{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:57:27Z","timestamp":1770483447942,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,31]],"date-time":"2016-12-31T00:00:00Z","timestamp":1483142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurolog\u00eda"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.nrl.2014.12.015","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T05:39:32Z","timestamp":1425015572000},"page":"92-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Esclerosis m\u00faltiple y embarazo: estudio unic\u00e9ntrico prospectivo y comparativo"],"prefix":"10.1016","volume":"32","author":[{"given":"J.P.","family":"Cuello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Mart\u00ednez Gin\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Martin Barriga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"de Andr\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nrl.2014.12.015_bib0180","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1055\/s-2007-991127","article-title":"Pregnancy and multiple sclerosis","volume":"27","author":"Houtchens","year":"2007","journal-title":"Semin Neurol"},{"key":"10.1016\/j.nrl.2014.12.015_bib0185","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"Compston","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.nrl.2014.12.015_bib0190","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S1474-4422(08)70042-5","article-title":"Environmental factors and multiple sclerosis","volume":"7","author":"Ebers","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.nrl.2014.12.015_bib0195","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/ana.21141","article-title":"Environmental risk factors for multiple sclerosis Part II: Noninfectious factors","volume":"61","author":"Ascherio","year":"2007","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nrl.2014.12.015_bib0200","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1136\/jnnp.2011.240432","article-title":"Latitude is significantly associated with the prevalence of multiple sclerosis: A meta-analysis","volume":"82","author":"Simpson","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.nrl.2014.12.015_bib0205","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1212\/01.wnl.0000316802.35974.34","article-title":"Temporal trends in the incidence of multiple sclerosis: A systematic review","volume":"71","author":"Alonso","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.nrl.2014.12.015_bib0210","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1056\/NEJM199807303390501","article-title":"Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in Multiple Sclerosis Group","volume":"339","author":"Confavreux","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nrl.2014.12.015_bib0215","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/j.1471-0528.2011.02931.x","article-title":"What can we really tell women with multiple sclerosis regarding pregnancy? A systematic review and meta-analysis of the literature","volume":"118","author":"Finkelsztejn","year":"2011","journal-title":"BJOG"},{"key":"10.1016\/j.nrl.2014.12.015_bib0220","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1177\/1352458507077896","article-title":"Pregnancy in multiple sclerosis patients treated with immunomodulators prior to or during part of the pregnancy: A descriptive study in the Spanish population","volume":"13","author":"De Las Heras","year":"2007","journal-title":"Mult Scler"},{"key":"10.1016\/j.nrl.2014.12.015_bib0225","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1212\/WNL.0b013e3182698c64","article-title":"Disease-modifying drugs for multiple sclerosis in pregnancy: A systematic review","volume":"79","author":"Lu","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.nrl.2014.12.015_bib0230","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.nrl.2013.04.009","article-title":"Workload of on-call emergency room neurologists in a Spanish tertiary care centre. A one-year prospective study","volume":"29","author":"Rodr\u00edguez Cruz","year":"2014","journal-title":"Neurologia"},{"key":"10.1016\/j.nrl.2014.12.015_bib0235","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria","volume":"69","author":"Polman","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nrl.2014.12.015_bib0240","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"10.1016\/j.nrl.2014.12.015_bib0245","doi-asserted-by":"crossref","first-page":"J97","DOI":"10.1016\/j.jaut.2011.08.001","article-title":"Antigenic challenge in the etiology of autoimmune disease in women","volume":"38","author":"Rogers","year":"2012","journal-title":"J Autoimmun"},{"key":"10.1016\/j.nrl.2014.12.015_bib0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2042-6410-2-1","article-title":"Sex differences in autoimmune diseases","volume":"2","author":"Voskuhl","year":"2011","journal-title":"Biol Sex Differ"},{"key":"10.1016\/j.nrl.2014.12.015_bib0255","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jri.2012.10.005","article-title":"Pregnancy and multiple sclerosis: Feto-maternal immune cross talk and its implications for disease activity","volume":"97","author":"Patas","year":"2013","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.nrl.2014.12.015_bib0260","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.imlet.2004.09.004","article-title":"Pregnancy-induced expansion of regulatory T-lymphocytes may mediate protection to multiple sclerosis activity","volume":"96","author":"S\u00e1nchez-Ram\u00f3n","year":"2005","journal-title":"Immunol Lett"},{"key":"10.1016\/j.nrl.2014.12.015_bib0265","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2362.2010.02414.x","article-title":"Estradiol-dependent perforin expression by human regulatory T-cells","volume":"41","author":"Valor","year":"2011","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.nrl.2014.12.015_bib0270","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1001\/archneur.62.9.1362","article-title":"Recent use of oral contraceptives and the risk of multiple sclerosis","volume":"62","author":"Alonso","year":"2005","journal-title":"Arch Neurol"},{"key":"10.1016\/j.nrl.2014.12.015_bib0275","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1212\/WNL.0b013e31824c4648","article-title":"Offspring number, pregnancy, and risk of a first clinical demyelinating event: The AusImmune Study","volume":"78","author":"Ponsonby","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.nrl.2014.12.015_bib0280","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1212\/WNL.55.6.848","article-title":"Oral contraceptives and the incidence of multiple sclerosis","volume":"55","author":"Hern\u00e1n","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.nrl.2014.12.015_bib0285","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1111\/j.1471-0528.1998.tb10008.x","article-title":"The influence of oral contraceptives on the risk of multiple sclerosis","volume":"105","author":"Thorogood","year":"1998","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.nrl.2014.12.015_bib0290","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000177937","article-title":"Increase in relapse rate during assisted reproduction technique in patients with multiple sclerosis","volume":"61","author":"Hellwig","year":"2009","journal-title":"Eur Neurol"},{"key":"10.1016\/j.nrl.2014.12.015_bib0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2013.02.001","article-title":"Artificial reproductive techniques in multiple sclerosis","author":"Hellwig","year":"2013","journal-title":"Clin Immunol"},{"key":"10.1016\/j.nrl.2014.12.015_bib0300","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/jnnp-2012-302235","article-title":"Increased risk of multiple sclerosis relapse after in vitro fertilisation","volume":"83","author":"Michel","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.nrl.2014.12.015_bib0305","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/brain\/awh152","article-title":"Pregnancy and multiple sclerosis (the PRIMS study): Clinical predictors of post-partum relapse","volume":"127","author":"Vukusic","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.nrl.2014.12.015_bib0310","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1136\/jnnp-2012-302848","article-title":"Term pregnancies and the clinical characteristics of multiple sclerosis: A population based study","volume":"83","author":"Ramagopalan","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.nrl.2014.12.015_bib0315","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1001\/archneur.1994.00540230058013","article-title":"Pregnancy and multiple sclerosis. A prospective study","volume":"51","author":"Sadovnick","year":"1994","journal-title":"Arch Neurol"},{"key":"10.1016\/j.nrl.2014.12.015_bib0320","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1177\/1352458513503054","article-title":"One can prevent post-partum MS relapses by exclusive breast feeding: No","volume":"19","author":"Vukusic","year":"2013","journal-title":"Mult Scler"},{"key":"10.1016\/j.nrl.2014.12.015_bib0325","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.clineuro.2012.04.024","article-title":"The effects of long-term exposure to disease-modifying drugs during pregnancy in multiple sclerosis","volume":"115","author":"Fragoso","year":"2013","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.nrl.2014.12.015_bib0330","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1191\/1352458504ms1079sr","article-title":"Intravenous corticosteroids in the postpartum period for reduction of acute exacerbations in multiple sclerosis","volume":"10","author":"De Seze","year":"2004","journal-title":"Mult Scler"},{"key":"10.1016\/j.nrl.2014.12.015_bib0335","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0083-6729(00)59008-6","article-title":"Glucocorticoid-regulated gene expression during cutaneous wound repair","volume":"59","author":"Beer","year":"2000","journal-title":"Vitam Horm"},{"key":"10.1016\/j.nrl.2014.12.015_bib0340","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/aas.12380","article-title":"Adverse effects of perioperative paracetamol, NSAIDs, glucocorticoids, gabapentinoids and their combinations: A topical review","volume":"58","author":"Mathiesen","year":"2014","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.nrl.2014.12.015_bib0345","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s00415-004-0495-z","article-title":"Effect of intravenous immunoglobulin treatment on pregnancy and postpartum-related relapses in multiple sclerosis","volume":"251","author":"Achiron","year":"2004","journal-title":"J Neurol"},{"key":"10.1016\/j.nrl.2014.12.015_bib0350","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/1756285608100416","article-title":"Immunomodulation and postpartum relapses in patients with multiple sclerosis","volume":"2","author":"Hellwig","year":"2009","journal-title":"Ther Adv Neurol Disord"}],"container-title":["Neurolog\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0213485315000146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0213485315000146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T20:27:42Z","timestamp":1537820862000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0213485315000146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0213485315000146"],"URL":"https:\/\/doi.org\/10.1016\/j.nrl.2014.12.015","relation":{},"ISSN":["0213-4853"],"issn-type":[{"value":"0213-4853","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Esclerosis m\u00faltiple y embarazo: estudio unic\u00e9ntrico prospectivo y comparativo","name":"articletitle","label":"Article Title"},{"value":"Neurolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nrl.2014.12.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 Sociedad Espa\u00f1ola de Neurolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}