{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:30:31Z","timestamp":1792611031563,"version":"4.5.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016215","name":"Universidad Aut\u00f3noma de Chihuahua","doi-asserted-by":"publisher","award":["UACH-24-009"],"award-info":[{"award-number":["UACH-24-009"]}],"id":[{"id":"10.13039\/100016215","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016215","name":"Universidad Aut\u00f3noma de Chihuahua","doi-asserted-by":"publisher","award":["5U54MD007592"],"award-info":[{"award-number":["5U54MD007592"]}],"id":[{"id":"10.13039\/100016215","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropeptides"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.npep.2025.102533","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T08:07:24Z","timestamp":1750061244000},"page":"102533","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Rapamycin reveals neuropeptide Y as a regulator of senescence and inflammatory pathways in arthritis"],"prefix":"10.1016","volume":"112","author":[{"given":"Susana Aide\u00e9","family":"Gonz\u00e1lez-Ch\u00e1vez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Chaparro-Barrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Loya-Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra Jazm\u00edn","family":"Rodr\u00edguez-Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Prieto-Carrasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato J.","family":"Aguilera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana P.","family":"Betancourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon E.","family":"Mohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Alberto","family":"Ruizesparza-Hinojos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio de Jes\u00fas","family":"Ram\u00edrez-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Berm\u00fadez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Pacheco-Tena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0143-4179(95)90054-3","article-title":"Neuropeptide Y- and vasoactive intestinal polypeptide-like immunoreactivity in adjuvant arthritis: effects of capsaicin treatment","volume":"29","author":"Ahmed","year":"1995","journal-title":"Neuropeptides"},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3390\/cells13010087","article-title":"A potent PDK4 inhibitor for treatment of heart failure with reduced ejection fraction","volume":"13","author":"Aizawa","year":"2023","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.npep.2025.102533_bb0015","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/j.immuni.2022.11.009","article-title":"The pathogenesis of rheumatoid arthritis","volume":"55","author":"Alivernini","year":"2022","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0317364","article-title":"Cellular senescence-associated genes in rheumatoid arthritis: identification and functional analysis","volume":"20","author":"Ao","year":"2025","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/00016359309041141","article-title":"A clinical study: relation between the intra-articular temperature of the temporomandibular joint and the presence of neuropeptide Y-like immunoreactivity in the joint fluid","volume":"51","author":"Appelgren","year":"1993","journal-title":"Acta Odontol. Scand."},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0030","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1248\/yakushi.127.153","article-title":"Transcriptional regulation of metabolic switching PDK4 gene under various physiological conditions","volume":"127","author":"Araki","year":"2007","journal-title":"Yakugaku Zasshi"},{"issue":"7","key":"10.1016\/j.npep.2025.102533_bb0035","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/gerona\/glw090","article-title":"Rapamycin: an InhibiTOR of aging emerges from the soil of Easter Island","volume":"71","author":"Arriola Apelo","year":"2016","journal-title":"GERONA"},{"issue":"9605","key":"10.1016\/j.npep.2025.102533_bb0040","first-page":"1760","article-title":"Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies","volume":"370","author":"Avi\u00f1a-Zubieta","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.npep.2025.102533_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.npep.2024.102478","article-title":"Neuropeptide Y Y2 receptors in acute and chronic pain and itch","volume":"108","author":"Basu","year":"2024","journal-title":"Neuropeptides"},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0050","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12979-020-00178-w","article-title":"Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression","volume":"17","author":"Bauer","year":"2020","journal-title":"Immun. Ageing"},{"issue":"5","key":"10.1016\/j.npep.2025.102533_bb0055","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0143-4179(96)90001-3","article-title":"Is the pretreatment effect of low dose Freund\u2019s adjuvant on adjuvant arthritis due to an activation of the nervous system?","volume":"30","author":"Bileviciute","year":"1996","journal-title":"Neuropeptides"},{"issue":"12","key":"10.1016\/j.npep.2025.102533_bb0060","doi-asserted-by":"crossref","first-page":"RP86633","DOI":"10.7554\/eLife.86633","article-title":"Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling","volume":"25","author":"Boyle","year":"2023","journal-title":"eLife"},{"issue":"5","key":"10.1016\/j.npep.2025.102533_bb0065","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/nprot.2007.173","article-title":"Collagen-induced arthritis","volume":"2","author":"Brand","year":"2007","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0070","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41584-020-00541-7","article-title":"Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis","volume":"17","author":"Buch","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"issue":"4","key":"10.1016\/j.npep.2025.102533_bb0075","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/annrheumdis-2011-200557","article-title":"Autophagy activation by rapamycin reduces severity of experimental osteoarthritis","volume":"71","author":"Caram\u00e9s","year":"2012","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0080","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1749-6632.1993.tb35855.x","article-title":"Effects of orally administered rapamycin in animal models of arthritis and other autoimmune diseases","volume":"685","author":"Carlson","year":"1993","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"8","key":"10.1016\/j.npep.2025.102533_bb0085","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1002\/art.27504","article-title":"Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis","volume":"62","author":"Cejka","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"11","key":"10.1016\/j.npep.2025.102533_bb0090","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1111\/j.1528-1167.2012.03674.x","article-title":"Rapamycin has age-, treatment paradigm-, and model-specific anticonvulsant effects and modulates neuropeptide Y expression in rats","volume":"53","author":"Chachua","year":"2012","journal-title":"Epilepsia"},{"issue":"12","key":"10.1016\/j.npep.2025.102533_bb0095","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1097\/01.MIB.0000437042.59208.9f","article-title":"Tumor necrosis factor\u2013neuropeptide Y cross talk regulates inflammation, epithelial barrier functions, and colonic motility","volume":"19","author":"Chandrasekharan","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.npep.2025.102533_bb0100","article-title":"The role of NPY in the regulation of bone metabolism","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0105","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11805-006-0067-3","article-title":"Expression of neuropeptide Y in human pituitary adenoma","volume":"3","author":"Chen","year":"2006","journal-title":"Chin. J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0110","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3892\/ol.2015.3179","article-title":"Identification and characterization of tumor suppressor and oncogenic miRNAs in gastric cancer","volume":"10","author":"Chen","year":"2015","journal-title":"Oncol. Lett."},{"issue":"10","key":"10.1016\/j.npep.2025.102533_bb0115","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.3389\/fimmu.2019.02344","article-title":"mTOR blockade by rapamycin in spondyloarthritis: impact on inflammation and new bone formation in vitro and in vivo","volume":"27","author":"Chen","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.npep.2025.102533_bb0120","doi-asserted-by":"crossref","DOI":"10.1177\/17448069241242982","article-title":"Mechanical and chemical itch regulated by neuropeptide Y-Y1 signaling","volume":"20","author":"Chen","year":"2024","journal-title":"Mol. Pain"},{"key":"10.1016\/j.npep.2025.102533_bb0125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.arr.2016.04.002","article-title":"IFI16, an amplifier of DNA-damage response: role in cellular senescence and aging-associated inflammatory diseases","volume":"28","author":"Choubey","year":"2016","journal-title":"Ageing Res. Rev."},{"issue":"16","key":"10.1016\/j.npep.2025.102533_bb0130","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1111\/bph.12751","article-title":"NPY \/ Y1 receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension","volume":"171","author":"Crnkovic","year":"2014","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.npep.2025.102533_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002117","article-title":"Conjunctival MicroRNA expression in inflammatory trachomatous scarring","volume":"7","author":"Derrick","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"6","key":"10.1016\/j.npep.2025.102533_bb0140","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/ncrna9060067","article-title":"Downregulation of exosomal hsa-miR-551b-3p in obesity and its link to type 2 diabetes mellitus","volume":"9","author":"Dracheva","year":"2023","journal-title":"ncRNA"},{"key":"10.1016\/j.npep.2025.102533_bb0145","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.nbd.2016.07.022","article-title":"Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases","volume":"95","author":"Duarte-Neves","year":"2016","journal-title":"Neurobiol. Dis."},{"issue":"3","key":"10.1016\/j.npep.2025.102533_bb0150","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1432-2277.2004.00070.x","article-title":"Efficacy of rapamycin in patient with juvenile rheumatoid arthritis","volume":"18","author":"Foroncewicz","year":"2005","journal-title":"Transpl. Int."},{"issue":"12","key":"10.1016\/j.npep.2025.102533_bb0155","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s00011-022-01649-0","article-title":"Immunosenescence of T cells: a key player in rheumatoid arthritis","volume":"71","author":"Gao","year":"2022","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.npep.2025.102533_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.862316","article-title":"PDK4 inhibition ameliorates melatonin therapy by modulating cerebral metabolism and remyelination in an EAE demyelinating mouse model of multiple sclerosis","volume":"13","author":"Ghareghani","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.npep.2025.102533_bb0165","series-title":"Assessment of Different Decalcifying Protocols on Osteopontin and Osteocalcin Immunostaining in Whole Bone Specimens of Arthritis Rat Model by Confocal Immunofluorescence","author":"Gonz\u00e1lez-Ch\u00e1vez","year":"2025"},{"issue":"12","key":"10.1016\/j.npep.2025.102533_bb0170","first-page":"1807","article-title":"Neuropeptides in synovium of patients with rheumatoid arthritis and osteoarthritis","volume":"15","author":"Gr\u00f6nblad","year":"1988","journal-title":"J. Rheumatol."},{"issue":"2","key":"10.1016\/j.npep.2025.102533_bb0175","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1369-1600.2011.00336.x","article-title":"Neuropeptide Y signaling modulates the expression of ethanol-induced behavioral sensitization in mice","volume":"17","author":"Hayes","year":"2012","journal-title":"Addict. Biol."},{"issue":"4","key":"10.1016\/j.npep.2025.102533_bb0180","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0901-5027(05)80181-X","article-title":"Concentrations of neuropeptides substance P, neurokinin A, calcitonin gene-related peptide, neuropeptide Y and vasoactive intestinal polypeptide in synovial fluid of the human temporomandibular joint","volume":"20","author":"Holmlund","year":"1991","journal-title":"Int. J. Oral Maxillofac. Surg."},{"issue":"Pt 3","key":"10.1016\/j.npep.2025.102533_bb0185","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1042\/bj20020754","article-title":"Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor alpha (PPARalpha)","volume":"366","author":"Holness","year":"2002","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0190","first-page":"1","article-title":"Accelerated epigenetic aging in rheumatoid arthritis","volume":"9","author":"Horvath","year":"2017","journal-title":"Genome Med."},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0195","doi-asserted-by":"crossref","first-page":"13596","DOI":"10.1038\/s41598-018-32016-x","article-title":"The regulation of miRNAs by reconstituted high-density lipoproteins in diabetes-impaired angiogenesis","volume":"8","author":"Hourigan","year":"2018","journal-title":"Sci. Rep."},{"issue":"15","key":"10.1016\/j.npep.2025.102533_bb0200","doi-asserted-by":"crossref","first-page":"8057","DOI":"10.3390\/ijms25158057","article-title":"Diagnostic potential of miR-143-5p, miR-143-3p, miR-551b-5p, and miR-574-3p in chemoresistance of locally advanced gastric cancer: A preliminary study","volume":"25","author":"Janiczek-Polewska","year":"2024","journal-title":"IJMS"},{"issue":"4","key":"10.1016\/j.npep.2025.102533_bb0205","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0143-4179(92)90125-G","article-title":"Neuropeptide Y immunoreactivity in the spleen and thymus of normal rats and following adjuvant-induced arthritis","volume":"23","author":"Jessop","year":"1992","journal-title":"Neuropeptides"},{"issue":"5","key":"10.1016\/j.npep.2025.102533_bb0210","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00109-023-02319-2","article-title":"SOST gene suppression stimulates osteocyte Wnt\/\u03b2-catenin signaling to prevent bone resorption and attenuates particle-induced osteolysis","volume":"101","author":"Jiao","year":"2023","journal-title":"J. Mol. Med."},{"issue":"7","key":"10.1016\/j.npep.2025.102533_bb0215","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/jbmr.3991","article-title":"Neuropeptide Y acts directly on cartilage homeostasis and exacerbates progression of osteoarthritis through NPY2R","volume":"35","author":"Kang","year":"2020","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.npep.2025.102533_bb0220","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqac213","article-title":"Neuropeptide Y promotes mTORC1 to regulate chondrocyte proliferation and hypertrophy","volume":"164","author":"Kang","year":"2023","journal-title":"Endocrinology"},{"key":"10.1016\/j.npep.2025.102533_bb0225","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1136\/annrheumdis-2015-eular.5366","article-title":"AB0075 MTOR: an unexpected role on the TNF-regulated MRNA transcriptome in rheumatoid fibroblast-like synoviocytes","volume":"74","author":"Karonitsch","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.npep.2025.102533_bb0230","doi-asserted-by":"crossref","first-page":"A18","DOI":"10.1136\/annrheumdis-2015-207259.41","article-title":"A2.6 MTOR plays a decisive role in the mesenchymal tissue response to inflammation in arthritis","volume":"74","author":"Karonitsch","year":"2015","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.npep.2025.102533_bb0235","doi-asserted-by":"crossref","first-page":"333","DOI":"10.18585\/inabj.v16i4.3067","article-title":"Andrographis paniculata ethanol extract alleviates high glucose-induced senescence of human umbilical vein endothelial cells via the regulation of mTOR and SIRT1 pathways","volume":"16","author":"Khatimah","year":"2024","journal-title":"Indones Biomed. J."},{"key":"10.1016\/j.npep.2025.102533_bb0240","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/s41419-024-06968-0","article-title":"PDK4-mediated metabolic reprogramming is a potential therapeutic target for neovascular age-related macular degeneration","volume":"15","author":"Kim","year":"2024","journal-title":"Cell Death Dis"},{"issue":"5","key":"10.1016\/j.npep.2025.102533_bb0245","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1177\/1535370219831437","article-title":"Placental neuropeptide Y (NPY) and NPY receptors expressions and serum NPY levels in preeclampsia","volume":"244","author":"Klinjampa","year":"2019","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"12","key":"10.1016\/j.npep.2025.102533_bb0250","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1177\/0269881119862529","article-title":"Neuropeptide Y reduces expression of social fear via simultaneous activation of Y1 and Y2 receptors","volume":"33","author":"Kornhuber","year":"2019","journal-title":"J. Psychopharmacol."},{"issue":"9\u201310","key":"10.1016\/j.npep.2025.102533_bb0255","doi-asserted-by":"crossref","first-page":"352","DOI":"10.2119\/molmed.2010.00049","article-title":"mTOR regulates the invasive properties of synovial fibroblasts in rheumatoid arthritis","volume":"16","author":"Laragione","year":"2010","journal-title":"Mol. Med."},{"issue":"2","key":"10.1016\/j.npep.2025.102533_bb0260","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1474-9726.2006.00199.x","article-title":"Senescence-associated \u03b2-galactosidase is lysosomal \u03b2-galactosidase","volume":"5","author":"Lee","year":"2006","journal-title":"Aging Cell"},{"issue":"2","key":"10.1016\/j.npep.2025.102533_bb0265","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12031-010-9423-0","article-title":"Y2 and Y4 receptor signalling attenuates the skeletal response of central NPY","volume":"43","author":"Lee","year":"2011","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.npep.2025.102533_bb0270","doi-asserted-by":"crossref","unstructured":"Lee, J.H., Kim, E.J., Kim, D.K., Lee, J.M., Park, S.B., Lee, Kyu, I, et al., 2025. Hypoxia induces PDK4 gene expression through induction of the orphan nuclear receptor ERR\u03b3. PLoS One 7 (9), e46324.","DOI":"10.1371\/journal.pone.0046324"},{"issue":"6","key":"10.1016\/j.npep.2025.102533_bb0275","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/acel.12122","article-title":"Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts","volume":"12","author":"Lerner","year":"2013","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0280","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13018-024-04583-5","article-title":"PDK4 inhibits osteoarthritis progression by activating the PPAR pathway","volume":"19","author":"Li","year":"2024","journal-title":"J. Orthop. Surg. Res."},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0285","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s12951-024-02444-1","article-title":"Macrophage-derived mir-100-5p orchestrates synovial proliferation and inflammation in rheumatoid arthritis through mTOR signaling","volume":"22","author":"Liu","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"5","key":"10.1016\/j.npep.2025.102533_bb0290","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1080\/03008207.2019.1583223","article-title":"Rapamycin attenuates articular cartilage degeneration by inhibiting \u03b2-catenin in a murine model of osteoarthritis","volume":"60","author":"Ma","year":"2019","journal-title":"Connect. Tissue Res."},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0295","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41420-023-01725-2","article-title":"PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway","volume":"9","author":"Ma","year":"2023","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0300","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/srep01275","article-title":"Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6","volume":"3","author":"MacCallum","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.npep.2025.102533_bb0305","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4172\/2155-9899.1000160","article-title":"Intracellular signaling pathways in rheumatoid arthritis","volume":"4","author":"Malemud","year":"2013","journal-title":"J. Clin. Cell Immunol."},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0310","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0306-4522(90)90199-E","article-title":"Substance P-, calcitonin gene-related peptide-and C-flanking peptide of neuropeptide Y-immunoreactive fibres are present in normal synovium but depleted in patients with rheumatoid arthritis","volume":"37","author":"Mapp","year":"1990","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.npep.2025.102533_bb0315","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1096\/fj.05-4770fje","article-title":"Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors","volume":"20","author":"Movafagh","year":"2006","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.npep.2025.102533_bb0320","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1021\/acsptsci.4c00333","article-title":"Neuropeptide Y and pain: insights from brain research","volume":"7","author":"Nelson","year":"2024","journal-title":"ACS Pharmacol. Transl. Sci."},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0325","first-page":"58","article-title":"Sirolimus selectively increases circulating Treg cell numbers and restores the Th17\/Treg balance in rheumatoid arthritis patients with low disease activity or in DAS28 remission who previously received conventional disease-modifying anti-rheumatic drugs","volume":"38","author":"Niu","year":"2020","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.npep.2025.102533_bb0330","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O\u2019Brien","year":"2018","journal-title":"Front. Endocrinol."},{"issue":"8","key":"10.1016\/j.npep.2025.102533_bb0335","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgae299","article-title":"Neuropeptide Y receptor activation preserves inner retinal integrity through PI3K\/Akt signaling in a glaucoma mouse model","volume":"3","author":"Palanivel","year":"2024","journal-title":"PNAS Nexus"},{"issue":"2","key":"10.1016\/j.npep.2025.102533_bb0340","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1139\/y02-166","article-title":"Mitogenic actions of neuropeptide Y in vascular smooth muscle cells: synergetic interactions with the \u03b2-adrenergic system","volume":"81","author":"Pons","year":"2003","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.npep.2025.102533_bb0345","doi-asserted-by":"crossref","first-page":"2400196","DOI":"10.1002\/advs.202400196","article-title":"Intermittent fasting targets osteocyte neuropeptide Y to relieve osteoarthritis","volume":"8","author":"Qian","year":"2024","journal-title":"Adv. Sci."},{"issue":"5","key":"10.1016\/j.npep.2025.102533_bb0350","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00011-021-01453-2","article-title":"Stability of housekeeping genes in inflamed joints of spontaneous and collagen-induced arthritis in DBA\/1 mice","volume":"70","author":"Qui\u00f1onez-Flores","year":"2021","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.npep.2025.102533_bb0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/8982163","article-title":"Serum neuropeptide Y levels are associated with TNF- \u03b1 levels and disease activity in rheumatoid arthritis","volume":"2020","author":"Ramirez-Villafa\u00f1a","year":"2020","journal-title":"J. Immunol. Res."},{"issue":"3","key":"10.1016\/j.npep.2025.102533_bb0360","doi-asserted-by":"crossref","first-page":"128","DOI":"10.2478\/rir-2022-0021","article-title":"The ABC-associated immunosenescence and lifestyle interventions in autoimmune disease","volume":"3","author":"Ruan","year":"2022","journal-title":"Rheumatol. Immunol. Res."},{"issue":"3","key":"10.1016\/j.npep.2025.102533_bb0365","first-page":"697","article-title":"Telomere length in peripheral blood mononuclear cells correlates inversely with disease activity in rheumatoid arthritis","volume":"58","author":"Schmid","year":"2008","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.npep.2025.102533_bb0370","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s11357-020-00274-1","article-title":"Effect of rapamycin on aging and age-related diseases\u2014past and future","volume":"43","author":"Selvarani","year":"2021","journal-title":"GeroScience"},{"issue":"4","key":"10.1016\/j.npep.2025.102533_bb0375","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.3892\/mmr.2017.7285","article-title":"Modulation of the immune response in rheumatoid arthritis with strategically released rapamycin","volume":"16","author":"Shao","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.npep.2025.102533_bb0380","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011361","article-title":"NPY Neuron-specific Y2 receptors regulate adipose tissue and trabecular bone but not cortical bone homeostasis in mice","volume":"5","author":"Shi","year":"2010","journal-title":"PLoS One"},{"issue":"23","key":"10.1016\/j.npep.2025.102533_bb0385","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1093\/hmg\/ddx341","article-title":"Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome","volume":"26","author":"Siegmund","year":"2017","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.npep.2025.102533_bb0390","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1002\/jcp.26276","article-title":"Therapeutic potency of mTOR signaling pharmacological inhibitors in the treatment of proinflammatory diseases, current status, and perspectives","volume":"233","author":"Soltani","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.npep.2025.102533_bb0395","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1054\/npep.1999.0756","article-title":"Exercise and variations in neuropeptide concentrations in rheumatoid arthritis","volume":"33","author":"Stenstr\u00f6m","year":"1999","journal-title":"Neuropeptides"},{"issue":"D1","key":"10.1016\/j.npep.2025.102533_bb0400","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein\u2013protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.npep.2025.102533_bb0405","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.706341","article-title":"Integrated analysis of hepatic miRNA and mRNA expression profiles in the spontaneous reversal process of liver fibrosis","volume":"12","author":"Tai","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.npep.2025.102533_bb0410","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1136\/annrheumdis-2015-eular.2710","article-title":"AB0061 MTOR inhibition by rapamycin is associated with downregulation of pro-infammatory cytokine TNF\u03b1, and genes involved in bone resoption (MMP-9 and Cathepsin K) in cultured peripheral blood mononuclear cells from rheumatoid arthritic patients","volume":"74","author":"Tchetina","year":"2015","journal-title":"Ann. Rheum. Dis."},{"issue":"5","key":"10.1016\/j.npep.2025.102533_bb0415","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cels.2018.10.007","article-title":"BioJupies: automated generation of interactive notebooks for RNA-Seq data analysis in the cloud","volume":"7","author":"Torre","year":"2018","journal-title":"Cell Syst."},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0420","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/jnc.12150","article-title":"Stress-induced changes in adrenal neuropeptide Y expression are regulated by a negative feedback loop","volume":"125","author":"Wang","year":"2013","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.npep.2025.102533_bb0425","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jot.2014.07.080","article-title":"Levels of neuropeptide Y in synovial fluid relate to pain in patients with knee osteoarthritis","volume":"2","author":"Wang","year":"2014","journal-title":"J. Orthopaed. Transl."},{"issue":"9","key":"10.1016\/j.npep.2025.102533_bb0430","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.molmed.2004.07.006","article-title":"Stem cell aging and autoimmunity in rheumatoid arthritis","volume":"10","author":"Weyand","year":"2004","journal-title":"Trends Mol. Med."},{"issue":"5","key":"10.1016\/j.npep.2025.102533_bb0435","doi-asserted-by":"crossref","first-page":"12899","DOI":"10.1080\/21655979.2022.2078942","article-title":"Curcumin alleviates rheumatoid arthritis progression through the phosphatidylinositol 3-kinase\/protein kinase B pathway: an in vitro and in vivo study","volume":"13","author":"Xu","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.npep.2025.102533_bb0440","first-page":"1","article-title":"Pim-2\/mTORC1 pathway shapes inflammatory capacity in rheumatoid arthritis synovial cells exposed to lipid peroxidations","volume":"2015","author":"Yin","year":"2015","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.npep.2025.102533_bb0445","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s13075-023-03181-w","article-title":"Mechanistic target of rapamycin (mTOR): a potential new therapeutic target for rheumatoid arthritis","volume":"25","author":"Zhang","year":"2023","journal-title":"Arthritis Res. Ther."},{"issue":"3","key":"10.1016\/j.npep.2025.102533_bb0450","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.160377","article-title":"Rapamycin improves Graves\u2019 orbitopathy by suppressing CD4+ cytotoxic T lymphocytes","volume":"8","author":"Zhang","year":"2023","journal-title":"JCI Insight"}],"container-title":["Neuropeptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417925000332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417925000332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T07:59:00Z","timestamp":1762243140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143417925000332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":90,"alternative-id":["S0143417925000332"],"URL":"https:\/\/doi.org\/10.1016\/j.npep.2025.102533","relation":{},"ISSN":["0143-4179"],"issn-type":[{"value":"0143-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapamycin reveals neuropeptide Y as a regulator of senescence and inflammatory pathways in arthritis","name":"articletitle","label":"Article Title"},{"value":"Neuropeptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.npep.2025.102533","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102533"}}