author":"Karsan","year":"2018","journal-title":"Continuum (Minneap. Minn.)"},{"key":"10.1016\/j.npep.2023.102399_bb0150","article-title":"Fluctuating regional brainstem diffusion imaging measures of microstructure across the migraine cycle","volume":"6","author":"Kasia","year":"2019","journal-title":"eneuro"},{"key":"10.1016\/j.npep.2023.102399_bb0155","doi-asserted-by":"crossref","first-page":"213","DOI":"10.18388\/pb.2018_133","article-title":"Somatostatin receptors in the brain","volume":"64","author":"Kossut","year":"2018","journal-title":"Postepy Biochem."},{"key":"10.1016\/j.npep.2023.102399_bb0160","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/nm.2216","article-title":"A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura","volume":"16","author":"Lafreni\u00e8re","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.npep.2023.102399_bb0165","first-page":"237","article-title":"Software-controlled testing for antidromic activation in neurophysiology","volume":"10","author":"Lambert","year":"1994","journal-title":"CABIOS"},{"key":"10.1016\/j.npep.2023.102399_bb0170","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1526-4610.2010.01669.x","article-title":"The lack of peripheral pathology in migraine headache","volume":"50","author":"Lambert","year":"2010","journal-title":"Headache"},{"key":"10.1016\/j.npep.2023.102399_bb0175","series-title":"Handbook of Animal Models in Neurological Disorders","article-title":"Light flash in rats as a model for triggering migraine headache","author":"Lambert","year":"2023"},{"key":"10.1016\/j.npep.2023.102399_bb0180","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1526-4610.2008.01230.x","article-title":"The mode of action of migraine triggers: an hypothesis","volume":"49","author":"Lambert","year":"2009","journal-title":"Headache"},{"key":"10.1016\/j.npep.2023.102399_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.npep.2018.04.006","article-title":"Does somatostatin have a role to play in migraine headache?","volume":"69","author":"Lambert","year":"2018","journal-title":"Neuropeptides"},{"key":"10.1016\/j.npep.2023.102399_bb0190","first-page":"97","article-title":"Nitrergic and glutamatergic neuronal mechanisms at the trigeminovascular first-order synapse","volume":"42","author":"Lambert","year":"2004","journal-title":"Neuropharmacol."},{"key":"10.1016\/j.npep.2023.102399_bb0195","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/j.1468-2982.2008.01572.x","article-title":"Cortico-NRM influences on trigeminovascular sensation","volume":"28","author":"Lambert","year":"2008","journal-title":"Cephalalgia"},{"key":"10.1016\/j.npep.2023.102399_bb0200","first-page":"104","article-title":"A role for both the PAG and the NRM in craniovascular sensation","volume":"426","author":"Lambert","year":"2010","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.npep.2023.102399_bb0205","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1177\/0333102411422383","article-title":"Effect of cortical spreading depression on basal and evoked traffic in the trigeminovascular sensory system","volume":"31","author":"Lambert","year":"2011","journal-title":"Cephalalgia"},{"key":"10.1016\/j.npep.2023.102399_bb0210","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/0333102413508239","article-title":"Stimulation of dural vessels excites the SI somatosensory cortex of the cat via a relay in the thalamus","volume":"34","author":"Lambert","year":"2014","journal-title":"Cephalalgia"},{"key":"10.1016\/j.npep.2023.102399_bb0215","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1152\/jn.1945.8.1.33","article-title":"Propagation of cortical spreading depression","volume":"8","author":"Leao","year":"1945","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.npep.2023.102399_bb0220","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/BF02474199","article-title":"Another tungsten microelectrode","volume":"10","author":"Levick","year":"1972","journal-title":"Med. Biol. Eng."},{"key":"10.1016\/j.npep.2023.102399_bb0225","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1468-2982.2004.00807.x","article-title":"Octreotide is not effective in the acute treatment of migraine","volume":"25","author":"Levy","year":"2005","journal-title":"Cephalalgia"},{"key":"10.1016\/j.npep.2023.102399_bb0230","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1093\/brain\/awh525","article-title":"The clinical characteristics of headache in patients with pituitary tumours","volume":"128","author":"Levy","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.npep.2023.102399_bb0235","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/cne.20962","article-title":"Sex differences in the anatomical and functional organization of the periaqueductal gray-rostral ventromedial medullary pathway in the rat: a potential circuit mediating the sexually dimorphic actions of morphine","volume":"496","author":"Loyd","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.npep.2023.102399_bb0240","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00429-019-02011-7","article-title":"Somatostatin receptors (SSTR1-5) on inhibitory interneurons in the barrel cortex","volume":"225","author":"Lukomska","year":"2020","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.npep.2023.102399_bb0245","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.01512","article-title":"Spectral and multifractal signature of cortical spreading depolarisation in aged rats","volume":"9","author":"Makra","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.npep.2023.102399_bb0250","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0006-8993(83)91091-0","article-title":"Mediobasal hypothalamic neurons are excited by the iontophoretic application of sodium","volume":"273","author":"Mandelbrod","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/j.npep.2023.102399_bb0255","doi-asserted-by":"crossref","first-page":"6654","DOI":"10.1523\/JNEUROSCI.0228-22.2022","article-title":"Enhanced feedback inhibition due to increased recruitment of somatostatin-expressing interneurons and enhanced cortical recurrent excitation in a genetic mouse model of migraine","volume":"42","author":"Marchionni","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.npep.2023.102399_bb0260","doi-asserted-by":"crossref","first-page":"10479","DOI":"10.1523\/JNEUROSCI.1088-18.2018","article-title":"Changes in brainstem pain modulation circuitry function over the migraine cycle","volume":"38","author":"Marciszewski","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.npep.2023.102399_bb0265","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/ana.20210","article-title":"Subcutaneous octreotide in cluster headache: randomized placebo-controlled double-blind crossover study","volume":"56","author":"Matharu","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.npep.2023.102399_bb0270","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1002\/hbm.24030","article-title":"Deep in the brain: changes in subcortical function immediately preceding a migraine attack","volume":"39","author":"Meylakh","year":"2018","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.npep.2023.102399_bb0275","first-page":"265","article-title":"Comment on Ingvardsen et al., PAIN 72 (1997) 407-415","volume":"76","author":"Moskowitz","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.npep.2023.102399_bb0280","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1523\/JNEUROSCI.13-03-01167.1993","article-title":"Neocortical spreading depression provokes the expression of c-fos protein-like immunoreactivity within trigeminal nucleus caudalis via trigeminovascular mechanisms","volume":"13","author":"Moskowitz","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.npep.2023.102399_bb0285","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/j.1526-4610.2012.02247.x","article-title":"Spontaneous trigeminal allodynia in rats: a model of primary headache","volume":"52","author":"Oshinsky","year":"2012","journal-title":"Headache"},{"key":"10.1016\/j.npep.2023.102399_bb0290","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1172\/JCI43766","article-title":"Central modulation of pain","volume":"120","author":"Ossipov","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.npep.2023.102399_bb0295","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2004"},{"key":"10.1016\/j.npep.2023.102399_bb0300","series-title":"Migraine- Basic Mechanisms and Treatment","first-page":"159","article-title":"Relevance of cortical ischaemia to the changes in cerebral blood flow seen during the migrainous aura","author":"Piper","year":"1992"},{"key":"10.1016\/j.npep.2023.102399_bb0305","first-page":"H96","article-title":"Cortical blood flow changes during spreading depression in cats","volume":"261","author":"Piper","year":"1991","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.npep.2023.102399_bb0310","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1007\/s12031-011-9678-0","article-title":"Colocalization of somatostatin receptors with DARPP-32 in cortex and striatum of rat brain","volume":"48","author":"Rajput","year":"2012","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.npep.2023.102399_bb0315","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1468-2982.2005.01048.x","article-title":"Glial cell line-derived neurotrophic factor and somatostatin levels in cerebrospinal fluid of patients affected by chronic migraine and fibromyalgia","volume":"26","author":"Sarchielli","year":"2006","journal-title":"Cephalalgia"},{"key":"10.1016\/j.npep.2023.102399_bb0320","first-page":"21","article-title":"Antidepressants as analgesics: an overview of central and peripheral mechanisms of action","volume":"26","author":"Sawynok","year":"2001","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.npep.2023.102399_bb0325","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0006-8993(98)00361-8","article-title":"Identification of somatostatin sst2(a) receptor expressing neurones in central regions involved in nociception","volume":"798","author":"Schindler","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.npep.2023.102399_bb0330","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0928-4257(00)00212-6","article-title":"Localization of five somatostatin receptors in the rat central nervous system using subtype-specific antibodies","volume":"94","author":"Schulz","year":"2000","journal-title":"J. Physiol. Paris"},{"key":"10.1016\/j.npep.2023.102399_bb0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-0115(00)00108-7","article-title":"Advances in understanding neuronal somatostatin receptors","volume":"90","author":"Selmer","year":"2000","journal-title":"Regul. Pept."},{"key":"10.1016\/j.npep.2023.102399_bb0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1744-8069-10-12","article-title":"Somatostatin and its 2A receptor in dorsal root ganglia and dorsal horn of mouse and human: expression, trafficking and possible role in pain","volume":"10","author":"Shi","year":"2014","journal-title":"Mol. Pain"},{"key":"10.1016\/j.npep.2023.102399_bb0345","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1523\/JNEUROSCI.4496-10.2011","article-title":"Trigeminal nociceptive transmission in migraineurs predicts migraine attacks","volume":"31","author":"Stankewitz","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.npep.2023.102399_bb0350","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/00004691-199701000-00004","article-title":"Stimulation of the central and peripheral nervous system for the control of pain","volume":"14","author":"Stantonhicks","year":"1997","journal-title":"J. Clin. Neurophysiol."},{"key":"10.1016\/j.npep.2023.102399_bb0355","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.npep.2015.03.006","article-title":"Migraine and neuropeptides","volume":"52","author":"Tajti","year":"2015","journal-title":"Neuropeptides"},{"key":"10.1016\/j.npep.2023.102399_bb0360","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.neuroscience.2007.06.048","article-title":"Somatostatin inhibits the excitability of rat small-diameter trigeminal ganglion neurons that innervate nasal mucosa and project to the upper cervical dorsal horn via activation of somatostatin 2a receptor","volume":"148","author":"Takeda","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.npep.2023.102399_bb0365","article-title":"Cortical spreading depolarisation-induced facial hyperalgesia, photophobia and hypomotility are ameliorated by sumatriptan and olcegepant","volume":"10","author":"Tang","year":"2020","journal-title":"Sci. Rep. (Nat. Publ. Group)"},{"key":"10.1016\/j.npep.2023.102399_bb0370","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/cne.902400306","article-title":"Somatostatin receptors: distribution in rat central nervous system and human frontal cortex","volume":"240","author":"Uhl","year":"1985","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.npep.2023.102399_bb0375","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0143-4179(92)90065-5","article-title":"Suboccipital cerebrospinal fluid and plasma concentrations of somatostatin, neuropeptide Y and beta-endorphin in patients with common migraine","volume":"22","author":"V\u00e9csei","year":"1992","journal-title":"Neuropeptides"},{"key":"10.1016\/j.npep.2023.102399_bb0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/brain\/101.1.1","article-title":"The gate control theory of pain mechanisms a re-examination and re-statement","volume":"101","author":"Wall","year":"1978","journal-title":"Brain"},{"key":"10.1016\/j.npep.2023.102399_bb0385","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.brainres.2009.09.070","article-title":"Inhibitory effects of somatostatin on the substantia gelatinosa neurons of trigeminal subnucleus caudalis via somatostatin type 2 receptors in juvenile mice","volume":"1304","author":"Yin","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.npep.2023.102399_bb0390","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/0333102420960039","article-title":"A potential role for two brainstem nuclei in craniovascular nociception and the triggering of migraine headache","volume":"41","author":"Zagami","year":"2021","journal-title":"Cephalalgia"},{"key":"10.1016\/j.npep.2023.102399_bb0395","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/ana.22329","article-title":"Activation of central trigeminovascular neurons by cortical spreading depression","volume":"69","author":"Zhang","year":"2011","journal-title":"Ann. Neurol."}],"container-title":["Neuropeptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014341792300080X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014341792300080X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:26:57Z","timestamp":1778668017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014341792300080X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":79,"alternative-id":["S014341792300080X"],"URL":"https:\/\/doi.org\/10.1016\/j.npep.2023.102399","relation":{},"ISSN":["0143-4179"],"issn-type":[{"value":"0143-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of somatostatin, a somatostatin agonist, and an antagonist, on a putative migraine trigger pathway","name":"articletitle","label":"Article Title"},{"value":"Neuropeptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.npep.2023.102399","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2023 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102399"}}