{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:48:51Z","timestamp":1788922131418,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["lzujbky-2023-it10"],"award-info":[{"award-number":["lzujbky-2023-it10"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473760"],"award-info":[{"award-number":["82473760"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204184"],"award-info":[{"award-number":["82204184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuropeptides"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.npep.2025.102565","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:27:59Z","timestamp":1760027279000},"page":"102565","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Inhibitory modulation of gastrointestinal motility in mice by Tyr-c[D-Lys-Gly-p-F-Phe-Asp]-D-Pro-NH2, a novel cyclic hexapeptide with multifunctional opioid agonism"],"prefix":"10.1016","volume":"114","author":[{"given":"Weifan","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengna","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.npep.2025.102565_bb0005","doi-asserted-by":"crossref","first-page":"3938","DOI":"10.1007\/s10620-020-06742-0","article-title":"High-dose opioid use among veterans with unexplained gastrointestinal symptoms versus","volume":"66","author":"Balbale","year":"2021","journal-title":"Dig. Dis. Sci."},{"issue":"2","key":"10.1016\/j.npep.2025.102565_bb0010","first-page":"97","article-title":"Kappa-opiate agonist-induced inhibition of gastrointestinal transit in different strains of mice","volume":"42","author":"Bansinath","year":"1991","journal-title":"Pharmacology"},{"issue":"6","key":"10.1016\/j.npep.2025.102565_bb0015","doi-asserted-by":"crossref","first-page":"30797","DOI":"10.1038\/srep30797","article-title":"Human native kappa opioid receptor functions not predicted by recombinant receptors: implications for drug design","volume":"5","author":"Broad","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.npep.2025.102565_bb0020","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0014-2999(92)90148-W","article-title":"Antidiarrheal and colonic antipropulsive effects of spinal and supraspinal administration of the natural \u03b4 opioid receptor agonist, [D-Ala2]deltorphin II, in the rat","volume":"218","author":"Broccardo","year":"1992","journal-title":"Eur. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.npep.2025.102565_bb0025","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1111\/nmo.12417","article-title":"Emerging treatments in neurogastroenterology: a multidisciplinary working group consensus statement on opioid-induced constipation","volume":"26","author":"Camilleri","year":"2014","journal-title":"Neurogastroenterol. Motil."},{"issue":"20","key":"10.1016\/j.npep.2025.102565_bb0030","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1111\/bph.14461","article-title":"GpTx-1 and [Ala5, Phe6, Leu26, Arg28 ]GpTx-1, two peptide NaV 1.7 inhibitors: analgesic and tolerance properties at the spinal level","volume":"175","author":"Chen","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.npep.2025.102565_bb0035","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jpain.2008.10.008","article-title":"Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain","volume":"10","author":"Chou","year":"2009","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.npep.2025.102565_bb0040","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1517\/14656566.2015.991306","article-title":"Naloxegol, a new drug for the treatment of opioid-induced constipation","volume":"16","author":"Corsetti","year":"2015","journal-title":"Expert. Opin. Pharmacother."},{"issue":"903","key":"10.1016\/j.npep.2025.102565_bb0045","article-title":"Pharmacological characterization of naloxegol: in vitro and in vivo studies","volume":"15","author":"Costanzini","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.npep.2025.102565_bb0050","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1474-8673.1994.tb00591.x","article-title":"Opiate and opiate antidiarrhoeal drug action on rat isolated intestine","volume":"14","author":"Coupar","year":"1994","journal-title":"J. Auton. Pharmacol."},{"issue":"1","key":"10.1016\/j.npep.2025.102565_bb0055","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ajgsup.2014.5","article-title":"Molecular physiology of enteric opioid receptors","volume":"2","author":"Galligan","year":"2014","journal-title":"Am J Gastroenterol Suppl."},{"key":"10.1016\/j.npep.2025.102565_bb0060","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/164_2016_116","article-title":"Insights into the role of opioid receptors in the GI tract: experimental evidence and therapeutic relevance","volume":"239","author":"Galligan","year":"2017","journal-title":"Handb. Exp. Pharmacol."},{"issue":"8","key":"10.1016\/j.npep.2025.102565_bb0065","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S2468-1253(17)30105-X","article-title":"Naldemedine versus placebo for opioid-induced constipation (COMPOSE-1 and COMPOSE-2): two multicentre, phase 3, double-blind, randomised, parallel-group trials","volume":"2","author":"Hale","year":"2017","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.npep.2025.102565_bb0070","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1592\/phco.22.3.240.33552","article-title":"Management of opioid-induced gastrointestin al effectsin patients receiving palliative care","volume":"22","author":"Herndon","year":"2002","journal-title":"Pharmacotherapy"},{"issue":"07","key":"10.1016\/j.npep.2025.102565_bb0075","first-page":"561","article-title":"Impact of chronic constipation on quality of life and economic burden of patients","volume":"16","author":"Jiang","year":"2017","journal-title":"Chin. J. Gener. Pract."},{"issue":"4","key":"10.1016\/j.npep.2025.102565_bb0080","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF00172116","article-title":"Opioid mu and kappa receptors on axons of cholinergic excitatory motor neurons supplying the circular muscle of guinea-pig ileum","volume":"338","author":"Johnson","year":"1988","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"issue":"3","key":"10.1016\/j.npep.2025.102565_bb0085","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.pain.2004.09.019","article-title":"Opioids in chronic non-cancer pain:systematic review of efficacy and safety","volume":"112","author":"Kalso","year":"2004","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.npep.2025.102565_bb0090","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1248\/bpb.b24-00048","article-title":"Fentanyl analogs exert antinociceptive effects via sodium channel blockade in mice","volume":"47","author":"Kasai","year":"2024","journal-title":"Biol. Pharm. Bull."},{"issue":"4","key":"10.1016\/j.npep.2025.102565_bb0095","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.3892\/mmr.2016.5698","article-title":"Berberine induces pacemaker potential inhibition via cGMP-dependent ATP-sensitive K+ channels by stimulating mu\/delta opioid receptors in cultured interstitial cells of Cajal from mouse small intestine","volume":"14","author":"Kim","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.npep.2025.102565_bb0100","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/bph.12696","article-title":"In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile","volume":"172","author":"Kuo","year":"2014","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.npep.2025.102565_bb0105","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nrgastro.2014.53","article-title":"Diagnosis and treatment of narcotic bowel syndrome","volume":"11","author":"Kurlander","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.npep.2025.102565_bb0110","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/nmo.12789","article-title":"Central administrations of hemopressin and related peptides inhibit gastrointestinal motility in mice","volume":"28","author":"Li","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"issue":"10","key":"10.1016\/j.npep.2025.102565_bb0115","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1093\/pm\/pnw255","article-title":"Opioid-induced constipation and bowel dysfunction: A clinical guideline","volume":"18","author":"Lissner","year":"2017","journal-title":"Pain Med."},{"issue":"2","key":"10.1016\/j.npep.2025.102565_bb0120","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuropharm.2008.05.003","volume":"55","author":"Matsumoto","year":"2008","journal-title":"Neuropharmacology"},{"issue":"3 Suppl","key":"10.1016\/j.npep.2025.102565_bb0125","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/10732748040110S302","article-title":"Assessing and managing opiate-induced constipation in adults with cancer","volume":"11","author":"McMillan","year":"2004","journal-title":"Cancer Control"},{"issue":"10","key":"10.1016\/j.npep.2025.102565_bb0130","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s40263-019-00660-0","article-title":"Opioid-induced tolerance and hyperalgesia","volume":"33","author":"Mercadante","year":"2019","journal-title":"CNS Drugs"},{"issue":"3","key":"10.1016\/j.npep.2025.102565_bb0135","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0304-3959(01)00324-4","article-title":"Symptoms duringcancer pain treatment following WHO-guidelines: a longitudinal follow-up study of symptom prevalence, severity and etiology","volume":"93","author":"Meuser","year":"2001","journal-title":"Pain"},{"issue":"5","key":"10.1016\/j.npep.2025.102565_bb0140","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1007\/s00726-010-0760-7","article-title":"New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4\u2032 positions and non-hydrazine linkers","volume":"40","author":"Mollicaa","year":"2011","journal-title":"Amino Acids"},{"issue":"3","key":"10.1016\/j.npep.2025.102565_bb0145","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2174\/157340720903140119151919","article-title":"The evolution of peptide synthesis: from early days to small molecular machines","volume":"9","author":"Mollicaa","year":"2013","journal-title":"Curr. Bioact. Compd."},{"issue":"5","key":"10.1016\/j.npep.2025.102565_bb0150","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1080\/08923973.2017.1354879","article-title":"Effects of ICI204,448, naloxone methiodide and levocetirizine on the scratching behavior induced by a \u03ba-opioid antagonist, nor-BNI, in ICR mice","volume":"39","author":"Nakasone","year":"2017","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"2","key":"10.1016\/j.npep.2025.102565_bb0155","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/2040622315627801","article-title":"Opioid-induced constipation: advances and clinical guidance","volume":"7","author":"Nelson","year":"2016","journal-title":"Ther. Adv. Chronic. Dis."},{"issue":"12","key":"10.1016\/j.npep.2025.102565_bb0160","first-page":"1499","article-title":"Progress on drug therapy for opioid-induced constipation","volume":"25","author":"Ni","year":"2022","journal-title":"Chin. Gener. Pract."},{"issue":"2","key":"10.1016\/j.npep.2025.102565_bb0165","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jclinane.2012.07.004","article-title":"Abdominal compartment syndrome following opioid-induced postoperative ileus","volume":"25","author":"Noord","year":"2013","journal-title":"J. Clin. Anesth."},{"issue":"10","key":"10.1016\/j.npep.2025.102565_bb0170","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1111\/nmo.12387","article-title":"Circular muscle contraction in the mice rectum plays a key role in morphine-induced constipation","volume":"26","author":"Ono","year":"2014","journal-title":"Neurogastroenterol. Motil."},{"issue":"3","key":"10.1016\/j.npep.2025.102565_bb0175","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1053\/j.gastro.2011.05.042","article-title":"Localization and regulation of fluorescently labeled delta opioid receptor, expressed in enteric neurons of mice","volume":"141","author":"Poole","year":"2011","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.npep.2025.102565_bb0180","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1001\/jamadermatol.2019.2610","article-title":"Incidence of long-term opioid use among opioid-naive patients with hidradenitis suppurativa in the United States","volume":"155","author":"Reddy","year":"2019","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.npep.2025.102565_bb0185","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev-med-062613-093100","article-title":"Opioid receptors","volume":"67","author":"Stein","year":"2016","journal-title":"Annu. Rev. Med."},{"issue":"1","key":"10.1016\/j.npep.2025.102565_bb0190","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/AAP.0000000000000341","article-title":"Efficacy and safety of methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain","volume":"41","author":"Viscusi","year":"2016","journal-title":"Reg. Anesth. Pain Med."},{"issue":"5","key":"10.1016\/j.npep.2025.102565_bb0195","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1476-5381.2012.02068.x","article-title":"Modulation of gastrointestinal function by MuDelta, a mixed \u03bc opioid receptor agonist\/ \u03bc opioid receptor antagonist","volume":"167","author":"Wade","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.npep.2025.102565_bb0200","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.neuropharm.2015.06.010","article-title":"Endomorphin-1 analogues (MELs) penetrate the blood-brain barrier and exhibit good analgesic effects with minimal side effects","volume":"97","author":"Wang","year":"2015","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.npep.2025.102565_bb0205","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13848","article-title":"Central and peripheral modulation of gastrointestinal transit in mice by DN-9, a multifunctional opioid\/NPFF receptor agonist","volume":"32","author":"Xu","year":"2020","journal-title":"Neurogastroenterol. Motil."},{"issue":"18","key":"10.1016\/j.npep.2025.102565_bb0210","doi-asserted-by":"crossref","first-page":"13394","DOI":"10.1021\/acs.jmedchem.1c00694","article-title":"Development of multifunctional and orally active cyclic peptide agonists of opioid\/neuropeptide FF receptors that produce potent, long-lasting, and peripherally restricted antinociception with diminished side effects","volume":"64","author":"Zhang","year":"2021","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.npep.2025.102565_bb0215","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1021\/acs.jmedchem.3c01347","article-title":"Structure-activity relationships of a novel cyclic hexapeptide that exhibits multifunctional opioid agonism and produces potent antinociceptive activity","volume":"67","author":"Zhang","year":"2024","journal-title":"J. Med. Chem."}],"container-title":["Neuropeptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417925000654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417925000654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:37:07Z","timestamp":1780634227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143417925000654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":43,"alternative-id":["S0143417925000654"],"URL":"https:\/\/doi.org\/10.1016\/j.npep.2025.102565","relation":{},"ISSN":["0143-4179"],"issn-type":[{"value":"0143-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibitory modulation of gastrointestinal motility in mice by Tyr-c[D-Lys-Gly-p-F-Phe-Asp]-D-Pro-NH2, a novel cyclic hexapeptide with multifunctional opioid agonism","name":"articletitle","label":"Article Title"},{"value":"Neuropeptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.npep.2025.102565","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102565"}}